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MSTRALTVLAVDDEAPALDELAYLLGRNPDVAEVLTASDATSALRELNRHTIDAVFLDINMPGLSGIELA GVLTNFAHRPAVVFVTAHDDKAVAAFDVGAVDYLLKPIRQNRLDEAVRRVGAAPSPTTETPADDQDSAVI PAELGGITHLVPRDSIGWVEAEGDYARLHSATGAHLVRIPLSTLETRWRDHGFQRIHRSYLVSLKQVTGL RTADGAVLVRLRANGASPAVELPVSRRQARELRDRLVRDPMRNLKPTGADD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5159 | - | - | 100% (261) | DNA-binding response regulator, putative |
| M. smegmatis MC2 155 | MSMEG_0937 | regX3 | 9e-12 | 33.56% (146) | DNA-binding response regulator RegX3 |
| M. smegmatis MC2 155 | MSMEG_0994 | resD | 2e-10 | 35.38% (130) | DNA-binding response regulator ResD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1055c | kdpE | 8e-12 | 34.18% (158) | transcriptional regulatory protein KdpE |
| M. gilvum PYR-GCK | Mflv_2143 | - | 1e-119 | 80.53% (262) | response regulator receiver protein |
| M. tuberculosis H37Rv | Rv1027c | kdpE | 8e-12 | 34.18% (158) | transcriptional regulatory protein KdpE |
| M. leprae Br4923 | MLBr_02123 | - | 6e-11 | 35.88% (131) | two-component response regulator |
| M. abscessus ATCC 19977 | MAB_0956c | - | 4e-12 | 38.76% (129) | transcriptional regulatory protein PrrA |
| M. marinum M | MMAR_0816 | regX3 | 3e-11 | 37.07% (116) | two-component sensory transduction protein RegX3 |
| M. avium 104 | MAV_1169 | - | 7e-12 | 35.26% (156) | KDP operon transcriptional regulatory protein KdpE |
| M. thermoresistible (build 8) | TH_4312 | - | 2e-11 | 31.97% (147) | PUTATIVE two component transcriptional regulator, winged helix |
| M. ulcerans Agy99 | MUL_4560 | regX3 | 2e-11 | 37.07% (116) | two component sensory transduction protein RegX3 |
| M. vanbaalenii PYR-1 | Mvan_4560 | - | 1e-120 | 81.89% (265) | response regulator receiver protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0816|M.marinum_M ------MTSVLIVEDEESLADPLAFLLRKEG--FEATVVTDGPAALAEFD
MUL_4560|M.ulcerans_Agy99 ------MTSVLIVEDEESLADPLAFLLRKEG--FEATVVTDGPAALAEFD
TH_4312|M.thermoresistible__bu ------MTSVLIVEDEESLADPLAFLLRKEG--FETTIVTDGPSALAEFE
Mb1055c|M.bovis_AF2122/97 ------MTLVLVIDDEPQILRALRINLTVRG--YQVITASTGAGALRAAA
Rv1027c|M.tuberculosis_H37Rv ------MTLVLVIDDEPQILRALRINLTVRG--YQVITASTGAGALRAAA
MAV_1169|M.avium_104 ------MTRVLVIDDEPQILRALRINLSVRG--YEVVTASTGAGALRAAA
