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MVIEKRDLFVRGMRAARGRLQSRLQVVVVAMLSCATITVVAPDSARADGGFESEGDQSQYDQFYTPPDPL PPGEPGDVIRTEPSRLALEPSGQLGAIMATGTRIMYRSTDTRGNPIAVTGTYFEPDNPWPGSGPRPLLRY APGTVGQGDQCALSRVFNQGIHWSPWLDLMVNYEETFVATMVARGFAIVMTDYEGLGTPGTHTYVNRLAE GHAVLDAARAAQRLPGTSLDPHGPVAFWGYSQGGGAAASAAELVSSYAPELDVVGTYAGAPPADLVEMLP YMDGNVLVGAAGCLINGFIYAYPELADAIHERMTPRGEDLLAKTRHQCVEETSFKFMFRHLRGYFTKDLD QLVREEPFKTLFEAQRLGRHQPSAPVLIVNNRYDPLVPWTQASQLGRDWCAQGAQVEFWTNEEPPFLNKA SVNHALTFWVDGERALQWVADRFNGRPAAPNCGQF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0787 | - | - | 100% (455) | lipase |
| M. ulcerans Agy99 | MUL_1566 | - | 6e-40 | 29.52% (393) | hypothetical protein MUL_1566 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1618c | - | 4e-38 | 29.52% (393) | hypothetical protein Mb1618c |
| M. gilvum PYR-GCK | Mflv_3621 | - | 2e-39 | 28.28% (389) | triacylglycerol lipase |
| M. tuberculosis H37Rv | Rv1592c | - | 3e-38 | 29.52% (393) | hypothetical protein Rv1592c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4351 | - | 1e-134 | 56.30% (405) | secretory lipase family protein |
| M. marinum M | MMAR_1029 | - | 0.0 | 98.87% (443) | lipase |
| M. avium 104 | MAV_5251 | - | 0.0 | 72.20% (428) | secretory lipase family protein |
| M. smegmatis MC2 155 | MSMEG_3197 | - | 3e-35 | 27.74% (393) | lipase |
| M. thermoresistible (build 8) | TH_3043 | - | 1e-173 | 70.32% (411) | PUTATIVE Triacylglycerol lipase |
| M. vanbaalenii PYR-1 | Mvan_2796 | - | 5e-40 | 29.05% (389) | triacylglycerol lipase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0787|M.ulcerans_Agy99 MVIEKRDLFVRGMRAARGRLQSRLQVVVVAMLSCATITVVAPDSARADGG
MMAR_1029|M.marinum_M ------------MRAARGRLQSRLQVVVVAMLSCATITVVAPDSARADGG
MAV_5251|M.avium_104 ------------MRDCY-RSVMRRVAGVFAALVLMAGTLTGPAIARADG-
TH_3043|M.thermoresistible__bu --------------------MVRGFAGSVCVLLIVSMGMSSP-LARAEDP
MAB_4351|M.abscessus_ATCC_1997 ----------------MASPAMRLWRLTAALAITIVSLWQLMPTARADD-
Mb1618c|M.bovis_AF2122/97 -------------------MVEPGNLAGATGAEWIGRPPHEELQRKVRP-
Rv1592c|M.tuberculosis_H37Rv -------------------MVEPGNLAGATGAEWIGRPPHEELQRKVRP-
MSMEG_3197|M.smegmatis_MC2_155 --------------------MDLSSAAKAADAEWIGRAPHEELDRDARP-
Mflv_3621|M.gilvum_PYR-GCK --------------------MDLGNVARSTGAEWIGQPRHEELRPRTRP-
Mvan_2796|M.vanbaalenii_PYR-1 --------------------MDLGNVARSTGAEWIGQPFHEPLRPRSRP-
MUL_0787|M.ulcerans_Agy99 FESEGDQSQYDQFYTPPDPLPPGEPGDVIRTEPSRLALEPSGQLGAIMAT
MMAR_1029|M.marinum_M FESEGDQSQYDQFYTPPDPLPPGEPGDVIRTEPSRLVLEPSGQLGAIMAT
MAV_5251|M.avium_104 -----DEPQYADFYTPPDPLPPGRPGDLIRTEPSRLVLEPSGQLGAIMAT
TH_3043|M.thermoresistible__bu FT---HEQKYTAFYTPPDPLPPGEPGDLIRTEPARLVLEPSGQLGAIMAT
