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QLPPPAMIKTAGWFCENAEMSPLGRRPSADDLLVLLAVGRTGKYTSAADELGLNHTTISRRIAALEQAMG GRVLARVAGGWELTDLGREALAAAEVVETAVRSLATDPAGQRALEGVVRISATDGFSAYIAAPAAAAVQR RHPGVAVEIVATTRRATQQRSGMDVEVVVGEPKVRRARALRLSDYCLGLYGSRDYLATHGTPATIAELQN HPLVYFIDSMLQVDDLDLATSFTPAMRESVTSTNVFVHVEATRAAAGIGLLPCFMADRHDDLVRVLPGQV SLTLTYWLVTRAETLRRPEVAAVVDAIRDRVRDRHHMLLGAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1470 | - | - | 100% (323) | LysR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2303c | - | 1e-06 | 27.41% (135) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv2282c | - | 1e-06 | 27.41% (135) | LysR family transcriptional regulator |
| M. leprae Br4923 | MLBr_02041 | oxyR | 5e-08 | 25.76% (132) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0055c | - | 8e-11 | 24.91% (293) | DNA-binding transcriptional regulator CynR |
| M. marinum M | MMAR_2756 | oxyR | 2e-10 | 24.60% (252) | hydrogen peroxide-inducible genes activator, OxyR |
| M. avium 104 | MAV_2838 | - | 6e-09 | 23.17% (246) | hydrogen peroxide-inducible genes activator |
| M. smegmatis MC2 155 | MSMEG_6028 | - | 1e-132 | 78.67% (300) | transcriptional regulator, LysR family protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2998 | oxyR | 3e-10 | 24.49% (245) | hydrogen peroxide-inducible genes activator, OxyR |
| M. vanbaalenii PYR-1 | Mvan_5301 | - | 1e-154 | 86.69% (323) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_02041|M.leprae_Br4923 --------------------MSDKSYQPTIAGLRAFVAVVEKGHFSAAAS
MAV_2838|M.avium_104 --------------------MPDKTYQPTIAGLRAFVAVAEKRQFSGAAT
MMAR_2756|M.marinum_M ------------MLATILIGMTDKSYQPTLAGLRAFVAVAEKQHFGSAAN
MUL_2998|M.ulcerans_Agy99 -----------------MIGITDKSYQPTLAGLRAFVAVAEKQHFGSAAN
Mb2303c|M.bovis_AF2122/97 --------------------MPLSSRMPGLTCFEIFLAIAEAGSLGGAAR
Rv2282c|M.tuberculosis_H37Rv --------------------MPLSSRMPGLTCFEIFLAIAEAGSLGGAAR
Mflv_1470|M.gilvum_PYR-GCK MQLPPPAMIKTAGWFCENAEMSPLGRRPSADDLLVLLAVGRTGKYTSAAD
Mvan_5301|M.vanbaalenii_PYR-1 MQLPRAAMAKTAPGICKNAEMSSPVRRPSADDLLVLLAVGRTGRYTTAAD
MSMEG_6028|M.smegmatis_MC2_155 ------------------MADAPASRRPSADDLLVLLAVGRTGRYTTAAD
MAB_0055c|M.abscessus_ATCC_199 ---------------------------MELRHIRYLLAVADHANFTRAAE
: ::*: **
MLBr_02041|M.leprae_Br4923 FLGVRQSTLSQALAALESGLGVQLIERSTRRVFVTTQGRHLLPRAQAAIE
MAV_2838|M.avium_104 ALGVSQSTLSQALAALEAGLGTQLVERSTRRVFLTPQGAELLPHAQAVVE
MMAR_2756|M.marinum_M ALGVSQSTLSQALAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVE
MUL_2998|M.ulcerans_Agy99 ALGVSQSTLSQALAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVE
Mb2303c|M.bovis_AF2122/97 ELGLTQQAVSRRLASMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLE
Rv2282c|M.tuberculosis_H37Rv ELGLTQQAVSRRLASMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLE
Mflv_1470|M.gilvum_PYR-GCK ELGLNHTTISRRIAALEQAMGGRVLARVAGGWELTDLGREALAAAEVVET
Mvan_5301|M.vanbaalenii_PYR-1 ELGLNHTTISRRIAALERAMGGRVLARVAGGWELTDLGREALAAAEAVET
MSMEG_6028|M.smegmatis_MC2_155 ELGINHTTISRRIAALEEALGGRVLTRGAGGWELTDLGRDALAAAETVEA
MAB_0055c|M.abscessus_ATCC_199 SLHISQPTLSQQIKQLERTLGVILLDRSGRAVRLTDAGEAYAQHARLALR
* : : ::*: : :* :. : * :* * *
MLBr_02041|M.leprae_Br4923 AMDAFTAAAAGESDPLRGGMRLGLIPTVAPYVLPTMLTGLTHRLPT----
MAV_2838|M.avium_104 AADAFTAAAAGSADPLRAGMRLGLIPTVAPYVLPTVLAGIAERRPG----
MMAR_2756|M.marinum_M AVEAFTTAAAGEADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLPT----
MUL_2998|M.ulcerans_Agy99 AVEAFTTAAAGEADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLPT----
Mb2303c|M.bovis_AF2122/97 VADEIDAGLGSLRTEGRQRIRVVASQTIAEQLMPHWMLSLRAADMRRGGT
Rv2282c|M.tuberculosis_H37Rv VADEIDAGLGSLRTEGRQRIRVVASQTIAEQLMPHWMLSLRAADMRRGGT
Mflv_1470|M.gilvum_PYR-GCK AVRSLATDPAG-QRALEGVVRISATDGFSAYIAAPAAAAVQRRHPG----
Mvan_5301|M.vanbaalenii_PYR-1 AVRSLATDAAG-QRALEGVVRISATDGFSAYIAAPAAAAVQRRHPK----
MSMEG_6028|M.smegmatis_MC2_155 AVTSLAADRR---RQLEGVVRISATDGFSAYIAAPAAAQVQREHPR----
MAB_0055c|M.abscessus_ATCC_199 DLDAGERAVHDMHDLSRGHLRIAMTPTFTAYFIGPLVHRFHSAHPG----
. :*. .: . .
MLBr_02041|M.leprae_Br4923 -LTLRVVEDQTEHLLTALREGALDAAMIALPVETAGIAEIPIYDEDFVLA
MAV_2838|M.avium_104 -LTLRVTEDQTERLLAVLREGALDAALIALPAETAGVTAIPIYDEDFVLA
MMAR_2756|M.marinum_M -LTVRVIEDQTERLLTALREGSLDTALIALPADYGGLTEIPIYEEDFVLA
MUL_2998|M.ulcerans_Agy99 -LTVRVIEDQTERLLTALREGSLDTALIALPADYGGLTEIPIYEEDFVLA
Mb2303c|M.bovis_AF2122/97 VPEVILTATNSEHAIAAVRDGIADLGFIENPCPPTGLGSVVVARDELVVV
Rv2282c|M.tuberculosis_H37Rv VPEVILTATNSEHAIAAVRDGIADLGFIENPCPPTGLGSVVVARDELVVV
Mflv_1470|M.gilvum_PYR-GCK ---VAVEIVATTRRATQQRSG-MDVEVVVGEPKVRRARALRLSDYCLGLY
Mvan_5301|M.vanbaalenii_PYR-1 ---VAVEIVATTRRATQQRSG-LDIEVVVGEPKVHRAKALRLGDYCLGLY
MSMEG_6028|M.smegmatis_MC2_155 ---IAVELVATTRRASQQRTS-LDLEIVVGAPQVRRAEAIRLGDYCLGLY
MAB_0055c|M.abscessus_ATCC_199 -ITLTVRETTQDRIEADLLADRLDLGIAFAGPHPAGIDHCALFTETLRLV
: : : : . * . : : :
MLBr_02041|M.leprae_Br4923 LPPGHPLSGK-RRVPTTALAQLPLLLLDEGHCLRDQTLDICRK---SGVQ
MAV_2838|M.avium_104 LPPGHPLAGK-RRVPATALADLPLLLLDEGHCLRDQALDVCHK---AGVR
MMAR_2756|M.marinum_M LPPGHPMADR-HGVPVAALSELPLLLLDEGHCLRDQALDVCQN---AGVR
MUL_2998|M.ulcerans_Agy99 LPPGHPMADR-HGVPVAALSELPLLLLDEGHCLRDQALDVCQN---AGVR
Mb2303c|M.bovis_AF2122/97 VPPGHKWARRSRVVSARELAQTPLVTREPNSGIRDSLTAALRDTLGEDMQ
Rv2282c|M.tuberculosis_H37Rv VPPGHKWARRSRVVSARELAQTPLVTREPNSGIRDSLTAALRDTLGEDMQ
Mflv_1470|M.gilvum_PYR-GCK GSRDYLATHG-TPATIAELQNHPLVYFIDS-MLQVDDLDLATS----FTP
Mvan_5301|M.vanbaalenii_PYR-1 ASRDYLAEHG-HPTSVADLQRFPLVYFIDA-MLQVDDLDLATS----FAP
MSMEG_6028|M.smegmatis_MC2_155 GARDYLAEHG-TPESVADLERYPLVYFIDS-MLQVDDLDLAPA----FAP
MAB_0055c|M.abscessus_ATCC_199 VGTGHRLAMRHRSLPVAQLSREALGLLSPDFATRQDIDAYFAG----LGV
.: . * .* : .
