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PRGGPRASCLDRLLETDRQEYLDRASELPADVARKRSVIRALEWTGETFGHHVRFAEIVLDQISDVPDPK ILELGAGHGALSRKLLDWHPTARLTVTDIEPASVAAIADSDVGAHPRATVRQMDATALDAADGEFDLAVF ALSFHHLPPAAAARVIAEGTRAADTLLIIDLPRPPAPLHLVRLATMLPWAPLVPFVHDGVISSLRAYSPA ALRALAAHAGEDIDIELRGGLFSPQVAVAARR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1326 | - | - | 100% (243) | methyltransferase type 11 |
| M. gilvum PYR-GCK | Mflv_2862 | - | 3e-06 | 33.96% (106) | methyltransferase type 11 |
| M. gilvum PYR-GCK | Mflv_1324 | - | 1e-05 | 34.38% (96) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2000 | - | 1e-58 | 47.47% (257) | hypothetical protein Mb2000 |
| M. tuberculosis H37Rv | Rv1978 | - | 2e-59 | 47.86% (257) | hypothetical protein Rv1978 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4700c | - | 5e-70 | 57.89% (247) | hypothetical protein MAB_4700c |
| M. marinum M | MMAR_1415 | - | 2e-12 | 41.67% (96) | hypothetical protein MMAR_1415 |
| M. avium 104 | MAV_0081 | - | 3e-53 | 48.09% (235) | hypothetical protein MAV_0081 |
| M. smegmatis MC2 155 | MSMEG_6231 | - | 4e-97 | 72.73% (242) | hypothetical protein MSMEG_6231 |
| M. thermoresistible (build 8) | TH_2189 | - | 5e-05 | 31.25% (96) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_0820 | - | 3e-06 | 30.08% (133) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_5469 | - | 1e-110 | 79.92% (244) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2000|M.bovis_AF2122/97 --------------------------------------------------
Rv1978|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0081|M.avium_104 --------------------------------------------------
Mflv_1326|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5469|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6231|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4700c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_1415|M.marinum_M --------------------------------------------------
TH_2189|M.thermoresistible__bu VIRRLMATALTALTTAVLAGCGDAGSWVEAKPAEGWSAQYGDAANSSYTS
MUL_0820|M.ulcerans_Agy99 --------------------------------------------------
Mb2000|M.bovis_AF2122/97 --------------------------------------------------
Rv1978|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0081|M.avium_104 --------------------------------------------------
Mflv_1326|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5469|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6231|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4700c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_1415|M.marinum_M --------------------------------------------------
TH_2189|M.thermoresistible__bu AAGAEALTLEWSRSVKGELAAQVAVGASGYLAVNAQTPAGCSLMVWEYAN
MUL_0820|M.ulcerans_Agy99 --------------------------------------------------
Mb2000|M.bovis_AF2122/97 --------------------------------------------------
Rv1978|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0081|M.avium_104 --------------------------------------------------
Mflv_1326|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5469|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6231|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4700c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_1415|M.marinum_M --------------------------------------------------
TH_2189|M.thermoresistible__bu SARQRWCTRLVQGGGRTSPLLDGFDNVYIGQPGAILSFPPTQWIRWRKPV
MUL_0820|M.ulcerans_Agy99 --------------------------------------------------
Mb2000|M.bovis_AF2122/97 --------------------------------------------------
Rv1978|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0081|M.avium_104 --------------------------------------------------
Mflv_1326|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5469|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6231|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4700c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_1415|M.marinum_M --------------------------------------------------
TH_2189|M.thermoresistible__bu IGMPTTPRILAPGELLVVTHLGQVLLFDAHRGTVTGTPLDLVAGVDPTDS
MUL_0820|M.ulcerans_Agy99 --------------------------------------------------
Mb2000|M.bovis_AF2122/97 ---------------------------------------------MGEAN
Rv1978|M.tuberculosis_H37Rv ---------------------------------------------MGEAN
MAV_0081|M.avium_104 ---------------------------------------------MSEAL
Mflv_1326|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5469|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6231|M.smegmatis_MC2_155 ---------------------------------------------MAYMA
MAB_4700c|M.abscessus_ATCC_199 ---------------------------------------------MFYVE
MMAR_1415|M.marinum_M --------------------------------------------------
TH_2189|M.thermoresistible__bu ERGLADCAGARXXXCWPPPRPPSTVTPRARDAARHPTARLPAMTETTEPG
MUL_0820|M.ulcerans_Agy99 --------------------------------------------------
Mb2000|M.bovis_AF2122/97 IREQAIATMPRGGPDASWLDRRFQTDALEYLDRDDVP----DEVKQKIIG
Rv1978|M.tuberculosis_H37Rv IREQAIATMPRGGPDASWLDRRFQTDALEYLDRDDVP----DEVKQKIIG
MAV_0081|M.avium_104 TVDPAIASMPRGGPDASWLDRRLQTEKLEYTDRYDIP----DEVKQTVVA
Mflv_1326|M.gilvum_PYR-GCK --------MPRGGPRASCLDRLLETDRQEYLDRASELPADVAR-KRSVIR
Mvan_5469|M.vanbaalenii_PYR-1 --------MPRGGPDASCLDRLLQTDRQEYLDRDSAGDAGLEQTKRSVIR
MSMEG_6231|M.smegmatis_MC2_155 TSTADIAAMPRGGPRASCLDRLLQTDRLEYLDRDDVD----QRVKRSVVR
MAB_4700c|M.abscessus_ATCC_199 NSARDISSMPRGGPNASWLDRRLQTDRLEYLDRDDVD-----DLKRRVMQ
MMAR_1415|M.marinum_M --------MPAMSRIESVFCRSAPWR----------------AATRRLVL
TH_2189|M.thermoresistible__bu IGSEGAGDLPAPNPHATAEQVEAAMRDSKLAQILYHD---WEAESYDDKW
MUL_0820|M.ulcerans_Agy99 --------MTNHHPRFGLQHSGESRDYLPAAGHDALLP------AYDLLS
:.
