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TDPIRRVLAAAAAVATVVGCAHATEPELRAGQLLTARPLTTVAALPSADNRLITYVSDDSAGEPIVVSGT VSVPKSEPPEGGWPVINWAHGTTGYADTCAPSAATADGLIQDYVQLVRPMLDRWVARGFAVVQTDYQGLG TPGGHPYVDGVSESNTVTDIVRAARHLDPGIGTAWVVLGHSQGGQAALFAAHDGPDRDPDLRLLGAVAMA PGGVDMGATVDLLRAGDPGVEVAQRFVPLLVLGAAVVDPSVDPDQIFTTRARPLLTTARNECLAQLNVVP TIPASQVLAPDADVRGLLAYLDRQDPLQLTPRVPVLIAQGTEDVAVNPVGVDKLAKALCGKGVDVDYNTY PGKDHRGVIAAAEVTVKDFVDAVMDGRSPENCPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2000 | - | - | 100% (385) | secretory lipase |
| M. gilvum PYR-GCK | Mflv_3922 | - | 3e-36 | 31.49% (343) | secretory lipase |
| M. gilvum PYR-GCK | Mflv_3621 | - | 9e-10 | 25.40% (315) | triacylglycerol lipase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1618c | - | 5e-10 | 26.32% (323) | hypothetical protein Mb1618c |
| M. tuberculosis H37Rv | Rv1592c | - | 5e-10 | 26.32% (323) | hypothetical protein Rv1592c |
| M. leprae Br4923 | MLBr_02603 | - | 3e-05 | 28.21% (234) | hypothetical protein MLBr_02603 |
| M. abscessus ATCC 19977 | MAB_0965 | - | 4e-35 | 31.79% (368) | putative lipase |
| M. marinum M | MMAR_1029 | - | 7e-25 | 30.23% (344) | lipase |
| M. avium 104 | MAV_5251 | - | 5e-26 | 31.16% (337) | secretory lipase family protein |
| M. smegmatis MC2 155 | MSMEG_2381 | - | 1e-39 | 31.08% (399) | hypothetical protein MSMEG_2381 |
| M. thermoresistible (build 8) | TH_0465 | - | 6e-36 | 31.27% (323) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_0787 | - | 6e-25 | 30.23% (344) | lipase |
| M. vanbaalenii PYR-1 | Mvan_2478 | - | 2e-36 | 31.98% (344) | secretory lipase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1618c|M.bovis_AF2122/97 -------------MVEPGNLAGATGAEWIGRPPHEELQRKVRPLLPSDD-
Rv1592c|M.tuberculosis_H37Rv -------------MVEPGNLAGATGAEWIGRPPHEELQRKVRPLLPSDD-
MMAR_1029|M.marinum_M ------------MRAARGRLQSRLQVVVVAMLSCATITVVAPDSARADGG
MUL_0787|M.ulcerans_Agy99 MVIEKRDLFVRGMRAARGRLQSRLQVVVVAMLSCATITVVAPDSARADGG
MAV_5251|M.avium_104 ------------MRDCYRSVMRRVAGVFAALVLMAG-TLTGPAIARADG-
MSMEG_2381|M.smegmatis_MC2_155 -------MLTGVS-----LICAPVCA--LVLAPT-AAWAAEPEWSNLDAR
