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MTDFDAIVVGAGHNGLTAAALLQQAGLRTVCLDFKLYAGGMASTVELFDGFRFEIAGSVQVPTSAVVSDA LELGDLPTVDLDVMSVQLRGVGDDPLVYYTDPMKLLTHLNDVHGAEAVNGMAGLMAWCQAPTRALGRFEA AQPPKTLDEMFACATNEFERQAISDILFGSVTDVLDRYLPDREKHGALRGMLAFLAVNTTYRGPATPGSA AALAFGLAVPDENATLIKKFRGGMGAVTEHLLQMFTAAGGELRLRTKVDEILVDGGRVTGVRLEDGATLS APVVVSNLAPDLTVNQLVDGSAIPADIRERFARIDHRGSYVQMHFALDGPPTFAEPYEVLNDPEYQSAIG IFTTPEELQQQWEDSRRGVVPADPAIALQIPSANDPTLAPPGKHAVSAFSLWFPLSEEISGYGALKTEMG RRVIDKITRLATDFEKLILRHTTFTPKHMGTMFNAPGGDYCHGLIHPEQMGPNRPGPKGYVDQPIPIAGL YLAGAGCHGGPGITFIPGYNAAQQVLAEH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1677 | - | - | 100% (519) | FAD dependent oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1847 | - | 2e-09 | 23.29% (395) | phytoene dehydrogenase-related protein |
| M. gilvum PYR-GCK | Mflv_1732 | - | 5e-06 | 50.00% (46) | hypothetical protein Mflv_1732 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3859c | - | 0.0 | 69.47% (524) | putative dehydrogenase |
| M. tuberculosis H37Rv | Rv3829c | - | 0.0 | 69.66% (524) | dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0948c | - | 4e-11 | 23.50% (549) | hypothetical protein MAB_0948c |
| M. marinum M | MMAR_5383 | - | 0.0 | 70.42% (524) | dehydrogenase |
| M. avium 104 | MAV_0198 | - | 0.0 | 73.18% (522) | FAD dependent oxidoreductase, putative |
| M. smegmatis MC2 155 | MSMEG_0664 | - | 1e-44 | 28.76% (539) | FAD dependent oxidoreductase |
| M. thermoresistible (build 8) | TH_2567 | - | 5e-14 | 28.23% (333) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_2934 | - | 0.0 | 61.58% (518) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5076 | - | 0.0 | 89.77% (518) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1677|M.gilvum_PYR-GCK -----MTDFDAIVVGAGHNGLTAAALLQQAGLRTVCLDFKLYAGGMASTV
Mvan_5076|M.vanbaalenii_PYR-1 -----MADFDAIVVGAGHNGLTAAALLQRAGLRTLCLDAKLYAGGMASTV
Mb3859c|M.bovis_AF2122/97 -----MTGYDAIVIGAGHNGLTAAVLLQRAGLRTACLDAKRYAGGMASTV
Rv3829c|M.tuberculosis_H37Rv -----MTGYDAIVIGAGHNGLTAAVLLQRAGLRTACLDAKRYAGGMASTV
MMAR_5383|M.marinum_M -----MAEYDAIVIGAGHNGLTAAVLLQRAGLRTLCLDAKLYAGGMASTV
MAV_0198|M.avium_104 -----MNDYDAIVIGAGHNGLTAAVLLQKAGLRTLCLDAKLYAGGMASTV
MUL_2934|M.ulcerans_Agy99 -----MTDYDAIVVGAGHNGLTAAAVLQRAGLRTLCMEANTYAGGMAATV
MSMEG_0664|M.smegmatis_MC2_155 ----MSNNYDALVIGGGHNGLVSAAYLARAGARTLVLESRSSLGGAATTE
MAB_0948c|M.abscessus_ATCC_199 MGLSESDRYDTVIVGGGHNALTAAAYLARAGQRVMLLERLDVFGGAAISA