Mb2000|M.bovis_AF2122/97 VLDRVG--TLTNLHEKYARIALKLVSDIPNPRILELGAGHGKLSAKILEL
Rv1978|M.tuberculosis_H37Rv VLDRVG--TLTNLHEKYARIALKLVSDIPNPRILELGAGHGKLSAKILEL
MAV_0081|M.avium_104 ALDRMG--TRAGYHERNARTALDIVADIANPRILELGAGHGKLSAEILTS
Mflv_1326|M.gilvum_PYR-GCK ALEWTG--ETFGHHVRFAEIVLDQISDVPDPKILELGAGHGALSRKLLDW
Mvan_5469|M.vanbaalenii_PYR-1 ALDWTG--EVFGNHEKFAKIALDEVADVADPRILELGAGHGGLSRKLLEW
MSMEG_6231|M.smegmatis_MC2_155 ALEWTG--DMFGNHEKFAAISLDLLAEVPDPRILELGAGHGSVSRRLLAN
MAB_4700c|M.abscessus_ATCC_199 SLDRAGRRRWIGIHEKCARMAIREVADVDRPKILELGAGLGGLSHKLLEM
MMAR_1415|M.marinum_M PWALQG------------------IEPVG--EVLEIGAGSGAMAAEMLAA
TH_2189|M.thermoresistible__bu SISYDQRCVDYARGRFDAIVPDHVQRELPYDNALELGCGTGFFLLNLIQS
MUL_0820|M.ulcerans_Agy99 RLLGMN---------KIHRTLITQAELADCGRILEIGCGTGNLAIKAKRA
. **:*.* * . .
Mb2000|M.bovis_AF2122/97 HPTATVTISDLDPTSVANIAAGELGTHPRARTQVIDATAIDGHGHSYDLA
Rv1978|M.tuberculosis_H37Rv HPTATVTISDLDPTSVANIAAGELGTHPRARTQVIDATAIDGHDHSYDLA
MAV_0081|M.avium_104 HPTATVTVSDLDPTSVANIAAGPLGADPRARTQVVDATAIDAPDDSYDLV
Mflv_1326|M.gilvum_PYR-GCK HPTARLTVTDIEPASVAAIADSDVGAHPRATVRQMDATALDAADGEFDLA
Mvan_5469|M.vanbaalenii_PYR-1 HPSARLTVTDVEPASVAAIAAGDLGSHPRATVRQMDATALDAADGEFDLA
MSMEG_6231|M.smegmatis_MC2_155 HPTAHVTVTDVDPAAVAAMADGELGDHPRAVVRAMDATDIDADDGSFDLA
MAB_4700c|M.abscessus_ATCC_199 HSTAQVTVTDVDPSFVAAVAAGEIGSHPRATVRQLDATEIDSPGGYYDLA
MMAR_1415|M.marinum_M QPDTRITVTDYDDAMVAAAAQRLAPFQTRATARQADATALPFGDNTFDTV
TH_2189|M.thermoresistible__bu GVARRGSVTDLSPGMVRVATRNGRSLGLDVDGRVADAEGIPYDDNTFDLV
MUL_0820|M.ulcerans_Agy99 QPRAEVIGSDPDPRALQRAQR-KTGNVEEVRFDQGYAQRLPYADGEFDRV
:* . : . * : . :* .
