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SGRHRKPTTSNVSVAKIAFTGAVLGGGGIAMAAQATAATDGEWDQVARCESGGNWSINTGNGYLGGLQFT QSTWAAHGGGEFAPSAQLASREQQIAVGERVLATQGRGAWPVCGRGLSNATPREVLPASAAMDAPLDAAA VNGEPAPLAPPPADPAPPVELAANDLPAPLGEPLPAAPADPAPPADLAPPAPADVAPPVELAVNDLPAPL GEPLPAAPADPAPPADLAPPAPADLAPPAPADLAPPAPADLAPPVELAVNDLPAPLGEPLPAAPAELAPP ADLAPASADLAPPAPADLAPPAPAELAPPAPADLAPPAAVNEQTAPGDQPATAPGGPVGLATDLELPEPD PQPADAPPPGDVTEAPAETPQVSNIAYTKKLWQAIRAQDVCGNDALDSLAQPYVIG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0867c | rpfA | - | 100% (407) | POSSIBLE RESUSCITATION-PROMOTING FACTOR RPFA |
| M. tuberculosis H37Rv | Rv1009 | rpfB | 2e-24 | 50.00% (108) | resuscitation-promoting factor rpfB |
| M. tuberculosis H37Rv | Rv2450c | rpfE | 1e-23 | 67.12% (73) | resuscitation-promoting factor RpfE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0891c | rpfA | 1e-138 | 65.88% (425) | resuscitation-promoting factor RpfA |
| M. gilvum PYR-GCK | Mflv_1703 | - | 9e-91 | 46.84% (427) | transglycosylase domain-containing protein |
| M. leprae Br4923 | MLBr_02151 | - | 6e-63 | 62.69% (201) | hypothetical protein MLBr_02151 |
| M. abscessus ATCC 19977 | MAB_0869c | - | 2e-73 | 44.88% (410) | resuscitation-promoting factor RpfA |
| M. marinum M | MMAR_4665 | rpfA | 1e-133 | 62.30% (435) | resuscitation-promoting factor RpfA |
| M. avium 104 | MAV_0996 | - | 9e-66 | 59.49% (237) | resuscitation-promoting factor RpfA |
| M. smegmatis MC2 155 | MSMEG_5700 | - | 1e-100 | 50.23% (444) | secreted protein |
| M. thermoresistible (build 8) | TH_0358 | - | 4e-24 | 51.35% (111) | PROBABLE RESUSCITATION-PROMOTING FACTOR RPFE |
| M. ulcerans Agy99 | MUL_0283 | rpfA | 1e-104 | 74.53% (267) | resuscitation-promoting factor RpfA |
| M. vanbaalenii PYR-1 | Mvan_5049 | - | 6e-90 | 48.97% (437) | FHA domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1703|M.gilvum_PYR-GCK MSGRHRKPAS--SAKSVAKIAFTG-AVIGGGGIALAGHAGAATDGEWDRV
Mvan_5049|M.vanbaalenii_PYR-1 MSGRHRKPAP--SAVNVAKIAFTG-AVIGGGGLALAGQAGAATDGEWDQV
MSMEG_5700|M.smegmatis_MC2_155 MSGRHRKPTSSSSAKNVAKIAFTG-AVLGGGGLGMAGQAMAATDGEWDQV
Rv0867c|M.tuberculosis_H37Rv MSGRHRKPTT--SNVSVAKIAFTG-AVLGGGGIAMAAQATAATDGEWDQV
Mb0891c|M.bovis_AF2122/97 MSGRHRKPTT--SNVSVAKIAFTG-AVLGGGGIAMAAQATAATDGEWDQV