TH_0465|M.thermoresistible__bu -------MMTTRAGWSRLIFAAVLCAAGLLIAPTPNAVAAAPNWSWLDAR
Mvan_2478|M.vanbaalenii_PYR-1 ----------------------------MGCATT--ADAATPTWSGLDAR
Mflv_2000|M.gilvum_PYR-GCK -----------------------------MTDPIRRVLAAAAAVATVVG-
MAB_0965|M.abscessus_ATCC_1997 ---------------------------------MLVLITAACARVEAEG-
MLBr_02603|M.leprae_Br4923 --------------------------------------------------
Mb1618c|M.bovis_AF2122/97 -----------PFYFPPAGYQHAVPGTVLRSRDVELAFMG---LIPQPVT
Rv1592c|M.tuberculosis_H37Rv -----------PFYFPPAGYQHAVPGTVLRSRDVELAFMG---LIPQPVT
MMAR_1029|M.marinum_M FESEGDQSQYDQFYTPPDPLPPGEPGDVIRTEPSRLVLEPSGQLGAIMAT
MUL_0787|M.ulcerans_Agy99 FESEGDQSQYDQFYTPPDPLPPGEPGDVIRTEPSRLALEPSGQLGAIMAT
MAV_5251|M.avium_104 -----DEPQYADFYTPPDPLPPGRPGDLIRTEPSRLVLEPSGQLGAIMAT
MSMEG_2381|M.smegmatis_MC2_155 ----------------RYDAPIPRAGTLIAAVPLDPALSVAG-----AER
TH_0465|M.thermoresistible__bu ----------------HYAGPIPAEPTLLESVRLDPALSVRG-----AGE
Mvan_2478|M.vanbaalenii_PYR-1 D-------------ASVLEAPVPAPGALLETVPLDPALSVAG-----AAG
Mflv_2000|M.gilvum_PYR-GCK --------------CAHATEPELRAGQLLTARPLTTVAALPS------AD
MAB_0965|M.abscessus_ATCC_1997 ---------------VAPQPPSPPPGEVLSDVPLSLAPDLDA-----IAD
MLBr_02603|M.leprae_Br4923 --------------------------------------------------
Mb1618c|M.bovis_AF2122/97 ATQLLYRTTN-MYGNPEATVTTVIVPAELAPG-QTCPLLSYQCAIDAMSS
Rv1592c|M.tuberculosis_H37Rv ATQLLYRTTN-MYGNPEATVTTVIVPAELAPG-QTCPLLSYQCAIDAMSS
MMAR_1029|M.marinum_M GTRIMYRSTD-TRGNPIAVTGTYFEPDNPWPGSGPRPLLSYAPGTVGQGD
MUL_0787|M.ulcerans_Agy99 GTRIMYRSTD-TRGNPIAVTGTYFEPDNPWPGSGPRPLLRYAPGTVGQGD
MAV_5251|M.avium_104 GTRIMYRSTD-TRGNPIAVTGTYFEPYNDWPYGGPRPLISYAPGTQGQGN
MSMEG_2381|M.smegmatis_MC2_155 AYRILYSTVD-QHDSPAVSTAAVFVPRGQAPE-GGWPVIAWAHGTVGLGD
TH_0465|M.thermoresistible__bu AYRILYSTVN-QYGQPAVSTAAVFVPHGEAPS-GGWPVVAWAHGTVGLGD
Mvan_2478|M.vanbaalenii_PYR-1 AYRILYSTVD-QHGRPAVSTAVVFTPKTPAPE-GGWPVVAWAHGTVGLGD
Mflv_2000|M.gilvum_PYR-GCK NRLITYVSDD-SAGEPIVVSGTVSVPKSEPPE-GGWPVINWAHGTTGYAD
MAB_0965|M.abscessus_ATCC_1997 GHLIRYMSTSGATGTPTEVTGVVFAPKGEPPQ-AGWPIVSVGHGTTGLDD
MLBr_02603|M.leprae_Br4923 ------MTITRTERNFYGVGGVRIVYDVWMPDTRPRAVIILAHGFGEHAR
: . * .:: .