MLBr_02041|M.leprae_Br4923 AELANTRAASLATAVQCVTGGLGVTLLPQSAAPVESVRSKLGLAQFAAPC
MAV_2838|M.avium_104 AELANTRAASLATAVQCVTGGLGVTLIPQSAVPVEASRSRLGLAQFAAPR
MMAR_2756|M.marinum_M AELADTRAASLATAVQCVNGGLGVTLIPQSAVSVEAARSRVGLAHFAAPT
MUL_2998|M.ulcerans_Agy99 AEHADTRADSLATAVQCVNGGLGVTLIPQSAVSVEAARSRVGLTHFAAPT
Mb2303c|M.bovis_AF2122/97 QAPPVLELSSAAAVRAAVLAGAGPAAMSRLAIADDLAFGRLLAVDIPALN
Rv2282c|M.tuberculosis_H37Rv QAPPVLELSSAAAVRAAVLAGAGPAAMSRLAIADDLAFGRLLAVDIPALN
Mflv_1470|M.gilvum_PYR-GCK AMRESVTSTNVFVHVEATRAAAGIGLLPCFMADRHDDLVRVLPGQVSLT-
Mvan_5301|M.vanbaalenii_PYR-1 AMRESVTSTNVFVHVEATRAAAGIGLLPCFMADRHPDLERVLAAAVSIR-
MSMEG_6028|M.smegmatis_MC2_155 AMHESVTSTNVFVHVEATRASAGIGLLPCFMADRHDDLVRVLPETVSVR-
MAB_0055c|M.abscessus_ATCC_199 APHIAVEANSISALLEFVKRGSLATVLPDAIAHEHS---DLHLVPLSPPL
. . . . :. . : ..
MLBr_02041|M.leprae_Br4923 PGRRIGLAFRSASGRSASYRQIAKIIGELISTEHHVRLVA-
MAV_2838|M.avium_104 PGRRIGLVFRSSSGRDDSYRELAGLIGELISSQHQVRLVK-
MMAR_2756|M.marinum_M PGRRIGLVYRASSGRDEAYRQLAAIMGESISNEQQVRLVN-
MUL_2998|M.ulcerans_Agy99 PGRRIGLVYRASSGRDEAYRQLAAIMGESISNEQQVRLVN-
Mb2303c|M.bovis_AF2122/97 LRRQLRAIWVG--GRTPPAGAIRDLLSHITSRST-------
Rv2282c|M.tuberculosis_H37Rv LRRQLRAIWVG--GRTPPAGAIRDLLSHITSRST-------
Mflv_1470|M.gilvum_PYR-GCK --LTYWLVTRAETLRRPEVAAVVDAIRDRVRDRHHMLLGAG
Mvan_5301|M.vanbaalenii_PYR-1 --LTYWLVTRAETLRRPEVAAVVDAIRDRVREQHDVLLGAG
MSMEG_6028|M.smegmatis_MC2_155 --LSYWLVARAETLRRPVVAVVVDAIRDRMADQRDVLLGVR
MAB_0055c|M.abscessus_ATCC_199 PIRTVELLRRSSAYHSAAARAFTEMVHAGARGR--------
. : . :