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PAWSGLDVRGYDAPIPAPGALLDAVPLDPALSVPGAGSAYRILYSTVDQHDRPAVSTAAVFLPRTPAPPG GWPVLAWAHGTVGLGDACTPSARERSDRDGDYLSHWLDEGYAVVGSDYTGLGTPGLMSYLNSVTTARGVV DSVLAAHHLDVDLSPKWAVVGQSQGGGAAVATARWATEFSAGSGLDYRGVVATGTPANVESIVKQAGPDM TVPPELGPMGSAYTAYIVAALREARPDLDLDRVLTPAGREAADRAETLCAADLAGSLTDLSVPGFFTAPV TSIPGAADAIDAYMGIPSSGYDRPVFLGVGMRDRDVPPGLTLRFADALSANGQDVTLKVYPDADHSGTVL TSVPDSTAFLARAFS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3922 | - | - | 100% (366) | secretory lipase |
| M. gilvum PYR-GCK | Mflv_2000 | - | 2e-36 | 31.49% (343) | secretory lipase |
| M. gilvum PYR-GCK | Mflv_3621 | - | 8e-05 | 23.08% (338) | triacylglycerol lipase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1618c | - | 2e-06 | 22.10% (371) | hypothetical protein Mb1618c |
| M. tuberculosis H37Rv | Rv1592c | - | 2e-06 | 22.10% (371) | hypothetical protein Rv1592c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0965 | - | 2e-22 | 29.02% (348) | putative lipase |
| M. marinum M | MMAR_1029 | - | 4e-21 | 29.45% (292) | lipase |
| M. avium 104 | MAV_5251 | - | 3e-16 | 27.36% (296) | secretory lipase family protein |
| M. smegmatis MC2 155 | MSMEG_2381 | - | 1e-157 | 72.53% (364) | hypothetical protein MSMEG_2381 |
| M. thermoresistible (build 8) | TH_0465 | - | 1e-149 | 68.77% (365) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_0787 | - | 4e-21 | 30.14% (292) | lipase |
| M. vanbaalenii PYR-1 | Mvan_2478 | - | 1e-180 | 82.88% (368) | secretory lipase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3922|M.gilvum_PYR-GCK -------------------------------------------------M
Mvan_2478|M.vanbaalenii_PYR-1 ---------------------------------------MGCATTADAAT
MSMEG_2381|M.smegmatis_MC2_155 ----------------MLTGVS-----LICAPVCA--LVLAPT-AAWAAE
TH_0465|M.thermoresistible__bu ----------------MMTTRAGWSRLIFAAVLCAAGLLIAPTPNAVAAA
MMAR_1029|M.marinum_M ------------MRAARGRLQSRLQVVVVAMLSCATITVVAPDSARADGG
MUL_0787|M.ulcerans_Agy99 MVIEKRDLFVRGMRAARGRLQSRLQVVVVAMLSCATITVVAPDSARADGG
MAV_5251|M.avium_104 ------------MRDCYRSVMRRVAGVFAALVLMAG-TLTGPAIARADG-
Mb1618c|M.bovis_AF2122/97 -------------------------MVEPGNLAGATGAEWIGRPPHEELQ
Rv1592c|M.tuberculosis_H37Rv -------------------------MVEPGNLAGATGAEWIGRPPHEELQ
MAB_0965|M.abscessus_ATCC_1997 ---------------------------------------MLVLITAACAR
Mflv_3922|M.gilvum_PYR-GCK PAWSGLDVRG---YDAPIPAPG----ALLDAVPLDPALSVPG-----AGS
Mvan_2478|M.vanbaalenii_PYR-1 PTWSGLDARDASVLEAPVPAPG----ALLETVPLDPALSVAG-----AAG
MSMEG_2381|M.smegmatis_MC2_155 PEWSNLDARR---YDAPIPRAG----TLIAAVPLDPALSVAG-----AER
TH_0465|M.thermoresistible__bu PNWSWLDARH---YAGPIPAEP----TLLESVRLDPALSVRG-----AGE
MMAR_1029|M.marinum_M FESEGDQSQYDQFYTPPDPLPPGEPGDVIRTEPSRLVLEPSGQLGAIMAT
MUL_0787|M.ulcerans_Agy99 FESEGDQSQYDQFYTPPDPLPPGEPGDVIRTEPSRLALEPSGQLGAIMAT
MAV_5251|M.avium_104 -----DEPQYADFYTPPDPLPPGRPGDLIRTEPSRLVLEPSGQLGAIMAT
Mb1618c|M.bovis_AF2122/97 RKVRPLLPSDDPFYFPPAGYQHAVPGTVLRSRDVELAFMGLIP---QPVT
Rv1592c|M.tuberculosis_H37Rv RKVRPLLPSDDPFYFPPAGYQHAVPGTVLRSRDVELAFMGLIP---QPVT
MAB_0965|M.abscessus_ATCC_1997 VEAEGVAPQP------PSPPPG----EVLSDVPLSLAPDLDA-----IAD
* :: .
