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TVALWVVVAAQTVGLIVLTVMLIVSRRSLSKARRAVGRRHGDDPGRRRRPPIGVAPLAVRTVMNTVHTAD AIVRKGIGGSVRSSIEDLAGWARIERPDLARVVSADGTVVLVFSDIEGSTELNASLGDRAWVKNLERHNT LIQRCVADHRGHVVKNQGDGFMIAFAEPADAIRSCCDVQRALARYPDR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1780 | - | - | 100% (189) | putative adenylate/guanylate cyclase |
| M. gilvum PYR-GCK | Mflv_2091 | - | 6e-34 | 44.81% (183) | putative adenylate/guanylate cyclase |
| M. gilvum PYR-GCK | Mflv_3535 | - | 2e-08 | 34.62% (78) | putative adenylate/guanylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1151c | - | 7e-29 | 52.00% (125) | hypothetical protein Mb1151c |
| M. tuberculosis H37Rv | Rv1120c | - | 2e-29 | 52.80% (125) | hypothetical protein Rv1120c |
| M. leprae Br4923 | MLBr_01399 | - | 2e-07 | 27.19% (114) | hypothetical protein MLBr_01399 |
| M. abscessus ATCC 19977 | MAB_2330 | - | 2e-06 | 26.29% (194) | putative purine cyclase-like protein |
| M. marinum M | MMAR_4340 | - | 3e-35 | 46.70% (182) | hypothetical protein MMAR_4340 |
| M. avium 104 | MAV_1250 | - | 4e-36 | 46.84% (190) | adenylate and guanylate cyclase catalytic domain-containing |
| M. smegmatis MC2 155 | MSMEG_3780 | - | 2e-07 | 35.71% (70) | adenylate and guanylate cyclase catalytic domain-containing |
| M. thermoresistible (build 8) | TH_1244 | - | 7e-40 | 48.15% (189) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_0150 | - | 4e-33 | 54.96% (131) | hypothetical protein MUL_0150 |
| M. vanbaalenii PYR-1 | Mvan_4613 | - | 4e-32 | 45.41% (185) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1151c|M.bovis_AF2122/97 --------------------------------------------------
Rv1120c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4340|M.marinum_M ----------------------------------------------MTDA
MUL_0150|M.ulcerans_Agy99 --------------------------------------------------
MAV_1250|M.avium_104 ----------------------------------------------MGDV
Mvan_4613|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1244|M.thermoresistible__bu --------------------VAARPLPLAVAAAPGSPIPRRVGQDGAVTQ
Mflv_1780|M.gilvum_PYR-GCK ----------------------------------------------MTVA
MLBr_01399|M.leprae_Br4923 --MPPSAKSTYP-------------GQVEGAPHDGTPSAPQEPDEDTVTV
MSMEG_3780|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2330|M.abscessus_ATCC_1997 MDVEPSGLDAEPDGEFDSGIRKRRRGRTRGPVRHDSAQVTDGIDTTADEV
Mb1151c|M.bovis_AF2122/97 --------------------------------------------------
