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KFTQYYLDCLSHASYLIADETTGRAVVVDPQRDVAGYLADAEEFGYTIELVIETHFHADFLSGHLELAKA TGAKIVYSSVAETEFESMGVADGERYSLGEVTLEFRHTPGHTPESMSVVVYEHSNDDVPYGVLTGDALFI GDVGRPDLLASIGFTREELAEKLYDSLRNKLMTLPDATRVYPAHGAGSACGKNLSTERWSTIGEQKQTNY ALRAPDLATFMALVTAGQPAAPSYFVYDAILNRKDRDLLDETEIPAAMRYEQVNQALRDGAILVDGRSPE EFATGHLRQAINIGLQGRYAEFAGSVVPADVDIVLFTEPGEELEAKNRLARIGFDRVIGHLDRPFEVMLA HPDDVQMASRLTATAFDQRTAEVADLQIVDVRNPGEVADGAIPHAITIPVGQLPARLGELDPAKPTVVYC AGGYRSSVAASVLRRNGFADVSDILGGYGAWRDARQGV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5385 | - | - | 100% (459) | metallo-beta-lactamase family protein |
| M. smegmatis MC2 155 | MSMEG_3810 | - | 9e-14 | 26.11% (180) | hydrolase |
| M. smegmatis MC2 155 | MSMEG_1334 | - | 3e-13 | 28.82% (229) | metallo-beta-lactamase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0651c | - | 3e-14 | 28.70% (230) | glyoxalase II |
| M. gilvum PYR-GCK | Mflv_0985 | - | 0.0 | 88.40% (457) | beta-lactamase domain-containing protein |
| M. tuberculosis H37Rv | Rv0634c | - | 3e-14 | 28.70% (230) | glyoxalase II |
| M. leprae Br4923 | MLBr_01912 | - | 5e-13 | 30.00% (230) | putative glyoxylase II |
| M. abscessus ATCC 19977 | MAB_2873c | - | 3e-13 | 29.56% (203) | hypothetical protein MAB_2873c |
| M. marinum M | MMAR_2442 | - | 3e-14 | 26.60% (188) | hypothetical protein MMAR_2442 |
| M. avium 104 | MAV_4532 | - | 3e-14 | 27.95% (229) | metallo-beta-lactamase family protein |
| M. thermoresistible (build 8) | TH_1234 | - | 0.0 | 84.25% (457) | metallo-beta-lactamase family protein |
| M. ulcerans Agy99 | MUL_1621 | - | 3e-14 | 27.17% (184) | hypothetical protein MUL_1621 |
| M. vanbaalenii PYR-1 | Mvan_4023 | - | 0.0 | 85.56% (457) | beta-lactamase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0651c|M.bovis_AF2122/97 MSK-DRLYFRQLLSG-------RDFAVGDMFATQMRNFAYLIGDRTTGDC
Rv0634c|M.tuberculosis_H37Rv MSK-DRLYFRQLLSG-------RDFAVGDMFATQMRNFAYLIGDRTTGDC
MAV_4532|M.avium_104 MSD-DRLYFRQLLSG-------RDFAAGDMFATQMRNFAYLIGDRQTGDC
MLBr_01912|M.leprae_Br4923 MSDSDRLYFRQLLSG-------RDFAVDDVVATQMRNFAYLIGDRQTGDC
Mflv_0985|M.gilvum_PYR-GCK ------------------------MKFIQYYLDCLSHASYLIADETTGRA
Mvan_4023|M.vanbaalenii_PYR-1 ------------------------MKFIQYYLDCLSHASYLIADETTGRA
MSMEG_5385|M.smegmatis_MC2_155 ------------------------MKFTQYYLDCLSHASYLIADETTGRA
TH_1234|M.thermoresistible__bu ------------------------MKFIQYYLDCLSHASYLIADDKTGRA
MMAR_2442|M.marinum_M MTVVDDNYTGHVDPGTVARRTLPGATILKASVGPMDNNAYLVTCSATGQT
MUL_1621|M.ulcerans_Agy99 MTVVDDNYTGHVDPGTVARRTLPGATILKASVGPVDNNAYLVTCSATGQT
MAB_2873c|M.abscessus_ATCC_199 ------------------------MLITGFPAGMFATNCYIVAPHEGGPA
. .*:: *