Mflv_3922|M.gilvum_PYR-GCK AYRILYSTVD-QHDRPAVSTAAVFLPRTPAPPGG-WPVLAWAHGTVGLGD
Mvan_2478|M.vanbaalenii_PYR-1 AYRILYSTVD-QHGRPAVSTAVVFTPKTPAPEGG-WPVVAWAHGTVGLGD
MSMEG_2381|M.smegmatis_MC2_155 AYRILYSTVD-QHDSPAVSTAAVFVPRGQAPEGG-WPVIAWAHGTVGLGD
TH_0465|M.thermoresistible__bu AYRILYSTVN-QYGQPAVSTAAVFVPHGEAPSGG-WPVVAWAHGTVGLGD
MMAR_1029|M.marinum_M GTRIMYRSTD-TRGNPIAVTGTYFEPDNPWPGSGPRPLLSYAPGTVGQGD
MUL_0787|M.ulcerans_Agy99 GTRIMYRSTD-TRGNPIAVTGTYFEPDNPWPGSGPRPLLRYAPGTVGQGD
MAV_5251|M.avium_104 GTRIMYRSTD-TRGNPIAVTGTYFEPYNDWPYGGPRPLISYAPGTQGQGN
Mb1618c|M.bovis_AF2122/97 ATQLLYRTTN-MYGNPEATVTTVIVPAELAPGQT-CPLLSYQCAIDAMSS
Rv1592c|M.tuberculosis_H37Rv ATQLLYRTTN-MYGNPEATVTTVIVPAELAPGQT-CPLLSYQCAIDAMSS
MAB_0965|M.abscessus_ATCC_1997 GHLIRYMSTSGATGTPTEVTGVVFAPKGEPPQAG-WPIVSVGHGTTGLDD
. : * :.. . * . . : * * *:: . . ..
Mflv_3922|M.gilvum_PYR-GCK ACTPSARERS------------DRDGDYLSHWLDEGYAVVGSDYTGLGTP
Mvan_2478|M.vanbaalenii_PYR-1 DCTPSALPRS------------GRDDEYLSHWLDQGYVVVGSDYAGLGTP
MSMEG_2381|M.smegmatis_MC2_155 DCAPSAQPRS------------ARDNEYLTHWLDQGYAVVGSDYAGLGTP
TH_0465|M.thermoresistible__bu DCTPSALPRS------------ARDDEYLSHWLDQGYAVVATDYVGLGTP
MMAR_1029|M.marinum_M QCALSRVFNQGIHWSPWLDLMVNYEETFVATMVARGFAIVMTDYEGLGTP
MUL_0787|M.ulcerans_Agy99 QCALSRVFNQGIHWSPWLDLMVNYEETFVATMVARGFAIVMTDYEGLGTP
MAV_5251|M.avium_104 QCAPSRMFNQGIHYSGGWDIMFNYEELFVATMVARGFAIVMTDYQGLGTP
Mb1618c|M.bovis_AF2122/97 RCFPSYALRRRAKALG---SLTQMELLMISAALAEGWAVSVPDHE--GPK
Rv1592c|M.tuberculosis_H37Rv RCFPSYALRRRAKALG---SLTQMELLMISAALAEGWAVSVPDHE--GPK
MAB_0965|M.abscessus_ATCC_1997 ECAVSRAPDLR------------GYIWLVRNLSKRGWVVAITDYEGLGVP
* * : .*:.: .*: *
Mflv_3922|M.gilvum_PYR-GCK GLMSYLNSVTTARGVVDSVLAAHHLD---VDLSPKWAVVGQSQGGGAAVA
Mvan_2478|M.vanbaalenii_PYR-1 GLMSYLNSVTTARGVVDSVLAAHHMD---LPLSPKWAVVGQSQGGGAAVA
MSMEG_2381|M.smegmatis_MC2_155 GLMSYLNSVATAHSVVDSVIAMHEMD---LPLSPEWAIVGQSQGGGAAVN
TH_0465|M.thermoresistible__bu GLMSYLNSVATAHAVIDSVVAAHQLD---LPLSPKWAIVGQSQGGGAAVN
MMAR_1029|M.marinum_M GTHTYVNRLAEGHAVLDAARAAQRLPGTSLDPHGPVAFWGYSQGGGAAAS
MUL_0787|M.ulcerans_Agy99 GTHTYVNRLAEGHAVLDAARAAQRLPGTSLDPHGPVAFWGYSQGGGAAAS
MAV_5251|M.avium_104 PMHTYVGRVAEGQAVLDAARAAMRLPGTSLDPHGPVAFWGYSQGGGATAS
Mb1618c|M.bovis_AF2122/97 GLWG--SPYEPGYRVLDGIRAALNSERVGLSPATPIGLWGYSGGGLASAW
