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M. thermoresistible (build 8) TH_0188 (-)

annotation: serine/threonine-protein kinase PknD
coordinates: 416339 - 416986
length: 216

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0188--100% (216)serine/threonine-protein kinase PknD
M. thermoresistible (build 8)TH_1965-1e-1236.28% (113) hypothetical protein MSMEG_6601
M. thermoresistible (build 8)TH_3554-6e-0933.03% (109) PUTATIVE -

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3909c-8e-0931.33% (150) hypothetical protein Mb3909c
M. gilvum PYR-GCKMflv_5210-1e-3453.79% (132) protein kinase
M. tuberculosis H37RvRv3879c-8e-0931.33% (150) hypothetical protein Rv3879c
M. leprae Br4923MLBr_00020-5e-0835.37% (82) hypothetical protein MLBr_00020
M. abscessus ATCC 19977MAB_4291-2e-0941.33% (75) hypothetical protein MAB_4291
M. marinum MMMAR_0618-8e-1334.51% (113) hypothetical protein MMAR_0618
M. avium 104MAV_2158-2e-4145.89% (207) serine/threonine protein kinase
M. smegmatis MC2 155MSMEG_4366-6e-4040.47% (215) serine/threonine-protein kinase PknD
M. ulcerans Agy99MUL_0583-8e-1233.33% (111) hypothetical protein MUL_0583
M. vanbaalenii PYR-1Mvan_1066-2e-3755.73% (131) protein kinase

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_0618|M.marinum_M               --------------------------------------------------
MUL_0583|M.ulcerans_Agy99           --------------------------------------------------
MAB_4291|M.abscessus_ATCC_1997      MANALGLSIGATQLVATPDDPQSQPVVRSSILTLHEDGPPEVGVPSQPGL
Mflv_5210|M.gilvum_PYR-GCK          -------MS--TPQGGARLGTRFGPYELHSVIGVGGMGEVYRAYDTARER
Mvan_1066|M.vanbaalenii_PYR-1       -------MS--TPKGGSRLGTRFGPYELQSVIGVGGMGEVYRAYDTARER
MSMEG_4366|M.smegmatis_MC2_155      -------MTPMASNGASRLGTRFGPYELRSLIGVGGMGEVYRAYDTVKGR
MAV_2158|M.avium_104                -------MS--SSSRGSRLGTRLGPYELRSLIGTGTLGEVYRAYDTVKDR
TH_0188|M.thermoresistible__bu      --------------------------------------------------
Mb3909c|M.bovis_AF2122/97           -----MSITRPTGSYARQMLDPGGWVEADEDTFYDRAQEYSQVLQRVTDV
Rv3879c|M.tuberculosis_H37Rv        -----MSITRPTGSYARQMLDPGGWVEADEDTFYDRAQEYSQVLQRVTDV
MLBr_00020|M.leprae_Br4923          -MTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQL
                                                                                      

MMAR_0618|M.marinum_M               --------------------------------------------------
MUL_0583|M.ulcerans_Agy99           --------------------------------------------------
MAB_4291|M.abscessus_ATCC_1997      TLTGFVGRVGDPVGIVAADGSVHRAEWALTEAMRVLIADAVSSANFTAPP
Mflv_5210|M.gilvum_PYR-GCK          MVAIKLLR------------PEMAADHSFQERFRRESRVAAR--------
Mvan_1066|M.vanbaalenii_PYR-1       MVAIKLLR------------PEMAADHSFQERFRRESRVAAR--------
MSMEG_4366|M.smegmatis_MC2_155      EVAVKLLR------------AEFAADPRFQERFRRESRVAAR--------
MAV_2158|M.avium_104                LVALKLLR------------GELDAG--FRQRLWRECRAVTR--------
TH_0188|M.thermoresistible__bu      --------------------------------------------------
Mb3909c|M.bovis_AF2122/97           LDTCRQQKGHVFEGGLWSGGAANAANGALGANINQLMTLQDY--------
Rv3879c|M.tuberculosis_H37Rv        LDTCRQQKGHVFEGGLWSGGAANAANGALGANINQLMTLQDY--------
MLBr_00020|M.leprae_Br4923          VIAALAHLD------------DDEPGGDLLGKLETAVRAG----------
                                                                                      