TH_2567|M.thermoresistible__bu --MTTEQEFDAIVIGAGAGGLFTAARLAHQGFRTVVVERLDKVGGRAS-T
:*::::*.* ..* :*. * : * *. :: ** *
Mflv_1677|M.gilvum_PYR-GCK ELFDG---FRFEIAGSVQVPTSAVVSDALELGDLPTVDLDVMSVQLRGVG
Mvan_5076|M.vanbaalenii_PYR-1 ELFDG---FRFEIAGSVQVPTSAVVSDALGLAELPTVDLDVMSVQLRGIG
Mb3859c|M.bovis_AF2122/97 ELFDG---YRFDIAGSVQFPTSSAVSSELGLDSLPTVDLEVMSVALRGVG
Rv3829c|M.tuberculosis_H37Rv ELFDG---YRFEIAGSVQFPTSSAVSSELGLDSLPTVDLEVMSVALRGVG
MMAR_5383|M.marinum_M ELFDG---YRFEIAGSVQFPTAAAVISELGLDTLPTVDLEVMSVALRGVG
MAV_0198|M.avium_104 ELFDG---YRFEIAGSVQFPTSQAVVDELGLDTIPTIDLDVMSVAVRGVG
MUL_2934|M.ulcerans_Agy99 ELIDG---FHFEIAGSVQFPTASQISKELGLDTLPTVAPEVMSTNIGESD
MSMEG_0664|M.smegmatis_MC2_155 APWDDAPHLRVTRLSYVMSLMPPTIVRDLALERHGYKVHPMGPYYQAFPE
MAB_0948c|M.abscessus_ATCC_199 PAFEG-VEARLSRYSYLVSLMPRQIIDDLGLDVR-LARRKYASYTPDPMN
TH_2567|M.thermoresistible__bu DDIDG-----FKVNNGAIVIETGGITQQTCEEVGAPFDIREPKPPILYRI
:. . . . :
Mflv_1677|M.gilvum_PYR-GCK DDPLVYYTDPMKLLTHLNDVHGAEAVNGMAGLMAWCQAPTRALGRFEAAQ
Mvan_5076|M.vanbaalenii_PYR-1 DDPLVYYTDPMKLLTHLNEVHGAEAVNGMAGLMAWCQAPTRAVGRFDAAQ
Mb3859c|M.bovis_AF2122/97 DDPVVQFTDPTKMLTHLHRVHGADAVTGMAGLLAWSQAPTRALGRFEAGT
Rv3829c|M.tuberculosis_H37Rv DDPVVQFTDPTKMLTHLHRVHGADAVTGMAGLLAWSQAPTRALGRFEAGT
MMAR_5383|M.marinum_M DDPLVQYTDPMKMFAHLNEVHGADAVTGMAGLLAWSQAPTRALGRFESDT
MAV_0198|M.avium_104 DDPLVQYSDPVKLFTHLNEVHGADAVNGMAGLMAWAQAPTRALDRFEAGT
MUL_2934|M.ulcerans_Agy99 EEAMIFYRDPLQLISHLGEKHGSAAVTGMAELIGWSQGPARALGRFEVRT
MSMEG_0664|M.smegmatis_MC2_155 GGSLTIYEDDPARTYEQLSRFSKKDADAWPKWNAWLEGIADVMGPLLTQV
MAB_0948c|M.abscessus_ATCC_199 GGQRGFLAGP----------------NDFAEFGALCDSVTRPMWDSMLQP
TH_2567|M.thermoresistible__bu GGK---------------------NVDVTGGGWGFLLGKLTRQGAKLVKG
. .
Mflv_1677|M.gilvum_PYR-GCK PP----KTLDEMFACATNEFERQAISDILFGSVTDVLDR----YLPDREK
Mvan_5076|M.vanbaalenii_PYR-1 RP----KSLDEMFACATNEFERQAISDMLFGSVTDVLDR----YLPDREK
Mb3859c|M.bovis_AF2122/97 LP----KSFDEMYACATNEFERSAIDDMLFGSVTDVLDR----HFPDREK
Rv3829c|M.tuberculosis_H37Rv LP----KSFDEMYACATNEFERSAIDDMLFGSVTDVLDR----HFPDREK
MMAR_5383|M.marinum_M LP----KTFDQMYACATNEFERSAIDDMLFGSVTDVLDR----YFPDREK
MAV_0198|M.avium_104 PP----KSLDEMYACATNEFERSAIDDMLFGSVTDILDR----YLPDREK
MUL_2934|M.ulcerans_Agy99 PP----RTLDEMYACATNQAERRAIHEMLFGSAMDVIDR----FLPDKEK
MSMEG_0664|M.smegmatis_MC2_155 PPNIGSHRPADLLDLAKLAWGQRGITSRAVADITRLLTMSIADLLDDWFE
MAB_0948c|M.abscessus_ATCC_199 LR-----RRGAVRTGAWEQLIETPIGEVIRAATPDDVRR-----------
TH_2567|M.thermoresistible__bu IG-------------AARNDSGLPEDEISTAEWVAKYTK-----------
* . .