MAB_4351|M.abscessus_ATCC_1997 -------RHYEEFYTPPNPLPAGQAGDLIRTEPQRLVLEPSGQLGAYMGT
Mb1618c|M.bovis_AF2122/97 -----LLPSDDPFYFPPAGYQHAVPGTVLRSRDVELAFMG---LIPQPVT
Rv1592c|M.tuberculosis_H37Rv -----LLPSDDPFYFPPAGYQHAVPGTVLRSRDVELAFMG---LIPQPVT
MSMEG_3197|M.smegmatis_MC2_155 -----GLPGEDPFYLPPAGYHHAEPGTVLRSRDVELAFLG---LVPQALH
Mflv_3621|M.gilvum_PYR-GCK -----VIPADDPFYEPPEGYEHARPGTVLRSRDVELAFLG---LIPQKFS
Mvan_2796|M.vanbaalenii_PYR-1 -----MIPAKDDFYEPPAGFEHARPGTVLRSRDVELAFLG---VIPQKFT
** ** . .* ::*:. .*.: : .
MUL_0787|M.ulcerans_Agy99 GTRIMYRSTDTRGNPIAVTGTYFEPDNPWPGSGPRPLLRYAPGTVGQGDQ
MMAR_1029|M.marinum_M GTRIMYRSTDTRGNPIAVTGTYFEPDNPWPGSGPRPLLSYAPGTVGQGDQ
MAV_5251|M.avium_104 GTRIMYRSTDTRGNPIAVTGTYFEPYNDWPYGGPRPLISYAPGTQGQGNQ
TH_3043|M.thermoresistible__bu GTRIMYRSTDSRGNPNVVTGMYFEPHNDWPHGGPRPLIAYGPGTQGQGDQ
MAB_4351|M.abscessus_ATCC_1997 GTRIMYRSNDARGNPVAVTGTYIEPSVPWTGRGPRPLLAYATLPYGMGEQ
Mb1618c|M.bovis_AF2122/97 ATQLLYRTTNMYGNPEATVTTVIVP-AELAPGQTCPLLSYQCAIDAMSSR
Rv1592c|M.tuberculosis_H37Rv ATQLLYRTTNMYGNPEATVTTVIVP-AELAPGQTCPLLSYQCAIDAMSSR
MSMEG_3197|M.smegmatis_MC2_155 ATQLLYRTTDRNGAPEAAVTTVIMP-PDARAG--CPIVSYQCAIDAISAT
Mflv_3621|M.gilvum_PYR-GCK ATQLLYRTTDLYGQPQATVTTVLAP-TERTDRRPLPIVSYQCAIDAVAGR
Mvan_2796|M.vanbaalenii_PYR-1 ATQLLYRTTDLNGEAQATVTTVVVP-SERTSDGPLPIVSYQCAIDAVAGR
.*:::**:.: * . ... . * *:: * . .
MUL_0787|M.ulcerans_Agy99 CALSRVFNQGIHWSPWLDLMVNYEETFVATMVARGFAIVMTDYEGLGTPG
MMAR_1029|M.marinum_M CALSRVFNQGIHWSPWLDLMVNYEETFVATMVARGFAIVMTDYEGLGTPG
MAV_5251|M.avium_104 CAPSRMFNQGIHYSGGWDIMFNYEELFVATMVARGFAIVMTDYQGLGTPP
TH_3043|M.thermoresistible__bu CAPSRMFSEGIHWTSGADIMFNYEEMFVATMVARGFAIVMTDYEGLGTPG
MAB_4351|M.abscessus_ATCC_1997 CAPSRLFDQGIHFSQGMDLMFNIEEGFVATLLARGFAIVVTDGIGMGVHG
Mb1618c|M.bovis_AF2122/97 CFPSYALRR---RAKALGSLTQMELLMISAALAEGWAVSVPDHE--GPKG
Rv1592c|M.tuberculosis_H37Rv CFPSYALRR---RAKALGSLTQMELLMISAALAEGWAVSVPDHE--GPKG
MSMEG_3197|M.smegmatis_MC2_155 CFPSYALRR---HAKVTGGLAQFELLLITAALAEGWAVSVPDHE--GLDG
Mflv_3621|M.gilvum_PYR-GCK CFPSYALRR---GAKALGAVAQFEFLLIAAALAEGWAVSVPDHE--GTTG