MMAR_4665|M.marinum_M MSGRHRKPTT--SNVSVAKIAFTG-AVLGGGGIALAGHAAAATDGEWDQV
MUL_0283|M.ulcerans_Agy99 MSGRHRKPTT--SNVSVAKIAFTG-AVLGGGGIALAGHAAAATDGEWDQV
MLBr_02151|M.leprae_Br4923 MSESYRKLTT--SSIIVAKITFTG-AMLDG-SIALAGQASPATDSEWDQV
MAV_0996|M.avium_104 --------------------------MLGGGAIAMAGQAAAATDGEWDQV
MAB_0869c|M.abscessus_ATCC_199 MSGRHSKPSK--ASAKAAKVAVAG-AGLVGGGLMMAATANAATDGEWDQV
TH_0358|M.thermoresistible__bu MN-NIRKALT--SSLKRALLLIAGTAALALVPMVLSTATAQADTVNWDAI
: : :: : * :** :
Mflv_1703|M.gilvum_PYR-GCK ASCESGGNWAINTGNGYHGGLQFSPSTWSGHGGGEFAPAAYLATKEEQIA
Mvan_5049|M.vanbaalenii_PYR-1 ARCESGGNWAINTGNGYHGGLQFSPGTWSGHGGGEYAPAAYLATKEEQIA
MSMEG_5700|M.smegmatis_MC2_155 ARCESGGNWAINTGNGYHGGLQFSPSTWRAHGGTEFAPAAYMATKEEQIA
Rv0867c|M.tuberculosis_H37Rv ARCESGGNWSINTGNGYLGGLQFTQSTWAAHGGGEFAPSAQLASREQQIA
Mb0891c|M.bovis_AF2122/97 ARCESGGNWSINTGNGYLGGLQFTQSTWAAHGGGEFAPSAQLASREQQIA
MMAR_4665|M.marinum_M ARCESGGNWAINTGNGYYGGVQFAQSTWASHGGGEYAPSAQLASREEQIA
MUL_0283|M.ulcerans_Agy99 ARCESGGNWAINTGNGYYGGVQFAQSTWASHGGGEYAPSAQLASREEQIA
MLBr_02151|M.leprae_Br4923 ARCESGGNWSINTGNGYLGGLQFSQGTWASHGGGEYAPSAQLATREQQIA
MAV_0996|M.avium_104 ARCESGGNWGINTGNGYHGGVQFSASTWAAHGGGEYAPSAELATREQQIA
MAB_0869c|M.abscessus_ATCC_199 ARCESGGNWAINTGNGYQGGLQFSPSTWINSGGGQYAPSAHLATKEQQIA
TH_0358|M.thermoresistible__bu AQCESGGNWASDTGNGFYGGLQFKPSTWAAHGG---TGSPARASREEQIR
* *******. :****: **:** .** ** : :. *::*:**
Mflv_1703|M.gilvum_PYR-GCK VAERVLASQGKGAWPTCGKVLSAATPRNVVDEPPA-PAPVDPLGLNGVLP
Mvan_5049|M.vanbaalenii_PYR-1 VAERVLASQGKGAWPSCGGPLSAATPRNVVAEP---PAPVDPVGLNGLLP
MSMEG_5700|M.smegmatis_MC2_155 VAERVLASQGKGAWPTCGRGLSGATPRNVVAEP-E-PAPLDAPGVNGELP
Rv0867c|M.tuberculosis_H37Rv VGERVLATQGRGAWPVCGRGLSNATPREVLPASAAMDAPLDAAAVNGEPA
Mb0891c|M.bovis_AF2122/97 VGERVLATQGRGAWPVCGRGLSNATPREVLPASAAMDAPLDAAAVNGEPA
MMAR_4665|M.marinum_M VAERVLATQGRGAWPVCGHGLSAATPRDV-PAPAALDAPLDAPGINGEPA
MUL_0283|M.ulcerans_Agy99 VAERVLATQGRGAWPVCGHGLSAATPRDV-PPPAALDAPLDAPGINGEPA
MLBr_02151|M.leprae_Br4923 VAERVLATQGSGAWPACGHGLSGPSLQEVLPAGMG------APWINGAPA
MAV_0996|M.avium_104 VAERVLATQGRGAWPVCGGPLSGPTPRDV-PAPAG----LDAPGVNG--V
MAB_0869c|M.abscessus_ATCC_199 VAEKVLAGQGRGAWPVCGRGLSGSTPRTAPAANITPAAHHEEQAAAEPAP
TH_0358|M.thermoresistible__bu VAERVLASQGLKAWPKCG---AHGTRPAVFRTP-------GAPAAGGVPA
*.*:*** ** *** ** : : .
