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SSAIDVSIIETSGLGDRSYLISADGTAVVVDPQRDIDRVLDLARERGVRISHVLETHIHNDYVTGGLELS RVTGAEYVVPAGDDVGYERRAVSDGDTVDAGPVRLQVMHTPGHTHHHVSYVLRDAGGSGDSVLGVFTGGS MLHGTTGRTDLLGDEHTQELSHAQFHSVRRLAAELPDTAEVYPTHGFGSFCSATPASGDSSTIADQRQTN PALTQDEQSYVDELIAGLGAYPAYYAHMGVINTEGPDPVDLSVPEPVDPDELRRRIEGGEWVVDLRNRTA FAAGHLGGTLGFELSDNFVTYLGWLYSWGSPLTLIGDDVDQIADARRELARIGVDNLTGSATGDIHDLAE GTPLRSYRVADFAALADAMQAQAPAVLDVRQSGEFADGHIAGAVNIPLHELSRRLDEVPDGEVWVHCASG YRSSIAASMIDRGDRTVVLVDDAFDQAEKTGLVS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0980 | - | - | 100% (455) | beta-lactamase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_0985 | - | 2e-54 | 33.02% (427) | beta-lactamase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_5123 | - | 4e-11 | 29.77% (215) | beta-lactamase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0651c | - | 1e-12 | 30.29% (208) | glyoxalase II |
| M. tuberculosis H37Rv | Rv0634c | - | 1e-12 | 30.29% (208) | glyoxalase II |
| M. leprae Br4923 | MLBr_01912 | - | 4e-11 | 29.50% (200) | putative glyoxylase II |
| M. abscessus ATCC 19977 | MAB_2873c | - | 2e-11 | 28.04% (214) | hypothetical protein MAB_2873c |
| M. marinum M | MMAR_2442 | - | 3e-11 | 28.18% (181) | hypothetical protein MMAR_2442 |
| M. avium 104 | MAV_2180 | - | 4e-11 | 28.86% (201) | metallo-beta-lactamase family protein |
| M. smegmatis MC2 155 | MSMEG_5385 | - | 4e-57 | 34.32% (437) | metallo-beta-lactamase family protein |
| M. thermoresistible (build 8) | TH_1234 | - | 8e-59 | 34.71% (435) | metallo-beta-lactamase family protein |
| M. ulcerans Agy99 | MUL_1621 | - | 3e-11 | 28.49% (179) | hypothetical protein MUL_1621 |
| M. vanbaalenii PYR-1 | Mvan_5835 | - | 0.0 | 73.94% (449) | beta-lactamase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2442|M.marinum_M MTVVDDNYTGHVDPGTVARRTLPGATILKASVGPMDNNAYLVTCSATGQT
MUL_1621|M.ulcerans_Agy99 MTVVDDNYTGHVDPGTVARRTLPGATILKASVGPVDNNAYLVTCSATGQT
Mb0651c|M.bovis_AF2122/97 MS-KDRLYFRQLLSG----RDFAVGDMFATQMR---NFAYLIGDRTTGDC
Rv0634c|M.tuberculosis_H37Rv MS-KDRLYFRQLLSG----RDFAVGDMFATQMR---NFAYLIGDRTTGDC
MLBr_01912|M.leprae_Br4923 MSDSDRLYFRQLLSG----RDFAVDDVVATQMR---NFAYLIGDRQTGDC
Mflv_0980|M.gilvum_PYR-GCK -----------------MSSAIDVSIIETSGLG---DRSYLISAD--GTA
Mvan_5835|M.vanbaalenii_PYR-1 ---------------------MDISIIETSGLG---DRSYLISHG--GSA
MSMEG_5385|M.smegmatis_MC2_155 ---------------------MKFTQYYLDCLS---HASYLIADETTGRA
TH_1234|M.thermoresistible__bu ---------------------MKFIQYYLDCLS---HASYLIADDKTGRA
MAV_2180|M.avium_104 ------------MMAGIDKIVTHGTFELDGGSWEVDNNIWIVGDD--SDV
MAB_2873c|M.abscessus_ATCC_199 ---------------------MLITGFPAGMFA---TNCYIVAPHEGGPA
::: .