Mb1618c|M.bovis_AF2122/97 RCFPSYALRR---RAKALGSLTQMELLMISAALAEGWAVSVPDHEGP---
Rv1592c|M.tuberculosis_H37Rv RCFPSYALRR---RAKALGSLTQMELLMISAALAEGWAVSVPDHEGP---
MMAR_1029|M.marinum_M QCALSRVFNQGIHWSPWLDLMVNYEETFVATMVARGFAIVMTDYEGLG-T
MUL_0787|M.ulcerans_Agy99 QCALSRVFNQGIHWSPWLDLMVNYEETFVATMVARGFAIVMTDYEGLG-T
MAV_5251|M.avium_104 QCAPSRMFNQGIHYSGGWDIMFNYEELFVATMVARGFAIVMTDYQGLG-T
MSMEG_2381|M.smegmatis_MC2_155 DCAPSAQPRS------------ARDNEYLTHWLDQGYAVVGSDYAGLG-T
TH_0465|M.thermoresistible__bu DCTPSALPRS------------ARDDEYLSHWLDQGYAVVATDYVGLG-T
Mvan_2478|M.vanbaalenii_PYR-1 DCTPSALPRS------------GRDDEYLSHWLDQGYVVVGSDYAGLG-T
Mflv_2000|M.gilvum_PYR-GCK TCAPSAATADG-----LIQDYVQLVRPMLDRWVARGFAVVQTDYQGLG-T
MAB_0965|M.abscessus_ATCC_1997 ECAVSRAPDLR------------GYIWLVRNLSKRGWVVAITDYEGLG-V
MLBr_02603|M.leprae_Br4923 -----------------------RYDHVAHYFAAAGLATYALDLRGHGRS
* . * *
Mb1618c|M.bovis_AF2122/97 --KGLWGSPYEPGYRVLDGIRAALNSERVGLSPATPIGLWGYSGGGLASA
Rv1592c|M.tuberculosis_H37Rv --KGLWGSPYEPGYRVLDGIRAALNSERVGLSPATPIGLWGYSGGGLASA
MMAR_1029|M.marinum_M PGTHTYVNRLAEGHAVLDAARAAQRLPGTSLDPHGPVAFWGYSQGGGAAA
MUL_0787|M.ulcerans_Agy99 PGTHTYVNRLAEGHAVLDAARAAQRLPGTSLDPHGPVAFWGYSQGGGAAA
MAV_5251|M.avium_104 PPMHTYVGRVAEGQAVLDAARAAMRLPGTSLDPHGPVAFWGYSQGGGATA
MSMEG_2381|M.smegmatis_MC2_155 PGLMSYLNSVATAHSVVDSVIAMHEMD---LPLSPEWAIVGQSQGGGAAV
TH_0465|M.thermoresistible__bu PGLMSYLNSVATAHAVIDSVVAAHQLD---LPLSPKWAIVGQSQGGGAAV
Mvan_2478|M.vanbaalenii_PYR-1 PGLMSYLNSVTTARGVVDSVLAAHHMD---LPLSPKWAVVGQSQGGGAAV
Mflv_2000|M.gilvum_PYR-GCK PGGHPYVDGVSESNTVTDIVRAARHLDP---GIGTAWVVLGHSQGGQAAL
MAB_0965|M.abscessus_ATCC_1997 PGPHPYLEPRSEGFNVIDAARAAVSLIP---GASTKWAAIGASQGGQATW
MLBr_02603|M.leprae_Br4923 AGKRVLVRDLSEYNADFDILVGIATRD----HPGLKRIVAGHSMGGAIVF
* . * * **
Mb1618c|M.bovis_AF2122/97 WAAEACGEYAP--DLDIVGAVLGSP-VGDLGHTFRRLN---------GTL
Rv1592c|M.tuberculosis_H37Rv WAAEACGEYAP--DLDIVGAVLGSP-VGDLGHTFRRLN---------GTL
MMAR_1029|M.marinum_M SAAELVSSYAP--ELDVVGTYAGAP-PADLVEMLPYMD---------GNV
MUL_0787|M.ulcerans_Agy99 SAAELVSSYAP--ELDVVGTYAGAP-PADLVEMLPYMD---------GNV
MAV_5251|M.avium_104 SAAELAAQYAP--DLHIVGTYAGAP-PADLKELLPYAD---------GSA
MSMEG_2381|M.smegmatis_MC2_155 NSARWATEFSRGTGLDYRGVVATGT-PFNVESIVKQAGPDMALPPNLGPA
TH_0465|M.thermoresistible__bu NSARWATEFSAGSGLDYRGVVATGT-PANIETVVKMGAPDMQLPPELGPA
Mvan_2478|M.vanbaalenii_PYR-1 ATARWASEFSAGSGLDYRGVVATGT-PANVETIVKQAGPDMVVPPELGPM
Mflv_2000|M.gilvum_PYR-GCK FAAHDGPDRDP--DLRLLGAVAMAPGGVDMGATVDLLRAG----DPGVEV
MAB_0965|M.abscessus_ATCC_1997 AASELAGDYAS--ELEFVGSANLSP-AADLTDMATHVGDG-----RYHWS
MLBr_02603|M.leprae_Br4923 AYGVERPDNYD--LMVLSGPAVAAQ-----------------------DM
. . : * .