Mb0651c|M.bovis_AF2122/97 VVVDP-AYAAGDLLDALESDDMQLSGVLVTHHHPDHVGGSMMGFQLPGLA
Rv0634c|M.tuberculosis_H37Rv VVVDP-AYAAGDLLDALESDDMQLSGVLVTHHHPDHVGGSMMGFQLPGLA
MAV_4532|M.avium_104 VVVDP-AYAASDLLDTLEADGMHLSGVLVTHHHPDHVGGSMMGFTLAGLA
MLBr_01912|M.leprae_Br4923 VVVDP-AYAAGDLVDALEADGMRLSGVLVTHHHPDHVGGVMMGFQLKGLT
Mflv_0985|M.gilvum_PYR-GCK VVVDP-QRDVAEYLSDAEEFGYTIELVIETHFHADFLSGHLELAEATGAK
Mvan_4023|M.vanbaalenii_PYR-1 VVVDP-QRDVAEYLADATEFGYTIELVIETHFHADFLSGHLELAKATGAK
MSMEG_5385|M.smegmatis_MC2_155 VVVDP-QRDVAGYLADAEEFGYTIELVIETHFHADFLSGHLELAKATGAK
TH_1234|M.thermoresistible__bu VVVDP-QRDVAEYLSDAEKYGYTIELVIETHFHADFLSGHLELAEATGAK
MMAR_2442|M.marinum_M LLIDA-ANDAEVLIDLIRRYAPKIALIVTSHQHFDHWQALQAVAEATGAP
MUL_1621|M.ulcerans_Agy99 LLIDA-ANDAEVLIDLIRRYAPKIALIVTSHQHFDHWQALQAVAEATGAP
MAB_2873c|M.abscessus_ATCC_199 VIVDPGQDAIGGVKEILAERDLTPEAVLLTHGHLDHTWTAQPLADEYGIP
:::*. :: :* * *. *
Mb0651c|M.bovis_AF2122/97 ELLERASVPVHVNTHEAL------WVSRVTGIPVGDLITHEHGDKVSVGD
Rv0634c|M.tuberculosis_H37Rv ELLERASVPVHVNTHEAL------WVSRVTGIPVGDLITHEHGDKVSVGD
MAV_4532|M.avium_104 ELVERAPVPVHVNSHEAL------WVSRVTGISASDLTAHENHDKVSIGD
MLBr_01912|M.leprae_Br4923 ELLERVTVPVHVNTHEAL------WISRVTGIDIGHLTTHEHRDKLSVGD
Mflv_0985|M.gilvum_PYR-GCK IVYSSVAETEFESMG------------------------VADGERYSLGD
Mvan_4023|M.vanbaalenii_PYR-1 IVYSSVAETEFESMG------------------------VADGQIYSLGE
MSMEG_5385|M.smegmatis_MC2_155 IVYSSVAETEFESMG------------------------VADGERYSLGE
TH_1234|M.thermoresistible__bu IVYSSVAETEFESMG------------------------VADGERYSLGD
MMAR_2442|M.marinum_M TAAHEIDAEPLPVKPDR---------------------LLANGDRVQIGE
MUL_1621|M.ulcerans_Agy99 TAAHEIDAEPLPVKPDR---------------------LLANGDRVQIGE
MAB_2873c|M.abscessus_ATCC_199 VYIHPDDRVMLADPLAGIGPGLGQFIQGQVFAEPKELVEIGDGDKLELAG
. : .:.
Mb0651c|M.bovis_AF2122/97 IDIELLHTPGHTPGSQCFLLDGR--------LVAGDTLFLEGCGRTDFPG
Rv0634c|M.tuberculosis_H37Rv IDIELLHTPGHTPGSQCFLLDGR--------LVAGDTLFLEGCGRTDFPG
MAV_4532|M.avium_104 IEIELLHTPGHTPGSQCFLLDGR--------LVAGDTLFLEGCGRTDFPG
MLBr_01912|M.leprae_Br4923 IEIELLHTPGHTPGSQCFLLDGL--------LVAGDTLFLEGCGRTDFPG
Mflv_0985|M.gilvum_PYR-GCK VTLEFRHTPGHTPESMSIVVYEHADDQVPYGVLTGDALFIGDVGRPDLLA
Mvan_4023|M.vanbaalenii_PYR-1 VTLKFLHTPGHTPESLSIVVYEHAGDEVPYGVLTGDALFIGDVGRPDLLA
MSMEG_5385|M.smegmatis_MC2_155 VTLEFRHTPGHTPESMSVVVYEHSNDDVPYGVLTGDALFIGDVGRPDLLA
TH_1234|M.thermoresistible__bu VTLEFLHTPGHTPESLSIVVYEHADDEIPYGVLTGDTLFIGDVGRPDLLA
MMAR_2442|M.marinum_M LSFDVIHLRGHTPGSIALALDGAATGG-VTQLFTGDCLFPGGVGKTWQPG
MUL_1621|M.ulcerans_Agy99 LSFDVIHLRGHTPGSIALALDGAATGG-VTQLFTGDCLFPGGVGKTWQPG
MAB_2873c|M.abscessus_ATCC_199 ITLTVDHTPGHTRGSVVFGIEVDSENGPVDVLFSGDTLFQMSIGRTDLPG
: : . * *** * . : :.:** ** . *:. .