Rv1592c|M.tuberculosis_H37Rv GLWG--SPYEPGYRVLDGIRAALNSERVGLSPATPIGLWGYSGGGLASAW
MAB_0965|M.abscessus_ATCC_1997 GPHPYLEPRSEGFNVIDAARAAVSLIP---GASTKWAAIGASQGGQATWA
. *:*. * . * * ** *:
Mflv_3922|M.gilvum_PYR-GCK TARWATEFSAGSGLDYRGVVATGTPANVESIVKQAGPDMTVPPELGPMGS
Mvan_2478|M.vanbaalenii_PYR-1 TARWASEFSAGSGLDYRGVVATGTPANVETIVKQAGPDMVVPPELGPMAN
MSMEG_2381|M.smegmatis_MC2_155 SARWATEFSRGTGLDYRGVVATGTPFNVESIVKQAGPDMALPPNLGPAAN
TH_0465|M.thermoresistible__bu SARWATEFSAGSGLDYRGVVATGTPANIETVVKMGAPDMQLPPELGPAAN
MMAR_1029|M.marinum_M AAELVSSYAP--ELDVVGTYAGAPPADLVEMLPYMDGNVLVG--------
MUL_0787|M.ulcerans_Agy99 AAELVSSYAP--ELDVVGTYAGAPPADLVEMLPYMDGNVLVG--------
MAV_5251|M.avium_104 AAELAAQYAP--DLHIVGTYAGAPPADLKELLPYADGSALVG--------
Mb1618c|M.bovis_AF2122/97 AAEACGEYAP--DLDIVGAVLGSPVGDLGHTFRRLNGTLLAG--------
Rv1592c|M.tuberculosis_H37Rv AAEACGEYAP--DLDIVGAVLGSPVGDLGHTFRRLNGTLLAG--------
MAB_0965|M.abscessus_ATCC_1997 ASELAGDYAS--ELEFVGSANLSPAADLTDMATHVGDGRYHWSQLSMMPT
::. .:: *. * .. ::
Mflv_3922|M.gilvum_PYR-GCK AYTAYIVAALREARPDLD--LDRVLTPAGREAADRAETLCAADLAGSLTD
Mvan_2478|M.vanbaalenii_PYR-1 AYTAYIVAALREARPDLG--VDRVLTPAGRAAADKAETSCAADLAGALDG
MSMEG_2381|M.smegmatis_MC2_155 SYTGYILAGFREARPDID--VDSVLTPAGLDAVAKAETLCKPQLDAALAG
TH_0465|M.thermoresistible__bu SYTAYILAAFREARPDID--VDSVLTPAGLEAVAKAETVCKPQLDSELAG
MMAR_1029|M.marinum_M -AAGYLINGFIYAYPELADAIHERMTPRGEDLLAKTRHQCVQETSFKFMF
MUL_0787|M.ulcerans_Agy99 -AAGCLINGFIYAYPELADAIHERMTPRGEDLLAKTRHQCVEETSFKFMF
MAV_5251|M.avium_104 -VVGYALNSVMAAYPEFADAIRSKMTPRGLAMLESVSRQCVGQTLLDFMF
Mb1618c|M.bovis_AF2122/97 -LPALVVAALQHSYPGLARVIKEHANDEGRQLLEQLTEMTTVDAVIRMAG
Rv1592c|M.tuberculosis_H37Rv -LPALVVAALQHSYPGLARVIKEHANDEGRQLLEQLTEMTTVDAVIRMAG
MAB_0965|M.abscessus_ATCC_1997 LLTGLSVT-VPELRPENFLHGSFQDIPRDKALLLGCHNGLDPARSAAIIR
. : . * . :
Mflv_3922|M.gilvum_PYR-GCK LSVPGFFTAPVTSIPGAADAIDAYMGIPSSGYDR--PVFLGVGMRDRDVP
Mvan_2478|M.vanbaalenii_PYR-1 MTVPGFFTAPVTSIPGAIEAIDDFMGVPASGYDR--PVFLGVGMQDRDVP
MSMEG_2381|M.smegmatis_MC2_155 MTPTDFFRAPLARLPGVDAALDAYMGTPTSGYDR--PIFLGVGMQDRDVP
TH_0465|M.thermoresistible__bu MTPAQFFSAPLASVPGLPEALDEYMGTPVTGYDR--PIFLGVGLLDRDVP
MMAR_1029|M.marinum_M RHLRGYFTKDLDQLVREEPFKTLFEAQRLGRHQPSAPVLIVNNRYDPLVP
MUL_0787|M.ulcerans_Agy99 RHLRGYFTKDLDQLVREEPFKTLFEAQRLGRHQPSAPVLIVNNRYDPLVP
