For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
HSARNKELSMPTPTDHDPESEAPPRRRLGRGAAIAIVLASVATLAVVIVMMISNPGPIHVQSIPAQPNPT SAGPTAPAAASPSTPVSPLPSAPAPTSTSSTPTTSTPSPTPSTAPSTTQTAGPAVDSQGFVDSARCDSGD RPIAIARTERSTMVVCESADGTLEYQGVRLRDGASLTLDDVTPIPAGFEVRNGGTTYRLSPTELVVLSGE ELQSRDPMVEFRVQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2088 | - | - | 100% (225) | hypothetical protein Mflv_2088 |
| M. gilvum PYR-GCK | Mflv_5210 | - | 3e-20 | 39.55% (134) | protein kinase |
| M. gilvum PYR-GCK | Mflv_3248 | - | 3e-13 | 38.24% (102) | hypothetical protein Mflv_3248 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1891 | apa | 7e-09 | 31.86% (113) | hypothetical protein Mb1891 |
| M. tuberculosis H37Rv | Rv1860 | apa | 7e-09 | 31.86% (113) | hypothetical protein Rv1860 |
| M. leprae Br4923 | MLBr_00431 | - | 1e-05 | 30.89% (123) | hypothetical protein MLBr_00431 |
| M. abscessus ATCC 19977 | MAB_4291 | - | 7e-07 | 26.00% (150) | hypothetical protein MAB_4291 |
| M. marinum M | MMAR_2944 | - | 8e-09 | 33.66% (101) | PPE family protein |
| M. avium 104 | MAV_2158 | - | 3e-21 | 30.92% (207) | serine/threonine protein kinase |
| M. smegmatis MC2 155 | MSMEG_4366 | - | 4e-18 | 30.59% (219) | serine/threonine-protein kinase PknD |
| M. thermoresistible (build 8) | TH_0188 | - | 1e-28 | 34.45% (209) | serine/threonine-protein kinase PknD |
| M. ulcerans Agy99 | MUL_0582 | - | 1e-07 | 27.12% (118) | hypothetical protein MUL_0582 |
| M. vanbaalenii PYR-1 | Mvan_4615 | - | 4e-49 | 51.61% (217) | hypothetical protein Mvan_4615 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2088|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4615|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2158|M.avium_104 -------------------------MS--SSSRGSRLGTRLGPYELRSLI
MSMEG_4366|M.smegmatis_MC2_155 -------------------------MTPMASNGASRLGTRFGPYELRSLI
TH_0188|M.thermoresistible__bu --------------------------------------------------
MAB_4291|M.abscessus_ATCC_1997 ---------------MANALGLSIGATQLVATPDDPQSQPVVRSSILTLH
MUL_0582|M.ulcerans_Agy99 ------------MWDMSESLGLSIGVANLVATRAG--GAPLRRASVLHLF
Mb1891|M.bovis_AF2122/97 --------------------------------------------------
Rv1860|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2944|M.marinum_M MTAPIWMAAPPEVHSALLSSGPGPGSLLVAAGEWTSLSITYAEAAEELAA
MLBr_00431|M.leprae_Br4923 --------------------------------------------------
Mflv_2088|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4615|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2158|M.avium_104 GTGT--------------LGEVYRAYDTVKDRLVALKLLRGELDAG--FR
MSMEG_4366|M.smegmatis_MC2_155 GVGG--------------MGEVYRAYDTVKGREVAVKLLRAEFAADPRFQ
TH_0188|M.thermoresistible__bu --------------------------------------------------