Mflv_1703|M.gilvum_PYR-GCK PPPAPLDPFAPPPP-------------------PPAPAPFDALAAPAPAP
Mvan_5049|M.vanbaalenii_PYR-1 PP--PVDPFAPPP----------------------APAPVDALAAPAP--
MSMEG_5700|M.smegmatis_MC2_155 PP-APVDMLAAPM-----------------------PAPEG--LPPAPEA
Rv0867c|M.tuberculosis_H37Rv PLAPPPADPAPPVELAANDLPAPLGEPLPAAPADPAPPADLAPPAPADVA
Mb0891c|M.bovis_AF2122/97 PLAPP---------------------------------------------
MMAR_4665|M.marinum_M PLAPP---------------------------------------------
MUL_0283|M.ulcerans_Agy99 PLAPP---------------------------------------------
MLBr_02151|M.leprae_Br4923 PLAPP---------------------------------------------
MAV_0996|M.avium_104 PQAPP---------------------------------------------
MAB_0869c|M.abscessus_ATCC_199 APEPPAE-------------------------------GDEQFVAEAP--
TH_0358|M.thermoresistible__bu ST------------------------------------------------
.
Mflv_1703|M.gilvum_PYR-GCK LPPAPETLPPAPVEQLAAPVPLPAPAPEAVPVDAMA-APAPLPPAPEALP
Mvan_5049|M.vanbaalenii_PYR-1 LPPAPEALP-------------PAPAP-AAPFDAMS-APAPLPPAPEALP
MSMEG_5700|M.smegmatis_MC2_155 LPPAPEALP-------------PAPEAPAPAPEALPPAPEALPPAPEALP
Rv0867c|M.tuberculosis_H37Rv PPVELAVNDLPAPLGEPLPAAPADPAPPADLAPPAPADLAPPAPADLAPP
Mb0891c|M.bovis_AF2122/97 -----------------------------------PADLAPPAPADLAPP
MMAR_4665|M.marinum_M -------------------------------------------PGDDVPP
MUL_0283|M.ulcerans_Agy99 -------------------------------------------PGDDVPP
MLBr_02151|M.leprae_Br4923 ------------------------------------------PPAEPAPP
MAV_0996|M.avium_104 --------------------------------------------ADAPPP
MAB_0869c|M.abscessus_ATCC_199 --------------------EAPAIDEAPAPEEAPAPEAQDVDFQSGPAP
TH_0358|M.thermoresistible__bu --------------------------------------------------
Mflv_1703|M.gilvum_PYR-GCK PAPLDAPAPAQTVAFDAVAAPA------PLP-APEALPPAPLPAPAPEAV
Mvan_5049|M.vanbaalenii_PYR-1 ------PAPAPAAPFDAMSAPA------PLPPAPEALP----PAPVVDAA
MSMEG_5700|M.smegmatis_MC2_155 PAP-EAPAPAPEALPPAPEAPAPV--AEALPPAPEALPPAPEAPPAPEAL
Rv0867c|M.tuberculosis_H37Rv A-PADLAPPVELAVNDLPAPLGEP-----LPAAPAELAP--PADLAPASA
Mb0891c|M.bovis_AF2122/97 A-PADLAPPVELAVNDLPAPLGEP-----LPAAPAELAP--PADLAPASA
MMAR_4665|M.marinum_M --PADPAPPVELAANDVPAPADLPPAPEDLPPAPEDLAPPAPADLPPAPE
MUL_0283|M.ulcerans_Agy99 --PADPAPPVELAANDVPAPADLPPAPEDLPPAPEDLAPPAPADLPPAPE
MLBr_02151|M.leprae_Br4923 QPPADNFPPTP---GDVPS-------------------------------
MAV_0996|M.avium_104 -------APVQLASFDRPAPPDAP---------APDAPPPAPADLPPAPA
MAB_0869c|M.abscessus_ATCC_199 EEPAPAPEPAPVDEAQAPAPELIAAPAPEAPVVDEAPAPEEAPAPEAPAA
TH_0358|M.thermoresistible__bu --------PTATTGCGAIRP------------------------------
*.