MMAR_0618|M.marinum_M               --------------------------------------------------
MUL_0583|M.ulcerans_Agy99           --------------------------------------------------
MAB_4291|M.abscessus_ATCC_1997      VLSASIPAHWSPQTVSTLRDAIDRVPAFAPGGRQLKLIPDARAALEALAA
Mflv_5210|M.gilvum_PYR-GCK          ---LQEPHVIPVHNFGEIDGVLYIDMRLV-EGASLKEVLRSDGPLQPARA
Mvan_1066|M.vanbaalenii_PYR-1       ---LQEPHVIPVHDFGEIDGVLYIDMRLV-EGASLKDVLRAEGALPPARA
MSMEG_4366|M.smegmatis_MC2_155      ---LQEPHVIPVHDFGDIDGVLYIDMRLV-EGASLKDILRTDGPLDPRRT
MAV_2158|M.avium_104                ---LQEPHVLPLHDFGEIDGVPFIDMQLVDDGGSLKELLREQGGLEPSRA
TH_0188|M.thermoresistible__bu      --------------------------------------------------
Mb3909c|M.bovis_AF2122/97           ---LATVITWHRHIAGLIEQAKSDIGNNVDGAQREIDILENDPSLDADER
Rv3879c|M.tuberculosis_H37Rv        ---LATVITWHRHIAGLIEQAKSDIGNNVDGAQREIDILENDPSLDADER
MLBr_00020|M.leprae_Br4923          ----NLAIAAQVEMEPDFEGMGTTLTAILFAGNRLGLVHIGDSRGYLLRD
                                                                                      

MMAR_0618|M.marinum_M               --------------------------------------------------
MUL_0583|M.ulcerans_Agy99           --------------------------------------------------
MAB_4291|M.abscessus_ATCC_1997      GPGTPDRGVVVVCDLGGSGSSITLADAARGFQQIGQTIRFADFSGQQIDQ
Mflv_5210|M.gilvum_PYR-GCK          VS-----------IIRQVAAALDDAHA--------NGLVHRDIKP-----
Mvan_1066|M.vanbaalenii_PYR-1       VS-----------ILRQVAAALDAAHA--------NGLVHRDIKP-----
MSMEG_4366|M.smegmatis_MC2_155      AS-----------IVAQVASALDAAHA--------DGLVHRDIKP-----
MAV_2158|M.avium_104                AS-----------ITGQVARALDAAHA--------AGLMHLDVKP-----
TH_0188|M.thermoresistible__bu      --------------------------------------------------
Mb3909c|M.bovis_AF2122/97           HT-----------AINSLVTATHGANVSLVAETAERVLESKNWKPPKNAL
Rv3879c|M.tuberculosis_H37Rv        HT-----------AINSLVTATHGANVSLVAETAERVLESKNWKPPKNAL
MLBr_00020|M.leprae_Br4923          GE---------------LTQITKDDTFVQTLVDEGRITAEEAHSHPQRSL
                                                                                      

MMAR_0618|M.marinum_M               --------------------------------------------------
MUL_0583|M.ulcerans_Agy99           --------------------------------------------------
MAB_4291|M.abscessus_ATCC_1997      MLLTQVLTDLNQDPEGTTSVGALTRLRDQCRLAKERLSGDTATSVPVQLP
Mflv_5210|M.gilvum_PYR-GCK          ENVLLTGDDFAYLVDFGIAHGGGEASVTSTGLVVGSSAYMAPERFSGERG
Mvan_1066|M.vanbaalenii_PYR-1       ENVLLTPDDFAYLVDFGIAHGGGEASVTSTGLVVGSSAYMAPERFSGERG
MSMEG_4366|M.smegmatis_MC2_155      ENVLLTGDDFAYLVDFGIAHVGGEASVTMTGMLIGSSAYMAPERFSGETV
MAV_2158|M.avium_104                ENILLTHDHFTYLADFGLAQAAGDEKLSRT--------YMAPERFTTGSL
TH_0188|M.thermoresistible__bu      --VVVA----AVIVLFGVAAG-----------------------------
Mb3909c|M.bovis_AF2122/97           EDLLQQKSPPPPDVPTLVVPSPGTPGTPGTPGTPITPGTPITPGTPITPG
Rv3879c|M.tuberculosis_H37Rv        EDLLQQKSPPPPDVPTLVVPSPGTPGTPGTP---------------ITPG
MLBr_00020|M.leprae_Br4923          IMRALTGHEVDPTLTMREARAGDRYLLCSDG-----LSDPVSDETILEAL
                                                                                      