MAB_4291|M.abscessus_ATCC_1997 EDGPPEVGVPSQ------PGLTLTGFVGRVGDPVGIVAADGSVHRAEWAL
MUL_0582|M.ulcerans_Agy99 QHQAAEVGLPEENPGLAGAGLVLRGFVERVGDQSPLIAADGTKYLGEALA
Mb1891|M.bovis_AF2122/97 ------------------MHQVDPNLTRRKGRLAALAIAA----------
Rv1860|M.tuberculosis_H37Rv ------------------MHQVDPNLTRRKGRLAALAIAA----------
MMAR_2944|M.marinum_M LLAAVQAGAWDGPTAEIYVAAHVPYLMWLIQASANSAAMAGQQQTAAAAY
MLBr_00431|M.leprae_Br4923 --------------------------------------------------
Mflv_2088|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4615|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2158|M.avium_104 QRLWRECRA----VTRLQEPHVLPLHDFGEIDGVPFIDMQLVDDGGSLKE
MSMEG_4366|M.smegmatis_MC2_155 ERFRRESRV----AARLQEPHVIPVHDFGDIDGVLYIDMRLV-EGASLKD
TH_0188|M.thermoresistible__bu --------------------------------------------------
MAB_4291|M.abscessus_ATCC_1997 TEAMRVLIADAVSSANFTAPPVLSASIPAHWSPQTVSTLRDAIDRVPAFA
MUL_0582|M.ulcerans_Agy99 VQALSALAR----TVGYGSPVTIAA--PAYWSGAQLGALRGALLTEPALA
Mb1891|M.bovis_AF2122/97 ------------MASASLVTVAVPATANADPEPAPPVPTTAASPPSTAAA
Rv1860|M.tuberculosis_H37Rv ------------MASASLVTVAVPATANADPEPAPPVPTTAASPPSTAAA
MMAR_2944|M.marinum_M TAALAAMPTLAELGANHTIHTGLVVTNFFGINTIPIAVNEADYVRMWIQA
MLBr_00431|M.leprae_Br4923 ----------------------MNNPRRSEWLGPSLAGSGPIEPQVHQYP
Mflv_2088|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4615|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2158|M.avium_104 LLREQGGLEPSRAASITGQVARALDAAHAAGLMHLDVKPENILLTHDHFT
MSMEG_4366|M.smegmatis_MC2_155 ILRTDGPLDPRRTASIVAQVASALDAAHADGLVHRDIKPENVLLTGDDFA
TH_0188|M.thermoresistible__bu --------------------------------------------------
MAB_4291|M.abscessus_ATCC_1997 PGGRQLKLIPDARAALEALAAGPGTPDRGVVVVCDLGGSGSSITLADAAR
MUL_0582|M.ulcerans_Agy99 PNGVAAAVVSDAAAALAALRPTPGFPASGVVALCDFGAGGTSVTLAQVGS
Mb1891|M.bovis_AF2122/97 PPAPATPVAPPPPAAANTPNAQPGDPNAAP--------------------
Rv1860|M.tuberculosis_H37Rv PPAPATPVAPPPPAAANTPNAQPGDPNAAP--------------------
MMAR_2944|M.marinum_M AAVMGGYQDVSATAVAAAPQPAPAPPIMNAAAPAAAAAQAAELPPDRQSQ
MLBr_00431|M.leprae_Br4923 PLTDPAYAEQAPYAPAYGASLPPWTPKKPP--------------------
Mflv_2088|M.gilvum_PYR-GCK ----------------------------MHSARNKELSMPTPTDHDPESE
Mvan_4615|M.vanbaalenii_PYR-1 --------------------------------------MPTSTDHDAPAH
MAV_2158|M.avium_104 YLADFGLAQAAGDEKLSRT--------YMAPERFTTGSLGPQTDIYSLAC
MSMEG_4366|M.smegmatis_MC2_155 YLVDFGIAHVGGEASVTMTGMLIGSSAYMAPERFSGETVGPPADIYALAC
TH_0188|M.thermoresistible__bu -------------------------------------------VVVAAVI
MAB_4291|M.abscessus_ATCC_1997 GFQQIGQTIRFADFSGQQIDQMLLTQVLT-----DLNQDPEGTTSVGALT
MUL_0582|M.ulcerans_Agy99 SLQQIGPTFRYREFSGDEIDQLILNHILTVTPGIDSAEVSGTATSMGSVT
Mb1891|M.bovis_AF2122/97 ------------------------------PPADPNAPPPPVIAPNAPQP
Rv1860|M.tuberculosis_H37Rv ------------------------------PPADPNAPPPPVIAPNAPQP
