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MDSYQLGSYSVGRVGFGAMQLPGPGVFGPPRDHDQAIAVLRRAVELGINHIDTAQIYGPNVANELIREAL HPYPADLALVSKVGGKRDAQGNWLPAQEPDDLYDQLEENLRTLDTDRLAAVNLRVFGSAGGAGPADLNRA LFDRQLSTMIRARDEGLIAGIGLSNIGVDHLRIALERTEIVCVQNAYNLVDRTSQPVLELCLEHGVAFVP FFPLGSGFVPDNPVLNHPAVVREARNLGRTPAQIALAWTLSVAPNVLLIPGTSSVTHLEENTAVRDVELD DETRRELDEAAH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5463 | - | - | 100% (292) | aldo/keto reductase |
| M. vanbaalenii PYR-1 | Mvan_2555 | - | 3e-53 | 41.96% (286) | aldo/keto reductase |
| M. vanbaalenii PYR-1 | Mvan_1769 | - | 6e-14 | 26.20% (271) | 2,5-didehydrogluconate reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2320 | - | 1e-11 | 27.22% (316) | hypothetical protein Mb2320 |
| M. gilvum PYR-GCK | Mflv_1329 | - | 1e-137 | 82.47% (291) | aldo/keto reductase |
| M. tuberculosis H37Rv | Rv2298 | - | 1e-11 | 27.22% (316) | hypothetical protein Rv2298 |
| M. leprae Br4923 | MLBr_00458 | - | 2e-55 | 43.71% (286) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4120c | - | 2e-23 | 29.51% (305) | aldo/keto reductase |
| M. marinum M | MMAR_2086 | - | 3e-56 | 44.06% (286) | oxidoreductase |
| M. avium 104 | MAV_0482 | - | 1e-108 | 68.94% (293) | putative oxidoreductase YdbC |
| M. smegmatis MC2 155 | MSMEG_2475 | - | 1e-113 | 72.92% (277) | putative oxidoreductase YdbC |
| M. thermoresistible (build 8) | TH_1525 | - | 2e-15 | 27.37% (274) | 2,5-diketo-D-gluconic acid reductase A |
| M. ulcerans Agy99 | MUL_2745 | - | 5e-13 | 26.67% (315) | hypothetical protein MUL_2745 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5463|M.vanbaalenii_PYR-1 ----------------------MDSYQLG-SYSVGRVGFGAMQLPGPG-V
Mflv_1329|M.gilvum_PYR-GCK ----------------------MDTFPLG-SHTVGRVGFGAMQLPGPG-V
MSMEG_2475|M.smegmatis_MC2_155 --------------------MGASTFALG-SFTVHRVGFGAMQLPGPH-V
MAV_0482|M.avium_104 ----------------------MDHVQLG-RYSLARIGFGAMQLPGSG-G
MLBr_00458|M.leprae_Br4923 MRRFWRTVVEVTSQNSQALAQASGAFTLGGDLKVNRLGFGAMRLTGKG-V
MMAR_2086|M.marinum_M ------------------MAAASATLTLGGDLTVNRLGFGAMRLTGDG-V
MAB_4120c|M.abscessus_ATCC_199 ----------------------MKHTWLG-ELSVSRIGLGAMSMSAYYRA
Mb2320|M.bovis_AF2122/97 ----------------------MKYLDVDGIGQVSRIGLGTWQFGSREWG
Rv2298|M.tuberculosis_H37Rv ----------------------MKYLDVDGIGQVSRIGLGTWQFGSREWG
MUL_2745|M.ulcerans_Agy99 ----------------------MKHLEVDGIGNVSRIGLGTWQFGSREWG
TH_1525|M.thermoresistible__bu -----------------VNMTTVPAITLNNGAQIPQVGFGVYQIPPDQ--
:. : ::*:*. :
Mvan_5463|M.vanbaalenii_PYR-1 FGPPR--DHDQAIAVLRRAVELGINHIDTAQIYGPNVANELIREALHPYP
Mflv_1329|M.gilvum_PYR-GCK FGPPR--DHDQALAVLRRVVELGINHIDTAQIYGPNVANELIREALHPYA
MSMEG_2475|M.smegmatis_MC2_155 FGPPR--DHDQAIAVLRRAIELGVDHIDTAQFYGPDVANELIYEALHPYP
MAV_0482|M.avium_104 FGPPR--DRDQALAVLRRAVELGVDHIDTAQFYGPDVANELIREALHPYP
MLBr_00458|M.leprae_Br4923 WGPPV--DRYEAVRVLRRAVELGVNFIDTADSYGPYVSEEIIAEALHPYK
MMAR_2086|M.marinum_M WGPPA--DRAEAVRVLRRAAELGVNFIDTADSYGPYVSEEIIHEALHPYT
MAB_4120c|M.abscessus_ATCC_199 IGSESGPDEATSIDTLRRALDLGVSLIDTAEIYGPFVNEELVGRAIAGRR
Mb2320|M.bovis_AF2122/97 YGDRY--ATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDR
Rv2298|M.tuberculosis_H37Rv YGDRY--ATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDR
MUL_2745|M.ulcerans_Agy99 YGDRY--ASGAARDIVARACALGVTLFDTAEVYGLGKSERILGEALGDER
TH_1525|M.thermoresistible__bu -----------TAAAVRTALDAGYRHIDTAQMYGNERGVAEGIRDAGLDR
: : . * :***: ** .
