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M. avium 104 MAV_5251 (-)

annotation: secretory lipase family protein
coordinates: 5402930 - 5404240
length: 436

VRDCYRSVMRRVAGVFAALVLMAGTLTGPAIARADGDEPQYADFYTPPDPLPPGRPGDLIRTEPSRLVLE
PSGQLGAIMATGTRIMYRSTDTRGNPIAVTGTYFEPYNDWPYGGPRPLISYAPGTQGQGNQCAPSRMFNQ
GIHYSGGWDIMFNYEELFVATMVARGFAIVMTDYQGLGTPPMHTYVGRVAEGQAVLDAARAAMRLPGTSL
DPHGPVAFWGYSQGGGATASAAELAAQYAPDLHIVGTYAGAPPADLKELLPYADGSALVGVVGYALNSVM
AAYPEFADAIRSKMTPRGLAMLESVSRQCVGQTLLDFMFRHIQPYFTEDINQLVNEEPFNSLFEAQRIGR
YKPNAPVLINSNRYDPLVPWTAANQLGRDWCAQGADVEFRTNEEPPFLNKLVINHALPMLVDGEPAMQWI
AARFRGEPTAPNCGQF
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. avium 104MAV_5251--100% (436)secretory lipase family protein
M. avium 104MAV_3194-1e-3727.63% (427) secretory lipase family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1618c-5e-3727.30% (392) hypothetical protein Mb1618c
M. gilvum PYR-GCKMflv_3621-4e-3626.60% (391) triacylglycerol lipase
M. tuberculosis H37RvRv1592c-4e-3727.30% (392) hypothetical protein Rv1592c
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_4351-1e-13557.78% (405) secretory lipase family protein
M. marinum MMMAR_1029-0.072.90% (428) lipase
M. smegmatis MC2 155MSMEG_3197-3e-3325.31% (403) lipase
M. thermoresistible (build 8)TH_3043-0.071.30% (432) PUTATIVE Triacylglycerol lipase
M. ulcerans Agy99MUL_0787-0.072.20% (428) lipase
M. vanbaalenii PYR-1Mvan_2796-8e-3826.77% (396) triacylglycerol lipase

CLUSTAL 2.0.9 multiple sequence alignment


MAV_5251|M.avium_104                ------------MRDCY-RSVMRRVAGVFAALVLMAGTLTGPAIARADG-
TH_3043|M.thermoresistible__bu      --------------------MVRGFAGSVCVLLIVSMGMSSP-LARAEDP
MMAR_1029|M.marinum_M               ------------MRAARGRLQSRLQVVVVAMLSCATITVVAPDSARADGG
MUL_0787|M.ulcerans_Agy99           MVIEKRDLFVRGMRAARGRLQSRLQVVVVAMLSCATITVVAPDSARADGG
MAB_4351|M.abscessus_ATCC_1997      ----------------MASPAMRLWRLTAALAITIVSLWQLMPTARADD-
Mb1618c|M.bovis_AF2122/97           -------------------MVEPGNLAGATGAEWIGRPPHEELQRKVRP-
Rv1592c|M.tuberculosis_H37Rv        -------------------MVEPGNLAGATGAEWIGRPPHEELQRKVRP-
MSMEG_3197|M.smegmatis_MC2_155      --------------------MDLSSAAKAADAEWIGRAPHEELDRDARP-
Mflv_3621|M.gilvum_PYR-GCK          --------------------MDLGNVARSTGAEWIGQPRHEELRPRTRP-
Mvan_2796|M.vanbaalenii_PYR-1       --------------------MDLGNVARSTGAEWIGQPFHEPLRPRSRP-
                                                                                      

MAV_5251|M.avium_104                -----DEPQYADFYTPPDPLPPGRPGDLIRTEPSRLVLEPSGQLGAIMAT
TH_3043|M.thermoresistible__bu      FT---HEQKYTAFYTPPDPLPPGEPGDLIRTEPARLVLEPSGQLGAIMAT
MMAR_1029|M.marinum_M               FESEGDQSQYDQFYTPPDPLPPGEPGDVIRTEPSRLVLEPSGQLGAIMAT
MUL_0787|M.ulcerans_Agy99           FESEGDQSQYDQFYTPPDPLPPGEPGDVIRTEPSRLALEPSGQLGAIMAT
MAB_4351|M.abscessus_ATCC_1997      -------RHYEEFYTPPNPLPAGQAGDLIRTEPQRLVLEPSGQLGAYMGT
Mb1618c|M.bovis_AF2122/97           -----LLPSDDPFYFPPAGYQHAVPGTVLRSRDVELAFMG---LIPQPVT
Rv1592c|M.tuberculosis_H37Rv        -----LLPSDDPFYFPPAGYQHAVPGTVLRSRDVELAFMG---LIPQPVT
MSMEG_3197|M.smegmatis_MC2_155      -----GLPGEDPFYLPPAGYHHAEPGTVLRSRDVELAFLG---LVPQALH
Mflv_3621|M.gilvum_PYR-GCK          -----VIPADDPFYEPPEGYEHARPGTVLRSRDVELAFLG---LIPQKFS
Mvan_2796|M.vanbaalenii_PYR-1       -----MIPAKDDFYEPPAGFEHARPGTVLRSRDVELAFLG---VIPQKFT
                                                ** **     . .* ::*:.  .*.:     : .    

