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TGYDAIVIGAGHNGLTAAVLLQRAGLRTACLDAKRYAGGMASTVELFDGYRFEIAGSVQFPTSSAVSSEL GLDSLPTVDLEVMSVALRGVGDDPVVQFTDPTKMLTHLHRVHGADAVTGMAGLLAWSQAPTRALGRFEAG TLPKSFDEMYACATNEFERSAIDDMLFGSVTDVLDRHFPDREKHGALRGSMTVLAVNTLYRGPATPGSAA ALAFGLGVPEGDFVRWKKLRGGIGALTTHLSQLLERTGGEVRLRSKVTEIVVDNSRSSARVRGVRTAAGD TLTSPIVVSAIAPDVTINELIDPAVLPSEIRDRYLRIDHRGSYLQMHFALAQPPAFAAPYQALNDPSMQA SMGIFCTPEQVQQQWEDCRRGIVPADPTVVLQIPSLHDPSLAPAGKQAASAFAMWFPIEGGSKYGGYGRA KVEMGQNVIDKITRLAPNFKGSILRYTTFTPKHMGVMFGAPGGDYCHALLHSDQIGPNRPGPKGFIGQPI PIAGLYLGSAGCHGGPGITFIPGYNAARQALADRRAANCCVLSGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3829c | - | - | 100% (536) | PROBABLE DEHYDROGENASE |
| M. tuberculosis H37Rv | Rv1432 | - | 2e-10 | 25.23% (535) | dehydrogenase |
| M. tuberculosis H37Rv | Rv0897c | - | 8e-08 | 48.94% (47) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3859c | - | 0.0 | 99.81% (536) | putative dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1677 | - | 0.0 | 69.66% (524) | FAD dependent oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4734 | - | 1e-07 | 22.71% (546) | dehydrogenase |
| M. marinum M | MMAR_5383 | - | 0.0 | 83.43% (525) | dehydrogenase |
| M. avium 104 | MAV_0198 | - | 0.0 | 79.81% (525) | FAD dependent oxidoreductase, putative |
| M. smegmatis MC2 155 | MSMEG_0664 | - | 9e-42 | 27.64% (550) | FAD dependent oxidoreductase |
| M. thermoresistible (build 8) | TH_4571 | - | 4e-12 | 24.04% (545) | PUTATIVE dehydrogenase |
| M. ulcerans Agy99 | MUL_2934 | - | 0.0 | 59.92% (524) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5076 | - | 0.0 | 70.29% (525) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1677|M.gilvum_PYR-GCK ----------------------MTDFDAIVVGAGHNGLTAAALLQQAGLR
Mvan_5076|M.vanbaalenii_PYR-1 ----------------------MADFDAIVVGAGHNGLTAAALLQRAGLR
Rv3829c|M.tuberculosis_H37Rv ----------------------MTGYDAIVIGAGHNGLTAAVLLQRAGLR
Mb3859c|M.bovis_AF2122/97 ----------------------MTGYDAIVIGAGHNGLTAAVLLQRAGLR
MMAR_5383|M.marinum_M ----------------------MAEYDAIVIGAGHNGLTAAVLLQRAGLR
MAV_0198|M.avium_104 ----------------------MNDYDAIVIGAGHNGLTAAVLLQKAGLR
MUL_2934|M.ulcerans_Agy99 ----------------------MTDYDAIVVGAGHNGLTAAAVLQRAGLR
MAB_4734|M.abscessus_ATCC_1997 ------------------------MSTAVIVGGGPNGLTAAILLAQQGVH
TH_4571|M.thermoresistible__bu VAAERSGADHGHLVPVPRRAGGGGVTTATVVGSGPNGLAAAVTLAKAGVA
MSMEG_0664|M.smegmatis_MC2_155 ---------------------MSNNYDALVIGGGHNGLVSAAYLARAGAR