Mflv_1677|M.gilvum_PYR-GCK HGALRGMLAFLAVNTTYRGPATPGSAAALAFG--LAVPDENATLIKKFRG
Mvan_5076|M.vanbaalenii_PYR-1 HGALRGMLAFLAVNTTYRGPATPGSAAALAFG--LAVPDENATLIKKFRG
Mb3859c|M.bovis_AF2122/97 HGALRGSMTVLAVNTLYRGPATPGSAAALAFG--LGVPEGDFVRWKKLRG
Rv3829c|M.tuberculosis_H37Rv HGALRGSMTVLAVNTLYRGPATPGSAAALAFG--LGVPEGDFVRWKKLRG
MMAR_5383|M.marinum_M HAALRGSMTVLAVNTIYRGPATPGSAAALAFG--LGIPDGDFVQMKKLSG
MAV_0198|M.avium_104 HGALRGSMTVLAVNTLYRGPATPGSAAALAFG--LGVPDGDTMQMKKLRG
MUL_2934|M.ulcerans_Agy99 HAVMRGILAFLAVNSTYRGPFTPGSAACLAFA--LAVPDDSTAMMTKLRG
MSMEG_0664|M.smegmatis_MC2_155 SPQIKGALAVNGVIGTWAGPYEPGTAYVMAHHSIGDVGDGQLGSWGFPEG
MAB_0948c|M.abscessus_ATCC_199 -----GVLLTDALIGTFASADDLSLQQNICFLY------HQMNPWDVPIG
TH_2567|M.thermoresistible__bu NEGVHGIFRNMCASVFAVGSEDLPARVFLTYFT----RKSAFKRFGFHPE
* : .. : .
Mflv_1677|M.gilvum_PYR-GCK GMGAVTEHLLQMFTAAGGELRLRTKVDEILVD----GGRVTGVRLEDGA-
Mvan_5076|M.vanbaalenii_PYR-1 GMGAVTEHLLQMFSAAGGELRLRSKVDEIIVE----DGRVAGVRLEDGS-
Mb3859c|M.bovis_AF2122/97 GIGALTTHLSQLLERTGGEVRLRSKVTEIVVDNSRSSARVRGVRTAAGD-
Rv3829c|M.tuberculosis_H37Rv GIGALTTHLSQLLERTGGEVRLRSKVTEIVVDNSRSSARVRGVRTAAGD-
MMAR_5383|M.marinum_M GIGALTAHLCRLFERDGGELRLRTKVSEILVDSAEAGARISGVRTEAGD-
MAV_0198|M.avium_104 GIGALTSHLCDVLERHGGELRLRTKVTEILVEHAGSGGRVTGVRTESGE-
MUL_2934|M.ulcerans_Agy99 GIGALTDHLRERFASAGGEIRFRSKVVEIVVD----RGAVSGVRLPDGS-
MSMEG_0664|M.smegmatis_MC2_155 GMGAVSAAIACSARSFGAEIRTNARVSRLLVR----NGRVEGAVLDNGD-
MAB_0948c|M.abscessus_ATCC_199 GMGAVTGSLEASARRHGAELLSGAEVLSISPD-----AEVRYRSDGGEH-
TH_2567|M.thermoresistible__bu GTIGLWRGLAGAVERHGGQVWLSTPATKILTD----GTAVQGVVVERDGR
* .: : *.:: : . : :
Mflv_1677|M.gilvum_PYR-GCK --TLSAPVVVSNLAPDLTVNQLVDGSAIPADIRERFARIDHRGSYVQMHF
Mvan_5076|M.vanbaalenii_PYR-1 --TLAAPMVVSAVAPDLTVNTLVDGGAVPPDVRERFSRIDHRGSYLQMHF
Mb3859c|M.bovis_AF2122/97 --TLTSPIVVSAIAPDVTINELIDPAVLPSEIRDRYLRIDHRGSYLQMHF
Rv3829c|M.tuberculosis_H37Rv --TLTSPIVVSAIAPDVTINELIDPAVLPSEIRDRYLRIDHRGSYLQMHF
MMAR_5383|M.marinum_M --IVAAPIVVSAIAPDVTINDLIDPTVLPSDVRDRYAHIDHRGSYLQMHF
MAV_0198|M.avium_104 --TLSAPIVVSGIAPDVTLNELLDPAALPADLRARYARIDHRGSYLQMHF