Mb1618c|M.bovis_AF2122/97 LAGLPALVVAALQHSYPGLARVIKEHAN------DEGRQLLEQLTEMTTV
Rv1592c|M.tuberculosis_H37Rv LAGLPALVVAALQHSYPGLARVIKEHAN------DEGRQLLEQLTEMTTV
MMAR_1029|M.marinum_M LVGAAGYLINGFIYAYPELADAIHERMT------PRGEDLLAKTRHQCVQ
MUL_0787|M.ulcerans_Agy99 LVGAAGCLINGFIYAYPELADAIHERMT------PRGEDLLAKTRHQCVE
MAV_5251|M.avium_104 LVGVVGYALNSVMAAYPEFADAIRSKMT------PRGLAMLESVSRQCVG
MSMEG_2381|M.smegmatis_MC2_155 ANSYTGYILAGFREARPDID--VDSVLT------PAGLDAVAKAETLCKP
TH_0465|M.thermoresistible__bu ANSYTAYILAAFREARPDID--VDSVLT------PAGLEAVAKAETVCKP
Mvan_2478|M.vanbaalenii_PYR-1 ANAYTAYIVAALREARPDLG--VDRVLT------PAGRAAADKAETSCAA
Mflv_2000|M.gilvum_PYR-GCK AQRFVPLLVLGAAVVDPSVD--PDQIFT------TRARPLLTTARNECLA
MAB_0965|M.abscessus_ATCC_1997 QLSMMPTLLTGLSVTVPELR--PENFLHGSFQDIPRDKALLLGCHNGLDP
MLBr_02603|M.leprae_Br4923 VSPLRAVVGKGLGLVAPGLP--------------------VHQLEVDAIS
. * .
Mb1618c|M.bovis_AF2122/97 DAVIRMAGRDMGDFLDEPLEDILSTPEVSHVFGDTKLGSAVPTPPVLIVQ
Rv1592c|M.tuberculosis_H37Rv DAVIRMAGRDMGDFLDEPLEDILSTPEISHVFGDTKLGSAVPTPPVLIVQ
MMAR_1029|M.marinum_M ETSFKFMFRHLRGYFTKDLDQLVREEPFKTLFEAQRLGRHQPSAPVLIVN
MUL_0787|M.ulcerans_Agy99 ETSFKFMFRHLRGYFTKDLDQLVREEPFKTLFEAQRLGRHQPSAPVLIVN
MAV_5251|M.avium_104 QTLLDFMFRHIQPYFTEDINQLVNEEPFNSLFEAQRIGRYKPNAPVLINS
MSMEG_2381|M.smegmatis_MC2_155 QLDAALAGMTPTDFFRAPLARLPGVDAALDAYMGTPTSGYDR--PIFLGV
TH_0465|M.thermoresistible__bu QLDSELAGMTPAQFFSAPLASVPGLPEALDEYMGTPVTGYDR--PIFLGV
Mvan_2478|M.vanbaalenii_PYR-1 DLAGALDGMTVPGFFTAPVTSIPGAIEAIDDFMGVPASGYDR--PVFLGV
Mflv_2000|M.gilvum_PYR-GCK QLN--VVPTIPASQVLAPDADVRGLLAYLDRQDPLQLT---PRVPVLIAQ
MAB_0965|M.abscessus_ATCC_1997 ARSAAIIRLRAKDFHGTSPADPIVFAAALKR-IALPLGPASG--PMFVYA
MLBr_02603|M.leprae_Br4923 RNRAVVAAYKDDPLVYHGKVPAGVGRVMLQVGETMTRRAPVLTTPLLVVH
. *:::
Mb1618c|M.bovis_AF2122/97 AVHDYLIDVSDIDALADSYTAGGANVTYHRDLFSEHVSLHPLSAPMTLRW
Rv1592c|M.tuberculosis_H37Rv AVHDYLIDVSDIDALADSYTAGGANVTYHRDLFSEHVSLHPLSAPMTLRW
