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DTFPLGSHTVGRVGFGAMQLPGPGVFGPPRDHDQALAVLRRVVELGINHIDTAQIYGPNVANELIREALH PYADGLALVSKVGGRRDEQGNWLPAQDPDDLRRQLEENLSTLDTDRLAAVNLRAFNHDDPSLPAVLDRDL FDRQLTAMIAARDEGLIAGIGLSNVSADHLRVALERTEIVCVQNAYNLLDRTSQPVLDLSAEHGIAFVPF FPLGSGFVADNPVLKHPAVVREAEKLGRTPAQIVLAWTLSVAPNVLLIPGTSSVAHLEQNTAVRDITLDD DTRRDLDAAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1329 | - | - | 100% (291) | aldo/keto reductase |
| M. gilvum PYR-GCK | Mflv_0942 | - | 2e-47 | 41.33% (271) | aldo/keto reductase |
| M. gilvum PYR-GCK | Mflv_4697 | - | 2e-15 | 26.99% (289) | 2,5-didehydrogluconate reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2996 | - | 2e-10 | 26.59% (252) | oxidoreductase |
| M. tuberculosis H37Rv | Rv2298 | - | 4e-10 | 26.98% (315) | hypothetical protein Rv2298 |
| M. leprae Br4923 | MLBr_00458 | - | 1e-56 | 44.76% (286) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4120c | - | 4e-22 | 28.85% (305) | aldo/keto reductase |
| M. marinum M | MMAR_2086 | - | 1e-56 | 44.06% (286) | oxidoreductase |
| M. avium 104 | MAV_0482 | - | 1e-107 | 67.81% (292) | putative oxidoreductase YdbC |
| M. smegmatis MC2 155 | MSMEG_2475 | - | 1e-113 | 72.86% (280) | putative oxidoreductase YdbC |
| M. thermoresistible (build 8) | TH_1525 | - | 2e-18 | 29.67% (273) | 2,5-diketo-D-gluconic acid reductase A |
| M. ulcerans Agy99 | MUL_1987 | - | 7e-12 | 26.24% (263) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_5463 | - | 1e-137 | 82.47% (291) | aldo/keto reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1329|M.gilvum_PYR-GCK ----------------------MDTFPLG-SHTVGRVGFGAMQLPGPG-V
Mvan_5463|M.vanbaalenii_PYR-1 ----------------------MDSYQLG-SYSVGRVGFGAMQLPGPG-V
MSMEG_2475|M.smegmatis_MC2_155 --------------------MGASTFALG-SFTVHRVGFGAMQLPGPH-V
MAV_0482|M.avium_104 ----------------------MDHVQLG-RYSLARIGFGAMQLPGSG-G
MLBr_00458|M.leprae_Br4923 MRRFWRTVVEVTSQNSQALAQASGAFTLGGDLKVNRLGFGAMRLTGKG-V
MMAR_2086|M.marinum_M ------------------MAAASATLTLGGDLTVNRLGFGAMRLTGDG-V
MAB_4120c|M.abscessus_ATCC_199 ----------------------MKHTWLG-ELSVSRIGLGAMSMSAYYRA
Mb2996|M.bovis_AF2122/97 -------------MTGESGAAAAPSITLNDEHTMPVLGLGVAELSDDE--
MUL_1987|M.ulcerans_Agy99 -------------MMPGAPSPSAPSIALNDENTMPVLGMGVAGLSDDE--
TH_1525|M.thermoresistible__bu -----------------VNMTTVPAITLNNGAQIPQVGFGVYQIPPDQ--
Rv2298|M.tuberculosis_H37Rv ----------------------MKYLDVDGIGQVSRIGLGTWQFGSRE--
:. : :*:*. :
Mflv_1329|M.gilvum_PYR-GCK FGPPR--DHDQALAVLRRVVELGINHIDTAQIYGPNVANELIREALHPYA
Mvan_5463|M.vanbaalenii_PYR-1 FGPPR--DHDQAIAVLRRAVELGINHIDTAQIYGPNVANELIREALHPYP
MSMEG_2475|M.smegmatis_MC2_155 FGPPR--DHDQAIAVLRRAIELGVDHIDTAQFYGPDVANELIYEALHPYP
MAV_0482|M.avium_104 FGPPR--DRDQALAVLRRAVELGVDHIDTAQFYGPDVANELIREALHPYP
MLBr_00458|M.leprae_Br4923 WGPPV--DRYEAVRVLRRAVELGVNFIDTADSYGPYVSEEIIAEALHPYK
MMAR_2086|M.marinum_M WGPPA--DRAEAVRVLRRAAELGVNFIDTADSYGPYVSEEIIHEALHPYT
MAB_4120c|M.abscessus_ATCC_199 IGSESGPDEATSIDTLRRALDLGVSLIDTAEIYGPFVNEELVGRAIAGRR