Mb2000|M.bovis_AF2122/97 VFALAFHHLP-------PTVACKAIAEATRVGKRFLIIDLKRQKPLSF--
Rv1978|M.tuberculosis_H37Rv VFALAFHHLP-------PTVACKAIAEATRVGKRFLIIDLKRQKPLSF--
MAV_0081|M.avium_104 VFAQAFHHLP-------PATAVRAIAEATRVGKRFLVIDLPRPRSVQL--
Mflv_1326|M.gilvum_PYR-GCK VFALSFHHLP-------PAAAARVIAEGTRAADTLLIIDLPRP-------
Mvan_5469|M.vanbaalenii_PYR-1 VFALSFHHLP-------PQLAARAIAEGARVADKLLIIDLPRP-------
MSMEG_6231|M.smegmatis_MC2_155 LFALSFHHLS-------PAQAAAVFAEGTRVARTLLIIDLPRP-------
MAB_4700c|M.abscessus_ATCC_199 VFALSLHHLP-------PELAARVFATGTRVARKLLIVDLPRP-------
MMAR_1415|M.marinum_M LTFIMLHHTVRWEQ--TLAEAVRVLAPHGTLIGYDLLSSWPTR-------
TH_2189|M.thermoresistible__bu VGHAVLHHIPDVEL--SLREVVRVLRPGGRFVFAGEPTTVGNSYARALST
MUL_0820|M.ulcerans_Agy99 LSSMMLHHLDEDAKSAAAAEAFRVLRPGGRLHLVDVGGDMSAHDGLAS--
: :** . .:
Mb2000|M.bovis_AF2122/97 ----TLSSVLLLPLH-LLLLPWSSMRSSMHDGFISALR---AYSPSALQT
Rv1978|M.tuberculosis_H37Rv ----TLSSVLLLPLH-LLLLPWSSMRSSMHDGFISALR---AYSPSALQT
MAV_0081|M.avium_104 ----LLTPLILAPFAAALALVRPSLKHVMHDAYISALR---AYSRSAFIA
Mflv_1326|M.gilvum_PYR-GCK -------PAPLHLVRLATMLPWAPLVPFVHDGVISSLR---AYSPAALRA
Mvan_5469|M.vanbaalenii_PYR-1 -------PAPLHVLRLAAMLPWAPLVPFLHDGVISSLR---AYSPSALRA
MSMEG_6231|M.smegmatis_MC2_155 -------PAPLHLLRLATMLPLAPLVPFVHDGVISSLR---CYSPSALRA
MAB_4700c|M.abscessus_ATCC_199 -------PVPLHLALLAVVLPLVAISPLQHDGFISSLR---AYSPSALRA
MMAR_1415|M.marinum_M -------TLHRLEGAPHRLIERGELQPVLRQLPLSASR---VRQNRLLVR
TH_2189|M.thermoresistible__bu LTWHVATTVTRLPGLQGWRRPQAELDESSRAAALEAVVDLHTFEPSDLER
MUL_0820|M.ulcerans_Agy99 -------RFIRHNLHVAGNLGDGIRRLLDTAGFDVAEVG--AQRHPLLGR
: :
Mb2000|M.bovis_AF2122/97 LARAADPGMQVEILP-APTRLFPPSLAVVFSRSSSAPTESSECSADRQPG
Rv1978|M.tuberculosis_H37Rv LARAADPGMQVEILP-APTRLFPPSLAVVFSRSSSAPTESSECSADRQPG
MAV_0081|M.avium_104 LGKAADPRMGVEFLPLSACRLRPGHVGIVFTRPRAS--------------
Mflv_1326|M.gilvum_PYR-GCK LAAHAGEDIDIELRG---G-LFSPQVAVAARR------------------
Mvan_5469|M.vanbaalenii_PYR-1 LATHADPAVDIELRG---G-LLSPQVAVATRR------------------
MSMEG_6231|M.smegmatis_MC2_155 LAAHAG--VALELRG---G-LTTPQIAIARRA------------------
MAB_4700c|M.abscessus_ATCC_199 LAHHADPAINVEFRS---RRGLGPTVVVASRP------------------
MMAR_1415|M.marinum_M FTAMKQASPS----------------------------------------
TH_2189|M.thermoresistible__bu MARNAGAVEVATASEEFTAAMLGWPVRTFEAAVPPGKLGWNWAKFAFGSW
MUL_0820|M.ulcerans_Agy99 LVYYRATRPCA---------------------------------------
:
Mb2000|M.bovis_AF2122/97 E------------------------------
Rv1978|M.tuberculosis_H37Rv E------------------------------
MAV_0081|M.avium_104 -------------------------------
Mflv_1326|M.gilvum_PYR-GCK -------------------------------
Mvan_5469|M.vanbaalenii_PYR-1 -------------------------------
MSMEG_6231|M.smegmatis_MC2_155 -------------------------------
MAB_4700c|M.abscessus_ATCC_199 -------------------------------
MMAR_1415|M.marinum_M -------------------------------
TH_2189|M.thermoresistible__bu TALSWVDANVWRRVMPKGWFYNVMVTGVKPS
MUL_0820|M.ulcerans_Agy99 -------------------------------