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MESMSERSGGRPQRVVVVGAGMVGLSTAWYLQEHGVEVTVVDSDGVAAGSSWGNAGWLTPSIATPLPEPA VLRYGVRALLSPSSPVYVPLTADPRLIGFLLRFARNSTASRWQKAMKALIPLNRDALAAFDRMEVQSSEQ SSPAEPFIAAYRTAADREVLLEEFAQIRAAGQSVNFEVLDGATARAQEPALSPEVDAAIAIHDERFVNPS AYVDALAAQVLARGGRIEAGVDVDSVSDTGDGVRVAGQRYDAAVVATGARLNKLLAPFGVRRTVQAGRGY SFTVKVDHLPRGPVYFPTQRVACTPVGDRLRIAGMMEFRAVDAPLDPRRIEVLKNAAGELLTGAHLDTRE DEWVGARPCTADGLPLIGRTRSSRVFAAGGHGMWGITLGPVTGRLLAEQIVTGRTPDALRAVDPLR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0955 | - | - | 100% (416) | D-amino-acid dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3081 | solA | 6e-07 | 24.91% (281) | N-methyltryptophan oxidase |
| M. gilvum PYR-GCK | Mflv_2278 | - | 3e-05 | 46.30% (54) | amine oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2503c | - | 3e-08 | 26.99% (226) | putative iron-sulfur binding oxidoreductase |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_2749 | - | 1e-10 | 29.13% (230) | FAD dependent oxidoreductase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_6291 | - | 1e-105 | 48.67% (415) | D-amino-acid dehydrogenase |
| M. thermoresistible (build 8) | TH_2138 | - | 1e-103 | 48.57% (420) | D-amino-acid dehydrogenase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_4780 | - | 1e-100 | 48.10% (420) | D-amino-acid dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6291|M.smegmatis_MC2_155 -----------MVD--GERIDGGPR--GAVVVGAGIVGLSTAWFLQERGV
TH_2138|M.thermoresistible__bu -----------MSQRFAERVDGGPR--SAIVIGAGIVGLSTAWFLQERGV
Mvan_4780|M.vanbaalenii_PYR-1 -----------MSG--GSGMDGGPR--SVIVVGAGIVGLSTAWFLQERGV
Mflv_0955|M.gilvum_PYR-GCK -----------MES-MSERSGGRPQ--RVVVVGAGMVGLSTAWYLQEHGV
MAB_2503c|M.abscessus_ATCC_199 MNSIWLEGRSGLVARVPLAPDDTTQTVDIAVIGAGITGLTTALLLARAGL
MAV_2749|M.avium_104 MTSLWMSERT-ERPWAASQLDQGPASADVIVVGAGITGLMTAALLARAGK
. . *:***:.** ** * . *
MSMEG_6291|M.smegmatis_MC2_155 DVTVVDRTGVAAGASWGNAGWVSPTLTIPLNDPAVLR-------------
TH_2138|M.thermoresistible__bu DVCVVDRTGVAAGASWGNAGWISPGLAIPLNEPGVLR-------------
Mvan_4780|M.vanbaalenii_PYR-1 DVTVVDRSGVAAGASWGNAGWVSPALTAPLNSPSVLR-------------
Mflv_0955|M.gilvum_PYR-GCK EVTVVDSDGVAAGSSWGNAGWLTPSIATPLPEPAVLR-------------