Mb2996|M.bovis_AF2122/97 -----------TERAVSAALEIGCRLIDTAYAYGNEAAVGRAIAASGVAR
MUL_1987|M.ulcerans_Agy99 -----------TERAVSAALEIGCRLIDTAAAYGNEAAVGRALAASGIPR
TH_1525|M.thermoresistible__bu -----------TAAAVRTALDAGYRHIDTAQMYGNERGVAEGIRDAGLDR
Rv2298|M.tuberculosis_H37Rv WGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDR
: : . * :*** **
Mflv_1329|M.gilvum_PYR-GCK DGLALVSKVGGRRDEQGN-WLPAQDPDDLRRQLEENLSTLDTDRLAAVNL
Mvan_5463|M.vanbaalenii_PYR-1 ADLALVSKVGGKRDAQGN-WLPAQEPDDLYDQLEENLRTLDTDRLAAVNL
MSMEG_2475|M.smegmatis_MC2_155 ENLAIVSKVGGTRDDQAN-WLPAQEPEQLRKDIETNLHTLKVDQLAAVNL
MAV_0482|M.avium_104 DQLAIVSKVGARRDDRGG-MHPAQQRDDLRRGIEDNLRTLGVGQLAAVNL
MLBr_00458|M.leprae_Br4923 G-LVIATKAGLLRTGRDV-WIPLGNPSYLRQELEMSLRRLNVDTIDLFQL
MMAR_2086|M.marinum_M G-LVIATKAGLLRTGPGV-WVPLGNPSYLRQECEMSLRRLGVDTIDLFQL
MAB_4120c|M.abscessus_ATCC_199 DEVVLATKFGLVSHGNGASQVLDSTPGNISTAVEGSLRRLGVDHIDLYYQ
Mb2996|M.bovis_AF2122/97 EELFVTTKLAT----------PDQGFTRSQEACRASLDRLGLDYVDLYLI
MUL_1987|M.ulcerans_Agy99 AELFVTTKVAT----------ADHGFTASREACKASLDRLGLDYVDLYLI
TH_1525|M.thermoresistible__bu GEVFITSKLNN----------PYHRPDDARRAFDRTLTELGSDYVDLFLI
Rv2298|M.tuberculosis_H37Rv TEVVVASKVFP----------VAPFPAVIKNRERASARRLQLNRIPLYQI
: :.:* . * . :
Mflv_1329|M.gilvum_PYR-GCK RAFN-HDDPSLPAVLDRDLFDRQLTAMIAARDEGLIAGIGLSNVSADHLR
Mvan_5463|M.vanbaalenii_PYR-1 RVFG-SAGGAGPADLNRALFDRQLSTMIRARDEGLIAGIGLSNIGVDHLR
MSMEG_2475|M.smegmatis_MC2_155 RVFD-DPDG---RAVNRELFERQLDAMIAARDEGLIGGIGLSNIVCEHLE
MAV_0482|M.avium_104 RIVDPDSLRSTRPALDRKQFEQQLTAMIEARDEGLIGGIGLSNITVEHLR
MLBr_00458|M.leprae_Br4923 HRID-----------PNFPLADQVGELFTLKNEGKIRHIGLSEINLDQLT
MMAR_2086|M.marinum_M HRID-----------RNYPLADQVGELLALKNEGKIRHIGLSEIDVDQLE
MAB_4120c|M.abscessus_ATCC_199 HRVD-----------PNVAIEDTIGAVAELVQQGKVRYIGLSEAAAGTIR
Mb2996|M.bovis_AF2122/97 HWPAPP----------VGKYVDAWGGMIQSRGEGHARSIGVSNFTAEHIE
MUL_1987|M.ulcerans_Agy99 HWPAPA----------VGKYVDAFGGLIQARGEGFTRSIGVSNFTEEHVS
TH_1525|M.thermoresistible__bu HWPLPMH--------YDGDFVSTWKTLEEFAADGRARSIGVSNFEPAHLD
Rv2298|M.tuberculosis_H37Rv HQPN-----------PVVPDSVIMPGMRDLLDSGDIGAAGVSNYSLARWR
: : .* *:*:
Mflv_1329|M.gilvum_PYR-GCK VALERT--EIVCVQNAYNLLDR-TSQPVLDLSAEHGIAFVPFFPLGSGFV
Mvan_5463|M.vanbaalenii_PYR-1 IALERT--EIVCVQNAYNLVDR-TSQPVLELCLEHGVAFVPFFPLGSGFV
MSMEG_2475|M.smegmatis_MC2_155 IALQRT--DIVCVQNAYNIADR-TSQPVLDLCTERGIAFVPFFPLGSAFV
MAV_0482|M.avium_104 FALERT--EIVCVQNAYNLVDR-AAQPVLDECTARGIAFVAYFPLGSGFS
MLBr_00458|M.leprae_Br4923 AAQQIT--EIVSVQNMYNLSAR-AAEPLLDAVTSRGIGFIPWSPLAAGPL
MMAR_2086|M.marinum_M AAQQIT--EIVSVQNMYNLAAR-GAEPLLEAATSQGIAFIPWFPLASGPL
MAB_4120c|M.abscessus_ATCC_199 RAHAVH--PITALQNEYSLWTRDIEDEILPTIRELGIGLVAYSPLGRGFL
Mb2996|M.bovis_AF2122/97 NLIDLT--FVTPAVNQIELHPLLNQDELRKANAQHTVVTQSYCPLALGRL
MUL_1987|M.ulcerans_Agy99 NVIDLT--FVTPAVNQVELHPLLNQDELRKANAQHNVVTQSYTPLALGQL
TH_1525|M.thermoresistible__bu LLAAET--STVPAVNQVEIHPYFGNNDVRRYCAEHGIAVEAWAPIAKGRV
Rv2298|M.tuberculosis_H37Rv KADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQGLL
. .: : : .: *:. .