MMAR_2442|M.marinum_M LLIDA-ANDAEVLIDLIRRYAPKIALIVTSHQHFDHWQ------ALQAVA
MUL_1621|M.ulcerans_Agy99 LLIDA-ANDAEVLIDLIRRYAPKIALIVTSHQHFDHWQ------ALQAVA
Mb0651c|M.bovis_AF2122/97 VVVDP-AYAAGDLLDALESDDMQLSGVLVTHHHPDHVGGSMMGFQLPGLA
Rv0634c|M.tuberculosis_H37Rv VVVDP-AYAAGDLLDALESDDMQLSGVLVTHHHPDHVGGSMMGFQLPGLA
MLBr_01912|M.leprae_Br4923 VVVDP-AYAAGDLVDALEADGMRLSGVLVTHHHPDHVGGVMMGFQLKGLT
Mflv_0980|M.gilvum_PYR-GCK VVVDP-QRDIDRVLDLARERGVRISHVLETHIHNDYVTG------GLELS
Mvan_5835|M.vanbaalenii_PYR-1 VVIDP-QRDIDRVLALADERATRITHVLETHLHNDYVTG------GLELS
MSMEG_5385|M.smegmatis_MC2_155 VVVDP-QRDVAGYLADAEEFGYTIELVIETHFHADFLSG------HLELA
TH_1234|M.thermoresistible__bu VVVDP-QRDVAEYLSDAEKYGYTIELVIETHFHADFLSG------HLELA
MAV_2180|M.avium_104 VVFDA-AHTAEPIVAAVGNR--NVVAVVCTHGHNDHVTV------APELG
MAB_2873c|M.abscessus_ATCC_199 VIVDPGQDAIGGVKEILAERDLTPEAVLLTHGHLDHTWT------AQPLA
::.*. :: :* * *. :
MMAR_2442|M.marinum_M EATGAPTAAHEIDAEP---------------------LPVKPDRLLANGD
MUL_1621|M.ulcerans_Agy99 EATGAPTAAHEIDAEP---------------------LPVKPDRLLANGD
Mb0651c|M.bovis_AF2122/97 ELLERASVPVHVNTHEALWVSR------------VTGIPVGDLITHEHGD
Rv0634c|M.tuberculosis_H37Rv ELLERASVPVHVNTHEALWVSR------------VTGIPVGDLITHEHGD
MLBr_01912|M.leprae_Br4923 ELLERVTVPVHVNTHEALWISR------------VTGIDIGHLTTHEHRD
Mflv_0980|M.gilvum_PYR-GCK RVTGAEYVVPAGDDVG------------------------YERRAVSDGD
Mvan_5835|M.vanbaalenii_PYR-1 RTVGAEYVVPAVDGIG------------------------YPHRAVTDGD
MSMEG_5385|M.smegmatis_MC2_155 KATGAKIVYSSVAETE------------------------FESMGVADGE
TH_1234|M.thermoresistible__bu EATGAKIVYSSVAETE------------------------FESMGVADGE
MAV_2180|M.avium_104 AALDAPVLLHPGDDVLWR-----------------MTHPDKDFRTIADGD
MAB_2873c|M.abscessus_ATCC_199 DEYGIPVYIHPDDRVMLADPLAGIGPGLGQFIQGQVFAEPKELVEIGDGD
. :
MMAR_2442|M.marinum_M RVQIGELSFDVIHLRGHTPGSIALALDGAATG---------GVTQLFT--
MUL_1621|M.ulcerans_Agy99 RVQIGELSFDVIHLRGHTPGSIALALDGAATG---------GVTQLFT--
Mb0651c|M.bovis_AF2122/97 KVSVGDIDIELLHTPGHTPGSQCFLLDGRLVA---------GDTLFLEGC
Rv0634c|M.tuberculosis_H37Rv KVSVGDIDIELLHTPGHTPGSQCFLLDGRLVA---------GDTLFLEGC
MLBr_01912|M.leprae_Br4923 KLSVGDIEIELLHTPGHTPGSQCFLLDGLLVA---------GDTLFLEGC
Mflv_0980|M.gilvum_PYR-GCK TVDAGPVRLQVMHTPGHTHHHVSYVLRDAGGSGDSVLGVFTGGSMLHGTT
