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MKFIQYYLDCLSHASYLIADETTGRAVVVDPQRDVAEYLSDAEEFGYTIELVIETHFHADFLSGHLELAE ATGAKIVYSSVAETEFESMGVADGERYSLGDVTLEFRHTPGHTPESMSIVVYEHADDQVPYGVLTGDALF IGDVGRPDLLASIGFTREELAEKLYDSLHNKLMTLPDATRVYPAHGAGSACGKNLSTDLWSTMGEQKETN YALRAPDKATFMALVTEGQPPAPSYFVYDAILNRKDRELLDQTKMPAAMTYEQVRDAMAAGAILVDGRGP EEFATGHLRGAVNIGLAGRYAEFAGSVVPTDVDIVLFTEPGQELEGKNRLARIGFDRVVGYLDRPFEVMF THPGDVQMASRLTAKAFDQRAAEVADLQIVDVRNPGEVAAGTIPNAITIPVGQLPARLGELDPAKPTVVY CAGGYRSSVAASLLRGNGFTDVSDILGGFGAWEETHQNA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0985 | - | - | 100% (459) | beta-lactamase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_0980 | - | 2e-54 | 33.02% (427) | beta-lactamase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_3810 | - | 4e-13 | 29.58% (213) | beta-lactamase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0651c | - | 3e-14 | 27.52% (218) | glyoxalase II |
| M. tuberculosis H37Rv | Rv0634c | - | 3e-14 | 27.52% (218) | glyoxalase II |
| M. leprae Br4923 | MLBr_00493 | - | 1e-13 | 30.05% (203) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_0121 | - | 2e-12 | 47.56% (82) | rhodanese-like protein |
| M. marinum M | MMAR_2442 | - | 5e-15 | 26.87% (201) | hypothetical protein MMAR_2442 |
| M. avium 104 | MAV_4532 | - | 2e-14 | 28.51% (221) | metallo-beta-lactamase family protein |
| M. smegmatis MC2 155 | MSMEG_5385 | - | 0.0 | 88.40% (457) | metallo-beta-lactamase family protein |
| M. thermoresistible (build 8) | TH_1234 | - | 0.0 | 84.75% (459) | metallo-beta-lactamase family protein |
| M. ulcerans Agy99 | MUL_1621 | - | 5e-15 | 27.41% (197) | hypothetical protein MUL_1621 |
| M. vanbaalenii PYR-1 | Mvan_4023 | - | 0.0 | 89.98% (459) | beta-lactamase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0985|M.gilvum_PYR-GCK MKFIQYYLDCLSHASYLIADETTGRAVVVDPQRDVAEYLSDAEEFGYTIE
Mvan_4023|M.vanbaalenii_PYR-1 MKFIQYYLDCLSHASYLIADETTGRAVVVDPQRDVAEYLADATEFGYTIE
MSMEG_5385|M.smegmatis_MC2_155 MKFTQYYLDCLSHASYLIADETTGRAVVVDPQRDVAGYLADAEEFGYTIE
TH_1234|M.thermoresistible__bu MKFIQYYLDCLSHASYLIADDKTGRAVVVDPQRDVAEYLSDAEKYGYTIE
MAB_0121|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0651c|M.bovis_AF2122/97 --------------------------------------------------
Rv0634c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4532|M.avium_104 --------------------------------------------------
MMAR_2442|M.marinum_M --------------------------------------------------
MUL_1621|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00493|M.leprae_Br4923 --------------------------------------------------
Mflv_0985|M.gilvum_PYR-GCK LVIETHFHADFLSGHLELAEATGAKIVYSSVAETEFESMGVADGERYSLG
Mvan_4023|M.vanbaalenii_PYR-1 LVIETHFHADFLSGHLELAKATGAKIVYSSVAETEFESMGVADGQIYSLG
MSMEG_5385|M.smegmatis_MC2_155 LVIETHFHADFLSGHLELAKATGAKIVYSSVAETEFESMGVADGERYSLG