Mvan_2796|M.vanbaalenii_PYR-1 CFPSYALRR---GAKALGSFAQFEFLLVAAALAEGWAVSVPDHE--GTSG
* * : . : . . : * :::: :*.*:*: :.* *
MUL_0787|M.ulcerans_Agy99 THT--YVNRLAEGHAVLDAARAAQRLPGTSLDPHGPVAFWGYSQGGGAAA
MMAR_1029|M.marinum_M THT--YVNRLAEGHAVLDAARAAQRLPGTSLDPHGPVAFWGYSQGGGAAA
MAV_5251|M.avium_104 MHT--YVGRVAEGQAVLDAARAAMRLPGTSLDPHGPVAFWGYSQGGGATA
TH_3043|M.thermoresistible__bu VHT--YVNRLAQGHALIDAARAAKRLPGTSLDPDGPVAFWGYSQGGGAAA
MAB_4351|M.abscessus_ATCC_1997 PQSPQFLNRVAAGTALIDAARAAMKLVDTSLDPHGPVAFWGFASGAHASL
Mb1618c|M.bovis_AF2122/97 LWG----SPYEPGYRVLDGIRAALNSERVGLSPATPIGLWGYSGGGLASA
Rv1592c|M.tuberculosis_H37Rv LWG----SPYEPGYRVLDGIRAALNSERVGLSPATPIGLWGYSGGGLASA
MSMEG_3197|M.smegmatis_MC2_155 MWG----APYEPGYHVLDGLRAALNSERLPLTDASPIGLWGYSGGGLASG
Mflv_3621|M.gilvum_PYR-GCK MWG----APFEPGYHVLDGIRAAVNHRPLGLAEDAPVGLWGYSGGGLASA
Mvan_2796|M.vanbaalenii_PYR-1 MWG----APHEPGYHVLDGVRAALNHGPLGLSPDAPVGLWGYSGGGLASA
* ::*. *** . * *:.:**:: *. *:
MUL_0787|M.ulcerans_Agy99 SAAELVSSYAPELDVVGTYAGAPPADLVEMLPYMDGNVLVGAAGCLINGF
MMAR_1029|M.marinum_M SAAELVSSYAPELDVVGTYAGAPPADLVEMLPYMDGNVLVGAAGYLINGF
MAV_5251|M.avium_104 SAAELAAQYAPDLHIVGTYAGAPPADLKELLPYADGSALVGVVGYALNSV
TH_3043|M.thermoresistible__bu SAAELASTYGPELDVVGTYAGSPPADLVALLPFADGSVLVGALGYALNGA
MAB_4351|M.abscessus_ATCC_1997 SAAEQVGSYAPELNVVGTYAYSPMTDLAAELPGIDGSFMAGTTGYILRGL
Mb1618c|M.bovis_AF2122/97 WAAEACGEYAPDLDIVGAVLGSPVGDLGHTFRRLNGTLLAGLPALVVAAL
Rv1592c|M.tuberculosis_H37Rv WAAEACGEYAPDLDIVGAVLGSPVGDLGHTFRRLNGTLLAGLPALVVAAL
MSMEG_3197|M.smegmatis_MC2_155 WAAEMSGSYAPELNIVGAVLGSPVGDLGHTFRRLNGTVFSGLPALVVAAL
Mflv_3621|M.gilvum_PYR-GCK WAAEVHDSYAPELNVVGAVLGSPVGDLGHAFRRLNGSIYSGLPAMVVAAL
Mvan_2796|M.vanbaalenii_PYR-1 WAAEVQDAYAPELNVVGAVLGSPVGDLGHTFRRLNGSIYAGLPALVVAAL
*** *.*:*.:**: :* ** : :*. * . : .
MUL_0787|M.ulcerans_Agy99 IYAYPELADAIHERMTPRGEDLLAKTRHQCVEETSFKFMFRHLRGYFTKD
MMAR_1029|M.marinum_M IYAYPELADAIHERMTPRGEDLLAKTRHQCVQETSFKFMFRHLRGYFTKD
MAV_5251|M.avium_104 MAAYPEFADAIRSKMTPRGLAMLESVSRQCVGQTLLDFMFRHIQPYFTED
TH_3043|M.thermoresistible__bu IAAYPEAEEKIRATLTPRGAHMLDEVKDQCVGETLMKFAFRHLQPYFNVD
