For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VTRPLTVLAVDDEAPALDELAYLLGKHPCVAEVFRAGDATSALRELNRRTIDAVFLDINMPGLSGIELAG VLTNYTQRPAIVFVTAHDDKAVAAFDVGAVDYLLKPIREDRLDEAVRRAATAHPATPAAASRTETGAAAP DSDVIPAELGGVTHLIPRDSIGWVEAEGDYARLHSASGSHLVRIPLSTLETRWRDHGFQRVHRSYLVALR LVTGLRTTDGAVLVRLRANGSSPAVELPVSRRQARELRDRVVRNPMRSLRPAGSTDDQQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4560 | - | - | 100% (269) | response regulator receiver protein |
| M. vanbaalenii PYR-1 | Mvan_0831 | - | 4e-11 | 36.84% (114) | two component transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4763 | - | 6e-11 | 35.62% (160) | two component transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0501 | regX3 | 2e-10 | 36.84% (114) | two component sensory transduction protein RegX3 |
| M. gilvum PYR-GCK | Mflv_2143 | - | 1e-129 | 86.19% (268) | response regulator receiver protein |
| M. tuberculosis H37Rv | Rv0491 | regX3 | 2e-10 | 36.84% (114) | two component sensory transduction protein RegX3 |
| M. leprae Br4923 | MLBr_02123 | - | 7e-10 | 34.44% (151) | two-component response regulator |
| M. abscessus ATCC 19977 | MAB_4047c | - | 4e-11 | 31.85% (157) | sensory transduction protein RegX3 |
| M. marinum M | MMAR_0635 | kdpE | 1e-10 | 38.02% (121) | transcriptional regulatory protein KdpE |
| M. avium 104 | MAV_4660 | - | 1e-10 | 36.84% (114) | DNA-binding response regulator |
| M. smegmatis MC2 155 | MSMEG_5159 | - | 1e-120 | 81.89% (265) | DNA-binding response regulator, putative |
| M. thermoresistible (build 8) | TH_4312 | - | 6e-10 | 34.21% (114) | PUTATIVE two component transcriptional regulator, winged helix |
| M. ulcerans Agy99 | MUL_4560 | regX3 | 2e-10 | 36.84% (114) | two component sensory transduction protein RegX3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0501|M.bovis_AF2122/97 ------MTSVLIVEDEESLADPLAFLLRKEG--FEATVVTDGPAALAEFD
Rv0491|M.tuberculosis_H37Rv ------MTSVLIVEDEESLADPLAFLLRKEG--FEATVVTDGPAALAEFD
MAV_4660|M.avium_104 ------MTSVLIVEDEESLADPLAFLLRKEG--FEATVVTDGSAALAEFD
MUL_4560|M.ulcerans_Agy99 ------MTSVLIVEDEESLADPLAFLLRKEG--FEATVVTDGPAALAEFD
MAB_4047c|M.abscessus_ATCC_199 ------MTSVLIVEDEDSLADPLAFLLRKEG--FEATIVNDGPSALAEFE
TH_4312|M.thermoresistible__bu ------MTSVLIVEDEESLADPLAFLLRKEG--FETTIVTDGPSALAEFE
