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SGKPKLVIGANGFLGSHVTRQLVADGAQVRAMVRAGANTRGIDDLSLTRFHGDVFDTAVLSEAMDGVDDV YYCVVDTRAWVRDTSPLFRTNVEGLRNVLDVAVTQPELRKFIFTSTYATVGRRRGHVATEDDVIGTRGLS DYVKSRVQAENLVMRYVAEAGLPAVAMCVSTTYGSGDWGRTPHGAFIAGAVFGKLPFTMEGIQLEVVGVT DAAKAMVLAADRGRVGERYLISERMIALKEVVRIAADEAGVPPPRRSISVPTLYALGALGDLRARLTGKD AELSLASVRMMRAEAPVDHSKAVRELGWQPRPVEESIREAARFWAAMRNAKGKSATPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5157 | - | - | 100% (339) | 3-beta hydroxysteroid dehydrogenase/isomerase family protein |
| M. avium 104 | MAV_1849 | - | 1e-97 | 55.11% (323) | dihydroflavonol-4-reductase family protein |
| M. avium 104 | MAV_1225 | - | 5e-13 | 24.78% (339) | 3-beta hydroxysteroid dehydrogenase/isomerase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0144 | - | 1e-149 | 80.85% (329) | putative oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1108 | - | 1e-124 | 67.76% (335) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv0139 | - | 1e-150 | 81.16% (329) | oxidoreductase |
| M. leprae Br4923 | MLBr_01942 | - | 3e-09 | 26.23% (183) | putative cholesterol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0718c | - | 1e-24 | 30.58% (327) | NAD-dependent epimerase/dehydratase |
| M. marinum M | MMAR_0349 | - | 1e-152 | 81.82% (330) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_6474 | - | 1e-129 | 70.30% (330) | nucleoside-diphosphate-sugar epimerase |
| M. thermoresistible (build 8) | TH_2143 | - | 6e-93 | 54.97% (322) | POSSIBLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_4771 | - | 1e-151 | 81.21% (330) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_5705 | - | 1e-130 | 70.15% (335) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1108|M.gilvum_PYR-GCK ------------MSAPVLVIGANGYLGSHVTRKLVAA----GNDVRVMVR
Mvan_5705|M.vanbaalenii_PYR-1 ------------MTA--LVIGANGYLGSHVTRRLVAD----GQDVRVMVR
MSMEG_6474|M.smegmatis_MC2_155 ------------MSTS-LVIGANGFLGSHVLRQLVADNT-DGSEIRAMVR
Mb0144|M.bovis_AF2122/97 -----------MN-APKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVR
Rv0139|M.tuberculosis_H37Rv -----------MN-APKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVR
MMAR_0349|M.marinum_M -----------MSVGPKLVIGANGFLGSHVTRMLIEDGA----QVRVMVR
MUL_4771|M.ulcerans_Agy99 -----------MSVGPKLVIGANGFLGSHVTRMLIEDGA----QVRVMVR
MAV_5157|M.avium_104 -----------MSGKPKLVIGANGFLGSHVTRQLVADGA----QVRAMVR
TH_2143|M.thermoresistible__bu ------------VAKKKLVIGASGFLGSHVTRQLVREGH----DVRVMVR
MAB_0718c|M.abscessus_ATCC_199 --------------MKTAVTGAAGFIGTNLVNLLVDNGH----EVIAIDR
MLBr_01942|M.leprae_Br4923 MLRGVGNASLTTELGRVLVTGGSGFVGANLVTALLERGY----QVRSFDR
* *. *::*::: *: :: : *
Mflv_1108|M.gilvum_PYR-GCK DGANTVGIDDLAVTRYVGDIWNTDVLREAMTGCEVVYYCVVDTRGW----
Mvan_5705|M.vanbaalenii_PYR-1 EGANTIGIDDLTVTRFVGDIWDDDVLREAMTGCDVVYYCVVDTRGW----
MSMEG_6474|M.smegmatis_MC2_155 PGANTVGIDDLDVTRFTGDIFDTEVLRAAMTGCDVVYYCVVDTRGW----
Mb0144|M.bovis_AF2122/97 PAANTRSIDDLPLTRFHGDVFDTATVAEAMAGCDDVYYCVVDTRAW----
Rv0139|M.tuberculosis_H37Rv PAANTRSIDDLPLTRFHGDVFDTATVAEAMAGCDDVYYCVVDTRAW----
MMAR_0349|M.marinum_M PTANTRSIDDLPVTRFHGDIFDTAVVREAMQGCDDVYYCVVDARAW----
MUL_4771|M.ulcerans_Agy99 PTANTRSIDDLPVTRFHGDIFDTAVVREAMQGCDDVYYCVVDARAW----
MAV_5157|M.avium_104 AGANTRGIDDLSLTRFHGDVFDTAVLSEAMDGVDDVYYCVVDTRAW----
TH_2143|M.thermoresistible__bu TTSMTRGIDDLDVERCHGDVFDDAALRAAMTGVDDVYYCVVDARMW----
MAB_0718c|M.abscessus_ATCC_199 VVPASP-ETREAVTWVSGDVLDPDSMTKALDGVEVVYHLVAVITLK----
MLBr_01942|M.leprae_Br4923 --APMPLPQHPQLEVLQGDITDATVCTTAMDSIDTVFHTAAIIELMGGAS
. : **: : *: . : *:: ..
Mflv_1108|M.gilvum_PYR-GCK --LRDPAPLFRTNVEGTRNVLDVAVEPGIAATLRKFVFTSSCVTVGRTRG
Mvan_5705|M.vanbaalenii_PYR-1 --LRDPAPLFRTNVEGTRNVLNIAVEPAVAAGLRKFVFTSSYVTVGRRRG
MSMEG_6474|M.smegmatis_MC2_155 --LRHPAPLFRTNVEGTRHVLDVALEPGIG--LRKFVYTSSYVTVGRRRG
Mb0144|M.bovis_AF2122/97 --LRDPSPLFRTNVAGLRNVLDVATD----ASLRRFVFTSSYATVGRRRG
Rv0139|M.tuberculosis_H37Rv --LRDPSPLFRTNVAGLRNVLDVATD----ASLRRFVFTSSYATVGRRRG
MMAR_0349|M.marinum_M --LRDPAPLFHTNVEGLRNVLDVAKN----AGLRRFVFTSSYATVDRRHG
MUL_4771|M.ulcerans_Agy99 --LRDPAPLFHTNVEGLRNVLDVAKN----AGLRRFVFTSSYATVDRRHG
MAV_5157|M.avium_104 --VRDTSPLFRTNVEGLRNVLDVAVTQ---PELRKFIFTSTYATVGRRRG
TH_2143|M.thermoresistible__bu --LRDPAPLFRTNVEGLRHVLDAAVE----ADLNRFLFTSTTGTMAINPY
MAB_0718c|M.abscessus_ATCC_199 --HED-ELCWRINTEGARTVAQAALT----VGARRMVHCSSIDSYSNSVA
MLBr_01942|M.leprae_Br4923 VTDEYRQRSYTVNVGGTENLLRAGQK----SGVKRFVYTASNSVVMGGTP
. : *. * . : . .:::. ::
Mflv_1108|M.gilvum_PYR-GCK RVATEADVISDPADLKSLTPYVRSRVQAENLVMEYARERGLPAVAMCVST
Mvan_5705|M.vanbaalenii_PYR-1 RVATEADVIAD----RGLTPYVRSRVQAENLVLEYARTRGLPAVAMCVST
MSMEG_6474|M.smegmatis_MC2_155 CVATEDDVIDL----RGVTPYVRSRVQAEELVLRYATERGLPAVAMCVST
Mb0144|M.bovis_AF2122/97 HVATEEDRVDT----RKVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVST
Rv0139|M.tuberculosis_H37Rv HVATEEDRVDT----RKVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVST
MMAR_0349|M.marinum_M HVATEEDRIGS----RRVSSYVQSRVQAEDLVMDYVAQHGLPAVAMCVST
MUL_4771|M.ulcerans_Agy99 HVATEEDRIGS----RRVSSYVQSRVQAEDLVMDYVAQHGLPAVAMCVST
MAV_5157|M.avium_104 HVATEDDVIGT----RGLSDYVKSRVQAENLVMRYVAEAGLPAVAMCVST
TH_2143|M.thermoresistible__bu RPVTEDDPHNW----TEGGAYIEARVAAEQLVLRYARERGLPAVALCIST
MAB_0718c|M.abscessus_ATCC_199 TIDEKSPRSAA----ADLPVYQRSKWGGEVAVRETIAS-GLDAVICNPTG
MLBr_01942|M.leprae_Br4923 ITGGDETMPYT---KRFNDLYTETKVVAEKFVLSQNGVPDGETMLTCSIR
. * .:: .* * . ::
Mflv_1108|M.gilvum_PYR-GCK TYGAGDWG-RTPHGAIIAGAAFGKLPFVMGGIELEAVG--IDDAAQAMLL
Mvan_5705|M.vanbaalenii_PYR-1 TYGAGDWG-RTPHGAIIAGAAFGKLPFVLGGIELEAVG--VEDAAHALLL
MSMEG_6474|M.smegmatis_MC2_155 TYGSGDWG-RTPHGAVIAGAAFGKLPFVMSGIDLEAVG--VDDAARALIL
Mb0144|M.bovis_AF2122/97 TYGGGDWG-RTPHGAFIAGAVFGRLPFTMRGIRLEAVG--VDDAARALIL
Rv0139|M.tuberculosis_H37Rv TYGGGDWG-RTPHGAFIAGAVFGRLPFTMRGIRLEAVG--VDDAARALIL
MMAR_0349|M.marinum_M TYGSGDWG-RTPHGAFIAGAVFGKLPFLMNGIKLEVVG--VDDAARAMIL
MUL_4771|M.ulcerans_Agy99 TYGSGDWG-RTPHGAFIVGAVFGKLPFLMNGIKLEVVG--VDDAARAMIL
MAV_5157|M.avium_104 TYGSGDWG-RTPHGAFIAGAVFGKLPFTMEGIQLEVVG--VTDAAKAMVL
TH_2143|M.thermoresistible__bu TYGPGDWQ-PTPHGRLLAMVATGRFPFYLG-WSAEVVG--IEDAARAMLL
MAB_0718c|M.abscessus_ATCC_199 VYGPVDLPNLSRINQLLFDSARGRLPGMVN-SQYDLVD--ARDVAAGLYL
MLBr_01942|M.leprae_Br4923 PSGIWGRGDQTMFRKAFESVVSGHVKVLIGSKNAKLDNSYVHNLVHGLIL
* . : : . *:. : . . : . .: *
Mflv_1108|M.gilvum_PYR-GCK AARKGRAG-----ERYLIS-EKMISNADVVRIAAEAAGVPAPTKKIP-LV
Mvan_5705|M.vanbaalenii_PYR-1 AAEKGRVG-----ERYLIS-EKMISNADVVRIAAEAAGVPAPSRTMP-LP
MSMEG_6474|M.smegmatis_MC2_155 AAESGRPG-----ERYLIS-EKLISNAEVARIAAEAAGVAPPRRSIP-LP
Mb0144|M.bovis_AF2122/97 AAERGHNG-----ERYLIS-ERMMPLQEVVRIAADEAGVPPPRWSIS-VP
Rv0139|M.tuberculosis_H37Rv AAERGRNG-----ERYLIS-ERMMPLQEVVRIAADEAGVPPPRWSIS-VP
MMAR_0349|M.marinum_M AAERGRSG-----QRYLIS-ERMIALKEVVRIAADEAGVAPPQRTIS-VP
MUL_4771|M.ulcerans_Agy99 AAERGRSG-----QRYLIS-ERMVALKEVVRIAADEAGVAPPQRTIS-VP
MAV_5157|M.avium_104 AADRGRVG-----ERYLIS-ERMIALKEVVRIAADEAGVPPPRRSIS-VP
TH_2143|M.thermoresistible__bu AAEQGRVG-----ERYIIS-DRYLHTREVHAIAAEAVGRRAPWFGLP-LP
MAB_0718c|M.abscessus_ATCC_199 AGEKGRTG-----ENYLLG-GHMGSLLQVCRLAARRAGKRGPRFAVP-MG
MLBr_01942|M.leprae_Br4923 AAEHLVPGGTAPGQAYFINDGEPINFFDFMGPIIKACGENWPRVRISGRL
*. * : *::. . :. * * :.
Mflv_1108|M.gilvum_PYR-GCK LSYAMAALGSAKSRLKGTDERMSLGSLRLMRAEAPVDCSKARRELGWQPR
Mvan_5705|M.vanbaalenii_PYR-1 LSYAMAALGSLKGRLKGTDERLSLDSLRLMRAEAPVDCGKAKRELGWQPR
MSMEG_6474|M.smegmatis_MC2_155 VSYLLAAIGTVKGKLRGTDERLSLRSLRLMRAECELDHSKAVRELGWQPR
Mb0144|M.bovis_AF2122/97 VLYALGALGSLRARLTGKDTELSLASVRMMRSEADVDHGKAVRELGWQPR
Rv0139|M.tuberculosis_H37Rv VLYALGALGSLRARLTGKDTELSLASVRMMRSEADVDHGKAVRELGWQPR
MMAR_0349|M.marinum_M TLYALGALGSLRARLTGKDAELSLESVRMMRAEAEVDHAKAVRELGWQPR
MUL_4771|M.ulcerans_Agy99 TLYALGALGSLRARLTGKDAELSLESVRMMRAEAEVDHAKAVRELGWQPR
MAV_5157|M.avium_104 TLYALGALGDLRARLTGKDAELSLASVRMMRAEAPVDHSKAVRELGWQPR
TH_2143|M.thermoresistible__bu VLSVAARGNDLAARLLRRDLMFAHVGLKMAELMSPLDHSKAERELGFKPE
MAB_0718c|M.abscessus_ATCC_199 LLNAAIPVIEPIGKLL-KNDALSRAAFNKLTVSPAVDITKARTELGYEPR
MLBr_01942|M.leprae_Br4923 VRNVMAVWQRLHFGFGLPKPPMEPLAVERVYLDNYFSIEKAHKELGYRPL
: . : ... .. ** ***:.*
Mflv_1108|M.gilvum_PYR-GCK -PVEESIREAAKFWVGLKAAKRQRTA-------------
Mvan_5705|M.vanbaalenii_PYR-1 -PVEESIREAAKFWVGLRAAKRAGKAAG-----------
MSMEG_6474|M.smegmatis_MC2_155 -PVEESIAEAAKFWVGLRAAKQARRGG------------
Mb0144|M.bovis_AF2122/97 -PVEESIREAARFWAAMRTVGKDPAAS------------
Rv0139|M.tuberculosis_H37Rv -PVEESIREAARFWAAMRTVGKDPAAS------------
MMAR_0349|M.marinum_M -PVEESIREAARFWASMRKNTQGARTGQSE---------
MUL_4771|M.ulcerans_Agy99 -PVEESIREAARFWASMRKNTQGARTGQPE---------
MAV_5157|M.avium_104 -PVEESIREAARFWAAMRNAKGKSATPR-----------
TH_2143|M.thermoresistible__bu -PVEDSIAKAARFFLEQHR--------------------
MAB_0718c|M.abscessus_ATCC_199 -STETTVNEFVDFLLGSGRL-------------------
MLBr_01942|M.leprae_Br4923 FTTEQAMAECLPYYTELFEQIKVAAKPHLASIAATPRPE
..* :: : :