Mvan_5463|M.vanbaalenii_PYR-1 ADLALVSKVGGKRDAQGN-WLPAQEPDDLYDQLEENLRTLDTDRLAAVNL
Mflv_1329|M.gilvum_PYR-GCK DGLALVSKVGGRRDEQGN-WLPAQDPDDLRRQLEENLSTLDTDRLAAVNL
MSMEG_2475|M.smegmatis_MC2_155 ENLAIVSKVGGTRDDQAN-WLPAQEPEQLRKDIETNLHTLKVDQLAAVNL
MAV_0482|M.avium_104 DQLAIVSKVGARRDDRGG-MHPAQQRDDLRRGIEDNLRTLGVGQLAAVNL
MLBr_00458|M.leprae_Br4923 G-LVIATKAGLLRTGRDV-WIPLGNPSYLRQELEMSLRRLNVDTIDLFQL
MMAR_2086|M.marinum_M G-LVIATKAGLLRTGPGV-WVPLGNPSYLRQECEMSLRRLGVDTIDLFQL
MAB_4120c|M.abscessus_ATCC_199 DEVVLATKFGLVSHGNGASQVLDSTPGNISTAVEGSLRRLGVDHIDLYYQ
Mb2320|M.bovis_AF2122/97 TEVVVASKVFP----------VAPFPAVIKNRERASARRLQLNRIPLYQI
Rv2298|M.tuberculosis_H37Rv TEVVVASKVFP----------VAPFPAVIKNRERASARRLQLNRIPLYQI
MUL_2745|M.ulcerans_Agy99 AEVVVASKIMP----------VAPFPAVVKQRERASARRLQLDRIPLYQI
TH_1525|M.thermoresistible__bu GEVFITSKLNN----------PYHRPDDARRAFDRTLTELGSDYVDLFLI
: :.:* . * . :
Mvan_5463|M.vanbaalenii_PYR-1 RVFG-SAGGAGPADLNRALFDRQLSTMIRARDEGLIAGIGLSNIGVDHLR
Mflv_1329|M.gilvum_PYR-GCK RAFN-HDDPSLPAVLDRDLFDRQLTAMIAARDEGLIAGIGLSNVSADHLR
MSMEG_2475|M.smegmatis_MC2_155 RVFD-DPDG---RAVNRELFERQLDAMIAARDEGLIGGIGLSNIVCEHLE
MAV_0482|M.avium_104 RIVDPDSLRSTRPALDRKQFEQQLTAMIEARDEGLIGGIGLSNITVEHLR
MLBr_00458|M.leprae_Br4923 HRID-----------PNFPLADQVGELFTLKNEGKIRHIGLSEINLDQLT
MMAR_2086|M.marinum_M HRID-----------RNYPLADQVGELLALKNEGKIRHIGLSEIDVDQLE
MAB_4120c|M.abscessus_ATCC_199 HRVD-----------PNVAIEDTIGAVAELVQQGKVRYIGLSEAAAGTIR
Mb2320|M.bovis_AF2122/97 HQPN-----------PVVPDSVIMPGMRDLLDSGDIGAAGVSNYSLARWR
Rv2298|M.tuberculosis_H37Rv HQPN-----------PVVPDSVIMPGMRDLLDSGDIGAAGVSNYSLARWR
MUL_2745|M.ulcerans_Agy99 HQPN-----------PVVPDSVIMPGIRELLDIGRIGAAGVSNYSLARWK
TH_1525|M.thermoresistible__bu HWPLP--------MHYDGDFVSTWKTLEEFAADGRARSIGVSNFEPAHLD
: : * *:*:
Mvan_5463|M.vanbaalenii_PYR-1 IALERT--EIVCVQNAYNLVDR-TSQPVLELCLEHGVAFVPFFPLGSGFV
Mflv_1329|M.gilvum_PYR-GCK VALERT--EIVCVQNAYNLLDR-TSQPVLDLSAEHGIAFVPFFPLGSGFV
MSMEG_2475|M.smegmatis_MC2_155 IALQRT--DIVCVQNAYNIADR-TSQPVLDLCTERGIAFVPFFPLGSAFV
MAV_0482|M.avium_104 FALERT--EIVCVQNAYNLVDR-AAQPVLDECTARGIAFVAYFPLGSGFS
MLBr_00458|M.leprae_Br4923 AAQQIT--EIVSVQNMYNLSAR-AAEPLLDAVTSRGIGFIPWSPLAAGPL
MMAR_2086|M.marinum_M AAQQIT--EIVSVQNMYNLAAR-GAEPLLEAATSQGIAFIPWFPLASGPL
MAB_4120c|M.abscessus_ATCC_199 RAHAVH--PITALQNEYSLWTRDIEDEILPTIRELGIGLVAYSPLGRGFL
Mb2320|M.bovis_AF2122/97 KADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQGLL
Rv2298|M.tuberculosis_H37Rv KADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQGLL
MUL_2745|M.ulcerans_Agy99 KADAALGRPVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAYSPLAQGLL
TH_1525|M.thermoresistible__bu LLAAET--STVPAVNQVEIHPYFGNNDVRRYCAEHGIAVEAWAPIAKGRV
. .: : : . . .: *:. .