MMAR_2944|M.marinum_M FLQWLKDIGYVDLYNKLIKPFVDWLANIPFLQALFSGFDPYLLTLGNPLT
MLBr_00431|M.leprae_Br4923 ----------------------------QQLPRYWQQDQPPPTDIPPEGL
Mflv_2088|M.gilvum_PYR-GCK APPRRRLG------------------------------------------
Mvan_4615|M.vanbaalenii_PYR-1 DVPGRALFS-----------------------------------------
MAV_2158|M.avium_104 VLYECLTGQPPFEGADPGELRSAHLLSPAPRPSIMRRGVGRAFDDIITRG
MSMEG_4366|M.smegmatis_MC2_155 LVYESLIGRPPYEAGDLRQLMSAHMFSAPPRPSIMRRGVPRAFDEVIATA
TH_0188|M.thermoresistible__bu VLFGVAAG------------LAAVLVSDRDGP------------------
MAB_4291|M.abscessus_ATCC_1997 RLRDQCRLAKERLSGDTATSVPVQLPG-ITTDVRLTRAELEGHLRGPLSN
MUL_0582|M.ulcerans_Agy99 LLLGGCRFAKEHLSAAPVATIATGAAGQPGADIRFSRNEFEQLITQPLDR
Mb1891|M.bovis_AF2122/97 VRIDNPVGG-----------------------------------------
Rv1860|M.tuberculosis_H37Rv VRIDNPVGG-----------------------------------------
MMAR_2944|M.marinum_M YLSPLNIAFALGYPMDFATYVTLLSQTFAFIGADLAAAFASGNPMTIGLT
MLBr_00431|M.leprae_Br4923 TLPPPHEPK-----------------------------------------
Mflv_2088|M.gilvum_PYR-GCK ----------RGAAIAIVLASVATLAVVIVMMIS----------------
Mvan_4615|M.vanbaalenii_PYR-1 ---------ARASAISIVVAAIATLGVVFVMLNAG---------------
MAV_2158|M.avium_104 MAKQRSARFASAGELARAASEAVFAAYEPVSAAAGLGGPRPLPAPPAQFD
MSMEG_4366|M.smegmatis_MC2_155 MAKDPAARYATAGELARAVSAAAAGEAPPSKPTPPQVPGRP-PTPTRQFS
TH_0188|M.thermoresistible__bu ---------APSSQLAVPPAQTTEPTGTTAAPTTG---------------
MAB_4291|M.abscessus_ATCC_1997 LINAIQDTVERNGIHPANITAVASVGGGASIPLVTQQLSERMRVPVITAP
MUL_0582|M.ulcerans_Agy99 FIGSVEDMLQRSGVPRPSLAAVAAVGGGAAIPLIGNRLSERLQVPVFTTA
Mb1891|M.bovis_AF2122/97 --------FSFALPAGWVESDAAHLDYGSALLSKT---------------
Rv1860|M.tuberculosis_H37Rv --------FSFALPAGWVESDAAHFDYGSALLSKT---------------
MMAR_2944|M.marinum_M ILFTSVEAIGTIITDTIALLKTLLEQTAVLLAALAPMLAAPLVPLAAGAV
MLBr_00431|M.leprae_Br4923 ---------SPHWFLWVVAGASVVLVVGLVMALIIAN-------------
Mflv_2088|M.gilvum_PYR-GCK --------------------NPGPIHVQSIPAQPNPTSAGPT--------
Mvan_4615|M.vanbaalenii_PYR-1 --------------------DKEAPQVQSIPAQPNTVSQWVT--------
MAV_2158|M.avium_104 D----PDDT------LGPPPVGERPPRGPAGRLPVVVTAVAV--------
MSMEG_4366|M.smegmatis_MC2_155 ELYPNPEHTGFTPYPPAYPSVPAPPRRTPTPPAPAAVAAPAVRTPGKKRF
TH_0188|M.thermoresistible__bu ------------------------PTRSSTPTTPTTRTTPTT--------
MAB_4291|M.abscessus_ATCC_1997 QPQLAAARGVALLATRPDLPPQDATAMRPVEQPPGDATMMRPVP------
MUL_0582|M.ulcerans_Agy99 QPIFSAAIGAAMLGQDQSSAGAPTGAGPAVDMPTNIVGAAGTIG------
Mb1891|M.bovis_AF2122/97 --------------------TGDPPFPGQPPPVANDTRIVLG--------
Rv1860|M.tuberculosis_H37Rv --------------------TGDPPFPGQPPPVANDTRIVLG--------
MMAR_2944|M.marinum_M LVPLGAKGLAALVAVPPPALPVAAPAAPPVALTPNVPPTPPAPAP-----
MLBr_00431|M.leprae_Br4923 ---------------------GAIKTQTAVPPLPAITESSSA--------
.