Mvan_5835|M.vanbaalenii_PYR-1 VIDAGPMRFEVLHTPGHTHHHVSYVLRDDTG---AVHGVFTGGSMLFGTT
MSMEG_5385|M.smegmatis_MC2_155 RYSLGEVTLEFRHTPGHTPESMSVVVYEHSND-DVPYGVLTGDALFIGDV
TH_1234|M.thermoresistible__bu RYSLGDVTLEFLHTPGHTPESLSIVVYEHADD-EIPYGVLTGDTLFIGDV
MAV_2180|M.avium_104 TIDVAGTELLALHTPGHSPGSVCWYAPELGVV-------FSGDTLFSGGP
MAB_2873c|M.abscessus_ATCC_199 KLELAGITLTVDHTPGHTRGSVVFGIEVDSEN-GPVDVLFSGDTLFQMSI
. . : * **: * : :
MMAR_2442|M.marinum_M GDCLFPGG--------VGKTWQP--GDFTQLVEDVSSRVFDVYPDSTVVY
MUL_1621|M.ulcerans_Agy99 GDCLFPGG--------VGKTWQP--GDFTQLVEDVSSRVFNVYPDSTVVY
Mb0651c|M.bovis_AF2122/97 GRTDFPGG--------DSDEMYRSLRQLAELPGDPTVFPGHWYSAEPSAS
Rv0634c|M.tuberculosis_H37Rv GRTDFPGG--------DSDEMYRSLRQLAELPGDPTVFPGHWYSAEPSAS
MLBr_01912|M.leprae_Br4923 GRTDFPGG--------NSDEMYRSLQQLAQLPGNPTVFPGHWYSTAPSAT
Mflv_0980|M.gilvum_PYR-GCK GRTDLLG--DEHTQELSHAQFHSVRRLAAELPDTAEVYPTHGFGSFCSAT
Mvan_5835|M.vanbaalenii_PYR-1 GRTDLVA--AEDTEELTHAQFHSVRRLADTLPTDTPVYPTHGFGSFCSAT
MSMEG_5385|M.smegmatis_MC2_155 GRPDLLASIGFTREELAEKLYDSLRNKLMTLPDATRVYPAHGAGSACGKN
TH_1234|M.thermoresistible__bu GRPDLLASIGYTREELADKLYDSLHHKLMTLPDATRVYPAHGAGSACGKN
MAV_2180|M.avium_104 GATGRSYS-------DFPTILQSISGRLGTLPGETVVHTGHG--------
MAB_2873c|M.abscessus_ATCC_199 GRTDLPGG-------NHQQLLDSIAAKLLTRDDSSVVLPGHG--------
* .
MMAR_2442|M.marinum_M PGHGDDTVLGVERPHLDEWRERGW--------------------------
MUL_1621|M.ulcerans_Agy99 PGHGDDTALGFERPHLDEWRERGW--------------------------
Mb0651c|M.bovis_AF2122/97 LSEVKRSNYVYRPASLDQWRMLMGG-------------------------
Rv0634c|M.tuberculosis_H37Rv LSEVKRSNYVYRPASLDQWRMLMGG-------------------------
MLBr_01912|M.leprae_Br4923 LSMVKCSNYVYRAADLNQWRMLMDS-------------------------
Mflv_0980|M.gilvum_PYR-GCK PASGDSSTIADQRQTNPALTQ-DEQSYVDELIAGLGAYPAYYAHMGVINT
Mvan_5835|M.vanbaalenii_PYR-1 PASGDESTIGEQRQSNPALTQ-DEQSYVDELLAGLSAYPTYYAHMGVINR
MSMEG_5385|M.smegmatis_MC2_155 LSTERWSTIGEQKQTNYALRAPDLATFMALVTAGQPAAPSYFVYDAILNR
TH_1234|M.thermoresistible__bu LSTELWSTIGEQRETNYALRAPDKATFIELVTEGQPPAPGYFVYDAILNR
MAV_2180|M.avium_104 ----DSTTIGDEIVHYEEWVARGH--------------------------
MAB_2873c|M.abscessus_ATCC_199 ----NATSIGDERRANPFLEGIQ---------------------------
: .
MMAR_2442|M.marinum_M --------------------------------------------------
MUL_1621|M.ulcerans_Agy99 --------------------------------------------------
Mb0651c|M.bovis_AF2122/97 --------------------------------------------------
Rv0634c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01912|M.leprae_Br4923 --------------------------------------------------
Mflv_0980|M.gilvum_PYR-GCK EGPDPVDLS-VPEPVDPDELRRRIEGGEWVVDLRNRTAFAAGHLGGTLGF
Mvan_5835|M.vanbaalenii_PYR-1 EGPAPVDLT-PPAPIDPAELRRRIEAGEWVVDLRNRTAFAAGHLQGTLGF
MSMEG_5385|M.smegmatis_MC2_155 KDRDLLDETEIPAAMRYEQVNQALRDGAILVDGRSPEEFATGHLRQAINI
TH_1234|M.thermoresistible__bu KNRGLLDETALPPVLSYDEMLAAVERGAVLVDGRSPEEFAQGHLRGAINI
MAV_2180|M.avium_104 --------------------------------------------------
MAB_2873c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_2442|M.marinum_M --------------------------------------------------
MUL_1621|M.ulcerans_Agy99 --------------------------------------------------
Mb0651c|M.bovis_AF2122/97 --------------------------------------------------
Rv0634c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01912|M.leprae_Br4923 --------------------------------------------------
Mflv_0980|M.gilvum_PYR-GCK ELSDNFVTYLGWLYSWGSPLTLIGDDVDQIADARRELARIGVDNLTGSAT
Mvan_5835|M.vanbaalenii_PYR-1 ELSGSFVSYFGWLYEWGAPVTLIGESPDQIAEAKRELVRIGVDRLTGSAT
MSMEG_5385|M.smegmatis_MC2_155 GLQGRYAEFAGSVVPADVDIVLFTE-PGEELEAKNRLARIGFDRVIGHLD
TH_1234|M.thermoresistible__bu GLDGRYAEFAGSVLPADVDIVLFTE-PGDELEAKNRLARIGFDRVIGHLD
MAV_2180|M.avium_104 --------------------------------------------------
MAB_2873c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_2442|M.marinum_M --------------------------------------------------
MUL_1621|M.ulcerans_Agy99 --------------------------------------------------
Mb0651c|M.bovis_AF2122/97 --------------------------------------------------
Rv0634c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01912|M.leprae_Br4923 --------------------------------------------------
Mflv_0980|M.gilvum_PYR-GCK G--DIHDLAEGTPLRSYRVADFAALADAMQAQAPAVLDVRQSGEFADGHI
Mvan_5835|M.vanbaalenii_PYR-1 G--DVDTLRAEAPLGSYEVGDFARLARERKTTAVAVLDVRQTNEFDQEHI
MSMEG_5385|M.smegmatis_MC2_155 RPFEVMLAHPDDVQMASRLTATAFDQRTAEVADLQIVDVRNPGEVADGAI
TH_1234|M.thermoresistible__bu RPFEVMMAHPDRVQVASRLTVKAFDQRAAELPDLQIVDVRNPGEVALGAI
MAV_2180|M.avium_104 --------------------------------------------------
MAB_2873c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_2442|M.marinum_M --------------------------------------------------
MUL_1621|M.ulcerans_Agy99 --------------------------------------------------
Mb0651c|M.bovis_AF2122/97 --------------------------------------------------
Rv0634c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01912|M.leprae_Br4923 --------------------------------------------------
Mflv_0980|M.gilvum_PYR-GCK AGAVNIPLHELSRRLDEVP-DGEVWVHCASGYRSSIAASMIDRGDRT-VV
Mvan_5835|M.vanbaalenii_PYR-1 PGAVSIPLHELPQRLDDVP-AGPVWVHCASGYRSSIAASYLDRAGIS-VV
MSMEG_5385|M.smegmatis_MC2_155 PHAITIPVGQLPARLGELDPAKPTVVYCAGGYRSSVAASVLRRNGFADVS
TH_1234|M.thermoresistible__bu PGAIAIPVGQLPDRLTELDPTRPTVVYCAGGYRSSVAASLLRRSGFTDVS
MAV_2180|M.avium_104 --------------------------------------------------
MAB_2873c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_2442|M.marinum_M ------------------
MUL_1621|M.ulcerans_Agy99 ------------------
Mb0651c|M.bovis_AF2122/97 ------------------
Rv0634c|M.tuberculosis_H37Rv ------------------
MLBr_01912|M.leprae_Br4923 ------------------
Mflv_0980|M.gilvum_PYR-GCK LVDDAFDQAEKTGLVS--
Mvan_5835|M.vanbaalenii_PYR-1 LIDDDFDNAVKLGLTVSG
MSMEG_5385|M.smegmatis_MC2_155 DILGGYGAWRDARQGV--
TH_1234|M.thermoresistible__bu DILGGYGAWVDARQVA--
MAV_2180|M.avium_104 ------------------
MAB_2873c|M.abscessus_ATCC_199 ------------------