MAB_4351|M.abscessus_ATCC_1997 FASYPELEQPIRESLTPRGLQMLDWSGHTCIMQTGIDYAFRHLQFWFNDD
Mb1618c|M.bovis_AF2122/97 QHSYPGLARVIKEHANDEGRQLLEQLTEMTTVDAVIRMAGRDMGDFLDEP
Rv1592c|M.tuberculosis_H37Rv QHSYPGLARVIKEHANDEGRQLLEQLTEMTTVDAVIRMAGRDMGDFLDEP
MSMEG_3197|M.smegmatis_MC2_155 ADIYPGLNRVIAEHATTEGRKLLQRLHKMSTIEAVLRLARKDMDDLVDLP
Mflv_3621|M.gilvum_PYR-GCK THVYPDLNRIIQQHATVEGKAMLARIEKMTTAHAMLSLVGKDMAHWVDRP
Mvan_2796|M.vanbaalenii_PYR-1 THIYPDLHRVIQEHATEDGKVMLARIEKMTTAHAMISLVGRDMAHMIDRP
** * . * :* .: : :.: .
MUL_0787|M.ulcerans_Agy99 LDQLVREEPFKTLFEAQRLGRHQPSAPVLIVNNRYDPLVPWTQASQLGRD
MMAR_1029|M.marinum_M LDQLVREEPFKTLFEAQRLGRHQPSAPVLIVNNRYDPLVPWTQASQLGRD
MAV_5251|M.avium_104 INQLVNEEPFNSLFEAQRIGRYKPNAPVLINSNRYDPLVPWTAANQLGRD
TH_3043|M.thermoresistible__bu IFTAVEEEPFKSLFELQRLGGLKPEGPVLINANRFDPLVPWAPAMQMGRD
MAB_4351|M.abscessus_ATCC_1997 ITHLAQLEPFKTLLAAQRVGNTKPTGPVYIAINRFDPLNDYNAARQSGLD
Mb1618c|M.bovis_AF2122/97 LEDILSTPEVSHVFGDTKLGSAVPTPPVLIVQAVHDYLIDVSDIDALADS
Rv1592c|M.tuberculosis_H37Rv LEDILSTPEISHVFGDTKLGSAVPTPPVLIVQAVHDYLIDVSDIDALADS
MSMEG_3197|M.smegmatis_MC2_155 LEQILDSPEVTEVFDDIKLGVATPNPPVLLIQAVHDELISVSSIDELAEK
Mflv_3621|M.gilvum_PYR-GCK LEEILLTPEVQHVFDSIKLGTSAPKVPVLIVQAVHDRIISVDDIDELTET
Mvan_2796|M.vanbaalenii_PYR-1 LEEILLSPEVQHVFDSIKLGTAAPKVPLLIVQAVHDRIISVDDIDALTET
: . :: ::* * *: : .* :
MUL_0787|M.ulcerans_Agy99 WCAQGAQVEFWTNEEPPFLNKASVNHALTFWVDGERALQWVADRFNGRPA
MMAR_1029|M.marinum_M WCAQGAQVEFWTNEEPPFLNKASVNHALTFWVDGERALQWVADRFNGLPA
MAV_5251|M.avium_104 WCAQGADVEFRTNEEPPFLNKLVINHALPMLVDGEPAMQWIAARFRGEPT
TH_3043|M.thermoresistible__bu WCAMGADVEARTNEQPPLFNKLIVNHGLPMLVDGEPAMQWIADRFKGVPT
MAB_4351|M.abscessus_ATCC_1997 YCAMNADVTFWTNEQPPLFNKLAINTFLPVFVDGERSMAWVTDRFNGVTT
Mb1618c|M.bovis_AF2122/97 YTAGGANVTYHR--------DLFSEHVSLHPLSAPMTLRWLTDRFAGKPL
Rv1592c|M.tuberculosis_H37Rv YTAGGANVTYHR--------DLFSEHVSLHPLSAPMTLRWLTDRFAGKPL
MSMEG_3197|M.smegmatis_MC2_155 YLTGGASVTYHR--------DLFSEHLLLHPMSAPMALRWLTDRFAARPL
Mflv_3621|M.gilvum_PYR-GCK YTAGGASVTYHR--------DMFSEHLLLHPMSAPMTLRWLRDRFAGRPI
Mvan_2796|M.vanbaalenii_PYR-1 YTSGGASVTYHR--------DMLSEHLLLHPMSAPMTLRWLRDRFAGRPL
: : .*.* . : :.. :: *: ** . .
MUL_0787|M.ulcerans_Agy99 APNCGQF----------------------------------------
MMAR_1029|M.marinum_M APNCGQF----------------------------------------
MAV_5251|M.avium_104 APNCGQF----------------------------------------
TH_3043|M.thermoresistible__bu APNCGRF----------------------------------------
MAB_4351|M.abscessus_ATCC_1997 SPNCGHF----------------------------------------
Mb1618c|M.bovis_AF2122/97 TDHRVRTTWPTIFNPMTYAGMARLAVIAAKVITGRKLSRRPL-----
Rv1592c|M.tuberculosis_H37Rv TDHRVRTTWPTIFNPMTYAGMARLAVIAAKVITGRKLSRRPL-----
MSMEG_3197|M.smegmatis_MC2_155 TANLVRSKWPTLLNPVTYVGMARLAGIAAKVVTGRALRRSPL-----
Mflv_3621|M.gilvum_PYR-GCK SAHIARTKWPTLLNPSTYRGMLTLGKITAKVVLGRRVERQPLSQFDL
Mvan_2796|M.vanbaalenii_PYR-1 RTHISRTKWPTLLNPSTYRGMLTLGKITAKVMLGRRVERQPLSRFDQ
: :