MLBr_02123|M.leprae_Br4923 MDTGVSSPRVLVVDDDSDVLASLERGLRLSG--FEVSTAIDGAEALRNAT
MAB_0956c|M.abscessus_ATCC_199 MVDGQGSPRVLVVDDDADVLASLERGLRLSG--FEVNTASDGAEALRCAT
Mflv_2143|M.gilvum_PYR-GCK ---MTKPLTVLAVDDEVPALDELAYLLDRHPCIAEVFRAGDATSALRELN
Mvan_4560|M.vanbaalenii_PYR-1 ---MTRPLTVLAVDDEAPALDELAYLLGKHPCVAEVFRAGDATSALRELN
MSMEG_5159|M.smegmatis_MC2_155 --MSTRALTVLAVDDEAPALDELAYLLGRNPDVAEVLTASDATSALRELN
** ::*: * * :. . .. **
MMAR_0816|M.marinum_M RSGADIVLLDLMLPGMSGTDVCKQLRARSS-VPVIMVTARDSEIDKVVGL
MUL_4560|M.ulcerans_Agy99 RSGADIVLLDLMLPGMSGTDVCKQLRARSS-VPVIMVTARDSEIDKVVGL
TH_4312|M.thermoresistible__bu RSGADIILLDLMLPGMSGTDVCRRLRAKSK-VPVIMVTARDSEIDKVVGL
Mb1055c|M.bovis_AF2122/97 EHPPDVVILDLGLPDMSGIDVLGGLRGWLT-APVIVLSARTDSSDKVQAL
Rv1027c|M.tuberculosis_H37Rv EHPPDVVILDLGLPDMSGIDVLGGLRGWLT-APVIVLSARTDSSDKVQAL
MAV_1169|M.avium_104 EHKPDVVILDLGLPDISGIDVLAGLRGWLT-APVIVLSARTDSSDKVEAL
MLBr_02123|M.leprae_Br4923 ETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDRVAGL
MAB_0956c|M.abscessus_ATCC_199 EHRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARTSVDDRVAGL
Mflv_2143|M.gilvum_PYR-GCK LRPIDAVFLDINMPGLSGIELAGVLANYAQRPAIVFVTAHDD--KAVAAF
Mvan_4560|M.vanbaalenii_PYR-1 RRTIDAVFLDINMPGLSGIELAGVLTNYTQRPAIVFVTAHDD--KAVAAF
MSMEG_5159|M.smegmatis_MC2_155 RHTIDAVFLDINMPGLSGIELAGVLTNFAHRPAVVFVTAHDD--KAVAAF
* :.**: :* :.* .: * .: .::*: . . * .:
MMAR_0816|M.marinum_M ELGADDYVTKPYSARELIARIRAVLRRGGDDD-----SEVSDGVLESGPV
MUL_4560|M.ulcerans_Agy99 ELGADDYVTKPYSARELIARIRAVLRRGGDDD-----SEVSDGVLESGPV
TH_4312|M.thermoresistible__bu ELGADDYVTKPYSARELIARIRAVLRRGSDLDG----ADVDDSVLEAGPV
Mb1055c|M.bovis_AF2122/97 DAGADDYVTKPFGMDEFLARLRAAVRRNTAAA------ELEQPVIETDSF
Rv1027c|M.tuberculosis_H37Rv DAGADDYVTKPFGMDEFLARLRAAVRRNTAAA------ELEQPVIETDSF
MAV_1169|M.avium_104 DAGADDYVTKPFGMDEFLARLRAAVRRNTAAS------EMEQPVVETESF
MLBr_02123|M.leprae_Br4923 EAGADDYLVKPFVLAELVARVKALLRRRGATA------TSSSETIAVGPL
MAB_0956c|M.abscessus_ATCC_199 EAGADDYLTKPFVLAELVARVKALLRRRGAVA------TSSTETITVGPL
Mflv_2143|M.gilvum_PYR-GCK DVGAVDYLLKPIREERLDEAVRRAAQAQAGPPPDD---ETPAPEPESDVV
Mvan_4560|M.vanbaalenii_PYR-1 DVGAVDYLLKPIREDRLDEAVRRAATAHPATPAAASRTETGAAAPDSDVI
MSMEG_5159|M.smegmatis_MC2_155 DVGAVDYLLKPIRQNRLDEAVRRVGAAPSPT------TETPADDQDSAVI
: ** **: ** .: :: .