MMAR_0618|M.marinum_M               --------------------------------------------------
MUL_0583|M.ulcerans_Agy99           --------------------------------------------------
MAB_4291|M.abscessus_ATCC_1997      GITTDVRLTRAELEGHLRGPLSNLINAIQDTVERNGIHPANITAVASVGG
Mflv_5210|M.gilvum_PYR-GCK          GPASDIYSLACLLYESLTGRAPFEAADVRQVWSAHMFAAPPRPSIMRRGV
Mvan_1066|M.vanbaalenii_PYR-1       GPASDVYSLACLLYESLTGRAPFEAADVRQVWSAHMFAPPPRPSIMRRGV
MSMEG_4366|M.smegmatis_MC2_155      GPPADIYALACLVYESLIGRPPYEAGDLRQLMSAHMFSAPPRPSIMRRGV
MAV_2158|M.avium_104                GPQTDIYSLACVLYECLTGQPPFEGADPGELRSAHLLSPAPRPSIMRRGV
TH_0188|M.thermoresistible__bu      --------LAAVLVSDRDGPAP-----------SSQLAVPPAQTTEPTGT
Mb3909c|M.bovis_AF2122/97           TPITPGTPITPIPGAPVTPITPTPGTPVTPVTPGKPVTPVTPVKPGTPGE
Rv3879c|M.tuberculosis_H37Rv        TPITPGTPITPIPGAPVTPITPTPGTPVTPVTPGKPVTPVTPVKPGTPGE
MLBr_00020|M.leprae_Br4923          QIPDVAESAYRLIELALRGGGPDNVTVVVADVIDYDYGQTQPILAGAVSG
                                                                                      

MMAR_0618|M.marinum_M               ----------------------------------------------MARH
MUL_0583|M.ulcerans_Agy99           ----------------------------------------------MARH
MAB_4291|M.abscessus_ATCC_1997      GASIPLVTQQLSERMRVPVITAPQPQLAAARGVALLATRPDLPPQDATAM
Mflv_5210|M.gilvum_PYR-GCK          SRAFDDVIARGMAKNPTERYATAGELARAAAAAAS----------AAPVA
Mvan_1066|M.vanbaalenii_PYR-1       SRTFDDVVARGMAKQPHDRYPTAGELARAASAAAE----------GAPAA
MSMEG_4366|M.smegmatis_MC2_155      PRAFDEVIATAMAKDPAARYATAGELARAVSAAAAG---------EAPPS
MAV_2158|M.avium_104                GRAFDDIITRGMAKQRSARFASAGELARAASEAVFA--------AYEPVS
TH_0188|M.thermoresistible__bu      T--------------------------------------------AAPTT
Mb3909c|M.bovis_AF2122/97           PTPITPVTPPVAPATPATPATPVTPAPAPHPQPAPAP-------APSPGP
Rv3879c|M.tuberculosis_H37Rv        PTPITPVTPPVAPATPATPATPVTPAPAPHPQPAPAP-------APSPGP
MLBr_00020|M.leprae_Br4923          EESQQMALPNTAASRASAIVPRKEIAKSMAPQVDKVHQQRWSQRQTGITL
                                                                                      