MAV_5251|M.avium_104                GTRIMYRSTDTRGNPIAVTGTYFEPYNDWPYGGPRPLISYAPGTQGQGNQ
TH_3043|M.thermoresistible__bu      GTRIMYRSTDSRGNPNVVTGMYFEPHNDWPHGGPRPLIAYGPGTQGQGDQ
MMAR_1029|M.marinum_M               GTRIMYRSTDTRGNPIAVTGTYFEPDNPWPGSGPRPLLSYAPGTVGQGDQ
MUL_0787|M.ulcerans_Agy99           GTRIMYRSTDTRGNPIAVTGTYFEPDNPWPGSGPRPLLRYAPGTVGQGDQ
MAB_4351|M.abscessus_ATCC_1997      GTRIMYRSNDARGNPVAVTGTYIEPSVPWTGRGPRPLLAYATLPYGMGEQ
Mb1618c|M.bovis_AF2122/97           ATQLLYRTTNMYGNPEATVTTVIVP-AELAPGQTCPLLSYQCAIDAMSSR
Rv1592c|M.tuberculosis_H37Rv        ATQLLYRTTNMYGNPEATVTTVIVP-AELAPGQTCPLLSYQCAIDAMSSR
MSMEG_3197|M.smegmatis_MC2_155      ATQLLYRTTDRNGAPEAAVTTVIMP-PDARAG--CPIVSYQCAIDAISAT
Mflv_3621|M.gilvum_PYR-GCK          ATQLLYRTTDLYGQPQATVTTVLAP-TERTDRRPLPIVSYQCAIDAVAGR
Mvan_2796|M.vanbaalenii_PYR-1       ATQLLYRTTDLNGEAQATVTTVVVP-SERTSDGPLPIVSYQCAIDAVAGR
                                    .*:::**:.:  * . ...   . *          *:: *     . .  

MAV_5251|M.avium_104                CAPSRMFNQGIHYSGGWDIMFNYEELFVATMVARGFAIVMTDYQGLGTPP
TH_3043|M.thermoresistible__bu      CAPSRMFSEGIHWTSGADIMFNYEEMFVATMVARGFAIVMTDYEGLGTPG
MMAR_1029|M.marinum_M               CALSRVFNQGIHWSPWLDLMVNYEETFVATMVARGFAIVMTDYEGLGTPG
MUL_0787|M.ulcerans_Agy99           CALSRVFNQGIHWSPWLDLMVNYEETFVATMVARGFAIVMTDYEGLGTPG
MAB_4351|M.abscessus_ATCC_1997      CAPSRLFDQGIHFSQGMDLMFNIEEGFVATLLARGFAIVVTDGIGMGVHG
Mb1618c|M.bovis_AF2122/97           CFPSYALRR---RAKALGSLTQMELLMISAALAEGWAVSVPDHE--GPKG
Rv1592c|M.tuberculosis_H37Rv        CFPSYALRR---RAKALGSLTQMELLMISAALAEGWAVSVPDHE--GPKG
MSMEG_3197|M.smegmatis_MC2_155      CFPSYALRR---HAKVTGGLAQFELLLITAALAEGWAVSVPDHE--GLDG
Mflv_3621|M.gilvum_PYR-GCK          CFPSYALRR---GAKALGAVAQFEFLLIAAALAEGWAVSVPDHE--GTTG
Mvan_2796|M.vanbaalenii_PYR-1       CFPSYALRR---GAKALGSFAQFEFLLVAAALAEGWAVSVPDHE--GTSG
                                    *  *  : .    :   . . : *  :::: :*.*:*: :.*    *   