MMAR_0635|M.marinum_M ------MTRVLVIDDEPQILRALRINFSVRG--YDVVTAATGAAALRAAA
MLBr_02123|M.leprae_Br4923 MDTGVSSPRVLVVDDDSDVLASLERGLRLSG--FEVSTAIDGAEALRNAT
Mvan_4560|M.vanbaalenii_PYR-1 ---MTRPLTVLAVDDEAPALDELAYLLGKHPCVAEVFRAGDATSALRELN
Mflv_2143|M.gilvum_PYR-GCK ---MTKPLTVLAVDDEVPALDELAYLLDRHPCIAEVFRAGDATSALRELN
MSMEG_5159|M.smegmatis_MC2_155 --MSTRALTVLAVDDEAPALDELAYLLGRNPDVAEVLTASDATSALRELN
** ::*: * : :. . .. **
Mb0501|M.bovis_AF2122/97 RAGADIVLLDLMLPGMSGTDVCKQLRARS-SVPVIMVTARDSEIDKVVGL
Rv0491|M.tuberculosis_H37Rv RAGADIVLLDLMLPGMSGTDVCKQLRARS-SVPVIMVTARDSEIDKVVGL
MAV_4660|M.avium_104 RAGADIVLLDLMLPGMSGTDVCKQLRARS-SVPVIMVTARDSEIDKVVGL
MUL_4560|M.ulcerans_Agy99 RSGADIVLLDLMLPGMSGTDVCKQLRARS-SVPVIMVTARDSEIDKVVGL
MAB_4047c|M.abscessus_ATCC_199 RAGADIVLLDLMLPGMSGTDVCKQLRAKS-SVPVIMVTARDSEIDKVVGL
TH_4312|M.thermoresistible__bu RSGADIILLDLMLPGMSGTDVCRRLRAKS-KVPVIMVTARDSEIDKVVGL
MMAR_0635|M.marinum_M EQRPDVVILDLGLPDMSGIEVLAGLRGWF-SAPVIVLSARSDSSDKVQAL
MLBr_02123|M.leprae_Br4923 ETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDRVAGL
Mvan_4560|M.vanbaalenii_PYR-1 RRTIDAVFLDINMPGLSGIELAGVLTNYTQRPAIVFVTAHDD--KAVAAF
Mflv_2143|M.gilvum_PYR-GCK LRPIDAVFLDINMPGLSGIELAGVLANYAQRPAIVFVTAHDD--KAVAAF
MSMEG_5159|M.smegmatis_MC2_155 RHTIDAVFLDINMPGLSGIELAGVLTNFAHRPAVVFVTAHDD--KAVAAF
* :.**: :* :.* .: * .: .::*:.. . * .:
Mb0501|M.bovis_AF2122/97 ELGADDYVTKPYSARELIARIRAVLRRGGDDDSEMS-------DGVLESG
Rv0491|M.tuberculosis_H37Rv ELGADDYVTKPYSARELIARIRAVLRRGGDDDSEMS-------DGVLESG
MAV_4660|M.avium_104 ELGADDYVTKPYSARELIARIRAVLRRGGDDDSEIS-------DGVLESG
MUL_4560|M.ulcerans_Agy99 ELGADDYVTKPYSARELIARIRAVLRRGGDDDSEVS-------DGVLESG
MAB_4047c|M.abscessus_ATCC_199 ELGADDYVTKPYSARELIARIRAVLRRGSDSEETASG------DGVLEAG
TH_4312|M.thermoresistible__bu ELGADDYVTKPYSARELIARIRAVLRRGSDLDGADVD------DSVLEAG
MMAR_0635|M.marinum_M DAGADDYVTKPFGMDELLARLRAAVRRAATATDTDQ--------PVIETS
MLBr_02123|M.leprae_Br4923 EAGADDYLVKPFVLAELVARVKALLRRRGATATSSS--------ETIAVG
Mvan_4560|M.vanbaalenii_PYR-1 DVGAVDYLLKPIREDRLDEAVRRAATAHPATPAAASRTETGAAAPDSDVI
Mflv_2143|M.gilvum_PYR-GCK DVGAVDYLLKPIREERLDEAVRRAAQAQAGPPPDD---ETPAPEPESDVV
MSMEG_5159|M.smegmatis_MC2_155 DVGAVDYLLKPIRQNRLDEAVRRVG---AAPSPTT---ETPADDQDSAVI
: ** **: ** .* ::
Mb0501|M.bovis_AF2122/97 PVRMDVERHVVSVNGDTITLPLKEFDLLEYLMRNSGRVLTRGQLIDRVWG