* ::*.* ***.:* * : *
Mflv_1677|M.gilvum_PYR-GCK TVCLDFKLYAGGMASTVELFDGFRFEIAGSVQVPTSAVVSDALELGDLPT
Mvan_5076|M.vanbaalenii_PYR-1 TLCLDAKLYAGGMASTVELFDGFRFEIAGSVQVPTSAVVSDALGLAELPT
Rv3829c|M.tuberculosis_H37Rv TACLDAKRYAGGMASTVELFDGYRFEIAGSVQFPTSSAVSSELGLDSLPT
Mb3859c|M.bovis_AF2122/97 TACLDAKRYAGGMASTVELFDGYRFDIAGSVQFPTSSAVSSELGLDSLPT
MMAR_5383|M.marinum_M TLCLDAKLYAGGMASTVELFDGYRFEIAGSVQFPTAAAVISELGLDTLPT
MAV_0198|M.avium_104 TLCLDAKLYAGGMASTVELFDGYRFEIAGSVQFPTSQAVVDELGLDTIPT
MUL_2934|M.ulcerans_Agy99 TLCMEANTYAGGMAATVELIDGFHFEIAGSVQFPTASQISKELGLDTLPT
MAB_4734|M.abscessus_ATCC_1997 VTVLEAADSVGGGVRSGAATG------PGLIHDYCSAIHPMAVGSPVLAG
TH_4571|M.thermoresistible__bu VTVLEAADEIGGGTRSFEAIV------PGLLHDHCSAIHPMAVGSPFINE
MSMEG_0664|M.smegmatis_MC2_155 TLVLESRSSLGGAATTEAPWDDAPHLRVTRLSYVMSLMPPTIVRDLALER
. :: ** . : : : : :
Mflv_1677|M.gilvum_PYR-GCK VDLDVMSVQ---LRGVGDDPLVYYTDPMKLLTHLNDVHGAEAVNGMAGLM
Mvan_5076|M.vanbaalenii_PYR-1 VDLDVMSVQ---LRGIGDDPLVYYTDPMKLLTHLNEVHGAEAVNGMAGLM
Rv3829c|M.tuberculosis_H37Rv VDLEVMSVA---LRGVGDDPVVQFTDPTKMLTHLHRVHGADAVTGMAGLL
Mb3859c|M.bovis_AF2122/97 VDLEVMSVA---LRGVGDDPVVQFTDPTKMLTHLHRVHGADAVTGMAGLL
MMAR_5383|M.marinum_M VDLEVMSVA---LRGVGDDPLVQYTDPMKMFAHLNEVHGADAVTGMAGLL
MAV_0198|M.avium_104 IDLDVMSVA---VRGVGDDPLVQYSDPVKLFTHLNEVHGADAVNGMAGLM
MUL_2934|M.ulcerans_Agy99 VAPEVMSTN---IGESDEEAMIFYRDPLQLISHLGEKHGSAAVTGMAELI
MAB_4734|M.abscessus_ATCC_1997 LDLEKHGLQ---WLWPEVDCAHPLDDGSCGVLYRDVAATANGLG--RDGR
TH_4571|M.thermoresistible__bu FGLDRHGLR---WRWPDIDCVHPLDDGTAGVLRRSVDHTAAGLG--PDGR
MSMEG_0664|M.smegmatis_MC2_155 HGYKVHPMGPYYQAFPEGGSLTIYEDDPARTYEQLSRFSKKDADAWPKWN
. *
Mflv_1677|M.gilvum_PYR-GCK AWCQAPTRALGRFEAAQPP----KTLDEMFACATNEFERQAISDILFGSV
Mvan_5076|M.vanbaalenii_PYR-1 AWCQAPTRAVGRFDAAQRP----KSLDEMFACATNEFERQAISDMLFGSV
Rv3829c|M.tuberculosis_H37Rv AWSQAPTRALGRFEAGTLP----KSFDEMYACATNEFERSAIDDMLFGSV
Mb3859c|M.bovis_AF2122/97 AWSQAPTRALGRFEAGTLP----KSFDEMYACATNEFERSAIDDMLFGSV
MMAR_5383|M.marinum_M AWSQAPTRALGRFESDTLP----KTFDQMYACATNEFERSAIDDMLFGSV
MAV_0198|M.avium_104 AWAQAPTRALDRFEAGTPP----KSLDEMYACATNEFERSAIDDMLFGSV
MUL_2934|M.ulcerans_Agy99 GWSQGPARALGRFEVRTPP----RTLDEMYACATNQAERRAIHEMLFGSA
MAB_4734|M.abscessus_ATCC_1997 RWRALFERPARNFDLLT----------ADIMGPLLRIPRHPLALTRFGVP
TH_4571|M.thermoresistible__bu VWRALFGRPVDRFDAVN----------DAVMGPLLRVPKHPLTLARFGAP
MSMEG_0664|M.smegmatis_MC2_155 AWLEGIADVMGPLLTQVPPNIGSHRPADLLDLAKLAWGQRGITSRAVADI
* : . : : ..
