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MKTLIGKCAVVSGSGRGIGREIALKLAAEGASVVVNDLDAEPARETVAAIEAAGGKAVACVGSVTDSDFG ERFVQTAMDSFGGLDIIVNNAGYTWDSVIQKMTDEQWDAILDVHLKAPFHILRAAQPVISGLVKRARESG DHVGCRKVVNISSLAGVGGNAGQANYAAAKAGVIGLTKALAKEWGRYNVTVNSVAFGLIKTRLTETPADR QGTIDVAGREIKVGVNPGLLSAMEQMIPLGRSGTPAEAAGAVYLLCTPESDYISAQTVVCGGGFNF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3989 | - | - | 100% (276) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_2341 | - | 3e-42 | 48.60% (214) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1975 | fabG | 7e-41 | 37.96% (274) | 3-ketoacyl-(acyl-carrier-protein) reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1385 | fabG | 1e-38 | 35.66% (272) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_1492 | - | 3e-40 | 45.13% (226) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv1350 | fabG | 1e-38 | 35.66% (272) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_02565 | fabG | 1e-32 | 36.13% (274) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_0608 | - | 3e-41 | 44.76% (210) | short chain dehydrogenase |
| M. marinum M | MMAR_4033 | fabG | 2e-42 | 38.97% (272) | 3-oxoacyl- |
| M. avium 104 | MAV_5088 | fabG | 5e-46 | 39.63% (270) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. smegmatis MC2 155 | MSMEG_2206 | fabG | 1e-40 | 38.24% (272) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. thermoresistible (build 8) | TH_3954 | - | 8e-47 | 42.80% (271) | PUTATIVE 3-oxoacyl-[acyl-carrier-protein] reductase |
| M. ulcerans Agy99 | MUL_3898 | fabG | 9e-41 | 38.35% (266) | 3-ketoacyl-(acyl-carrier-protein) reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1492|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0608|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3989|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4033|M.marinum_M --------------------------------------------------
MUL_3898|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2206|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5088|M.avium_104 --------------------------------------------------
TH_3954|M.thermoresistible__bu --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mflv_1492|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0608|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3989|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4033|M.marinum_M --------------------------------------------------
MUL_3898|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2206|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5088|M.avium_104 --------------------------------------------------
TH_3954|M.thermoresistible__bu --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
Mflv_1492|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0608|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3989|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4033|M.marinum_M --------------------------------------------------
MUL_3898|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2206|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5088|M.avium_104 --------------------------------------------------
TH_3954|M.thermoresistible__bu --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
Mflv_1492|M.gilvum_PYR-GCK ---------------------------------------------MGLLD
MAB_0608|M.abscessus_ATCC_1997 --------------------------------------------MPGLLD
Mvan_3989|M.vanbaalenii_PYR-1 ---------------------------------------------MKTLI
Mb1385|M.bovis_AF2122/97 --------------------------------------------MASLLN
Rv1350|M.tuberculosis_H37Rv --------------------------------------------MASLLN
MMAR_4033|M.marinum_M --------------------------------------------MSVSLL
MUL_3898|M.ulcerans_Agy99 --------------------------------------------MCGAHR
MSMEG_2206|M.smegmatis_MC2_155 -----------------------------------------------MLT
MAV_5088|M.avium_104 --------------------------------------------MAESLL
TH_3954|M.thermoresistible__bu --------------------------------------------MPSALL
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
Mflv_1492|M.gilvum_PYR-GCK GR------------VVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLD
MAB_0608|M.abscessus_ATCC_1997 GR------------VVIITGAGRGIGRAHALAFAAEGARVVVNDIGVGLD
Mvan_3989|M.vanbaalenii_PYR-1 GK------------CAVVSGSGRGIGREIALKLAAEGASVVVNDLDA---
Mb1385|M.bovis_AF2122/97 AR------------TAVITGGAQGLGLAIGQRFVAEGARVVLGDVNL---
Rv1350|M.tuberculosis_H37Rv AR------------TAVITGGAQGLGLAIGQRFVAEGARVVLGDVNL---
MMAR_4033|M.marinum_M NG-----------QIAVVTGGAQGLGLAIAERFVSEGARVVLGDVNL---
MUL_3898|M.ulcerans_Agy99 DRG---------YVYPVVTGGAQGLGLAIAERFVSEGARVVLGDVNL---
MSMEG_2206|M.smegmatis_MC2_155 GQ------------TAVVTGGAQGLGLAIAKRFISEGARVVLGDLNS---
MAV_5088|M.avium_104 LG-----------KVAVVTGAGQGIGREIARALHRHGARVVLADLDG---
TH_3954|M.thermoresistible__bu AE-----------KVAVVTGAGRGIGREIARVLHAHGAEVVLADLDA---
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVES---
:::*.. *:* . . .** ** *:
Mflv_1492|M.gilvum_PYR-GCK GSPAGGGSAAQTVVDEIIAAGGEAVTSGANVADWGQAEGLIQTAVDAFG-
MAB_0608|M.abscessus_ATCC_1997 GS--AGISPAQEVVEEITAAGGEAVTNGDDVADWSGAKNLIDTAVNSFG-
Mvan_3989|M.vanbaalenii_PYR-1 -------EPARETVAAIEAAGGKAVACVGSVTDSDFGERFVQTAMDSFG-
Mb1385|M.bovis_AF2122/97 -------EATEVAAKRLGG-DDVALAVRCDVTQADDVDILIRTAVERFG-
Rv1350|M.tuberculosis_H37Rv -------EATEVAAKRLGG-DDVALAVRCDVTQADDVDILIRTAVERFG-
MMAR_4033|M.marinum_M -------EATEAAAKQLGG-GEVAVAVRCDVTKADEVETLLQTALERFG-
MUL_3898|M.ulcerans_Agy99 -------EATEAAAKQLGG-GEVAVAVRCDVTKADEVETLLQAALERFG-
MSMEG_2206|M.smegmatis_MC2_155 -------EATEAAVEELGG-SEVAAAVRCDVTSSADVDALVQAAVERFG-
MAV_5088|M.avium_104 -------SAARSAAAQIDDSGANCTGLACDVTSEEQVGALVAGTVREHG-
TH_3954|M.thermoresistible__bu -------DAAAQAAAEVDG-----TGVGCDVTAEDQMKRLVADTVAKHG-
MLBr_02565|M.leprae_Br4923 -----AAEALDETANRVGG-----TTLSLDVTADDAVDKITEHLHDYQGG
.. .. : .*: : *
Mflv_1492|M.gilvum_PYR-GCK GLDVLVNNAGIVRDRMFANTSEEEFDAVTAVHLKGHFATMRHAAAYWR--
MAB_0608|M.abscessus_ATCC_1997 RLDVLVNNAGFLRDRMLANMSEEEWDAVIRVHLKGHFAPLRHAAAYWR--
Mvan_3989|M.vanbaalenii_PYR-1 GLDIIVNNAGYTWDSVIQKMTDEQWDAILDVHLKAPFHILRAAQPVISGL
Mb1385|M.bovis_AF2122/97 GLDVMVNNAGITRDATMRTMTEEQFDQVIAVHLKGTWNGTRLAAAIMR--
Rv1350|M.tuberculosis_H37Rv GLDVMVNNAGITRDATMRTMTEEQFDQVIAVHLKGTWNGTRLAAAIMR--
MMAR_4033|M.marinum_M GLDIMVNNAGITRDATMRKMTEEQFDQVIDVHLKGTWNGIRLAAAIMR--
MUL_3898|M.ulcerans_Agy99 GLDIMVNNAGITRDATMRKMTEEQFDQVIDVHLKGTWNGIRLAAAIMR--
MSMEG_2206|M.smegmatis_MC2_155 GLDIMVNNAGITRDATLRKMTEEQFDQVIAVHLKGTWNGTKAAAAIMR--
MAV_5088|M.avium_104 GLDVFVNNAGITRDASLKRMTVADFDAVIAVHLRGTWLGVREAAAVMR--
TH_3954|M.thermoresistible__bu RLDLFVNNAGITRDASLKRMTVADFDAVVTVHLRGTWLGVREATAVMR--
MLBr_02565|M.leprae_Br4923 HADILVNNAGITRDKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGS--
*::***** * : :* : *:* . .
Mflv_1492|M.gilvum_PYR-GCK --AKSKAGDTVDAR-IINTSSGAGLQGSVGQANYSAAKAGIAALTLVAAA
MAB_0608|M.abscessus_ATCC_1997 --DEFKAGNAVDAR-IINTSSAAGLQGSVGQGNYAAAKAGIATLTLQAAA
Mvan_3989|M.vanbaalenii_PYR-1 VKRARESGDHVGCRKVVNISSLAGVGGNAGQANYAAAKAGVIGLTKALAK
Mb1385|M.bovis_AF2122/97 ---ERKRGA------IVNMSSVSGKVGMVGQTNYSAAKAGIVGMTKAAAK
Rv1350|M.tuberculosis_H37Rv ---ERKRGA------IVNMSSVSGKVGMVGQTNYSAAKAGIVGMTKAAAK
MMAR_4033|M.marinum_M ---ENKRGA------IVNMSSVSGKVGMVGQTNYSAAKAGIVGMTKAAAK
MUL_3898|M.ulcerans_Agy99 ---ENKRGA------IVNMSSVSGKVGMVGQTNYSAAKAGIVGMTKAAAK
MSMEG_2206|M.smegmatis_MC2_155 ---ENKRGA------IVNMSSISGKVGLIGQTNYSAAKAGIVGMTKAAAK
MAV_5088|M.avium_104 ---ERKTGS------IVNMSSLSGKAGNPGQTNYSAAKAGIVGLTKAAAK
TH_3954|M.thermoresistible__bu ---EQKSGS------IVNISSLSGKSGNPGQTNYSAAKAGIIGLTKAAAK
MLBr_02565|M.leprae_Br4923 ---ISKGGR------VIVLSSMAGIAGNRGQTNYATAKAGVIGLTQALAP
: * :: ** :* * ** **::****: :* *
Mflv_1492|M.gilvum_PYR-GCK EMGRYGVSVNAIAPSARTRMTETVFADMMAT-QDKDFDAMAPENVSPLVV
MAB_0608|M.abscessus_ATCC_1997 EMGRYGITVNAIAPAARTRMTEAVFAETMAKPEDGAFDAMAPENVSPLVV
Mvan_3989|M.vanbaalenii_PYR-1 EWGRYNVTVNSVAFGLIKTRLTETPADRQGTIDVAGREIKVGVNPG-LLS
Mb1385|M.bovis_AF2122/97 ELAHLGIRVNAIAPGLIRSAMTEAMP-------------------QRIWD
Rv1350|M.tuberculosis_H37Rv ELAHLGIRVNAIAPGLIRSAMTEAMP-------------------QRIWD
MMAR_4033|M.marinum_M ELAHVGVRVNAIAPGLIRSAMTEAMP-------------------QRIWD
MUL_3898|M.ulcerans_Agy99 ELAHVGVRVNAIAPGLIRSAMTEAMP-------------------QRIWD
MSMEG_2206|M.smegmatis_MC2_155 ELAYLGVRVNAIQPGLIRSAMTEAMP-------------------QRIWD
MAV_5088|M.avium_104 ELAHHNVRVNAIQPGLIRTPMTAAMP-------------------PDVFA
TH_3954|M.thermoresistible__bu EVAHHNVRVNAIQPGLIRTPMTETMP-------------------AEVFA
MLBr_02565|M.leprae_Br4923 GLAEKGITINAVAPGFIETQMTAAIP-------------------LATRE
. .: :*:: . . .
Mflv_1492|M.gilvum_PYR-GCK WLGSVESRDVTGKMFEVEGGKIRVAEGWAHGPEIDKGARWDPAELGPVVG
MAB_0608|M.abscessus_ATCC_1997 WLGSPESREVTGKVFEVEAGIIRVAEGWAHGPQVDKGARWDPSELGPVVT
Mvan_3989|M.vanbaalenii_PYR-1 AMEQMIPLGRSGTPAEAAGAVYLLCTPESDYISAQTVVCGGGFNF-----
Mb1385|M.bovis_AF2122/97 QKLAEVPMGRAGEPSEVASVAVFLASDLSSYMTGTVLDVTGGRFI-----
Rv1350|M.tuberculosis_H37Rv QKLAEVPMGRAGEPSEVASVAVFLASDLSSYMTGTVLDVTGGRFI-----
MMAR_4033|M.marinum_M QKLAEVPMGRAGEPSEVASVALFLACDLSSYMTGTVLDVTGGRFI-----
MUL_3898|M.ulcerans_Agy99 QKLAEVPMGRAGEPSEVASVALFLACDLSSYMTGTVLDVTGGRFI-----
MSMEG_2206|M.smegmatis_MC2_155 EKLAEIPMGRAGEPDEVAKVALFLASDLSSYMTGTVLEVTGGRHV-----
MAV_5088|M.avium_104 EREAAVPMKRAGEPEEVAGAVVFLASELSSYITGTVLGVGGGRYM-----
TH_3954|M.thermoresistible__bu EREAAVPMKRAGEPAEVAGAVVFLGSDLSSYITGSVIEVGGGRYM-----
MLBr_02565|M.leprae_Br4923 VGRRLNSLLQGGLPVDVAETIAYFAIPASNAVTGNVIRVCGQAMLGA---
. * :. . : . .
Mflv_1492|M.gilvum_PYR-GCK DLLAKARTPVPVYGA--
MAB_0608|M.abscessus_ATCC_1997 DLLDKARTPVPVYGSQG
Mvan_3989|M.vanbaalenii_PYR-1 -----------------
Mb1385|M.bovis_AF2122/97 -----------------
Rv1350|M.tuberculosis_H37Rv -----------------
MMAR_4033|M.marinum_M -----------------
MUL_3898|M.ulcerans_Agy99 -----------------
MSMEG_2206|M.smegmatis_MC2_155 -----------------
MAV_5088|M.avium_104 -----------------
TH_3954|M.thermoresistible__bu -----------------
MLBr_02565|M.leprae_Br4923 -----------------