Mb0651c|M.bovis_AF2122/97 GD-------SDEMYRSLR-QLAELPGDPTVFPGH--------WYSAEPSA
Rv0634c|M.tuberculosis_H37Rv GD-------SDEMYRSLR-QLAELPGDPTVFPGH--------WYSAEPSA
MAV_4532|M.avium_104 GD-------SDEMYRSLQ-RLAKLPGDPTVFPGH--------WYSAEPSA
MLBr_01912|M.leprae_Br4923 GN-------SDEMYRSLQ-QLAQLPGNPTVFPGH--------WYSTAPSA
Mflv_0985|M.gilvum_PYR-GCK SIGFTREELAEKLYDSLHNKLMTLPDATRVYPAHGAGSACGKNLSTDLWS
Mvan_4023|M.vanbaalenii_PYR-1 SIGFTREELADKLYDSLHTKLMTLPDATRVYPAHGAGSACGKNLSTDLWS
MSMEG_5385|M.smegmatis_MC2_155 SIGFTREELAEKLYDSLRNKLMTLPDATRVYPAHGAGSACGKNLSTERWS
TH_1234|M.thermoresistible__bu SIGYTREELADKLYDSLHHKLMTLPDATRVYPAHGAGSACGKNLSTELWS
MMAR_2442|M.marinum_M DF-------TQLVEDVSSRVFDVYPDSTVVYPGHG---------------
MUL_1621|M.ulcerans_Agy99 DF-------TQLVEDVSSRVFNVYPDSTVVYPGHG---------------
MAB_2873c|M.abscessus_ATCC_199 GN-------HQQLLDSIAAKLLTRDDSSVVLPGHG---------------
. : : : . . * *.*
Mb0651c|M.bovis_AF2122/97 SLSEVKRSNYVYRPASLDQWRMLMGG------------------------
Rv0634c|M.tuberculosis_H37Rv SLSEVKRSNYVYRPASLDQWRMLMGG------------------------
MAV_4532|M.avium_104 SLSEVKRSNYVYRASDLDQWRMLMGG------------------------
MLBr_01912|M.leprae_Br4923 TLSMVKCSNYVYRAADLNQWRMLMDS------------------------
Mflv_0985|M.gilvum_PYR-GCK TMGEQKETNYALRAPDKATFMALVTEGQPPAPSYFVYDAILNRKDRELLD
Mvan_4023|M.vanbaalenii_PYR-1 TMGEQKATNYALRAPDKATFMELVTEGQPPAPSYFVYDAILNRKDRELLD
MSMEG_5385|M.smegmatis_MC2_155 TIGEQKQTNYALRAPDLATFMALVTAGQPAAPSYFVYDAILNRKDRDLLD
TH_1234|M.thermoresistible__bu TIGEQRETNYALRAPDKATFIELVTEGQPPAPGYFVYDAILNRKNRGLLD
MMAR_2442|M.marinum_M -----DDTVLGVERPHLDEWRERGW-------------------------
MUL_1621|M.ulcerans_Agy99 -----DDTALGFERPHLDEWRERGW-------------------------
MAB_2873c|M.abscessus_ATCC_199 ------NATSIGDERRANPFLEGIQ-------------------------
: :
Mb0651c|M.bovis_AF2122/97 --------------------------------------------------
Rv0634c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4532|M.avium_104 --------------------------------------------------
MLBr_01912|M.leprae_Br4923 --------------------------------------------------
Mflv_0985|M.gilvum_PYR-GCK QTKMPAAMTYEQVRDAMAAGAILVDGRGPEEFATGHLRGAVNIGLAGRYA
Mvan_4023|M.vanbaalenii_PYR-1 ETKMPEAMSYEQVRDAVKAGAVLVDGRNPEEFALGHLRGAVNIGLEGRYA
MSMEG_5385|M.smegmatis_MC2_155 ETEIPAAMRYEQVNQALRDGAILVDGRSPEEFATGHLRQAINIGLQGRYA
TH_1234|M.thermoresistible__bu ETALPPVLSYDEMLAAVERGAVLVDGRSPEEFAQGHLRGAINIGLDGRYA
MMAR_2442|M.marinum_M --------------------------------------------------
MUL_1621|M.ulcerans_Agy99 --------------------------------------------------
MAB_2873c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0651c|M.bovis_AF2122/97 --------------------------------------------------
Rv0634c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4532|M.avium_104 --------------------------------------------------