TH_1234|M.thermoresistible__bu LVIETHFHADFLSGHLELAEATGAKIVYSSVAETEFESMGVADGERYSLG
MAB_0121|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0651c|M.bovis_AF2122/97 --------------------------------------------------
Rv0634c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4532|M.avium_104 --------------------------------------------------
MMAR_2442|M.marinum_M --------------------------------------------------
MUL_1621|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00493|M.leprae_Br4923 --------------------------------------------------
Mflv_0985|M.gilvum_PYR-GCK DVTLEFRHTPGHTPESMSIVVYEHADDQVPYGVLTGDALFIGDVGRPDLL
Mvan_4023|M.vanbaalenii_PYR-1 EVTLKFLHTPGHTPESLSIVVYEHAGDEVPYGVLTGDALFIGDVGRPDLL
MSMEG_5385|M.smegmatis_MC2_155 EVTLEFRHTPGHTPESMSVVVYEHSNDDVPYGVLTGDALFIGDVGRPDLL
TH_1234|M.thermoresistible__bu DVTLEFLHTPGHTPESLSIVVYEHADDEIPYGVLTGDTLFIGDVGRPDLL
MAB_0121|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0651c|M.bovis_AF2122/97 --------------------------------------------------
Rv0634c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4532|M.avium_104 --------------------------------------------------
MMAR_2442|M.marinum_M --------------------------------------------------
MUL_1621|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00493|M.leprae_Br4923 --------------------------------------------------
Mflv_0985|M.gilvum_PYR-GCK ASIGFTREELAEKLYDSLHNKLMTLPDATRVYPAHGAGSACGKNLSTDLW
Mvan_4023|M.vanbaalenii_PYR-1 ASIGFTREELADKLYDSLHTKLMTLPDATRVYPAHGAGSACGKNLSTDLW
MSMEG_5385|M.smegmatis_MC2_155 ASIGFTREELAEKLYDSLRNKLMTLPDATRVYPAHGAGSACGKNLSTERW
TH_1234|M.thermoresistible__bu ASIGYTREELADKLYDSLHHKLMTLPDATRVYPAHGAGSACGKNLSTELW
MAB_0121|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0651c|M.bovis_AF2122/97 ------------------------MSKDRLYFRQLLSG----RDFAVGDM
Rv0634c|M.tuberculosis_H37Rv ------------------------MSKDRLYFRQLLSG----RDFAVGDM
MAV_4532|M.avium_104 ------------------------MSDDRLYFRQLLSG----RDFAAGDM
MMAR_2442|M.marinum_M -----------------------MTVVDDNYTGHVDPGTVARRTLPGATI
MUL_1621|M.ulcerans_Agy99 -----------------------MTVVDDNYTGHVDPGTVARRTLPGATI
MLBr_00493|M.leprae_Br4923 ----------------------MLITGFPAGMLQCNCYVLADRAGTDAVI
Mflv_0985|M.gilvum_PYR-GCK STMGEQKETNYALRAPDKATFMALVTEGQPPAPSYFVYDAILNRKDRELL
Mvan_4023|M.vanbaalenii_PYR-1 STMGEQKATNYALRAPDKATFMELVTEGQPPAPSYFVYDAILNRKDRELL
MSMEG_5385|M.smegmatis_MC2_155 STIGEQKQTNYALRAPDLATFMALVTAGQPAAPSYFVYDAILNRKDRDLL
TH_1234|M.thermoresistible__bu STIGEQRETNYALRAPDKATFIELVTEGQPPAPGYFVYDAILNRKNRGLL
MAB_0121|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0651c|M.bovis_AF2122/97 FAT---QMRNFAYLIGDRTTGDCVVVDPAYAAGDLLDALESDDMQLSGVL
Rv0634c|M.tuberculosis_H37Rv FAT---QMRNFAYLIGDRTTGDCVVVDPAYAAGDLLDALESDDMQLSGVL
MAV_4532|M.avium_104 FAT---QMRNFAYLIGDRQTGDCVVVDPAYAASDLLDTLEADGMHLSGVL
