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TGFADRLFDLTDRVVLITGGSRGLGREMAVAAAHCGADVIIASRKYDACVATAEEITAQTGRAALPYGVH VGRWDELDGLVDAAYARFGKVDVLVNNAGMSPVYDKQSDVTEKLFDAVVNLNLKGPFRLSALIGERMVAD GGGSIVNVSTHGSLRPHPSFIPYAASKAGLNAMTEGLALAFGPSVRVNTLMPGPFLTDISNAWNFEGTDN PFRGSALQRAGQPAEIVGAALFLMSDASSFTTGSIVRADGGSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1202 | - | - | 100% (254) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_4818 | - | 5e-39 | 37.90% (248) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_1569 | - | 6e-32 | 35.06% (251) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2788c | fabG | 1e-38 | 37.04% (243) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. tuberculosis H37Rv | Rv2766c | fabG | 1e-38 | 37.04% (243) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 8e-19 | 29.44% (248) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4913c | - | 3e-69 | 53.31% (242) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_5310 | - | 1e-108 | 77.29% (251) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_0311 | - | 1e-110 | 77.69% (251) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_6340 | - | 1e-110 | 78.80% (250) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_3628 | - | 1e-128 | 90.44% (251) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_4384 | - | 1e-108 | 77.29% (251) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_5605 | - | 1e-123 | 85.66% (251) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2788c|M.bovis_AF2122/97 -------------MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVL
Rv2766c|M.tuberculosis_H37Rv -------------MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVL
Mflv_1202|M.gilvum_PYR-GCK --------MTGFADRLFDLTDRVVLITGGSRGLGREMAVAAAHCGADVII
TH_3628|M.thermoresistible__bu ------VVHVGYADELFDLTDRVVLITGGSRGLGREMAMAAARCGADVII
Mvan_5605|M.vanbaalenii_PYR-1 -----MTASGGFADQLFDLTDRVVLVTGGSRGLGREMAFAAARCGADVVI
MMAR_5310|M.marinum_M ---------MGYADQLFDLTDHVVLITGGSRGLGRQMAFAAARCGADVVI
MUL_4384|M.ulcerans_Agy99 ---------MGYADQLFDLTDHVVLITGGSRGLGRQMAFAAARCGANVVI
MAV_0311|M.avium_104 ---------MGYAEQLFDLADRVVLITGGSRGLGREMAFGAARCGADVVI
MSMEG_6340|M.smegmatis_MC2_155 ---------MGYADQLFDLTDRVVLITGGSRGLGREMAFGAARCGADVII
MAB_4913c|M.abscessus_ATCC_199 -----------------MLQDKVVVVTGGSRGLGRAMVRAFAAHGADVVI
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
: .: ::**..**:* :. . * * :
Mb2788c|M.bovis_AF2122/97 TARRQE----AADEAAAQVGDRALGVGAHAVDEDAARRCVDLTLERFGSV
Rv2766c|M.tuberculosis_H37Rv TARRQE----AADEAAAQVGDRALGVGAHAVDEDAARRCVDLTLERFGSV
Mflv_1202|M.gilvum_PYR-GCK ASRKYDACVATAEEITAQTGRAALPYGVHVGRWDELDGLVDAAYARFGKV
TH_3628|M.thermoresistible__bu ASRKMDNCVATAQEITEQTGRAALPYQVHVGRWDQLDGLVEAAYDRFGKV
Mvan_5605|M.vanbaalenii_PYR-1 ASRKYEACVATADEIAAETGRAAFPYQVHVGRWDELDGLVDAAYDRFGRV
MMAR_5310|M.marinum_M ASRNLDNCVATATEIESETGRCAMAYQVHVGRWDQLDGLVAASYERFGKI
MUL_4384|M.ulcerans_Agy99 ASRNLDNCVATATEIESETGRSALAYQVHVGRWDQLDGLVAASYERFGKI
MAV_0311|M.avium_104 ASRNLDNCVATAQQIEHETGRRAMAYQVHVGRWDQLDGLVEASYDRFGKI
MSMEG_6340|M.smegmatis_MC2_155 ASRNLDSCVVTAEEIASETGRTAFPYSVHVGHWDELDGLVDAAYERFGKV
MAB_4913c|M.abscessus_ATCC_199 ASRKIDSCQELAAQVEAEHGRRALPVACNVSSWEQCDHLVDTVYREFGRV
MLBr_01807|M.leprae_Br4923 THR------------ASVVPDWFFGVECDVTDNDAIGAAFKAVEEHQGPV
: * : .. : . . * :