MAB_2503c|M.abscessus_ATCC_199 EVVVLEARSAGDGTTGNSTGKISALHGTKLSRIAHRHGHAVARAYTTGNT
MAV_2749|M.avium_104 DVLVLEARTVGACATANTTAKISLLQGSQLSKVLPRHGREVTRAYVDGNR
:* *:: .. :: ..:. :: * :
MSMEG_6291|M.smegmatis_MC2_155 YGLRSLASPTAPLHIPLTAGVGLWAFLTRFALNCRLSSWTRAAKANLPLN
TH_2138|M.thermoresistible__bu YGLRNLLSPTAPLHLPLTRDLRQWAFLTRFAANCRRSSWTRALLANKPLN
Mvan_4780|M.vanbaalenii_PYR-1 EGLRALADPAAPLHIPVRADTALARFLLRFAANCRPSAWERAVRANAILN
Mflv_0955|M.gilvum_PYR-GCK YGVRALLSPSSPVYVPLTADPRLIGFLLRFARNSTASRWQKAMKALIPLN
MAB_2503c|M.abscessus_ATCC_199 EGRDWLLRYCEEHGVPTQTEDAYTYAQTREGTAGARDEWNACLQAGLPVR
MAV_2749|M.avium_104 EGQEWVLGHCEAHGVAVQREDAYTYAQSVRGVPSARAEFEACQAVGLPVV
* : :. . : . . :
MSMEG_6291|M.smegmatis_MC2_155 EECIEAYDVLMANGVDAVTTDAPITALFET------DRQAGHLLTELQRM
TH_2138|M.thermoresistible__bu DEAIEAYDVLTANGVDAPVTDAPITAVFRD------PREAGRLRDELRRV
Mvan_4780|M.vanbaalenii_PYR-1 DEAIETFDVLVSNGVDAPVTDTSLAVAFRD------AGHAELFLTELNHL
Mflv_0955|M.gilvum_PYR-GCK RDALAAFDRMEVQSSEQSSPAEPFIAAYRT------AADREVLLEEFAQI
MAB_2503c|M.abscessus_ATCC_199 WETTADTPFPYYGGVRLPDQAQFNPAQLVESMVAQLEDHGAHFFSGMRVR
MAV_2749|M.avium_104 WQDDAEVPFAYHGGVRLADQAQFDPMPFLDSLAVELLGRGGRLVEHTRVR
: . :
MSMEG_6291|M.smegmatis_MC2_155 ADLGQDVKFTQLTSDEVREQVPLASPRITTAVSVEGQRFVDPGRFVHALA
TH_2138|M.thermoresistible__bu AETGRDVEVTELSGADLRERVPLASAEITVGLEIHGQRYVDPARFVQALA
Mvan_4780|M.vanbaalenii_PYR-1 RSTGQQLHVETLTGAALHEQVPLASSNVAAVVNVSGQRFVDPGRFTHALG
Mflv_0955|M.gilvum_PYR-GCK RAAGQSVNFEVLDGATARAQEPALSPEVDAAIAIHDERFVNPSAYVDALA
MAB_2503c|M.abscessus_ATCC_199 SISGRGP-LRIKGDYAHDAGAGEFALEAQRCVLATGTPILDRGGFFAKLT
MAV_2749|M.avium_104 RVSWRGKGVRVHANQGSDAAGHDVELHADQLVLATGIPILDRGGYFARVK
: . . . : . :: . : :
MSMEG_6291|M.smegmatis_MC2_155 DA-----VVARGATIRT-GEVLDVQPSKPGVRIVLADG-EIQSDAAVIAT
TH_2138|M.thermoresistible__bu DS-----VVDRGATIHR-MDITGVDSGPGGVTVHSAGGQELSAGAVVIAT
Mvan_4780|M.vanbaalenii_PYR-1 FA-----VAERGATMLS-GEVCRVSGSRDGALLELRDRELLRGDAVVLAT
Mflv_0955|M.gilvum_PYR-GCK AQ-----VLARGGRIEAGVDVDSVSDTGDGVRVAG-----QRYDAAVVAT
MAB_2503c|M.abscessus_ATCC_199 ANRSYCMSFDVPGPITRAMYLSVDAPLRSVRYAPSSTGDRLVVGGAGHVV
MAV_2749|M.avium_104 PSRSYCLAFKVPGNITRPMMISTDSPTRSVRYAPVPDGERLIVGGAGHTV
. : : ... ..