MLBr_01912|M.leprae_Br4923 --------------------------------------------------
Mflv_0985|M.gilvum_PYR-GCK EFAGSVVPTDVDIVLFTEPGQELEGKNRLARIGFDRVVGYLDRPFEVMFT
Mvan_4023|M.vanbaalenii_PYR-1 EFAGSVVPTDVDIVLFTEPGQELEGKTRLARIGFDRVIGYLERPFEAMLD
MSMEG_5385|M.smegmatis_MC2_155 EFAGSVVPADVDIVLFTEPGEELEAKNRLARIGFDRVIGHLDRPFEVMLA
TH_1234|M.thermoresistible__bu EFAGSVLPADVDIVLFTEPGDELEAKNRLARIGFDRVIGHLDRPFEVMMA
MMAR_2442|M.marinum_M --------------------------------------------------
MUL_1621|M.ulcerans_Agy99 --------------------------------------------------
MAB_2873c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0651c|M.bovis_AF2122/97 --------------------------------------------------
Rv0634c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4532|M.avium_104 --------------------------------------------------
MLBr_01912|M.leprae_Br4923 --------------------------------------------------
Mflv_0985|M.gilvum_PYR-GCK HPGDVQMASRLTAKAFDQRAAEVADLQIVDVRNPGEVAAGTIPNAITIPV
Mvan_4023|M.vanbaalenii_PYR-1 HQDEVQVASRLTAKAFDARAAELADLQIVDVRNPGEVAAGMIPDAVSIPV
MSMEG_5385|M.smegmatis_MC2_155 HPDDVQMASRLTATAFDQRTAEVADLQIVDVRNPGEVADGAIPHAITIPV
TH_1234|M.thermoresistible__bu HPDRVQVASRLTVKAFDQRAAELPDLQIVDVRNPGEVALGAIPGAIAIPV
MMAR_2442|M.marinum_M --------------------------------------------------
MUL_1621|M.ulcerans_Agy99 --------------------------------------------------
MAB_2873c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0651c|M.bovis_AF2122/97 --------------------------------------------------
Rv0634c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4532|M.avium_104 --------------------------------------------------
MLBr_01912|M.leprae_Br4923 --------------------------------------------------
Mflv_0985|M.gilvum_PYR-GCK GQLPARLGELDPAKPTVVYCAGGYRSSVAASLLRGNGFTDVSDILGGFGA
Mvan_4023|M.vanbaalenii_PYR-1 GQLPARLGELDPAKPTVVYCAGGYRSSVAASLLRAHGFADVSDILGGYGA
MSMEG_5385|M.smegmatis_MC2_155 GQLPARLGELDPAKPTVVYCAGGYRSSVAASVLRRNGFADVSDILGGYGA
TH_1234|M.thermoresistible__bu GQLPDRLTELDPTRPTVVYCAGGYRSSVAASLLRRSGFTDVSDILGGYGA
MMAR_2442|M.marinum_M --------------------------------------------------
MUL_1621|M.ulcerans_Agy99 --------------------------------------------------
MAB_2873c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0651c|M.bovis_AF2122/97 --------
Rv0634c|M.tuberculosis_H37Rv --------
MAV_4532|M.avium_104 --------
MLBr_01912|M.leprae_Br4923 --------
Mflv_0985|M.gilvum_PYR-GCK WEETHQNA
Mvan_4023|M.vanbaalenii_PYR-1 WDEAHQNA
MSMEG_5385|M.smegmatis_MC2_155 WRDARQGV
TH_1234|M.thermoresistible__bu WVDARQVA
MMAR_2442|M.marinum_M --------
MUL_1621|M.ulcerans_Agy99 --------
MAB_2873c|M.abscessus_ATCC_199 --------