Mflv_2088|M.gilvum_PYR-GCK ------------------APAAASPSTPVSPLPSAPAPTSTSSTPTTSTP
Mvan_4615|M.vanbaalenii_PYR-1 ------------------APARDKP-IPVAPRPQAPA-------------
MAV_2158|M.avium_104 ----LMLIAG--VVLSVKTVVGTHHNNSAPPPAPTTRALAPP--PPTTPP
MSMEG_4366|M.smegmatis_MC2_155 TRTQMMLVVATVVLFGIAAVLATMLVGGDDNASTGNTGITPPEGATSTSE
TH_0188|M.thermoresistible__bu -------------------TTSPERTSPVPSASPATPPATPPTSPTSPVA
MAB_4291|M.abscessus_ATCC_1997 --------------TGTGTFAAPVAAAANEEPELAWSQDDSAPDLAPLQE
MUL_0582|M.ulcerans_Agy99 --------------AMTEVSPTAWANQAG-SAAASESASDNAKSATYRAL
Mb1891|M.bovis_AF2122/97 -------------------RLDQKLYASAEATDSKAAARLGSDMGEFYMP
Rv1860|M.tuberculosis_H37Rv -------------------RLDQKLYASAEATDSKAAARLGSDMGEFYMP
MMAR_2944|M.marinum_M -------------------VDASTLTLTQAPPPPPSTAPPPVSGAGLGVG
MLBr_00431|M.leprae_Br4923 --------------------------TPTPTTKTSPTPTAGPAPSTTGSG
Mflv_2088|M.gilvum_PYR-GCK SPTPSTAPSTTQTAGPAVDSQGFVDS-ARCDSGD-------------RPI
Mvan_4615|M.vanbaalenii_PYR-1 ---------------LAMDGRGFVNTAARCDAAA-------------RAV
MAV_2158|M.avium_104 PPLTPTLSR----PVTGADGLGFIGETARCDPGN-------------PPA
MSMEG_4366|M.smegmatis_MC2_155 STTTTTSNRSATANVSGTDEQGFVGHTARCDSDA-------------TPA
TH_0188|M.thermoresistible__bu SPVTP-------AAVPGADRQGFIGHAARCDSGS-------------TPA
MAB_4291|M.abscessus_ATCC_1997 TGYQSGYTVDLDDEYQGPTEATTARPELRFSHGP---YADEDDYDDYPPL
MUL_0582|M.ulcerans_Agy99 AWSQDADTGNEPVPYTGPDATGEYGREPATDYAPRYDYPDQDRYAEAAPL
Mb1891|M.bovis_AF2122/97 YPGTRINQETVSLDANGVSGSASYYEVKFSDPSK--------------PN
Rv1860|M.tuberculosis_H37Rv YPGTRINQETVSLDANGVSGSASYYEVKFSDPSK--------------PN
MMAR_2944|M.marinum_M MENFGYMVGGLGADAKSAARASARKKAPRPDGAEVP-------VVAPAPS
MLBr_00431|M.leprae_Br4923 TLTQTIGPSAMLDVVYSITGQGRAISVTYMDTGD-------------VIQ
. .