Mflv_1703|M.gilvum_PYR-GCK P------FDALSAPAPVEPIVAPIPVDAPP--SAVVTA------------
Mvan_5049|M.vanbaalenii_PYR-1 N------IAPLDAPLP-----PPAPVDAPPAQSAIIAA------------
MSMEG_5700|M.smegmatis_MC2_155 PPAPEAQIVDASLQVPADVPPAPPVEPAPPAPVDAVAAPE----------
Rv0867c|M.tuberculosis_H37Rv D---------LAPPAPADLAPPAPAELAPPAPADLAP-------------
Mb0891c|M.bovis_AF2122/97 D---------LAPPAPADLAPPAPAELAPPAPADLAP-------------
MMAR_4665|M.marinum_M D---------LPP-APQDLPP-APEDVAAPAPADLPPAPEDVAPPVELVG
MUL_0283|M.ulcerans_Agy99 D---------LPP-APQDLPP-APEDVAAPAPADLP--------------
MLBr_02151|M.leprae_Br4923 --------------------------------------------------
MAV_0996|M.avium_104 D---------LPPAPPADATPPAPPADAPAPDGDFHG-------------
MAB_0869c|M.abscessus_ATCC_199 DDQVLP-YELQSGPAPAEPAPAPEPAPAPAAAPEIPLPAG----------
TH_0358|M.thermoresistible__bu --------------------------------------------------
Mflv_1703|M.gilvum_PYR-GCK -VNWDTAPAPAPGDPQMWSLGLDAPLQPAPVTP-----PLPAPAP---ET
Mvan_5049|M.vanbaalenii_PYR-1 -ANWDTAPVPG-EHPQLWSLGVDAPLQPAPVLPP---APAPAPAP---AA
MSMEG_5700|M.smegmatis_MC2_155 NQNWDQAPAPA-DQPQTWALHVGGPLPLDPVLPAPAPAPAPAPAPGAPAA
Rv0867c|M.tuberculosis_H37Rv ----------------------------------------PAAVNEQTAP
Mb0891c|M.bovis_AF2122/97 ----------------------------------------PAAVNEQTAP
MMAR_4665|M.marinum_M NDVPAPVDLPPAPEDLPPAPEDLAPPAPADLPPAPEDLAPPAPADLPPAP
MUL_0283|M.ulcerans_Agy99 ----------------------------------------PAPADLPPAP
MLBr_02151|M.leprae_Br4923 --------------------------------------------------
MAV_0996|M.avium_104 -----------------------------------------------FVP
MAB_0869c|M.abscessus_ATCC_199 ---------------------------------------VPDAADIGFAA
TH_0358|M.thermoresistible__bu --------------------------------------------------
Mflv_1703|M.gilvum_PYR-GCK VAAPAPVVGVPAGQAG-PVPA-------------APAEVPHLVSPDNPPP
Mvan_5049|M.vanbaalenii_PYR-1 VAAPAPDPLAPLGAVEVPAPAYDIANQAISGELPVPSEVPHLASPDNLPP
MSMEG_5700|M.smegmatis_MC2_155 VAAPAPDPLAPAPNADVAPTP--------------PEGVPHLASPENLPP
Rv0867c|M.tuberculosis_H37Rv GDQPATAPGGPVGLATDLELPEPD-----------------PQPADAPPP
Mb0891c|M.bovis_AF2122/97 GDQPATAPGGPVGLATDLELPEPD-----------------PQPADAPPP
MMAR_4665|M.marinum_M EDLAPPAPADLPPAPEDLAPPAPAD-------LPPAPEDLPPAPEDLPPP
MUL_0283|M.ulcerans_Agy99 EDLAP---------------------------------------------
MLBr_02151|M.leprae_Br4923 --------------------------------------------------