MMAR_2442|M.marinum_M LKASVGPMDNNAYLVTCSATGQTLLIDAANDAEVLIDLIRRYAPKIALIV
MUL_1621|M.ulcerans_Agy99 LKASVGPVDNNAYLVTCSATGQTLLIDAANDAEVLIDLIRRYAPKIALIV
MLBr_00493|M.leprae_Br4923 VDPGQRAMGPLRRILDENRLTPSAVLLTHGHIDHMWSAQKVSDTYGCPTY
Mflv_0985|M.gilvum_PYR-GCK DQTKMPAAMTYEQVRDAMAAGAILVDGRGPEEFATGHLRGAVNIGLAGRY
Mvan_4023|M.vanbaalenii_PYR-1 DETKMPEAMSYEQVRDAVKAGAVLVDGRNPEEFALGHLRGAVNIGLEGRY
MSMEG_5385|M.smegmatis_MC2_155 DETEIPAAMRYEQVNQALRDGAILVDGRSPEEFATGHLRQAINIGLQGRY
TH_1234|M.thermoresistible__bu DETALPPVLSYDEMLAAVERGAVLVDGRSPEEFAQGHLRGAINIGLDGRY
MAB_0121|M.abscessus_ATCC_1997 ------------------------------MSFPTG--------------
Mb0651c|M.bovis_AF2122/97 VTHHHPDHVGGSMMGFQLPGLAELLERASVPVHVNTHEALWVS-------
Rv0634c|M.tuberculosis_H37Rv VTHHHPDHVGGSMMGFQLPGLAELLERASVPVHVNTHEALWVS-------
MAV_4532|M.avium_104 VTHHHPDHVGGSMMGFTLAGLAELVERAPVPVHVNSHEALWVS-------
MMAR_2442|M.marinum_M TSHQHFDHWQ------ALQAVAEATG-APTAAHEIDAEPLPVK-------
MUL_1621|M.ulcerans_Agy99 TSHQHFDHWQ------ALQAVAEATG-APTAAHEIDAEPLPVK-------
MLBr_00493|M.leprae_Br4923 IHPEDRFMLTDPLFGFGPRVAQVVTG----AFFREPKQVVELD-------
.
Mflv_0985|M.gilvum_PYR-GCK AEFAGSVVPTDVDIVLFTEPGQELEGKNRLARIGFDRVVGYLDRPFEVMF
Mvan_4023|M.vanbaalenii_PYR-1 AEFAGSVVPTDVDIVLFTEPGQELEGKTRLARIGFDRVIGYLERPFEAML
MSMEG_5385|M.smegmatis_MC2_155 AEFAGSVVPADVDIVLFTEPGEELEAKNRLARIGFDRVIGHLDRPFEVML
TH_1234|M.thermoresistible__bu AEFAGSVLPADVDIVLFTEPGDELEAKNRLARIGFDRVIGHLDRPFEVMM
MAB_0121|M.abscessus_ATCC_1997 ---------------------------DDVPQVGIDEIS-----------
Mb0651c|M.bovis_AF2122/97 ---------RVTGIPVGDLITHEHGDKVSVGDIDIELLHTP---------
Rv0634c|M.tuberculosis_H37Rv ---------RVTGIPVGDLITHEHGDKVSVGDIDIELLHTP---------
MAV_4532|M.avium_104 ---------RVTGISASDLTAHENHDKVSIGDIEIELLHTP---------
MMAR_2442|M.marinum_M ---------PDR--------LLANGDRVQIGELSFDVIHLR---------
MUL_1621|M.ulcerans_Agy99 ---------PDR--------LLANGDRVQIGELSFDVIHLR---------
MLBr_00493|M.leprae_Br4923 ----------------------RDGDKLDLGSVTVNVDHTP---------
: : .:
Mflv_0985|M.gilvum_PYR-GCK THPGDVQMASRLTAKAFDQRAAEVADLQIVD---VRNPGEVAAGTIPNAI
Mvan_4023|M.vanbaalenii_PYR-1 DHQDEVQVASRLTAKAFDARAAELADLQIVD---VRNPGEVAAGMIPDAV
MSMEG_5385|M.smegmatis_MC2_155 AHPDDVQMASRLTATAFDQRTAEVADLQIVD---VRNPGEVADGAIPHAI
TH_1234|M.thermoresistible__bu AHPDRVQVASRLTVKAFDQRAAELPDLQIVD---VRNPGEVALGAIPGAI
MAB_0121|M.abscessus_ATCC_1997 --------------------AALSLGVKLLD---VREDDEWAAGHIEGAQ
Mb0651c|M.bovis_AF2122/97 ------------------GHTPGSQCFLLDG---RLVAGDTLFLEGCGRT
Rv0634c|M.tuberculosis_H37Rv ------------------GHTPGSQCFLLDG---RLVAGDTLFLEGCGRT
MAV_4532|M.avium_104 ------------------GHTPGSQCFLLDG---RLVAGDTLFLEGCGRT
MMAR_2442|M.marinum_M ------------------GHTPGSIALALDG---AATGGVTQLFT--GDC
MUL_1621|M.ulcerans_Agy99 ------------------GHTPGSIALALDG---AATGGVTQLFT--GDC
MLBr_00493|M.leprae_Br4923 ------------------GHTRGSVCFWVAADTDVVLTGDTLFERTIGRT
: . : .