Mflv_1677|M.gilvum_PYR-GCK TDVLDR----YLPDREKHGALRGMLAFLAVNTTYRGPATPGSAAALAFGL
Mvan_5076|M.vanbaalenii_PYR-1 TDVLDR----YLPDREKHGALRGMLAFLAVNTTYRGPATPGSAAALAFGL
Rv3829c|M.tuberculosis_H37Rv TDVLDR----HFPDREKHGALRGSMTVLAVNTLYRGPATPGSAAALAFGL
Mb3859c|M.bovis_AF2122/97 TDVLDR----HFPDREKHGALRGSMTVLAVNTLYRGPATPGSAAALAFGL
MMAR_5383|M.marinum_M TDVLDR----YFPDREKHAALRGSMTVLAVNTIYRGPATPGSAAALAFGL
MAV_0198|M.avium_104 TDILDR----YLPDREKHGALRGSMTVLAVNTLYRGPATPGSAAALAFGL
MUL_2934|M.ulcerans_Agy99 MDVIDR----FLPDKEKHAVMRGILAFLAVNSTYRGPFTPGSAACLAFAL
MAB_4734|M.abscessus_ATCC_1997 TVLPAA----ATAQLFRTRQARALFGGIAAHAFR--PLHYPMTSAIGLGI
TH_4571|M.thermoresistible__bu TVLPAS----ALARVFRTPAARALWGGVAAHAFR--PLHLPMTSAIGVGI
MSMEG_0664|M.smegmatis_MC2_155 TRLLTMSIADLLDDWFESPQIKGALAVNGVIGTWAGPYEPGTAYVMAHHS
: . :. .. * : :.
Mflv_1677|M.gilvum_PYR-GCK A--VPDENATLIKKFRGGMGAVTEHLLQMFTAAGGELRLRTKVDEILVD-
Mvan_5076|M.vanbaalenii_PYR-1 A--VPDENATLIKKFRGGMGAVTEHLLQMFSAAGGELRLRSKVDEIIVE-
Rv3829c|M.tuberculosis_H37Rv G--VPEGDFVRWKKLRGGIGALTTHLSQLLERTGGEVRLRSKVTEIVVDN
Mb3859c|M.bovis_AF2122/97 G--VPEGDFVRWKKLRGGIGALTTHLSQLLERTGGEVRLRSKVTEIVVDN
MMAR_5383|M.marinum_M G--IPDGDFVQMKKLSGGIGALTAHLCRLFERDGGELRLRTKVSEILVDS
MAV_0198|M.avium_104 G--VPDGDTMQMKKLRGGIGALTSHLCDVLERHGGELRLRTKVTEILVEH
MUL_2934|M.ulcerans_Agy99 A--VPDDSTAMMTKLRGGIGALTDHLRERFASAGGEIRFRSKVVEIVVD-
MAB_4734|M.abscessus_ATCC_1997 I--TAG-HRHGWPVAAGGSQSITDALSSLLAQFGGRIETGVHVTSFTQLP
TH_4571|M.thermoresistible__bu I--TAG-HRHGWAVAEGGSRAITDAMAARLRELGGTIETGVRVRDIADLP
MSMEG_0664|M.smegmatis_MC2_155 IGDVGDGQLGSWGFPEGGMGAVSAAIACSARSFGAEIRTNARVSRLLVRN
** ::: : *. :. :* :
Mflv_1677|M.gilvum_PYR-GCK ---GGRVTGVRLEDGATLSAPVVVSNLAPDLTVNQLVDGSAIPADIRERF
Mvan_5076|M.vanbaalenii_PYR-1 ---DGRVAGVRLEDGSTLAAPMVVSAVAPDLTVNTLVDGGAVPPDVRERF
Rv3829c|M.tuberculosis_H37Rv SRSSARVRGVRTAAGDTLTSPIVVSAIAPDVTINELIDPAVLPSEIRDRY
Mb3859c|M.bovis_AF2122/97 SRSSARVRGVRTAAGDTLTSPIVVSAIAPDVTINELIDPAVLPSEIRDRY
MMAR_5383|M.marinum_M AEAGARISGVRTEAGDIVAAPIVVSAIAPDVTINDLIDPTVLPSDVRDRY
MAV_0198|M.avium_104 AGSGGRVTGVRTESGETLSAPIVVSGIAPDVTLNELLDPAALPADLRARY
MUL_2934|M.ulcerans_Agy99 ---RGAVSGVRLPDGSVIGTPVVVSNLAPDVTLAKLVGPEHVPADLLARL
MAB_4734|M.abscessus_ATCC_1997 ------------------TADVTLFDLSPTQVADILRD--HLPTSVARGL
TH_4571|M.thermoresistible__bu ------------------PTTITVFDLAPEAVAEILGD--RLPPRVARAY
MSMEG_0664|M.smegmatis_MC2_155 ----GRVEGAVLDNGDEIHAPVVVTTLHPKTAFLDHIPRTELPQDFVGDI
: :.: : * . :* .