MAV_5251|M.avium_104                MHT--YVGRVAEGQAVLDAARAAMRLPGTSLDPHGPVAFWGYSQGGGATA
TH_3043|M.thermoresistible__bu      VHT--YVNRLAQGHALIDAARAAKRLPGTSLDPDGPVAFWGYSQGGGAAA
MMAR_1029|M.marinum_M               THT--YVNRLAEGHAVLDAARAAQRLPGTSLDPHGPVAFWGYSQGGGAAA
MUL_0787|M.ulcerans_Agy99           THT--YVNRLAEGHAVLDAARAAQRLPGTSLDPHGPVAFWGYSQGGGAAA
MAB_4351|M.abscessus_ATCC_1997      PQSPQFLNRVAAGTALIDAARAAMKLVDTSLDPHGPVAFWGFASGAHASL
Mb1618c|M.bovis_AF2122/97           LWG----SPYEPGYRVLDGIRAALNSERVGLSPATPIGLWGYSGGGLASA
Rv1592c|M.tuberculosis_H37Rv        LWG----SPYEPGYRVLDGIRAALNSERVGLSPATPIGLWGYSGGGLASA
MSMEG_3197|M.smegmatis_MC2_155      MWG----APYEPGYHVLDGLRAALNSERLPLTDASPIGLWGYSGGGLASG
Mflv_3621|M.gilvum_PYR-GCK          MWG----APFEPGYHVLDGIRAAVNHRPLGLAEDAPVGLWGYSGGGLASA
Mvan_2796|M.vanbaalenii_PYR-1       MWG----APHEPGYHVLDGVRAALNHGPLGLSPDAPVGLWGYSGGGLASA
                                                *  ::*. *** .     *    *:.:**:: *. *: 

MAV_5251|M.avium_104                SAAELAAQYAPDLHIVGTYAGAPPADLKELLPYADGSALVGVVGYALNSV
TH_3043|M.thermoresistible__bu      SAAELASTYGPELDVVGTYAGSPPADLVALLPFADGSVLVGALGYALNGA
MMAR_1029|M.marinum_M               SAAELVSSYAPELDVVGTYAGAPPADLVEMLPYMDGNVLVGAAGYLINGF
MUL_0787|M.ulcerans_Agy99           SAAELVSSYAPELDVVGTYAGAPPADLVEMLPYMDGNVLVGAAGCLINGF
MAB_4351|M.abscessus_ATCC_1997      SAAEQVGSYAPELNVVGTYAYSPMTDLAAELPGIDGSFMAGTTGYILRGL
Mb1618c|M.bovis_AF2122/97           WAAEACGEYAPDLDIVGAVLGSPVGDLGHTFRRLNGTLLAGLPALVVAAL
Rv1592c|M.tuberculosis_H37Rv        WAAEACGEYAPDLDIVGAVLGSPVGDLGHTFRRLNGTLLAGLPALVVAAL
MSMEG_3197|M.smegmatis_MC2_155      WAAEMSGSYAPELNIVGAVLGSPVGDLGHTFRRLNGTVFSGLPALVVAAL
Mflv_3621|M.gilvum_PYR-GCK          WAAEVHDSYAPELNVVGAVLGSPVGDLGHAFRRLNGSIYSGLPAMVVAAL
Mvan_2796|M.vanbaalenii_PYR-1       WAAEVQDAYAPELNVVGAVLGSPVGDLGHTFRRLNGSIYAGLPALVVAAL
                                     ***    *.*:*.:**:   :*  **   :   :*.   *  .  : . 

MAV_5251|M.avium_104                MAAYPEFADAIRSKMTPRGLAMLESVSRQCVGQTLLDFMFRHIQPYFTED
TH_3043|M.thermoresistible__bu      IAAYPEAEEKIRATLTPRGAHMLDEVKDQCVGETLMKFAFRHLQPYFNVD
MMAR_1029|M.marinum_M               IYAYPELADAIHERMTPRGEDLLAKTRHQCVQETSFKFMFRHLRGYFTKD
MUL_0787|M.ulcerans_Agy99           IYAYPELADAIHERMTPRGEDLLAKTRHQCVEETSFKFMFRHLRGYFTKD
MAB_4351|M.abscessus_ATCC_1997      FASYPELEQPIRESLTPRGLQMLDWSGHTCIMQTGIDYAFRHLQFWFNDD
Mb1618c|M.bovis_AF2122/97           QHSYPGLARVIKEHANDEGRQLLEQLTEMTTVDAVIRMAGRDMGDFLDEP
Rv1592c|M.tuberculosis_H37Rv        QHSYPGLARVIKEHANDEGRQLLEQLTEMTTVDAVIRMAGRDMGDFLDEP
MSMEG_3197|M.smegmatis_MC2_155      ADIYPGLNRVIAEHATTEGRKLLQRLHKMSTIEAVLRLARKDMDDLVDLP
Mflv_3621|M.gilvum_PYR-GCK          THVYPDLNRIIQQHATVEGKAMLARIEKMTTAHAMLSLVGKDMAHWVDRP
Mvan_2796|M.vanbaalenii_PYR-1       THIYPDLHRVIQEHATEDGKVMLARIEKMTTAHAMISLVGRDMAHMIDRP
                                       **     *    .  *  :*         .: :    :.:   .   