Mflv_2088|M.gilvum_PYR-GCK AIARTERSTMVVCESADGTLEYQGVRLRDG--------------------
Mvan_4615|M.vanbaalenii_PYR-1 AIARTARSAVVVCQGPDGSYEYQGIRLRDG--------------------
MAV_2158|M.avium_104 AVVRTAKSLAVVCQNLSGSYYYRGERIRDG--------------------
MSMEG_4366|M.smegmatis_MC2_155 ALIRTATSLAIICERDSGGYYYRGERLRDG--------------------
TH_0188|M.thermoresistible__bu AMVRTDNSLAVVCETRSGDYYYRGERLSDG--------------------
MAB_4291|M.abscessus_ATCC_1997 PWYRRPLVWF-IAAAAVAGIAFTGMMVSLTSSESPAPATTTPSVNVVPST
MUL_0582|M.ulcerans_Agy99 PWYKRAAVVFSLAAAGLAILVAVVLGLTLGTSNNKPVNTTVP--------
Mb1891|M.bovis_AF2122/97 GQIWTGVIGSPAANAPDAGPPQRWFVVWLGTAN-----------------
Rv1860|M.tuberculosis_H37Rv GQIWTGVIGSPAANAPDAGPPQRWFVVWLGTAN-----------------
MMAR_2944|M.marinum_M EPARSQRRRRTKVGQLGRGFEYMDLESETAPDSMTG--------------
MLBr_00431|M.leprae_Br4923 TEFNVVLPWS----------------------------------------
Mflv_2088|M.gilvum_PYR-GCK --------------------------------------ASLTLDDVTPIP
Mvan_4615|M.vanbaalenii_PYR-1 --------------------------------------AALQLDDVRPMA
MAV_2158|M.avium_104 --------------------------------------AHIELSNAERVE
MSMEG_4366|M.smegmatis_MC2_155 --------------------------------------ANLKIDDAQRSG
TH_0188|M.thermoresistible__bu --------------------------------------ASIELRNARPAG
MAB_4291|M.abscessus_ATCC_1997 GDAPAEPPPSPEPPPPPQTHTVTQSVQPPPPSPEPPPPPPPTTTTTTTPP
MUL_0582|M.ulcerans_Agy99 --APSPEPITTTILGPNSSPTVTVITPTPPSTTTTSPSATTTTTQPTTTT
Mb1891|M.bovis_AF2122/97 --------------------------------------NPVDKGAAKALA
Rv1860|M.tuberculosis_H37Rv --------------------------------------NPVDKGAAKALA
MMAR_2944|M.marinum_M -------------------------------------SERITTASGLAGS
MLBr_00431|M.leprae_Br4923 --------------------------------------KQVSLSKSAVHP
Mflv_2088|M.gilvum_PYR-GCK AGFEVRN--GGTTYRLSPTELVVLSGEELQSRDPMVEFRVQ---------
Mvan_4615|M.vanbaalenii_PYR-1 VGFEARN--EGTTYRLSPTELVVISGESLQSRDAVVEYRAG---------
MAV_2158|M.avium_104 DGFDVTNPVDGVVYEVRPNRLRIISFGHVDSSEPVLQYATAS--------
MSMEG_4366|M.smegmatis_MC2_155 DGYVAVNPADGARYEVSPEGLTIMSNGHVDSSEPPEEYGSK---------
TH_0188|M.thermoresistible__bu DGFDAVNPADGTRYEVRPDRLTIISNGRIDANEPVQQYAGR---------
MAB_4291|M.abscessus_ATCC_1997 TTTTTTTTTTTTTTTTTTTPTTTTTQPTTTTTQPTSTSRPAITIPG-LPP
MUL_0582|M.ulcerans_Agy99 TTTTTTTTTPPTTTTTQPTTTRTTTTQPTTTAPPTTTQQPSTTTAAPITP
Mb1891|M.bovis_AF2122/97 ESIRPLVAPPPAPAPAPAEPAPAPAPAGEVAPTPTTPTPQRTLPA-----
Rv1860|M.tuberculosis_H37Rv ESIRPLVAPPPAPAPAPAEPAPAPAPAGEVAPTPTTPTPQRTLPA-----
MMAR_2944|M.marinum_M AGTFGFSGVAGKSGDRTAAGLIKLAGDGYDDGPRTPAMPSTWDGDPAPSP
MLBr_00431|M.leprae_Br4923 ASVTIVNIGHDVTCSVTVAGVQIRQHTGVGLTICDAPR------------
Mflv_2088|M.gilvum_PYR-GCK -------
Mvan_4615|M.vanbaalenii_PYR-1 -------
MAV_2158|M.avium_104 -------
MSMEG_4366|M.smegmatis_MC2_155 -------
TH_0188|M.thermoresistible__bu -------
MAB_4291|M.abscessus_ATCC_1997 IPIGPRN
MUL_0582|M.ulcerans_Agy99 TTEAPGA
Mb1891|M.bovis_AF2122/97 -------
Rv1860|M.tuberculosis_H37Rv -------
MMAR_2944|M.marinum_M D------
MLBr_00431|M.leprae_Br4923 -------