Mflv_1677|M.gilvum_PYR-GCK ARIDHRGSYVQMHFALDGPPTFAEPYEVLNDPEYQSAIGIFTTPEELQQQ
Mvan_5076|M.vanbaalenii_PYR-1 SRIDHRGSYLQMHFALDGAPTFAEPYEMLNDPGYQSAIGIFTTPEELQQQ
Rv3829c|M.tuberculosis_H37Rv LRIDHRGSYLQMHFALAQPPAFAAPYQALNDPSMQASMGIFCTPEQVQQQ
Mb3859c|M.bovis_AF2122/97 LRIDHRGSYLQMHFALAQPPAFAAPYQALNDPSMQASMGIFCTPEQVQQQ
MMAR_5383|M.marinum_M AHIDHRGSYLQMHFALEEAPAFAAPYEALNDPAMQASIGIFCTPEEVQQQ
MAV_0198|M.avium_104 ARIDHRGSYLQMHFALQEAPVFAAPYQVLNEPAMQASIGLFCTPEEVQQQ
MUL_2934|M.ulcerans_Agy99 AGRDHRASFVQIHFALDALPEFAPPYELLNEPGMQQSVGIFGTPEEQQQQ
MAB_4734|M.abscessus_ATCC_1997 SRFRYGPGAFKVDFAIEDGVPWTNP-----DAGRAGTVHLGGTFAEVAST
TH_4571|M.thermoresistible__bu RAFRRGPGAFKVDFAVEGGVPWCNP-----DAHRAGTVHVGGTFEEIAAT
MSMEG_0664|M.smegmatis_MC2_155 EHWKSRSGVVKINLALAELPNFTADPSSGIAEHHTGSVEMAPTMEFIEAA
. .::.:*: : :: : *
Mflv_1677|M.gilvum_PYR-GCK WEDSRRGVVPADPAIALQIPSANDPTLAPPGKHAVSAFSLWFPLSEEISG
Mvan_5076|M.vanbaalenii_PYR-1 WEDSRRGVVPADPAIALQIPSANDPGLAPPGKHAVSAFALWFPLSEERAS
Rv3829c|M.tuberculosis_H37Rv WEDCRRGIVPADPTVVLQIPSLHDPSLAPAGKQAASAFAMWFPIEGGSKY
Mb3859c|M.bovis_AF2122/97 WEDCRRGIVPADPTVVLQIPSLHDPSLAPAGKQAASAFAMWFPIEGGSKY
MMAR_5383|M.marinum_M WEDCRRGIVPADPTVVLQVPSVHDPDLAPPGKHAASAFAMWFPIEGEQDS
MAV_0198|M.avium_104 WEQARRGVVPADPTVVLQIPSQNDPGLAPEGKHAASAFALWFPIEGEVD-
MUL_2934|M.ulcerans_Agy99 WETCRRGIVPENPSMGMQIPSVHDSGLAPPGKHAASAYAYAFPVEVDRDQ
MAB_4734|M.abscessus_ATCC_1997 ERAVHAGRMPERPFVLVGQQYLADPGRSNGNIHPLWTYAHVP--------
TH_4571|M.thermoresistible__bu ERDVNAGRMPERPFVLVAQQYVADPGRSVGDIHPVWSYAHVP--------
MSMEG_0664|M.smegmatis_MC2_155 FQDARNGKPALLPFSDGVIPTTLDTTLNPDGTHIMSLFTQWVPAEWAAEP
. . * . * *. . : ::
Mflv_1677|M.gilvum_PYR-GCK --YGALKTEMGRRVIDKITRLATDFEKLILRHTTFTPKHMGTMFN-APGG
Mvan_5076|M.vanbaalenii_PYR-1 --YGEMKAEMGQRVIDKITRLAPDFESLMLRHTTFTPKHMGTMFG-APGG
Rv3829c|M.tuberculosis_H37Rv GGYGRAKVEMGQNVIDKITRLAPNFKGSILRYTTFTPKHMGVMFG-APGG
Mb3859c|M.bovis_AF2122/97 GGYGRAKVEMGQNVIDKITRLAPNFKGSILRYTTFTPKHMGVMFG-APGG