MMAR_0618|M.marinum_M               DPPDYGAGDPTAYGNYGYGD------------------------------
MUL_0583|M.ulcerans_Agy99           DPPDYGAGDPTAYGNYGYGD------------------------------
MAB_4291|M.abscessus_ATCC_1997      RPVEQPPGDATMMRPVPTGTGTFAAPVAAAANEEPELAWSQDDSAPDLAP
Mflv_5210|M.gilvum_PYR-GCK          EPVPPVTP----PSTRQFSGVHP---------------------AMTP-P
Mvan_1066|M.vanbaalenii_PYR-1       ETVAPVTP----PSTRQFSTVYP---------------------TPPPMP
MSMEG_4366|M.smegmatis_MC2_155      KPTPPQVPGRPPTPTRQFSELYPNPEHTGFTPYPPAYPSVPAPPRRTPTP
MAV_2158|M.avium_104                AAAGLGGPRPLPAPPAQFDDPDD-----------------------TLGP
TH_0188|M.thermoresistible__bu      GPTRSSTP---TTPTTRTTPTT------------------------TTSP
Mb3909c|M.bovis_AF2122/97           QPVTPATPGPSGPATPGTPGGEPAPHVKPAALAEQPGVPGQHAGGGTQSG
Rv3879c|M.tuberculosis_H37Rv        QPVTPATPGPSGPATPGTPGGEPAPHVKPAALAEQPGVPGQHAGGGTQSG
MLBr_00020|M.leprae_Br4923          TLLVLLVLAGVAIGRWVIRDNYYIAEYSG------------------KVS
                                                                                      

MMAR_0618|M.marinum_M               -QGGGYGQ----------QPPPEPTPGWRKPLALAG--------------
MUL_0583|M.ulcerans_Agy99           -QRGGYGQ----------QPPPEPTPGWRKPLALAG--------------
MAB_4291|M.abscessus_ATCC_1997      LQETGYQSGYTVDLDDEYQGPTEATTARPELRFSHGPYADEDDYDDYPPL
Mflv_5210|M.gilvum_PYR-GCK          PAPAPIAA-------ARRPGRGQGALVAGIVVMFVAAAVLA---------
Mvan_1066|M.vanbaalenii_PYR-1       PMPAVAPP-------ARRFSRGQVGLVAATVVMFTAALVLA---------
MSMEG_4366|M.smegmatis_MC2_155      PAPAAVAAPAVRTPGKKRFTRTQMMLVVATVVLFGIAAVLA---------
MAV_2158|M.avium_104                PPVGERPP-------RGPAGRLPVVVTAVAVLMLIAGVVLS---------
TH_0188|M.thermoresistible__bu      ERTSPVPS------------------------------------------
Mb3909c|M.bovis_AF2122/97           PAHADESAASVTPAAASGVPGARAAAAAPSGTAVGAGARSS---------
Rv3879c|M.tuberculosis_H37Rv        PAHADESAASVTPAAASGVPGARAAAAAPSGTAVGAGARSS---------
MLBr_00020|M.leprae_Br4923          IVRGIQGSLLGMPLHEPYLVGCLNTRNELSLISYGQSGGHLN--------
                                                                                      

MMAR_0618|M.marinum_M               --------WGVLIAVLIGLIIFGIIQLAHGRPTPASVTKTVTATMTTTTP
MUL_0583|M.ulcerans_Agy99           --------WGVLIAVLIGLIIFGIIQLAHGRPTPASVTKTVTATMTTTTP
MAB_4291|M.abscessus_ATCC_1997      PWYRRPLVWFIAAAAVAGIAFTGMMVSLTSSESPAPATTTPSVNVVPSTG
Mflv_5210|M.gilvum_PYR-GCK          --LVLVFTGGSDPQP-PRIAAP----PSSSSDTSTPPSTSAVEGVSGTDS
Mvan_1066|M.vanbaalenii_PYR-1       --AVLVFSGGDTGSPSPRIAAP----PSSSSEAPSTSSASAVEGVSGTDS
MSMEG_4366|M.smegmatis_MC2_155      --TMLVGGDDNASTGNTGITPPEGATSTSESTTTTTSNRSATANVSGTDE
MAV_2158|M.avium_104                --VKTVVGTHHNNSAPPPAPTTRALAPPPPTTPPPPLTPTLSRPVTGADG
TH_0188|M.thermoresistible__bu      -----------ASPATPPATPP-------TSPTSPVASPVTPAAVPGADR
Mb3909c|M.bovis_AF2122/97           --VGTAAASGAGSHAATGRAPVATSDKAAAPSTRAASARTAPPARPPSTD
Rv3879c|M.tuberculosis_H37Rv        --VGTAAASGAGSHAATGRAPVATSDKAAAPSTRAASARTAPPARPPSTD
MLBr_00020|M.leprae_Br4923          ----------CQVMTLRDLRPSGGAQVQAGLPGGNLDQAESQLRKLLADS
                                                                                   :  

