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SEALTVDPAIASMPRGGPDASWLDRRLQTEKLEYTDRYDIPDEVKQTVVAALDRMGTRAGYHERNARTAL DIVADIANPRILELGAGHGKLSAEILTSHPTATVTVSDLDPTSVANIAAGPLGADPRARTQVVDATAIDA PDDSYDLVVFAQAFHHLPPATAVRAIAEATRVGKRFLVIDLPRPRSVQLLLTPLILAPFAAALALVRPSL KHVMHDAYISALRAYSRSAFIALGKAADPRMGVEFLPLSACRLRPGHVGIVFTRPRAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0081 | - | - | 100% (269) | hypothetical protein MAV_0081 |
| M. avium 104 | MAV_3903 | - | 1e-07 | 32.46% (114) | methyltransferase, UbiE/COQ5 family protein |
| M. avium 104 | MAV_4317 | - | 3e-06 | 28.23% (124) | putative methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2000 | - | 2e-88 | 63.77% (265) | hypothetical protein Mb2000 |
| M. gilvum PYR-GCK | Mflv_1326 | - | 3e-53 | 48.09% (235) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv1978 | - | 3e-89 | 64.15% (265) | hypothetical protein Rv1978 |
| M. leprae Br4923 | MLBr_01723 | - | 2e-06 | 31.73% (104) | hypothetical protein MLBr_01723 |
| M. abscessus ATCC 19977 | MAB_4700c | - | 8e-62 | 53.36% (238) | hypothetical protein MAB_4700c |
| M. marinum M | MMAR_1415 | - | 4e-09 | 35.87% (92) | hypothetical protein MMAR_1415 |
| M. smegmatis MC2 155 | MSMEG_6231 | - | 7e-57 | 50.00% (238) | hypothetical protein MSMEG_6231 |
| M. thermoresistible (build 8) | TH_2189 | - | 2e-06 | 33.65% (104) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_1900 | - | 2e-07 | 33.04% (112) | hypothetical protein MUL_1900 |
| M. vanbaalenii PYR-1 | Mvan_5469 | - | 3e-59 | 52.54% (236) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2000|M.bovis_AF2122/97 --------------------------------------------------
Rv1978|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0081|M.avium_104 --------------------------------------------------
Mflv_1326|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5469|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6231|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4700c|M.abscessus_ATCC_199 --------------------------------------------------
TH_2189|M.thermoresistible__bu VIRRLMATALTALTTAVLAGCGDAGSWVEAKPAEGWSAQYGDAANSSYTS
MUL_1900|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
MMAR_1415|M.marinum_M --------------------------------------------------
Mb2000|M.bovis_AF2122/97 --------------------------------------------------
Rv1978|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0081|M.avium_104 --------------------------------------------------
Mflv_1326|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5469|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6231|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4700c|M.abscessus_ATCC_199 --------------------------------------------------
TH_2189|M.thermoresistible__bu AAGAEALTLEWSRSVKGELAAQVAVGASGYLAVNAQTPAGCSLMVWEYAN
MUL_1900|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
MMAR_1415|M.marinum_M --------------------------------------------------
Mb2000|M.bovis_AF2122/97 --------------------------------------------------
Rv1978|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0081|M.avium_104 --------------------------------------------------
Mflv_1326|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5469|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6231|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4700c|M.abscessus_ATCC_199 --------------------------------------------------
TH_2189|M.thermoresistible__bu SARQRWCTRLVQGGGRTSPLLDGFDNVYIGQPGAILSFPPTQWIRWRKPV
MUL_1900|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
MMAR_1415|M.marinum_M --------------------------------------------------
Mb2000|M.bovis_AF2122/97 --------------------------------------------------
Rv1978|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0081|M.avium_104 --------------------------------------------------
Mflv_1326|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5469|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6231|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4700c|M.abscessus_ATCC_199 --------------------------------------------------
TH_2189|M.thermoresistible__bu IGMPTTPRILAPGELLVVTHLGQVLLFDAHRGTVTGTPLDLVAGVDPTDS
MUL_1900|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
MMAR_1415|M.marinum_M --------------------------------------------------
Mb2000|M.bovis_AF2122/97 ------------------------------------------MGEANIRE
Rv1978|M.tuberculosis_H37Rv ------------------------------------------MGEANIRE
MAV_0081|M.avium_104 ------------------------------------------MSEALTVD
Mflv_1326|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5469|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6231|M.smegmatis_MC2_155 ------------------------------------------MAYMATST
MAB_4700c|M.abscessus_ATCC_199 ------------------------------------------MFYVENSA
TH_2189|M.thermoresistible__bu ERGLADCAGARXXXCWPPPRPPSTVTPRARDAARHPTARLPAMTETTEPG
MUL_1900|M.ulcerans_Agy99 ------------------------------------------MTRSSE--
MLBr_01723|M.leprae_Br4923 ------------------------------------------MTRSTE--
MMAR_1415|M.marinum_M --------------------------------------------------
Mb2000|M.bovis_AF2122/97 QAIA-----TMPRGGPDASWLDRRFQTDALEYLDRDDVP----DEVKQKI
Rv1978|M.tuberculosis_H37Rv QAIA-----TMPRGGPDASWLDRRFQTDALEYLDRDDVP----DEVKQKI
MAV_0081|M.avium_104 PAIA-----SMPRGGPDASWLDRRLQTEKLEYTDRYDIP----DEVKQTV
Mflv_1326|M.gilvum_PYR-GCK ----------MPRGGPRASCLDRLLETDRQEYLDRASELPADVAR-KRSV
Mvan_5469|M.vanbaalenii_PYR-1 ----------MPRGGPDASCLDRLLQTDRQEYLDRDSAGDAGLEQTKRSV
MSMEG_6231|M.smegmatis_MC2_155 ADIA-----AMPRGGPRASCLDRLLQTDRLEYLDRDDVD----QRVKRSV
MAB_4700c|M.abscessus_ATCC_199 RDIS-----SMPRGGPNASWLDRRLQTDRLEYLDRDDVD-----DLKRRV
TH_2189|M.thermoresistible__bu IGSEGAGDLPAPNPHATAEQVEAAMRDSKLAQILYHDWEAES-YDDKWSI
MUL_1900|M.ulcerans_Agy99 IPAD-----AAPNPHATAEEVEAARHDSKLAQVLYHDWEAEN-YDEKWSI
MLBr_01723|M.leprae_Br4923 ISAN-----AVPNPHATAEQVAAARKDSKLAQVLYHDWEAEN-YDEKWSI
MMAR_1415|M.marinum_M --------------MPAMSRIESVFCRSAP--------------------
. . : .
Mb2000|M.bovis_AF2122/97 IGVLDRVG--TLTNLHEKYARIALKLVSDIPNPRILELGAGHGKLSAKIL
Rv1978|M.tuberculosis_H37Rv IGVLDRVG--TLTNLHEKYARIALKLVSDIPNPRILELGAGHGKLSAKIL
MAV_0081|M.avium_104 VAALDRMG--TRAGYHERNARTALDIVADIANPRILELGAGHGKLSAEIL
Mflv_1326|M.gilvum_PYR-GCK IRALEWTG--ETFGHHVRFAEIVLDQISDVPDPKILELGAGHGALSRKLL
Mvan_5469|M.vanbaalenii_PYR-1 IRALDWTG--EVFGNHEKFAKIALDEVADVADPRILELGAGHGGLSRKLL
MSMEG_6231|M.smegmatis_MC2_155 VRALEWTG--DMFGNHEKFAAISLDLLAEVPDPRILELGAGHGSVSRRLL
MAB_4700c|M.abscessus_ATCC_199 MQSLDRAGRRRWIGIHEKCARMAIREVADVDRPKILELGAGLGGLSHKLL
TH_2189|M.thermoresistible__bu SYDQRCVD----YARGRFDAIVPDHVQRELPYDNALELGCGTGFFLLNLI
MUL_1900|M.ulcerans_Agy99 SYDQRCVE----YARGRFDAIVPAQVHADLPYERALELGCGTGFFLLNLI
MLBr_01723|M.leprae_Br4923 SYDQRCVD----YVRHCFDAIVPDELFTELPYDCALELGCGTGFFLLNLI
MMAR_1415|M.marinum_M ------------WRAATRRLVLPWALQGIEPVGEVLEIGAGSGAMAAEML
**:*.* * . .::
Mb2000|M.bovis_AF2122/97 ELHPTATVTISDLDPTSVANIAAGELGTHPRARTQVIDATAIDGHGHSYD
Rv1978|M.tuberculosis_H37Rv ELHPTATVTISDLDPTSVANIAAGELGTHPRARTQVIDATAIDGHDHSYD
MAV_0081|M.avium_104 TSHPTATVTVSDLDPTSVANIAAGPLGADPRARTQVVDATAIDAPDDSYD
Mflv_1326|M.gilvum_PYR-GCK DWHPTARLTVTDIEPASVAAIADSDVGAHPRATVRQMDATALDAADGEFD
Mvan_5469|M.vanbaalenii_PYR-1 EWHPSARLTVTDVEPASVAAIAAGDLGSHPRATVRQMDATALDAADGEFD
MSMEG_6231|M.smegmatis_MC2_155 ANHPTAHVTVTDVDPAAVAAMADGELGDHPRAVVRAMDATDIDADDGSFD
MAB_4700c|M.abscessus_ATCC_199 EMHSTAQVTVTDVDPSFVAAVAAGEIGSHPRATVRQLDATEIDSPGGYYD
TH_2189|M.thermoresistible__bu QSGVARRGSVTDLSPGMVRVATRNGRSLGLDVDGRVADAEGIPYDDNTFD
MUL_1900|M.ulcerans_Agy99 QAGVARRGSVTDLSPGMVKVATRNGQSLGLDIDGRVADAEGIPYDDDTFD
MLBr_01723|M.leprae_Br4923 QSGVARRGSVTDLSPGMVKIATRNGQSLGLDINGRVADAEGIPYDDNTFD
MMAR_1415|M.marinum_M AAQPDTRITVTDYDDAMVAAAAQRLAPFQTRATARQADATALPFGDNTFD
:::* . * : : ** : . :*
Mb2000|M.bovis_AF2122/97 LAVFALAFHHLP-PTVACKAIAEATRVGKRFLIIDLKRQKPLSFTLSSVL
Rv1978|M.tuberculosis_H37Rv LAVFALAFHHLP-PTVACKAIAEATRVGKRFLIIDLKRQKPLSFTLSSVL
MAV_0081|M.avium_104 LVVFAQAFHHLP-PATAVRAIAEATRVGKRFLVIDLPRPRSVQLLLTPLI
Mflv_1326|M.gilvum_PYR-GCK LAVFALSFHHLP-PAAAARVIAEGTRAADTLLIIDLPRP--------PAP
Mvan_5469|M.vanbaalenii_PYR-1 LAVFALSFHHLP-PQLAARAIAEGARVADKLLIIDLPRP--------PAP
MSMEG_6231|M.smegmatis_MC2_155 LALFALSFHHLS-PAQAAAVFAEGTRVARTLLIIDLPRP--------PAP
MAB_4700c|M.abscessus_ATCC_199 LAVFALSLHHLP-PELAARVFATGTRVARKLLIVDLPRP--------PVP
TH_2189|M.thermoresistible__bu LVVGHAVLHHIPDVELSLREVVRVLRPGGRFVFAGEPTTVGNSYARALST
MUL_1900|M.ulcerans_Agy99 LVVGHAVLHHIPDVELSLREVMRVLKPGGRFVFAGEPTTVGNEYARTLST
MLBr_01723|M.leprae_Br4923 LVVGHAVLHHIPDVELSLREVLRVLKPGGRFVFAGEPTDVGNRYARVFAD
MMAR_1415|M.marinum_M TVLTFIMLHHTVRWEQTLAEAVRVLAPHGTLIGYDLLSS-----------
.: :** : :: .
Mb2000|M.bovis_AF2122/97 LLPLH-LLLLPWSSMRSSMHDG-------------FISALRAYSPSALQT
Rv1978|M.tuberculosis_H37Rv LLPLH-LLLLPWSSMRSSMHDG-------------FISALRAYSPSALQT
MAV_0081|M.avium_104 LAPFAAALALVRPSLKHVMHDA-------------YISALRAYSRSAFIA
Mflv_1326|M.gilvum_PYR-GCK LHLVRLATMLPWAPLVPFVHDG-------------VISSLRAYSPAALRA
Mvan_5469|M.vanbaalenii_PYR-1 LHVLRLAAMLPWAPLVPFLHDG-------------VISSLRAYSPSALRA
MSMEG_6231|M.smegmatis_MC2_155 LHLLRLATMLPLAPLVPFVHDG-------------VISSLRCYSPSALRA
MAB_4700c|M.abscessus_ATCC_199 LHLALLAVVLPLVAISPLQHDG-------------FISSLRAYSPSALRA
TH_2189|M.thermoresistible__bu LTWHVATTVTRLPGLQGWRRPQAELDESSRAAALEAVVDLHTFEPSDLER
MUL_1900|M.ulcerans_Agy99 LTWRIATNVTKLPGLGGWRRPQEELDESSRAAALEAIVDLHTFAPEDLER
MLBr_01723|M.leprae_Br4923 LTWKVTIRVVQLPGLSAWRRTQVEIDENSRAAALEWVVDLHTFEPKVLET
MMAR_1415|M.marinum_M -----------WPTRTLHRLEG---------------APHRLIERGELQP
: :
Mb2000|M.bovis_AF2122/97 LARAADPGMQVEILP-APTRLFPPSLAVVFSRSSSAPTESSECSADRQPG
Rv1978|M.tuberculosis_H37Rv LARAADPGMQVEILP-APTRLFPPSLAVVFSRSSSAPTESSECSADRQPG
MAV_0081|M.avium_104 LGKAADPRMGVEFLPLSACRLRPGHVGIVFTRPRAS--------------
Mflv_1326|M.gilvum_PYR-GCK LAAHAGEDIDIELRG---G-LFSPQVAVAARR------------------
Mvan_5469|M.vanbaalenii_PYR-1 LATHADPAVDIELRG---G-LLSPQVAVATRR------------------
MSMEG_6231|M.smegmatis_MC2_155 LAAHAG--VALELRG---G-LTTPQIAIARRA------------------
MAB_4700c|M.abscessus_ATCC_199 LAHHADPAINVEFRS---RRGLGPTVVVASRP------------------
TH_2189|M.thermoresistible__bu MARNAGAVEVATASEEFTAAMLGWPVRTFEAAVPPGKLGWNWAKFAFGSW
MUL_1900|M.ulcerans_Agy99 MAKNAGAIRVETASEEFSAAMFGWPVRTFESSVPPGRLGWNWARFAFNGW
MLBr_01723|M.leprae_Br4923 MATNAGAVQVKTVTEEFTAAMLGWPLRTFESTMPPSKLGWGWARFAFTSW
MMAR_1415|M.marinum_M VLRQLPLSASRVRQN----RLLVRFTAMKQASPS----------------
:
Mb2000|M.bovis_AF2122/97 E------------------------------
Rv1978|M.tuberculosis_H37Rv E------------------------------
MAV_0081|M.avium_104 -------------------------------
Mflv_1326|M.gilvum_PYR-GCK -------------------------------
Mvan_5469|M.vanbaalenii_PYR-1 -------------------------------
MSMEG_6231|M.smegmatis_MC2_155 -------------------------------
MAB_4700c|M.abscessus_ATCC_199 -------------------------------
TH_2189|M.thermoresistible__bu TALSWVDANVWRRVMPKGWFYNVMVTGVKPS
MUL_1900|M.ulcerans_Agy99 KALGWMDANVWRHVAPKGWFYNVMVTGVKPS
MLBr_01723|M.leprae_Br4923 KTLSWVDANVWRRVIPKSWFYNIIITGVKPS
MMAR_1415|M.marinum_M -------------------------------