MMAR_1029|M.marinum_M NRYDPLVPWTQASQLGRDWCAQGAQVEFWTN--EEPPFLNKASVNHALTF
MUL_0787|M.ulcerans_Agy99 NRYDPLVPWTQASQLGRDWCAQGAQVEFWTN--EEPPFLNKASVNHALTF
MAV_5251|M.avium_104 NRYDPLVPWTAANQLGRDWCAQGADVEFRTN--EEPPFLNKLVINHALPM
MSMEG_2381|M.smegmatis_MC2_155 GMQDRDVPPNLTLQLDEALRANGQDVTLKVYPDEDHSGTVLASVPDSTPF
TH_0465|M.thermoresistible__bu GLLDRDVPPQSTLKFYDQLVAHNQNVELRIYPHEDHSGTVLASLPDSTPF
Mvan_2478|M.vanbaalenii_PYR-1 GMQDRDVPPSLTLRFSEKLSANGEDVTLKVYPDSDHSGTVLASMPDSTRF
Mflv_2000|M.gilvum_PYR-GCK GTEDVAVNPVGVDKLAKALCGKGVDVDYNTYPGKDHRGVIAAAEVTVKDF
MAB_0965|M.abscessus_ATCC_1997 GGADRLIEAGWIHAAVRRACALGDTVQEVVSPGKGHVD--PEGERLGVQW
MLBr_02603|M.leprae_Br4923 GSEDRLVLVDGSHRLVECVGS--TDVELKVYPGLYHEVFNEPERDQVLED
* : . *
Mb1618c|M.bovis_AF2122/97 LTDRFAGKPLTDHRVRTTWPTIFNPMTYAGMARLAVIAAKVITGRKLSRR
Rv1592c|M.tuberculosis_H37Rv LTDRFAGKPLTDHRVRTTWPTIFNPMTYAGMARLAVIAAKVITGRKLSRR
MMAR_1029|M.marinum_M WVDGERALQWVADRFNG-LPAAPNCGQF----------------------
MUL_0787|M.ulcerans_Agy99 WVDGERALQWVADRFNG-RPAAPNCGQF----------------------
MAV_5251|M.avium_104 LVDGEPAMQWIAARFRG-EPTAPNCGQF----------------------
MSMEG_2381|M.smegmatis_MC2_155 LRAAFDRG------------------------------------------
TH_0465|M.thermoresistible__bu LAAAFAD-------------------------------------------
Mvan_2478|M.vanbaalenii_PYR-1 LARAFS--------------------------------------------
Mflv_2000|M.gilvum_PYR-GCK VDAVMDGRSPENCPR-----------------------------------
MAB_0965|M.abscessus_ATCC_1997 IADRFAGLPAPSNC------------------------------------
MLBr_02603|M.leprae_Br4923 VVCWILKRL-----------------------------------------
Mb1618c|M.bovis_AF2122/97 PL
Rv1592c|M.tuberculosis_H37Rv PL
MMAR_1029|M.marinum_M --
MUL_0787|M.ulcerans_Agy99 --
MAV_5251|M.avium_104 --
MSMEG_2381|M.smegmatis_MC2_155 --
TH_0465|M.thermoresistible__bu --
Mvan_2478|M.vanbaalenii_PYR-1 --
Mflv_2000|M.gilvum_PYR-GCK --
MAB_0965|M.abscessus_ATCC_1997 --
MLBr_02603|M.leprae_Br4923 --