MMAR_0618|M.marinum_M               TTTTTAPTKTTTTTTTTTTTTTTTTTT-------------TTTTTTTTTT
MUL_0583|M.ulcerans_Agy99           -TTTTAPTKTTTTTTTTTTTTTTTTTT-------------TTTTT-----
MAB_4291|M.abscessus_ATCC_1997      DAPAEPPPSPEPPPPPQTHTVTQSVQPPPPSPEPPPPPPPTTTTTTTPPT
Mflv_5210|M.gilvum_PYR-GCK          QGFVGHTARCDSGDTPAALIRTSLS---------LAIICDRGDGDYYYRG
Mvan_1066|M.vanbaalenii_PYR-1       QGFVGHTARCDSGSTPAALIRTSLS---------LAIICETSDGDYYYRG
MSMEG_4366|M.smegmatis_MC2_155      QGFVGHTARCDSDATPAALIRTATS---------LAIICERDSGGYYYRG
MAV_2158|M.avium_104                LGFIGETARCDPGNPPAAVVRTAKS---------LAVVCQNLSGSYYYRG
TH_0188|M.thermoresistible__bu      QGFIGHAARCDSGSTPAAMVRTDNS---------LAVVCETRSGDYYYRG
Mb3909c|M.bovis_AF2122/97           HIDKPDRSESADDGTPVSMIPVSAARAARDAATAAASARQRGRGDALRLA
Rv3879c|M.tuberculosis_H37Rv        HIDKPDRSESADDGTPVSMIPVSAARAARDAATAAASARQRGRGDALRLA
MLBr_00020|M.leprae_Br4923          LLPTCPPPRATSPPGPFTMPTDSGT----------------PQPTNTASP
                                           .       . :                                

MMAR_0618|M.marinum_M               TTTTTPTTTTTTTTAPTTTTTTTTNPMSPGAMPTFPSQLTPSIP------
MUL_0583|M.ulcerans_Agy99           -TTTTPTTTTTTTTAPTTTTTTTTNPMSPGAMPTFPSQLTPSIP------
MAB_4291|M.abscessus_ATCC_1997      TTTTTTTTTTTTTTTTTTPTTTTTQPTTTTTQPTSTSRPAITIP------
Mflv_5210|M.gilvum_PYR-GCK          ERLRDGANREIDGARRSGDGFTVTG-SDGARYDVQPDQLTISSG------
Mvan_1066|M.vanbaalenii_PYR-1       ERLRDGANREIQGAQRSGDGFVVTG-SDGARYDVQPDQLTISSN------
MSMEG_4366|M.smegmatis_MC2_155      ERLRDGANLKIDDAQRSGDGYVAVNPADGARYEVSPEGLTIMSN------
MAV_2158|M.avium_104                ERIRDGAHIELSNAERVEDGFDVTNPVDGVVYEVRPNRLRIISF------
TH_0188|M.thermoresistible__bu      ERLSDGASIELRNARPAGDGFDAVNPADGTRYEVRPDRLTIISN------
Mb3909c|M.bovis_AF2122/97           RRIAAALNASDNNAGDYGFFWITAVTTDGSIVVANSYGLAYIPDGMELPN
Rv3879c|M.tuberculosis_H37Rv        RRIAAALNASDNNAGDYGFFWITAVTTDGSIVVANSYGLAYIPDGMELPN
MLBr_00020|M.leprae_Br4923          TSTTPPTITSSSGTAPTNISPTSSPASTAPTTPVGTSQTVTILP------
                                                 :                   . .              