MMAR_0816|M.marinum_M RMDVERHVVSVNGDAITLPLKEFDLLEYLMRNSGRVLTR--GQLIDRVWG
MUL_4560|M.ulcerans_Agy99 RMDVERHVVSVNGDAITLPLKEFDLLEYLMRNSGRVLTR--GQLIDRVWG
TH_4312|M.thermoresistible__bu RMDVDRHVVTVRGEPITLPLKEFELLEYLLRNSGRVLTR--GQLIDRVWG
Mb1055c|M.bovis_AF2122/97 TVDLAGKKVIKDGAEVHLTPTEWGMLEMLARNRGKLVGR--GELLKEVWG
Rv1027c|M.tuberculosis_H37Rv TVDLAGKKVIKDGAEVHLTPTEWGMLEMLARNRGKLVGR--GELLKEVWG
MAV_1169|M.avium_104 TVDLAAKKVTKNGSEVHLTPTEWGMLEVLVRNRGKLVGR--EELLKEVWG
MLBr_02123|M.leprae_Br4923 EVDIPGRRARVNGVDVDLTKREFDLLAVLAEHKTTVLSR--AQLLELVWG
MAB_0956c|M.abscessus_ATCC_199 EVEIPGRRARINGVEVDLTKREFDLLAVLAEHKTAVLSR--AQLLELVWG
Mflv_2143|M.gilvum_PYR-GCK PAELGGVTHLIPRNSIGWIEAEGDYARLHSASGSHLVRIPLSTLETRWRE
Mvan_4560|M.vanbaalenii_PYR-1 PAELGGVTHLIPRDSIGWVEAEGDYARLHSASGSHLVRIPLSTLETRWRD
MSMEG_5159|M.smegmatis_MC2_155 PAELGGITHLVPRDSIGWVEAEGDYARLHSATGAHLVRIPLSTLETRWRD
:: : * :: *
MMAR_0816|M.marinum_M ADYVGDTKTLDVHVKRLR----------SKIEADPANPVHLVTVRG-LGY
MUL_4560|M.ulcerans_Agy99 ADYVGDTKTLDVHVKRLR----------SKIEADPANPVHLVTVRG-LGY
TH_4312|M.thermoresistible__bu ADYVGDTKTLDVHVKRLR----------SKIEEDPANPVHLVTVRG-LGY
Mb1055c|M.bovis_AF2122/97 PAYATETHYLRVYLAQLR----------RKLEDDPSHPKHLLTESG-MGY
Rv1027c|M.tuberculosis_H37Rv PAYATETHYLRVYLAQLR----------RKLEDDPSHPKHLLTESG-MGY
MAV_1169|M.avium_104 PAYATETHYLRVYLAQLR----------RKLENDPSHPKHLLTESG-MGY
MLBr_02123|M.leprae_Br4923 YDFAADTNVVDVFIGYLR----------RKLEAN-SGPRLLHTVRG-VGF
MAB_0956c|M.abscessus_ATCC_199 YDFAADTNVVDVFIGYLR----------RKLEAG-GAPRLLHTVRG-VGF
Mflv_2143|M.gilvum_PYR-GCK HGFQRVHRSYLVALKLVTGLRTSDGAVLVRLRANGGSPAVELPVSRRQAR
Mvan_4560|M.vanbaalenii_PYR-1 HGFQRVHRSYLVALRLVTGLRTTDGAVLVRLRANGSSPAVELPVSRRQAR
MSMEG_5159|M.smegmatis_MC2_155 HGFQRIHRSYLVSLKQVTGLRTADGAVLVRLRANGASPAVELPVSRRQAR
: . * : : ::. . . * . .
MMAR_0816|M.marinum_M KLEG--------------------
MUL_4560|M.ulcerans_Agy99 KLEG--------------------
TH_4312|M.thermoresistible__bu KLEG--------------------
Mb1055c|M.bovis_AF2122/97 RFEA--------------------
Rv1027c|M.tuberculosis_H37Rv RFEA--------------------
MAV_1169|M.avium_104 RFEA--------------------
MLBr_02123|M.leprae_Br4923 VLRMQ-------------------
MAB_0956c|M.abscessus_ATCC_199 VLRSQ-------------------
Mflv_2143|M.gilvum_PYR-GCK ELRDRLVRSPMRNLRPAGGSDDQ-
Mvan_4560|M.vanbaalenii_PYR-1 ELRDRVVRNPMRSLRPAGSTDDQQ
MSMEG_5159|M.smegmatis_MC2_155 ELRDRLVRDPMRNLKPTGADD---
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