Rv1120c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4340|M.marinum_M LHIAVYVLAGVAALEAAALIALWRLLARARQEN-----DELRQRADSRNW
MUL_0150|M.ulcerans_Agy99 ----------------------------------------MRQRADSRNW
MAV_1250|M.avium_104 LHVTVYILAGLAAVEAGALAVLWRRLVRSRAEL-----DELRQRTDARNW
Mvan_4613|M.vanbaalenii_PYR-1 --MALLVLAAVVVGLAVALAVQSRRLRTARQEA-----DELRRRLDTRQM
TH_1244|M.thermoresistible__bu IAIVVVALAGLALAEAVALAVLWGRLRRERRAA-----DELRRRLDTRTT
Mflv_1780|M.gilvum_PYR-GCK LWVVVAAQTVGLIVLTVMLIVSRRSLSKARRAVGRRHGDDPGRRRRPPIG
MLBr_01399|M.leprae_Br4923 PAPALIRRSSVSMP-NAAQWLHTTNRSPRLVAMVRRARRLLPGDPDFGDP
MSMEG_3780|M.smegmatis_MC2_155 -----------------------------MVAAVRRFRRALPGDPEFGDP
MAB_2330|M.abscessus_ATCC_1997 PSTESASRHFARASRTAGSWFRKMDRDPAVVAALRRARRSLPGDPYFGDP
Mb1151c|M.bovis_AF2122/97 MLSGGREAVKTVWQTANLVRKEGFGAAVRSSIEDPADWAEVERPDLARVT
Rv1120c|M.tuberculosis_H37Rv MLSGGREAVKTVWQTANLVRKEGFGAAVRSSIEDPADWAEVERPDLARVT
MMAR_4340|M.marinum_M LLTGGREAVKTVWQTANLMRKEGFGAAVRSSIEDLADWAEVERPDLARVT
MUL_0150|M.ulcerans_Agy99 LLTGGREAVKTVWQTANLMRKEGFGAAVRSSIEDLADWAEVERPDLARVT
MAV_1250|M.avium_104 LLAGGREAVKTVWNTANLVRKEGFGAAVRSSIEELADWAEVERPDLARVT
Mvan_4613|M.vanbaalenii_PYR-1 LVTGSTKAVKTVWQTANILRRDGFGAAVRSSIEELADWAEVERPDLARLA
TH_1244|M.thermoresistible__bu LMAGGREAVRTVWQTANILRTDGLGAAARSSIEDLADWAEVERPDLARLA
Mflv_1780|M.gilvum_PYR-GCK VAPLAVRTVMNTVHTADAIVRKGIGGSVRSSIEDLAGWARIERPDLARVV
MLBr_01399|M.leprae_Br4923 LSTAGEGGPRAAARAADRLLGDRGAASREVSLSVLQVWQALTEAIARRPV
MSMEG_3780|M.smegmatis_MC2_155 LSVAGDGGPRAAARVADRLL-ERDAASREVSLGALQVWQALTERVSGRPA
MAB_2330|M.abscessus_ATCC_1997 LSTSGFGGASAVARAADRLVTDRDTAVREFGFGALQIWQAFTEKVSKQPA
: . . ..*: : . . . .: * . . : .
Mb1151c|M.bovis_AF2122/97 -PDARVVILFSDIEESTALDERIGDRTWVKLIGAHDKLVHELVRRWSGHM
Rv1120c|M.tuberculosis_H37Rv -PDGRVVILFSDIEESTALDERIGDRTWVKLIGAHDKLVHELVRRWSGHM
MMAR_4340|M.marinum_M -PDGRVVILFSDIEESTALNERIGDRAWVKLIGAHDKMVHEFVHRHGGHV
MUL_0150|M.ulcerans_Agy99 -PDGRVVILFSDIEESTVLNERIGNRAWVKLIGAHDKMVHEFVHRHGGHV
MAV_1250|M.avium_104 -PDGRVVILFTDIEESTALNERIGDRAWVKLISSHDKLVSDLVRRQSGHV
Mvan_4613|M.vanbaalenii_PYR-1 -PNGRVAIMFSDIEESTALNERIGDRAFVRLLGRHDKPVRRHVDAHDGYV
TH_1244|M.thermoresistible__bu -ANGKVVILFSDIEGSTALNNRIGDRAWVRLIDRHSRLVRRFVKKHDGYV
Mflv_1780|M.gilvum_PYR-GCK SADGTVVLVFSDIEGSTELNASLGDRAWVKNLERHNTLIQRCVADHRGHV
MLBr_01399|M.leprae_Br4923 --NPEVTLVFTDLVGFSGWSLQAGDEATLALLRQVARAVESPLLDAGGHI
MSMEG_3780|M.smegmatis_MC2_155 --NREVTLVFTDLVGFSSWSLRAGDDATLRLLRRVAQVAEPPLLEAGGHI
MAB_2330|M.abscessus_ATCC_1997 --NREVTLVFTDLVGFSGWALEAGDEATLKLLRRVASVSEPPLLSAGGQV
: *.::*:*: : *: : : : : * :