Rv0491|M.tuberculosis_H37Rv PVRMDVERHVVSVNGDTITLPLKEFDLLEYLMRNSGRVLTRGQLIDRVWG
MAV_4660|M.avium_104 PVRMDVERHVVSVNGDTITLPLKEFDLLEYLMRNSGRVLTRGQLIDRVWG
MUL_4560|M.ulcerans_Agy99 PVRMDVERHVVSVNGDAITLPLKEFDLLEYLMRNSGRVLTRGQLIDRVWG
MAB_4047c|M.abscessus_ATCC_199 PVRMDVDRHTVSVNGEAITLPLKEFDLLEYLIRNSGRVLTRGQLIDRVWG
TH_4312|M.thermoresistible__bu PVRMDVDRHVVTVRGEPITLPLKEFELLEYLLRNSGRVLTRGQLIDRVWG
MMAR_0635|M.marinum_M SFTVDLATKKVIKNGSEVHLTPTEWGMLEMLVRNRGKLVGREELLKEVWG
MLBr_02123|M.leprae_Br4923 PLEVDIPGRRARVNGVDVDLTKREFDLLAVLAEHKTTVLSRAQLLELVWG
Mvan_4560|M.vanbaalenii_PYR-1 PAELGGVTHLIPRDSIGWVEAEGDYARLHSASGSHLVRIPLSTLETRWRD
Mflv_2143|M.gilvum_PYR-GCK PAELGGVTHLIPRNSIGWIEAEGDYARLHSASGSHLVRIPLSTLETRWRE
MSMEG_5159|M.smegmatis_MC2_155 PAELGGITHLVPRDSIGWVEAEGDYARLHSATGAHLVRIPLSTLETRWRD
. :. : . . :: * : *
Mb0501|M.bovis_AF2122/97 ADYVGDTKTLDVHVKRLR----------SKIEADPANPVHLVTVRG-LGY
Rv0491|M.tuberculosis_H37Rv ADYVGDTKTLDVHVKRLR----------SKIEADPANPVHLVTVRG-LGY
MAV_4660|M.avium_104 ADYVGDTKTLDVHVKRLR----------SKIEADPANPVHLVTVRG-LGY
MUL_4560|M.ulcerans_Agy99 ADYVGDTKTLDVHVKRLR----------SKIEADPANPVHLVTVRG-LGY
MAB_4047c|M.abscessus_ATCC_199 ADYVGDTKTLDVHVKRLR----------SKIEADPANPVHLVTVRG-LGY
TH_4312|M.thermoresistible__bu ADYVGDTKTLDVHVKRLR----------SKIEEDPANPVHLVTVRG-LGY
MMAR_0635|M.marinum_M PAYAKETHYLRVYLAQLR----------RKLEDDPAHPRHLLTEAG-MGY
MLBr_02123|M.leprae_Br4923 YDFAADTNVVDVFIGYLR----------RKLEAN-SGPRLLHTVRG-VGF
Mvan_4560|M.vanbaalenii_PYR-1 HGFQRVHRSYLVALRLVTGLRTTDGAVLVRLRANGSSPAVELPVSRRQAR
Mflv_2143|M.gilvum_PYR-GCK HGFQRVHRSYLVALKLVTGLRTSDGAVLVRLRANGGSPAVELPVSRRQAR
MSMEG_5159|M.smegmatis_MC2_155 HGFQRIHRSYLVSLKQVTGLRTADGAVLVRLRANGASPAVELPVSRRQAR
: . * : : ::. : . * . .
Mb0501|M.bovis_AF2122/97 KLEG--------------------
Rv0491|M.tuberculosis_H37Rv KLEG--------------------
MAV_4660|M.avium_104 KLEG--------------------
MUL_4560|M.ulcerans_Agy99 KLEG--------------------
MAB_4047c|M.abscessus_ATCC_199 KLEG--------------------
TH_4312|M.thermoresistible__bu KLEG--------------------
MMAR_0635|M.marinum_M RFDG--------------------
MLBr_02123|M.leprae_Br4923 VLRMQ-------------------
Mvan_4560|M.vanbaalenii_PYR-1 ELRDRVVRNPMRSLRPAGSTDDQQ
Mflv_2143|M.gilvum_PYR-GCK ELRDRLVRSPMRNLRPAGGSDDQ-
MSMEG_5159|M.smegmatis_MC2_155 ELRDRLVRDPMRNLKPTGADD---
: