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MPESDELNAVVDAAVEQVLLGGPRRYTRSQVSQLSGVPVERARTLWVALGFAAADSDDEVAFTDADVSAI RTFAALGSATAANQQSQIAAARTLGQAMARLAEWQADLLTREVGGRLAAEGDDASAESSANAATQTIATL TALQNYAWQRHLAAALHRANETGSTTRQLLVGFADMVGYTRLSRHLDPDELASLLETFETALTEAITTHG GWVIKNVGDEVMFAAASAAAGARIAVAMNTAITEAAQTIPDMPQIRVGLAYGQVLSRFGDLYGTVVNIAA RLTGVARPGTILLDDGAAAALGDDGEFSLRHLRGVRVKGFSRLGSHVLRARKR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4771 | - | - | 100% (333) | putative adenylate cyclase |
| M. abscessus ATCC 19977 | MAB_4523 | - | 3e-09 | 27.47% (182) | putative adenylate cyclase |
| M. abscessus ATCC 19977 | MAB_0490c | - | 3e-08 | 27.61% (163) | putative adenylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2235 | - | 3e-30 | 30.94% (307) | hypothetical protein Mb2235 |
| M. gilvum PYR-GCK | Mflv_2243 | - | 3e-27 | 30.99% (313) | putative adenylate/guanylate cyclase |
| M. tuberculosis H37Rv | Rv2212 | - | 3e-30 | 30.94% (307) | hypothetical protein Rv2212 |
| M. leprae Br4923 | MLBr_01399 | - | 6e-09 | 28.11% (185) | hypothetical protein MLBr_01399 |
| M. marinum M | MMAR_3257 | - | 9e-29 | 29.32% (307) | adenylate cyclase |
| M. avium 104 | MAV_1415 | - | 5e-25 | 27.33% (311) | chain A, Myco adenylyl cyclase, holoenzyme, inhibited state |
| M. smegmatis MC2 155 | MSMEG_4279 | - | 6e-30 | 29.32% (324) | adenylate and guanylate cyclase catalytic domain-containing |
| M. thermoresistible (build 8) | TH_1842 | - | 2e-25 | 29.35% (310) | ADENYLYL CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLATE CYCLASE) |
| M. ulcerans Agy99 | MUL_4940 | cyaA | 2e-21 | 25.76% (295) | adenylate cyclase, CyaA |
| M. vanbaalenii PYR-1 | Mvan_4452 | - | 5e-24 | 28.52% (305) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2235|M.bovis_AF2122/97 -----------------MYDSLDFDALEAAGIANPRERAGLLTYLDELGF
Rv2212|M.tuberculosis_H37Rv -----------------MYDSLDFDALEAAGIANPRERAGLLTYLDELGF
MMAR_3257|M.marinum_M --------------MSGSPDPLDFEALEAAGIANPRERADLIKYLDDLGF
MSMEG_4279|M.smegmatis_MC2_155 --------------------MVDFDALEAAGIADARRRAGLISYLDRLGF
Mflv_2243|M.gilvum_PYR-GCK --------------------METSGLLDGLEGAARAERAELIGWLLDRGV
Mvan_4452|M.vanbaalenii_PYR-1 --------------MAEDLDLETSELLDGLEGDARGERAELIRWLVGRGV
TH_1842|M.thermoresistible__bu --------------MADDVDIEASGLLDDLTGEAREQRAELIAWLIERGY
MAV_1415|M.avium_104 MTSHDGLPALYVDDVHDGDDRDIEDLLDGLQGTARTERAELVRWLLAQGI
MUL_4940|M.ulcerans_Agy99 --------------MAADVDIEASGLLDGLEGTARQDRAELIAWLLERGF
MAB_4771|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01399|M.leprae_Br4923 --------------------------------------------------
Mb2235|M.bovis_AF2122/97 TVEEMVQAERRGRLFGLAGDVLLWSGPPIYTLATAADELGLSADDVARAW
Rv2212|M.tuberculosis_H37Rv TVEEMVQAERRGRLFGLAGDVLLWSGPPIYTLATAADELGLSADDVARAW
MMAR_3257|M.marinum_M TLEEMAEAERRGRLFGLAGDVLQWPGPPIYTLTAAGEQLGLSADDIAHIW
MSMEG_4279|M.smegmatis_MC2_155 TAEEMVDAERRGRLFGLAGDRLQASGPAIHSLASAADELGLPVAEVERAW
Mflv_2243|M.gilvum_PYR-GCK AVDEIRG---NPAPMLLASRRVIGDDGEYVSARQAADRAGVELELFERIQ
Mvan_4452|M.vanbaalenii_PYR-1 GIDQIRG---NPAPMLLASRRVIGDDGLYVSARQAAANAGVDLELFERIQ
TH_1842|M.thermoresistible__bu SIEEIRE---SVSPMLLASRRLIGDDSRYVSAAEISRSTGMDLGLLQRML
MAV_1415|M.avium_104 TAEEIRT---TNPPLLLATRHLIGDDGTYVSTREISETYGIDMALLQRVQ
MUL_4940|M.ulcerans_Agy99 SFEHIQAS--AAAPVMLPAYRVLGDDGTLVSAREICAATGIELDVLQRLQ
MAB_4771|M.abscessus_ATCC_1997 ----MPESDELNAVVDAAVEQVLLGGPRRYTRSQVSQLSGVPVERARTLW
MLBr_01399|M.leprae_Br4923 --------------------MPPSAKSTYPGQVEGAPHDGTPSAPQEPDE
*
Mb2235|M.bovis_AF2122/97 SLLGLT-VAGPDVPTLSQADVDALATWVALKAL-VGEDG-AFGLLRVLGT
Rv2212|M.tuberculosis_H37Rv SLLGLT-VAGPDVPTLSQADVDALATWVALKAL-VGEDG-AFGLLRVLGT
MMAR_3257|M.marinum_M ALLGLT-VAGPDVPTLSQADVDALATWLAVKSV-VGEDG-AFGLLRVLGA
MSMEG_4279|M.smegmatis_MC2_155 AALGLT-VAGVDVPALSAADVEGLRTWSEMRAF-LGDQA-ATGLLRVIGS
Mflv_2243|M.gilvum_PYR-GCK RAMGLPRVEDPDAEVFLRADAEAAKFTRDFLDVGIGLDE-LVQITRLLGD
Mvan_4452|M.vanbaalenii_PYR-1 RAMGLPRVDDADAQVFLRADAEAAKFTRDFLDAGIDPDE-LVQITRLLGD
TH_1842|M.thermoresistible__bu RALGLPRVDDPDAVVHLRADAEAAARAQRFIEAGVDPDQ-MVQIAAVLSE
MAV_1415|M.avium_104 RAIGLVRVDDPDAAVHMRADGEAAAFTQRFVDVGLDPDQ-VVLVAQVLAE
MUL_4940|M.ulcerans_Agy99 RAVSLPRIDDPDEAVLPRADAEAVRHAKVFLDIGYDLED-AVAVMRVLVE
MAB_4771|M.abscessus_ATCC_1997 VALGFAAADSDDEVAFTDADVSAIRTFAALGSATAANQQSQIAAARTLGQ
MLBr_01399|M.leprae_Br4923 DTVTVP------APALIRRSSVSMPNAAQWLHTTNRSPR-LVAMVRRARR
: . . . .
Mb2235|M.bovis_AF2122/97 AMARLAEAES-TMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALI
Rv2212|M.tuberculosis_H37Rv AMARLAEAES-TMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALI
MMAR_3257|M.marinum_M AMARLAEAES-TMIRAGTPDIQMTYTNDELATAQAYRAVAEFVPRIGTLI
MSMEG_4279|M.smegmatis_MC2_155 ALARISEAES-SMVRATSPDIMIDVTHDELATAQAYRTAAAYIPRIGALM
Mflv_2243|M.gilvum_PYR-GCK GLARAAEAMRYAALAAVIRPAATELETAKASEELVGNVAPLLGPMIQEVL
Mvan_4452|M.vanbaalenii_PYR-1 GLSRAAEAMRYAALAAVIRPGATELEIAQQSEALVAGLAPLLGPMIQEVL
TH_1842|M.thermoresistible__bu GLAKAAELMRSTVVAAVLQPGKTELQIAQDAEALVRRLAPLLGPMIQDLL
MAV_1415|M.avium_104 GLSRAAEVMRYSALSAIMRPGATELEIAKASKALVTQIAPLLGPMIQQML
MUL_4940|M.ulcerans_Agy99 SLGHAAAMMREAALKTLLRPGFSEIELAEASEQLAQAAIPLLPPMMDDLM
MAB_4771|M.abscessus_ATCC_1997 AMARLAEWQADLLTREVG--GRLAAEGDDASAESSANAATQTIATLTALQ
MLBr_01399|M.leprae_Br4923 LLPGDPDFGDPLSTAGEGGPRAAARAADRLLGDRGAASREVSLSVLQVWQ
: . . :
Mb2235|M.bovis_AF2122/97 DTVHRHHLASARTYFEGVIGD--TSASVTCGIGFADLSSFTALTQALTPA
Rv2212|M.tuberculosis_H37Rv DTVHRHHLASARTYFEGVIGD--TSASVTCGIGFADLSSFTALTQALTPA
MMAR_3257|M.marinum_M DIVHRHHLTSARTHFEGVTRD--ASASVVCGIGFADLSSFTVLTQTLTPT
MSMEG_4279|M.smegmatis_MC2_155 DAAHRHHLMSTRTYFEHVIRD--GSTTGECGVGFADLSDFTALTQMLTTV
Mflv_2243|M.gilvum_PYR-GCK LLQLRHAIETEAINATERAEGQHLPGARLVTIGFADLVGFTRLGEALPPE
Mvan_4452|M.vanbaalenii_PYR-1 LLQLRHAIETEAVNATERAEGQHLPGARLVTIGFADLVGFTRLGEAVPPE
TH_1842|M.thermoresistible__bu LLQLRHAMETEAVSVTERAQGVPLPGARLVSIAFADLVGFTRLGEAVPPE
MAV_1415|M.avium_104 FMQLRHMMETEAVNAAERAAGKPLPGARQITVAFADLVGFTRIGEAVSPE
MUL_4940|M.ulcerans_Agy99 RLELRHSVETEAVNAAERAAG-TLPGARPVTVAFADMAGFTRLGEVMPAE
MAB_4771|M.abscessus_ATCC_1997 NYAWQRHLAAALHRANETGST-----TRQLLVGFADMVGYTRLSRHLDPD
MLBr_01399|M.leprae_Br4923 ALTEAIARRPVNP---------------EVTLVFTDLVGFSGWSLQAGDE
. : *:*: .::
Mb2235|M.bovis_AF2122/97 QLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPER----LVRAA
Rv2212|M.tuberculosis_H37Rv QLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPER----LVRAA
MMAR_3257|M.marinum_M ELQGLLNEFGAAVADVVHADGGRVVKFIGDAVMWVSSTPQR----LAQAA
MSMEG_4279|M.smegmatis_MC2_155 ELTDLLNEFSSAASDVVHAAGGRVVKFIGDAVMWVATTPHL----LARAA
Mflv_2243|M.gilvum_PYR-GCK DLERLAQRLADLTREIAVAP-VRFIKTIGDEVMLVSPEPAP----LLETM
Mvan_4452|M.vanbaalenii_PYR-1 DLEQLSQRLADMTREFAVAP-VRFIKTIGDEVMLVSPEPAP----LLDTL
TH_1842|M.thermoresistible__bu ELEQLAARLADLAREVAEPP-VRFIKTIGDAVMLVSVDPAE----LLAAM
MAV_1415|M.avium_104 ELGQLANRLAILARDVTVPP-VRFVKTIGDAVMFVCPEPRP----LLDVV
MUL_4940|M.ulcerans_Agy99 DLERVAARLADLAHDAATMP-VRFVKSIGDAVMLVCPEPAP----LLRAA
MAB_4771|M.abscessus_ATCC_1997 ELASLLETFETALTEAITTHGGWVIKNVGDEVMFAAASAAAGARIAVAMN
MLBr_01399|M.leprae_Br4923 ATLALLRQVARAVESPLLDAGGHIVKRMGDGIMAVFRDPSVAVQ-AVLAA
: . . .:* :** :* . .
Mb2235|M.bovis_AF2122/97 VDLVDHPGARAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPG
Rv2212|M.tuberculosis_H37Rv VDLVDHPGARAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPG
MMAR_3257|M.marinum_M VDLVHHPRAREEGLQVRAGLAYGTALAINGDYFGTPVNLAARLVAAAAPG
MSMEG_4279|M.smegmatis_MC2_155 VDLVEHPKARQAHVRVRAGLDFGAVLAINGDYFGNSVNLAARLVQAAEPG
Mflv_2243|M.gilvum_PYR-GCK LRLVEETEGDDDFPRLRAGVATGMAVSRAGDWFGSPVNLAARMTGAARPG
Mvan_4452|M.vanbaalenii_PYR-1 LRLVDETEDDDDFPRLRAGVATGLAVSRAGDWFGSPVNLAARVTGAARPG
TH_1842|M.thermoresistible__bu LELIDGTGADQDFPRVRAGMATGMAVSRAGDWYGSPVNLASRVTGVARPG
MAV_1415|M.avium_104 LKLVEAVDTDNEFPRLRAGVASGTAVSRAGDWFGSPVNVASRVTAVARPG
MUL_4940|M.ulcerans_Agy99 LDLAAAAANN--LPPLRIGVASGAAVTRAGDWFGSPVNLASRVTSIAYPG
MAB_4771|M.abscessus_ATCC_1997 TAITEAAQTIPDMPQIRVGLAYGQVLSRFGDLYGTVVNIAARLTGVARPG
MLBr_01399|M.leprae_Br4923 TEAMKSVEVGGYTPRIRVGIHTGRPQRLAADWLGVDVNIAARVMERATKG
:* *: * .* * **:*:*: * *
Mb2235|M.bovis_AF2122/97 QILAAAQLRDMLP---DWPALAHG--------PLTLKGFDAPVMAFELHD
Rv2212|M.tuberculosis_H37Rv QILAAAQLRDMLP---DWPALAHG--------PLTLKGFDAPVMAFELHD
MMAR_3257|M.marinum_M QVLADAALHDQLP---DWPTIPRG--------KLTLKGFDDPVNAFELQG
MSMEG_4279|M.smegmatis_MC2_155 QVLVSAALREALG---DWPATGPR--------ELKLKGFDHPIPAFALT-
Mflv_2243|M.gilvum_PYR-GCK TVLVAEAAREAIGEDDRFAWSFAG--------AKHLKGIKSDVKSFRARW
Mvan_4452|M.vanbaalenii_PYR-1 SVLVAEATREAIGEDERFTWSFAG--------GKHLKGFKSDVKTFRARR
TH_1842|M.thermoresistible__bu SVLVAEATREAIGDDERFRWSFAG--------SRRLKGIKGEVKLYRARR
MAV_1415|M.avium_104 TVLVADSVWDVIGDNGEFSGSFAG--------ARRLKGIKNEVKLFRVRR
MUL_4940|M.ulcerans_Agy99 TVVVAESTRDAVGNAGDFEWFSIG--------AQRIRGMRAEVKLFRVEP
MAB_4771|M.abscessus_ATCC_1997 TILLDDGAAAALGDDGEFSLRHLR--------GVRVKGFSRLGSHVLRAR
MLBr_01399|M.leprae_Br4923 GIMISGPTLDLIPQSDLKELGIITRRVRKPMFTSKFTGIPPDMVIYRIKA
:: : . *:
Mb2235|M.bovis_AF2122/97 NPRARDADTPSPAASD-
Rv2212|M.tuberculosis_H37Rv NPRARDADTPSPAASD-
MMAR_3257|M.marinum_M SADRPDGGQAGPRCGD-
MSMEG_4279|M.smegmatis_MC2_155 -----------PRESG-
Mflv_2243|M.gilvum_PYR-GCK APADSH-----------
Mvan_4452|M.vanbaalenii_PYR-1 TTNL-------------
TH_1842|M.thermoresistible__bu AE---------------
MAV_1415|M.avium_104 GG---------------
MUL_4940|M.ulcerans_Agy99 ARPAGRG----------
MAB_4771|M.abscessus_ATCC_1997 KR---------------
MLBr_01399|M.leprae_Br4923 RRELTASDETAQTNSLT