MAV_5251|M.avium_104                INQLVNEEPFNSLFEAQRIGRYKPNAPVLINSNRYDPLVPWTAANQLGRD
TH_3043|M.thermoresistible__bu      IFTAVEEEPFKSLFELQRLGGLKPEGPVLINANRFDPLVPWAPAMQMGRD
MMAR_1029|M.marinum_M               LDQLVREEPFKTLFEAQRLGRHQPSAPVLIVNNRYDPLVPWTQASQLGRD
MUL_0787|M.ulcerans_Agy99           LDQLVREEPFKTLFEAQRLGRHQPSAPVLIVNNRYDPLVPWTQASQLGRD
MAB_4351|M.abscessus_ATCC_1997      ITHLAQLEPFKTLLAAQRVGNTKPTGPVYIAINRFDPLNDYNAARQSGLD
Mb1618c|M.bovis_AF2122/97           LEDILSTPEVSHVFGDTKLGSAVPTPPVLIVQAVHDYLIDVSDIDALADS
Rv1592c|M.tuberculosis_H37Rv        LEDILSTPEISHVFGDTKLGSAVPTPPVLIVQAVHDYLIDVSDIDALADS
MSMEG_3197|M.smegmatis_MC2_155      LEQILDSPEVTEVFDDIKLGVATPNPPVLLIQAVHDELISVSSIDELAEK
Mflv_3621|M.gilvum_PYR-GCK          LEEILLTPEVQHVFDSIKLGTSAPKVPVLIVQAVHDRIISVDDIDELTET
Mvan_2796|M.vanbaalenii_PYR-1       LEEILLSPEVQHVFDSIKLGTAAPKVPLLIVQAVHDRIISVDDIDALTET
                                    :        .  ::   ::*   *  *: :    .* :            

MAV_5251|M.avium_104                WCAQGADVEFRTNEEPPFLNKLVINHALPMLVDGEPAMQWIAARFRGEPT
TH_3043|M.thermoresistible__bu      WCAMGADVEARTNEQPPLFNKLIVNHGLPMLVDGEPAMQWIADRFKGVPT
MMAR_1029|M.marinum_M               WCAQGAQVEFWTNEEPPFLNKASVNHALTFWVDGERALQWVADRFNGLPA
MUL_0787|M.ulcerans_Agy99           WCAQGAQVEFWTNEEPPFLNKASVNHALTFWVDGERALQWVADRFNGRPA
MAB_4351|M.abscessus_ATCC_1997      YCAMNADVTFWTNEQPPLFNKLAINTFLPVFVDGERSMAWVTDRFNGVTT
Mb1618c|M.bovis_AF2122/97           YTAGGANVTYHR--------DLFSEHVSLHPLSAPMTLRWLTDRFAGKPL
Rv1592c|M.tuberculosis_H37Rv        YTAGGANVTYHR--------DLFSEHVSLHPLSAPMTLRWLTDRFAGKPL
MSMEG_3197|M.smegmatis_MC2_155      YLTGGASVTYHR--------DLFSEHLLLHPMSAPMALRWLTDRFAARPL
Mflv_3621|M.gilvum_PYR-GCK          YTAGGASVTYHR--------DMFSEHLLLHPMSAPMTLRWLRDRFAGRPI
Mvan_2796|M.vanbaalenii_PYR-1       YTSGGASVTYHR--------DMLSEHLLLHPMSAPMTLRWLRDRFAGRPL
                                    : : .*.*            .   :      :..  :: *:  ** . . 

MAV_5251|M.avium_104                APNCGQF----------------------------------------
TH_3043|M.thermoresistible__bu      APNCGRF----------------------------------------
MMAR_1029|M.marinum_M               APNCGQF----------------------------------------
MUL_0787|M.ulcerans_Agy99           APNCGQF----------------------------------------
MAB_4351|M.abscessus_ATCC_1997      SPNCGHF----------------------------------------
Mb1618c|M.bovis_AF2122/97           TDHRVRTTWPTIFNPMTYAGMARLAVIAAKVITGRKLSRRPL-----
Rv1592c|M.tuberculosis_H37Rv        TDHRVRTTWPTIFNPMTYAGMARLAVIAAKVITGRKLSRRPL-----
MSMEG_3197|M.smegmatis_MC2_155      TANLVRSKWPTLLNPVTYVGMARLAGIAAKVVTGRALRRSPL-----
Mflv_3621|M.gilvum_PYR-GCK          SAHIARTKWPTLLNPSTYRGMLTLGKITAKVVLGRRVERQPLSQFDL
Mvan_2796|M.vanbaalenii_PYR-1       RTHISRTKWPTLLNPSTYRGMLTLGKITAKVMLGRRVERQPLSRFDQ
                                      :  :