Mvan_5463|M.vanbaalenii_PYR-1 PDNP--------------------------VLNHPAVVREARNLGRTPAQ
Mflv_1329|M.gilvum_PYR-GCK ADNP--------------------------VLKHPAVVREAEKLGRTPAQ
MSMEG_2475|M.smegmatis_MC2_155 PDNP--------------------------VLGNPTVKKLAGELGYTPAQ
MAV_0482|M.avium_104 TDNP--------------------------VLGNPALRRAAVRLDATPAQ
MLBr_00458|M.leprae_Br4923 AAP------------------------------DGPLQRIAVNHHATPSQ
MMAR_2086|M.marinum_M AAP------------------------------DGPLRKIADDHHATPSQ
MAB_4120c|M.abscessus_ATCC_199 TGAIGSRDQLAEGDFRREQPRFSAENFDANLALVEEVRSVASSIGATSAQ
Mb2320|M.bovis_AF2122/97 GGKYG--LENRPGGVRALNPLFGTENLRRIEPLLATLRAIAVDVDAKPAQ
Rv2298|M.tuberculosis_H37Rv GGKYG--LENRPGGVRALNPLFGTENLRRIEPLLATLRAIAVDVDAKPAQ
MUL_2745|M.ulcerans_Agy99 GGKYG--VDNRPAGVRAVNPLFGTENLRRIEPLLQTLRAVAIDVDAKPAQ
TH_1525|M.thermoresistible__bu ADDP-------------------------------VIAGIADRLGRTPAQ
: * ..:*
Mvan_5463|M.vanbaalenii_PYR-1 IALAWTLSVAPNVLLIPGTSSVTHLEENTAVRDVELDDETRRELDEAAH-
Mflv_1329|M.gilvum_PYR-GCK IVLAWTLSVAPNVLLIPGTSSVAHLEQNTAVRDITLDDDTRRDLDAAA--
MSMEG_2475|M.smegmatis_MC2_155 IALAATLSLAPNILLIPGTSSVAHLEENIAVADIELPADATF--------
MAV_0482|M.avium_104 IALAWTLSVAPSIALIPGTSSVGHLEENLAAADITLDAETRAELAEAAP-
MLBr_00458|M.leprae_Br4923 LALAWLLKRSPVMLPIPGTSRVAHLEENVAAAEISLSDDEFEMLSAAGAQ
MMAR_2086|M.marinum_M LALAWLLKRSPVMLPIPGTSRVAHLQENVAAAEIVLSDQEFEALSVAGAA
MAB_4120c|M.abscessus_ATCC_199 VALAWLLARGDDIVPIPGTTKVSRVNENVGAVDIELLPEHLVRLECLAAA
Mb2320|M.bovis_AF2122/97 VALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIELSAQSRDALTDAARA
Rv2298|M.tuberculosis_H37Rv VALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIELSAQSRDALTDAARA
MUL_2745|M.ulcerans_Agy99 VALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIELSADARAALTEAARA
TH_1525|M.thermoresistible__bu VTLRWHIQ--RGDIVLPKSVTPERVRSNIALFDFELSDADMAAISALDKG
:.* : :* : ::. * . :. *
Mvan_5463|M.vanbaalenii_PYR-1 ---------------------
Mflv_1329|M.gilvum_PYR-GCK ---------------------
MSMEG_2475|M.smegmatis_MC2_155 ---------------------
MAV_0482|M.avium_104 ---------------------
MLBr_00458|M.leprae_Br4923 ---------------------
MMAR_2086|M.marinum_M HGG------------------
MAB_4120c|M.abscessus_ATCC_199 AGDRYNAEHLARLEG------
Mb2320|M.bovis_AF2122/97 FRPVSTGRFLTDMVREKVSRR
Rv2298|M.tuberculosis_H37Rv FRPVSTGRFLTDMVREKVSRR
MUL_2745|M.ulcerans_Agy99 FHPVSARRFLTDTVREKLGRR
TH_1525|M.thermoresistible__bu EAGRMGPHPDKFDMI------