MUL_2934|M.ulcerans_Agy99 --VIGTPVVVSNLAPDVTLAKLVGPEHVPADLLARLAGRDHRASFVQIHF
MSMEG_0664|M.smegmatis_MC2_155 --EIHAPVVVTTLHPKTAFLDHIPRTELPQDFVGDIEHWKSRSGVVKINL
MAB_0948c|M.abscessus_ATCC_199 --TVAGDRVLSGVSP-----------TVLAGLLGETPPAGQPGAQVKVNL
TH_2567|M.thermoresistible__bu QLTLTAPVVVSDVGPAATVT-LLGEENVPADYRKMVKKGDRPTSMISVNF
: *:: : * : . :.:::
Mflv_1677|M.gilvum_PYR-GCK ALDGPPTFAEPYEVLNDPEYQSAIGIFTTPEELQQQWEDSRRGVVPADP-
Mvan_5076|M.vanbaalenii_PYR-1 ALDGAPTFAEPYEMLNDPGYQSAIGIFTTPEELQQQWEDSRRGVVPADP-
Mb3859c|M.bovis_AF2122/97 ALAQPPAFAAPYQALNDPSMQASMGIFCTPEQVQQQWEDCRRGIVPADP-
Rv3829c|M.tuberculosis_H37Rv ALAQPPAFAAPYQALNDPSMQASMGIFCTPEQVQQQWEDCRRGIVPADP-
MMAR_5383|M.marinum_M ALEEAPAFAAPYEALNDPAMQASIGIFCTPEEVQQQWEDCRRGIVPADP-
MAV_0198|M.avium_104 ALQEAPVFAAPYQVLNEPAMQASIGLFCTPEEVQQQWEQARRGVVPADP-
MUL_2934|M.ulcerans_Agy99 ALDALPEFAPPYELLNEPGMQQSVGIFGTPEEQQQQWETCRRGIVPENP-
MSMEG_0664|M.smegmatis_MC2_155 ALAELPNFTADPSSGIAEHHTGSVEMAPTMEFIEAAFQDARNGKPALLP-
MAB_0948c|M.abscessus_ATCC_199 LLRRLPRLRDE-NVTPEQAFGGTFHVNETYTQLEYAYQQASHGRIPDPLP
TH_2567|M.thermoresistible__bu ASRE--------------------RLVDVPGMLS--FAKSRR--------
: . . : . .
Mflv_1677|M.gilvum_PYR-GCK ----AIALQIPSANDPTLAPPGKHAVSAFSLWFPLSE-EISG--YGALKT
Mvan_5076|M.vanbaalenii_PYR-1 ----AIALQIPSANDPGLAPPGKHAVSAFALWFPLSE-ERAS--YGEMKA
Mb3859c|M.bovis_AF2122/97 ----TVVLQIPSLHDPSLAPAGKQAASAFAMWFPIEG-GSKYGGYGRAKV
Rv3829c|M.tuberculosis_H37Rv ----TVVLQIPSLHDPSLAPAGKQAASAFAMWFPIEG-GSKYGGYGRAKV
MMAR_5383|M.marinum_M ----TVVLQVPSVHDPDLAPPGKHAASAFAMWFPIEG-EQDSHEYGQAKT
MAV_0198|M.avium_104 ----TVVLQIPSQNDPGLAPEGKHAASAFALWFPIEG-EVD---YGQAKI
MUL_2934|M.ulcerans_Agy99 ----SMGMQIPSVHDSGLAPPGKHAASAYAYAFPVEV-DRDQ--HGHLKR
MSMEG_0664|M.smegmatis_MC2_155 ----FSDGVIPTTLDTTLNPDGTHIMSLFTQWVPAEW-AAEP--HTEELD
MAB_0948c|M.abscessus_ATCC_199 CEIYCHSLADPSILSPELRASGAHTLTVFGLHTPHGLGASAEQLQQAVLA
TH_2567|M.thermoresistible__bu ----LAYIANFTDTCPEMAPEGWNLYVGTAVPKPSIG--------DFDQA
: . : . * : *
Mflv_1677|M.gilvum_PYR-GCK EMGRRVIDKITRLATDFEKLILRHTTFTPKHMGTMFNAPGGDYCHGLIHP