Mflv_1329|M.gilvum_PYR-GCK ADNP--------------------------VLKHPAVVREAEKLGRTPAQ
Mvan_5463|M.vanbaalenii_PYR-1 PDNP--------------------------VLNHPAVVREARNLGRTPAQ
MSMEG_2475|M.smegmatis_MC2_155 PDNP--------------------------VLGNPTVKKLAGELGYTPAQ
MAV_0482|M.avium_104 TDNP--------------------------VLGNPALRRAAVRLDATPAQ
MLBr_00458|M.leprae_Br4923 AAP------------------------------DGPLQRIAVNHHATPSQ
MMAR_2086|M.marinum_M AAP------------------------------DGPLRKIADDHHATPSQ
MAB_4120c|M.abscessus_ATCC_199 TGAIGSRDQLAEGDFRREQPRFSAENFDANLALVEEVRSVASSIGATSAQ
Mb2996|M.bovis_AF2122/97 LDNP-------------------------------TVTSIASEYVKTPAQ
MUL_1987|M.ulcerans_Agy99 ADNP-------------------------------TVTSIAGEYGKTPTQ
TH_1525|M.thermoresistible__bu ADDP-------------------------------VIAGIADRLGRTPAQ
Rv2298|M.tuberculosis_H37Rv GGKYG--LENRPGGVRALNPLFGTENLRRIEPLLATLRAIAVDVDAKPAQ
: * ..:*
Mflv_1329|M.gilvum_PYR-GCK IVLAWTLSVAPNVLLIPGTSSVAHLEQNTAVRDITLDDDTRRDLDAAA--
Mvan_5463|M.vanbaalenii_PYR-1 IALAWTLSVAPNVLLIPGTSSVTHLEENTAVRDVELDDETRRELDEAAH-
MSMEG_2475|M.smegmatis_MC2_155 IALAATLSLAPNILLIPGTSSVAHLEENIAVADIELPADATF--------
MAV_0482|M.avium_104 IALAWTLSVAPSIALIPGTSSVGHLEENLAAADITLDAETRAELAEAAP-
MLBr_00458|M.leprae_Br4923 LALAWLLKRSPVMLPIPGTSRVAHLEENVAAAEISLSDDEFEMLSAAGAQ
MMAR_2086|M.marinum_M LALAWLLKRSPVMLPIPGTSRVAHLQENVAAAEIVLSDQEFEALSVAGAA
MAB_4120c|M.abscessus_ATCC_199 VALAWLLARGDDIVPIPGTTKVSRVNENVGAVDIELLPEHLVRLECLAAA
Mb2996|M.bovis_AF2122/97 VLLRWNLQLGN--AVVVRSARPERIASNFDVFDFELAAEHMDALGGLNDG
MUL_1987|M.ulcerans_Agy99 VLLRWNLQLGN--AVIFGSSNAEHIVTNLDVFEFELASQHMDAINGLNDG
TH_1525|M.thermoresistible__bu VTLRWHIQRGD--IVLPKSVTPERVRSNIALFDFELSDADMAAISALDKG
Rv2298|M.tuberculosis_H37Rv VALAWLISLPG-VVAIPGASSVEQLEFNVAAADIELSAQSRDALTDAARA
: * : : : :: * :. *
Mflv_1329|M.gilvum_PYR-GCK ---------------------
Mvan_5463|M.vanbaalenii_PYR-1 ---------------------
MSMEG_2475|M.smegmatis_MC2_155 ---------------------
MAV_0482|M.avium_104 ---------------------
MLBr_00458|M.leprae_Br4923 ---------------------
MMAR_2086|M.marinum_M HGG------------------
MAB_4120c|M.abscessus_ATCC_199 AGDRYNAEHLARLEG------
Mb2996|M.bovis_AF2122/97 --TRVREDPLTYAGT------
MUL_1987|M.ulcerans_Agy99 --TRLREDPMTFAGV------
TH_1525|M.thermoresistible__bu EAGRMGPHPDKFDMI------
Rv2298|M.tuberculosis_H37Rv FRPVSTGRFLTDMVREKVSRR