MMAR_0618|M.marinum_M               ---------TVINLPPGL--------------------------------
MUL_0583|M.ulcerans_Agy99           ---------TVINLPPGL--------------------------------
MAB_4291|M.abscessus_ATCC_1997      ---------GLPPIPIGPRN------------------------------
Mflv_5210|M.gilvum_PYR-GCK          ----GSVDSAEPALEYGSAQ------------------------------
Mvan_1066|M.vanbaalenii_PYR-1       ----GSVDSAEPALEYGSAQ------------------------------
MSMEG_4366|M.smegmatis_MC2_155      ----GHVDSSEPPEEYGSK-------------------------------
MAV_2158|M.avium_104                ----GHVDSSEPVLQYATAS------------------------------
TH_0188|M.thermoresistible__bu      ----GRIDANEPVQQYAGR-------------------------------
Mb3909c|M.bovis_AF2122/97           KVYLASADHAIPVDEIARCATYPVLAVQAWAAFHDMTLRAVIGTAEQLAS
Rv3879c|M.tuberculosis_H37Rv        KVYLASADHAIPVDEIARCATYPVLAVQAWAAFHDMTLRAVIGTAEQLAS
MLBr_00020|M.leprae_Br4923          ------PPPPQPGIDCRAVA------------------------------
                                                                                      

MMAR_0618|M.marinum_M               --------------------------------------------------
MUL_0583|M.ulcerans_Agy99           --------------------------------------------------
MAB_4291|M.abscessus_ATCC_1997      --------------------------------------------------
Mflv_5210|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1066|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_4366|M.smegmatis_MC2_155      --------------------------------------------------
MAV_2158|M.avium_104                --------------------------------------------------
TH_0188|M.thermoresistible__bu      --------------------------------------------------
Mb3909c|M.bovis_AF2122/97           SDPGVAKIVLEPDDIPESGKMTGRSRLEVVDPSAAAQLADTTDQRLLDLL
Rv3879c|M.tuberculosis_H37Rv        SDPGVAKIVLEPDDIPESGKMTGRSRLEVVDPSAAAQLADTTDQRLLDLL
MLBr_00020|M.leprae_Br4923          --------------------------------------------------
                                                                                      

MMAR_0618|M.marinum_M               --------------------------------------------------
MUL_0583|M.ulcerans_Agy99           --------------------------------------------------
MAB_4291|M.abscessus_ATCC_1997      --------------------------------------------------
Mflv_5210|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1066|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_4366|M.smegmatis_MC2_155      --------------------------------------------------
MAV_2158|M.avium_104                --------------------------------------------------
TH_0188|M.thermoresistible__bu      --------------------------------------------------
Mb3909c|M.bovis_AF2122/97           PPAPVDVNPPGDERHMLWFELMKPMTSTATGREAAHLRAFRAYAAHSQEI
Rv3879c|M.tuberculosis_H37Rv        PPAPVDVNPPGDERHMLWFELMKPMTSTATGREAAHLRAFRAYAAHSQEI
MLBr_00020|M.leprae_Br4923          --------------------------------------------------
                                                                                      

MMAR_0618|M.marinum_M               ---------------------------------------
MUL_0583|M.ulcerans_Agy99           ---------------------------------------
MAB_4291|M.abscessus_ATCC_1997      ---------------------------------------
Mflv_5210|M.gilvum_PYR-GCK          ---------------------------------------
Mvan_1066|M.vanbaalenii_PYR-1       ---------------------------------------
MSMEG_4366|M.smegmatis_MC2_155      ---------------------------------------
MAV_2158|M.avium_104                ---------------------------------------
TH_0188|M.thermoresistible__bu      ---------------------------------------
Mb3909c|M.bovis_AF2122/97           ALHQAHTATDAAVQRVAVADWLYWQYVTGLLDRALAAAS
Rv3879c|M.tuberculosis_H37Rv        ALHQAHTATDAAVQRVAVADWLYWQYVTGLLDRALAAAC
MLBr_00020|M.leprae_Br4923          ---------------------------------------