Mvan_5076|M.vanbaalenii_PYR-1 EMGQRVIDKITRLAPDFESLMLRHTTFTPKHMGTMFGAPGGDYCHGLIHP
Mb3859c|M.bovis_AF2122/97 EMGQNVIDKITRLAPNFKGSILRYTTFTPKHMGVMFGAPGGDYCHALLHS
Rv3829c|M.tuberculosis_H37Rv EMGQNVIDKITRLAPNFKGSILRYTTFTPKHMGVMFGAPGGDYCHALLHS
MMAR_5383|M.marinum_M EMGQRVIDKVTRLAPNFERSIIRHTTFTPKHMGVMFGAPGGDYCHGLLHP
MAV_0198|M.avium_104 EMGQRVIDKITRLAPNFEDSIIRHTTFTPRHMGVMFGAPGGDYCHGLLNA
MUL_2934|M.ulcerans_Agy99 IMARRVIDKITRFAPNFKDIVIRYITFAPYHMQTMFGAPSGDFCHGLLHP
MSMEG_0664|M.smegmatis_MC2_155 AYADRLIELYDQVAPGFKASITHRDIVGPYDMEHEYGLIGGNIFHGELSL
MAB_0948c|M.abscessus_ATCC_199 SLSSVLAEPITDVVATDTHGRPCIETKTTIDLESALGMTAGNIFHGGLQW
TH_2567|M.thermoresistible__bu AETELLLQDLRDNIDDFDNRARILNIAITRDDWPPQRAVAG---FDLPHD
: : . . .* .
Mflv_1677|M.gilvum_PYR-GCK EQMGPNRPGPKGYVDQPIPIAG--LYLAGAGCHGGPGITFIPGYNAAQQV
Mvan_5076|M.vanbaalenii_PYR-1 EQMGPNRPGPKGYADQPIPVDG--LYLASAGCHGGPGITFIPGYNAAQQV
Mb3859c|M.bovis_AF2122/97 DQIGPNRPGPKGFIGQPIPIAG--LYLGSAGCHGGPGITFIPGYNAARQA
Rv3829c|M.tuberculosis_H37Rv DQIGPNRPGPKGFIGQPIPIAG--LYLGSAGCHGGPGITFIPGYNAARQA
MMAR_5383|M.marinum_M DQIGQNRPGPRGFIGQPIPIAG--LYLGSAGCHGGPGITFIPGFNAGRAA
MAV_0198|M.avium_104 NQVGPNRPGPRGFLGQPIPIEG--LYLGSAGCHGGPGITFIPGYNAARQA
MUL_2934|M.ulcerans_Agy99 DLMGPNRPGPGGFLDFPIPIDG--LYLGGAGCHGGPGITFIPGYNAAYQV
MSMEG_0664|M.smegmatis_MC2_155 EQLFHMRPAP-GYADYRTPIAG--LYNGSSATHAGGGVCGIPGWQAARAV
MAB_0948c|M.abscessus_ATCC_199 PFAEDDDPLETAAQRWGVATNHDRILLCGSGSRRGGGVSGLGGYHAARAV
TH_2567|M.thermoresistible__bu TPFANLWNVGDGVKEYAN---------GGTTACAETAKLVVDKILASHRP
. .: . : *.
Mflv_1677|M.gilvum_PYR-GCK LAEH---------------------
Mvan_5076|M.vanbaalenii_PYR-1 LADRT--------------------
Mb3859c|M.bovis_AF2122/97 LADRRAANCCVLSGR----------
Rv3829c|M.tuberculosis_H37Rv LADRRAANCCVLSGR----------
MMAR_5383|M.marinum_M LADR---------------------
MAV_0198|M.avium_104 LTDRSG-------------------
MUL_2934|M.ulcerans_Agy99 LEDVATRQTSG--------------
MSMEG_0664|M.smegmatis_MC2_155 LADKKRARRSEALRKRLPAALGGRS
MAB_0948c|M.abscessus_ATCC_199 LETH---------------------
TH_2567|M.thermoresistible__bu AASR---------------------