Mb2788c|M.bovis_AF2122/97 DILINNAGTNPAYGPLLEQDHARFAKIFDVNLWAPLMWTSLVVTAWMGEH
Rv2766c|M.tuberculosis_H37Rv DILINNAGTNPAYGPLLEQDHARFAKIFDVNLWAPLMWTSLVVTAWMGEH
Mflv_1202|M.gilvum_PYR-GCK DVLVNNAGMSPVYDKQSDVTEKLFDAVVNLNLKGPFRLSALIGERMVADG
TH_3628|M.thermoresistible__bu DVLVNNAGMSPVYDKQSDVTEQLFDAVVNLNLKGPFRLSALIGERMVADG
Mvan_5605|M.vanbaalenii_PYR-1 DVLVNNAGMSPLYESLSAVTEKLFDSVVNLNLKGPFRLSVLVGDRMVADG
MMAR_5310|M.marinum_M DTLINNAGMSPLYDKLSDVTEKLFDAVLNLNLKGPFRLSALVGERMVAAG
MUL_4384|M.ulcerans_Agy99 DTLINNAGMSPLYDKLSDVTEKLFDAVLNLNLKGPFRLSALVGERMVAAD
MAV_0311|M.avium_104 DTLINNAGMSPLYDKLTDVTEKLFDAVVNLNLKGPFRLSALVGERMVAAG
MSMEG_6340|M.smegmatis_MC2_155 DVLVNNAGMSPLYESLSAVTEKLYDAVFNLNLKGPFRLSALIGERMVADG
MAB_4913c|M.abscessus_ATCC_199 DVLVNNAGLSPLYPSLDQVSEALFDKVIGVNLKGPFRLSASIATKMAAGA
MLBr_01807|M.leprae_Br4923 EVLVANAGITSDMLIMR-MSEEQFQKVIDVNLTGVFRVAKLASRNMIKQR
: *: *** .. . : :..:** . : :
Mb2788c|M.bovis_AF2122/97 GGAVVNTASIGGMHQSPAMGMYNATKAALIHVTKQLALELSP-RIRVNAI
Rv2766c|M.tuberculosis_H37Rv GGAVVNTASIGGMHQSPAMGMYNATKAALIHVTKQLALELSP-RIRVNAI
Mflv_1202|M.gilvum_PYR-GCK GGSIVNVSTHGSLRPHPSFIPYAASKAGLNAMTEGLALAFGP-SVRVNTL
TH_3628|M.thermoresistible__bu GGSIINVSTHGSLRPHPTFIPYAASKAGLNVMTEGLALAFGP-TVRVNTL
Mvan_5605|M.vanbaalenii_PYR-1 GGSIINVSTHGSIRPHPSFVPYAASKAGLNAMTEALALAYGP-TVRVNTL
MMAR_5310|M.marinum_M GGSIINVSSAGSLRPSADIIPYAAAKAGLNAMTEGLARAFGP-TVRVNTL
MUL_4384|M.ulcerans_Agy99 GGSIINVSSAGSLRPSADIIPYAAAKAGLNAMTEGLARAFGP-TVRVNTL
MAV_0311|M.avium_104 RGSIINVSTAGSLRPTPDIVPYAASKAGLNAMTEALAKAFGP-AVRVNTL
MSMEG_6340|M.smegmatis_MC2_155 GGRIINVSSSGSLRPDQYMLPYAAAKAGLNVLTEGLAKAYGP-TVRVNTL
MAB_4913c|M.abscessus_ATCC_199 GGSIINISSIEAVRPDATALPYAAAKAGLNALTLGLSHTFGP-TVRTNTI
MLBr_01807|M.leprae_Br4923 FGRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSRSITANVV
* : .: .: * *:*:.* :: *: .. : .*.:
Mb2788c|M.bovis_AF2122/97 CPGVVRTRLAEALWKDHED-PLAATIALGRIGEPADIASAVAFLVSDAAS
Rv2766c|M.tuberculosis_H37Rv CPGVVRTRLAEALWKDHED-PLAATIALGRIGEPADIASAVAFLVSDAAS
Mflv_1202|M.gilvum_PYR-GCK MPGPFLTDISNAWNFEGTD-NPFRGSALQRAGQPAEIVGAALFLMSDASS
TH_3628|M.thermoresistible__bu MPGPFLTDISKAWNLPEGS-NPFAGSALQRAGQPAEIVGAALFLMSDASS
Mvan_5605|M.vanbaalenii_PYR-1 MPGPFLTDISDAWTFTDGDTNPFGHSALQRAGQPAEIVGAALFLMSDASS
MMAR_5310|M.marinum_M MAGPFLTDVSKAWNLDAATQNPFGHLTLRRAGNPPEIVGAALFLASDASS
MUL_4384|M.ulcerans_Agy99 MAGPFLTDVSKAWNLDAATQNPFGHLALRRAGNPPEIVGAALFLASDASS
MAV_0311|M.avium_104 MAGPFLTDVSRAWNLEAAQENPFRHLALQRAGDPREIVGAALFLASDASS
MSMEG_6340|M.smegmatis_MC2_155 MAGPFLTDVSRAWNMSGD---PFSHLALRRAGDPREIVGAALFLMSDASS
MAB_4913c|M.abscessus_ATCC_199 QCGLFNTDIAAAWP-EGFAEALIPSIPLRRVGEPEDIVGAALYLASEASA
MLBr_01807|M.leprae_Br4923 APGFIDTEMTRAMDSKYQE-AALQAIPLGRIGAVEEIAGAVSFLASEDAG
* . * :: * .* * * :*..*. :* *: :.
Mb2788c|M.bovis_AF2122/97 WITGETMIIDGGLLLGNALGFRAAPSTEH
Rv2766c|M.tuberculosis_H37Rv WITGETMIIDGGLLLGNALGFRAAPSTEH
Mflv_1202|M.gilvum_PYR-GCK FTTGSIVRADGGSA---------------
TH_3628|M.thermoresistible__bu FTTGSIVRADGGSV---------------
Mvan_5605|M.vanbaalenii_PYR-1 FTTGSIVRADGGIP---------------
MMAR_5310|M.marinum_M FTTGSILRADGGIP---------------
MUL_4384|M.ulcerans_Agy99 FTTGSILRADGGIP---------------
MAV_0311|M.avium_104 FTTGSILRADGGIP---------------
MSMEG_6340|M.smegmatis_MC2_155 FTTGSIVRADGGLP---------------
MAB_4913c|M.abscessus_ATCC_199 YCTGTTIRLDGGIL---------------
MLBr_01807|M.leprae_Br4923 YISGAVIPVDGGLGMGH------------
: :* : ***