MMAR_5383|M.marinum_M HEYGQAKTEMGQRVIDKVTRLAPNFERSIIRHTTFTPKHMGVMFG-APGG
MAV_0198|M.avium_104 --YGQAKIEMGQRVIDKITRLAPNFEDSIIRHTTFTPRHMGVMFG-APGG
MUL_2934|M.ulcerans_Agy99 --HGHLKRIMARRVIDKITRFAPNFKDIVIRYITFAPYHMQTMFG-APSG
MAB_4734|M.abscessus_ATCC_1997 ---HGFTGDATQALIDQIERFAPGFRDRIVATAVRSTTDMTVYNPNYVGG
TH_4571|M.thermoresistible__bu ---HGYPGDATEAVVAQIERFAPGFRDRIVGYRTESAEGMARFNANFTGG
MSMEG_0664|M.smegmatis_MC2_155 --HTEELDAYADRLIELYDQVAPGFKASITHRDIVGPYDMEHEYG-LIGG
:: :.*..*. : . * .*
Mflv_1677|M.gilvum_PYR-GCK DYCHGLIHPEQMGPNRPGPKGYVDQPIPIAGLYLAGAGCHGGPGITFIPG
Mvan_5076|M.vanbaalenii_PYR-1 DYCHGLIHPEQMGPNRPGPKGYADQPIPVDGLYLASAGCHGGPGITFIPG
Rv3829c|M.tuberculosis_H37Rv DYCHALLHSDQIGPNRPGPKGFIGQPIPIAGLYLGSAGCHGGPGITFIPG
Mb3859c|M.bovis_AF2122/97 DYCHALLHSDQIGPNRPGPKGFIGQPIPIAGLYLGSAGCHGGPGITFIPG
MMAR_5383|M.marinum_M DYCHGLLHPDQIGQNRPGPRGFIGQPIPIAGLYLGSAGCHGGPGITFIPG
MAV_0198|M.avium_104 DYCHGLLNANQVGPNRPGPRGFLGQPIPIEGLYLGSAGCHGGPGITFIPG
MUL_2934|M.ulcerans_Agy99 DFCHGLLHPDLMGPNRPGPGGFLDFPIPIDGLYLGGAGCHGGPGITFIPG
MAB_4734|M.abscessus_ATCC_1997 DIVTGAKDIRQLVFG--PRTTAHPYRLGIPGMYICSAATPPGPGAHGMCG
TH_4571|M.thermoresistible__bu DILTGAKDIRQLTFG--PRITLSPYATGAPGYYICSAATPPGPGAHGMCG
MSMEG_0664|M.smegmatis_MC2_155 NIFHGELSLEQLFHMRPAPG-YADYRTPIAGLYNGSSATHAGGGVCGIPG
: . : * * .:. * * : *
Mflv_1677|M.gilvum_PYR-GCK YNAAQQVLAEH---------------------
Mvan_5076|M.vanbaalenii_PYR-1 YNAAQQVLADRT--------------------
Rv3829c|M.tuberculosis_H37Rv YNAARQALADRRAANCCVLSGR----------
Mb3859c|M.bovis_AF2122/97 YNAARQALADRRAANCCVLSGR----------
MMAR_5383|M.marinum_M FNAGRAALADR---------------------
MAV_0198|M.avium_104 YNAARQALTDRSG-------------------
MUL_2934|M.ulcerans_Agy99 YNAAYQVLEDVATRQTSG--------------
MAB_4734|M.abscessus_ATCC_1997 AHAAAEALRHLRASI-----------------
TH_4571|M.thermoresistible__bu YHAAQTALRELAR-------------------
MSMEG_0664|M.smegmatis_MC2_155 WQAARAVLADKKRARRSEALRKRLPAALGGRS
:*. .* .