MSMEG_6291|M.smegmatis_MC2_155 G---------AWLSRLVKAW-VPTPVRAGRGYSFTVPVDRPVPTPIYLPD
TH_2138|M.thermoresistible__bu G---------AWLHQLAQRW-VRVPVQAGRGYSFTVPVDRPVPAPVYLPE
Mvan_4780|M.vanbaalenii_PYR-1 G---------AWLPALTGRR-IRVGLQAGRGYSFTVPVDRALPGPVYLPE
Mflv_0955|M.gilvum_PYR-GCK G---------ARLNKLLAPFGVRRTVQAGRGYSFTVKVDHLPRGPVYFPT
MAB_2503c|M.abscessus_ATCC_199 GHPAHAREALRELAGWAQTHYPGATRTHSWAAQDYATISELPYAGPLLPG
MAV_2749|M.avium_104 GREKSPSAALDELSAWTRKHFPGAVQTHFWSAQDYTPIDHLPYVGPILPN
* * . . . :.. :*
MSMEG_6291|M.smegmatis_MC2_155 AR----------------VACTPYQGGLRVAGTMEFRSPDDPVQPARVDA
TH_2138|M.thermoresistible__bu VR----------------VACTPCAAGLRVAGTMEFRDPDAPLISKRVDA
Mvan_4780|M.vanbaalenii_PYR-1 AR----------------VACTPYRGGLRVAGTMEFRRPSEPLAQRRIDA
Mflv_0955|M.gilvum_PYR-GCK QR----------------VACTPVGDRLRIAGMMEFRAVDAPLDPRRIEV
MAB_2503c|M.abscessus_ATCC_199 GKRIYLATGYDKWGMTNGIAASLALSSQILGGRMDWANAFASWSALDLRA
MAV_2749|M.avium_104 SETIFVATGFNKWGMTNGAAAALALSSRILGGRMDWARAFASWSPHELSG
. *.: :.* *:: . :
MSMEG_6291|M.smegmatis_MC2_155 IIASATPLLDGVRWDERTDVWVGPRPVTPDGRPLVG--------------
TH_2138|M.thermoresistible__bu IVAAARPLLDGVRWDERGPSWVGPRPVTPDGRPLIG--------------
Mvan_4780|M.vanbaalenii_PYR-1 IIASATPLLDGVRWTERTDAWVGPRPVTDDGKPLIG--------------
Mflv_0955|M.gilvum_PYR-GCK LKNAAGELLTGAHLDTREDEWVGARPCTADGLPLIGR-------------
MAB_2503c|M.abscessus_ATCC_199 IPAAIRLGSRVARDFASG--WAT-AMLTSR--------------------
MAV_2749|M.avium_104 LATAVQANLEVGFNLTKG--WITPAVRIGRRSPVDGDGGVVSGPPWHLQA
: : *
MSMEG_6291|M.smegmatis_MC2_155 ---------EVAPGVYVAGGHGMWGLAHGPITGRLLAEYLTTGKEPDALR
TH_2138|M.thermoresistible__bu ---------AVAEDVYVAAGHGMWGLTHGPVTGRLLAEQITTGKQPDVLD
Mvan_4780|M.vanbaalenii_PYR-1 ---------QLASAMYVAGGHGMWGLAHGPATGRLLAEQIVTGKQPEAVR
Mflv_0955|M.gilvum_PYR-GCK ---------TRSSRVFAAGGHGMWGITLGPVTGRLLAEQIVTGRTPDALR
MAB_2503c|M.abscessus_ATCC_199 ------PEH--APVCTHLGGITTWNDAEDIWECPLHGSCFDSGGSVLWGP
MAV_2749|M.avium_104 RCRVDGTEHRVSPVCPHLGGIVNWNDADKAWECPLHGSRFAPDGTLLEGP
: .* *. : * .. : ..
MSMEG_6291|M.smegmatis_MC2_155 EFNPLR---------------
TH_2138|M.thermoresistible__bu EFDPLR---------------
Mvan_4780|M.vanbaalenii_PYR-1 PFDPLRGRGRATPTEVLTLPL
Mflv_0955|M.gilvum_PYR-GCK AVDPLR---------------
MAB_2503c|M.abscessus_ATCC_199 ATEPLDRLPADGAR-------
MAV_2749|M.avium_104 ATRDLT-----ASR-------
*