MAV_0996|M.avium_104 AGMP----------------------------------------------
MAB_0869c|M.abscessus_ATCC_199 GKAAFDAGPVASNGIPTSPEAVAG-------------VVRHLPDPNNLPP
TH_0358|M.thermoresistible__bu --------------------------------------------------
Mflv_1703|M.gilvum_PYR-GCK GTTVTP-QGPQQSPNVTYLKEIWHAIQTQEISGSDALLALTQRPLTANG-
Mvan_5049|M.vanbaalenii_PYR-1 GTAMAP-QGPRQSPNVTYLKEIWHAIQTQEISGADALLALTQRPLTTPDT
MSMEG_5700|M.smegmatis_MC2_155 GTTETPDQIPGQGPNMTYLREIWHAIQTQDISGKDALLALTQRPLTTPDV
Rv0867c|M.tuberculosis_H37Rv GDVTEAPAETPQVSNIAYTKKLWQAIRAQDVCGNDALDSLAQPYVIG---
Mb0891c|M.bovis_AF2122/97 GDVTEAPAETPQVSNIAYTKKLWQAIRAQDVCGNDALDSLAQPYVIG---
MMAR_4665|M.marinum_M ADADNPPVDVHEASTVAYTKKLWQAIVGQNISGNDALDALAQPTVFA---
MUL_0283|M.ulcerans_Agy99 ------PVDVHEASTVAYTKKLWQAIVGQNISGNDALDALAQPAVFA---
MLBr_02151|M.leprae_Br4923 --------------------------------------PLARP-------
MAV_0996|M.avium_104 ----------DHVSEAGYTQRLWEAIRAQDVQGNDALDALVQPAPSA---
MAB_0869c|M.abscessus_ATCC_199 G---TTDVAPGDSRGVSYLKDIVFAMQTQDVKASDAILALAQR-------
TH_0358|M.thermoresistible__bu ----------GAVLGLVDLRQVCAAFLTPLGVG-----------------
Mflv_1703|M.gilvum_PYR-GCK -GGPAP---MAPV---GAPAPAPEAPVQGAAAPLPAPA-------VPAPA
Mvan_5049|M.vanbaalenii_PYR-1 PGGTPP---IAP----GAPG-APVAPLAG-PAPAPAP--------VPAPA
MSMEG_5700|M.smegmatis_MC2_155 PGGAAPNRPVAPPPAPGDPALAPAPAPLGAPAPAPAPEPAPVGAPAPVGA
Rv0867c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0891c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4665|M.marinum_M --------------------------------------------------
MUL_0283|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02151|M.leprae_Br4923 --------------------------------------------------
MAV_0996|M.avium_104 --------------------------------------------------
MAB_0869c|M.abscessus_ATCC_199 --------------------------------------------------
TH_0358|M.thermoresistible__bu --------------------------------------------------
Mflv_1703|M.gilvum_PYR-GCK PVLPPA
Mvan_5049|M.vanbaalenii_PYR-1 PVLPPA
MSMEG_5700|M.smegmatis_MC2_155 PVPPPA
Rv0867c|M.tuberculosis_H37Rv ------
Mb0891c|M.bovis_AF2122/97 ------
MMAR_4665|M.marinum_M ------
MUL_0283|M.ulcerans_Agy99 ------
MLBr_02151|M.leprae_Br4923 ------
MAV_0996|M.avium_104 ------
MAB_0869c|M.abscessus_ATCC_199 ------
TH_0358|M.thermoresistible__bu ------