MAV_5251|M.avium_104 RHIQPYFTEDINQLVNEEPFNSLFEAQRIGRYKPNAPVLINSNRYDPLVP
Mb1618c|M.bovis_AF2122/97 RDMGDFLDEPLEDILSTPEVSHVFGDTKLGSAVPTPPVLIVQAVHDYLID
Rv1592c|M.tuberculosis_H37Rv RDMGDFLDEPLEDILSTPEISHVFGDTKLGSAVPTPPVLIVQAVHDYLID
MAB_0965|M.abscessus_ATCC_1997 LRAKDFHGTSPADPIVFAAALKR-IALPLGPASG--PMFVYAGGADRLIE
: *::: * :
Mflv_3922|M.gilvum_PYR-GCK PGLTLRFADALSANGQDVTLKVYPDA--------DHSGTVLTSVPDSTAF
Mvan_2478|M.vanbaalenii_PYR-1 PSLTLRFSEKLSANGEDVTLKVYPDS--------DHSGTVLASMPDSTRF
MSMEG_2381|M.smegmatis_MC2_155 PNLTLQLDEALRANGQDVTLKVYPDE--------DHSGTVLASVPDSTPF
TH_0465|M.thermoresistible__bu PQSTLKFYDQLVAHNQNVELRIYPHE--------DHSGTVLASLPDSTPF
MMAR_1029|M.marinum_M WTQASQLGRDWCAQGAQVEFWTNEEPPFLNKASVNHALTFWVDGERALQW
MUL_0787|M.ulcerans_Agy99 WTQASQLGRDWCAQGAQVEFWTNEEPPFLNKASVNHALTFWVDGERALQW
MAV_5251|M.avium_104 WTAANQLGRDWCAQGADVEFRTNEEPPFLNKLVINHALPMLVDGEPAMQW
Mb1618c|M.bovis_AF2122/97 VSDIDALADSYTAGGANVTYHRDLFS--------EHVSLHPLSAPMTLRW
Rv1592c|M.tuberculosis_H37Rv VSDIDALADSYTAGGANVTYHRDLFS--------EHVSLHPLSAPMTLRW
MAB_0965|M.abscessus_ATCC_1997 AGWIHAAVRRACALGDTVQEVVSPGK----------GHVDPEGERLGVQW
* . * . :
Mflv_3922|M.gilvum_PYR-GCK LARAFS--------------------------------------------
Mvan_2478|M.vanbaalenii_PYR-1 LARAFS--------------------------------------------
MSMEG_2381|M.smegmatis_MC2_155 LRAAFDRG------------------------------------------
TH_0465|M.thermoresistible__bu LAAAFAD-------------------------------------------
MMAR_1029|M.marinum_M VADRFNGLPAAPNCGQF---------------------------------
MUL_0787|M.ulcerans_Agy99 VADRFNGRPAAPNCGQF---------------------------------
MAV_5251|M.avium_104 IAARFRGEPTAPNCGQF---------------------------------
Mb1618c|M.bovis_AF2122/97 LTDRFAGKPLTDHRVRTTWPTIFNPMTYAGMARLAVIAAKVITGRKLSRR
Rv1592c|M.tuberculosis_H37Rv LTDRFAGKPLTDHRVRTTWPTIFNPMTYAGMARLAVIAAKVITGRKLSRR
MAB_0965|M.abscessus_ATCC_1997 IADRFAGLPAPSNC------------------------------------
: *
Mflv_3922|M.gilvum_PYR-GCK --
Mvan_2478|M.vanbaalenii_PYR-1 --
MSMEG_2381|M.smegmatis_MC2_155 --
TH_0465|M.thermoresistible__bu --
MMAR_1029|M.marinum_M --
MUL_0787|M.ulcerans_Agy99 --
MAV_5251|M.avium_104 --
Mb1618c|M.bovis_AF2122/97 PL
Rv1592c|M.tuberculosis_H37Rv PL
MAB_0965|M.abscessus_ATCC_1997 --