Mb1151c|M.bovis_AF2122/97 VTSQGDGFMIAFARAEQAVRCGIDIQDALRNSAKRKRNQGIRVRIGTTWG
Rv1120c|M.tuberculosis_H37Rv VTSQGDGFMIAFARAEQAVRCGIDIQDALRNSAKRKRNQGIRVRIGTTWG
MMAR_4340|M.marinum_M VKSQGDGFMIAFARAEQAVRCGLDIQRALSREAKRKPRNGIRVRIGIHMG
MUL_0150|M.ulcerans_Agy99 VKSQGDGFMIAFARAEQAVRCGLDIQHALSREAKRKPRNGIRVRIGIHMG
MAV_1250|M.avium_104 VKSQGDGFMVAFARPEQAVRCGIELQRALRRNANRKRHEEIRVRIGIHMG
Mvan_4613|M.vanbaalenii_PYR-1 VKSQGDGFMVAFARPEQAVRCGLAIQHSLD-----KRPNGIRVRIGIHVG
TH_1244|M.thermoresistible__bu IKSQGDGFMVAFARPEQAVRCSVELQRALR-----KRPDRIRVRIGIHLG
Mflv_1780|M.gilvum_PYR-GCK VKNQGDGFMIAFAEPADAIRSCCDVQRALA-----RYPDR----------
MLBr_01399|M.leprae_Br4923 VKRMGDGIMAVFRDPSVAVQAVLAATEAMKSVEVGGYTP--RIRVGIHTG
MSMEG_3780|M.smegmatis_MC2_155 VKRMGDGMMAVFGDPATAVRAVLVALDAVKGIEVDGYTP--RMRVGIHTG
MAB_2330|M.abscessus_ATCC_1997 VKRMGDGIMAVFDDPVTALRAIIPARDALKNVEIQGYTP--VMRIGIHAG
:. ***:* .* . *::. ::
Mb1151c|M.bovis_AF2122/97 --ARCG------TVTICSAATSQ---------------------------
Rv1120c|M.tuberculosis_H37Rv --ARCG------TVTICSAATSQ---------------------------
MMAR_4340|M.marinum_M RSVRRGDDLFGRNVAMAARVAGQAGGGQILVSEPVRDAVRDCGDIR----
MUL_0150|M.ulcerans_Agy99 RSVRRGDDLFGRNVAMAARVAGQAVGGQILVSEPVRDAVRDCGDIR----
MAV_1250|M.avium_104 RSVRRGDDLFGRNVAMAARVAAQAAGGEILVSQPVRDALSRSDGIR----
Mvan_4613|M.vanbaalenii_PYR-1 KSVLRGDDLFGRNVAMAARVAAEADGGEVLVSSAVRDALTDADDIV----
TH_1244|M.thermoresistible__bu RSVRRGDDLFGRNVALAARVAGAAEGGEVLVSQAVRDALNSAGDAGSDEV
Mflv_1780|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_01399|M.leprae_Br4923 RPQRLAADWLGVDVNIAARVMERATKGGIMISGPTLDLIPQSDLKELGII
MSMEG_3780|M.smegmatis_MC2_155 RPQRIGSDWLGVDVNITARVMERAAKGGLMVSHATLAGIADGELAELGVT
MAB_2330|M.abscessus_ATCC_1997 TPQRIGSDWLGVDVNIAARVMESAAKGGLAISQPALAKVPLAFLDHMGLT
Mb1151c|M.bovis_AF2122/97 --------------------------------------------
Rv1120c|M.tuberculosis_H37Rv --------------------------------------------
MMAR_4340|M.marinum_M ----VDDGRDVELKGFSGSYRLFGVETAPECEPD----------
MUL_0150|M.ulcerans_Agy99 ----VDDGRDVELKGFSGSYRLFGVETAPECEPD----------
MAV_1250|M.avium_104 ----FDDGREVELKGFSGTYRLFAVLASPDPG------------
Mvan_4613|M.vanbaalenii_PYR-1 ----VDGERDAHLKGFSGSHTLYSVRSASASR------------
TH_1244|M.thermoresistible__bu AGFDVDDGREVSLKGFPGRHRLFAVRGQAGFRPRPRPE------
Mflv_1780|M.gilvum_PYR-GCK --------------------------------------------
MLBr_01399|M.leprae_Br4923 TRRVRKPMFTSKFTGIPPDMVIYRIKARRELTASDETAQTNSLT
MSMEG_3780|M.smegmatis_MC2_155 VKRERRQLFSARPDGVPEDLVMYRVRTPSRLPAARPREQEPPDA
MAB_2330|M.abscessus_ATCC_1997 PTPVRRPLFSSRPAGVPENMKMYLLETRRQLPAPGDDGRV----