Mflv_0985|M.gilvum_PYR-GCK TIPVG---QLPARLGELDPAKPTVVYCAGGYRSSVAASLLRGNGFTDVSD
Mvan_4023|M.vanbaalenii_PYR-1 SIPVG---QLPARLGELDPAKPTVVYCAGGYRSSVAASLLRAHGFADVSD
MSMEG_5385|M.smegmatis_MC2_155 TIPVG---QLPARLGELDPAKPTVVYCAGGYRSSVAASVLRRNGFADVSD
TH_1234|M.thermoresistible__bu AIPVG---QLPDRLTELDPTRPTVVYCAGGYRSSVAASLLRRSGFTDVSD
MAB_0121|M.abscessus_ATCC_1997 HIPLG---DVPSRMDELDPDAPLWVICHAGGRSQRAAAYLNRNGF-DVSN
Mb0651c|M.bovis_AF2122/97 DFPGGDSDEMYRSLRQLAELPGDPTVFPGHWYSAEPSASLSEVKRSNYVY
Rv0634c|M.tuberculosis_H37Rv DFPGGDSDEMYRSLRQLAELPGDPTVFPGHWYSAEPSASLSEVKRSNYVY
MAV_4532|M.avium_104 DFPGGDSDEMYRSLQRLAKLPGDPTVFPGHWYSAEPSASLSEVKRSNYVY
MMAR_2442|M.marinum_M LFPGGVGKTWQP--GDFTQLVEDVSSRVFDVYPDSTVVYPGHGDDTVLGV
MUL_1621|M.ulcerans_Agy99 LFPGGVGKTWQP--GDFTQLVEDVSSRVFNVYPDSTVVYPGHGDDTALGF
MLBr_00493|M.leprae_Br4923 DLFGGSGRDLYRSIVEKLLVLDDKTVVLPGHGNSTTIGAER---------
: * .
Mflv_0985|M.gilvum_PYR-GCK ILGGFGAWEETHQNA--
Mvan_4023|M.vanbaalenii_PYR-1 ILGGYGAWDEAHQNA--
MSMEG_5385|M.smegmatis_MC2_155 ILGGYGAWRDARQGV--
TH_1234|M.thermoresistible__bu ILGGYGAWVDARQVA--
MAB_0121|M.abscessus_ATCC_1997 VSGGMLAWVQAGKPTIS
Mb0651c|M.bovis_AF2122/97 RPASLDQWRMLMGG---
Rv0634c|M.tuberculosis_H37Rv RPASLDQWRMLMGG---
MAV_4532|M.avium_104 RASDLDQWRMLMGG---
MMAR_2442|M.marinum_M ERPHLDEWRERGW----
MUL_1621|M.ulcerans_Agy99 ERPHLDEWRERGW----
MLBr_00493|M.leprae_Br4923 ---RFNPFLEGL-----
: