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MSGGSGMDGGPRSVIVVGAGIVGLSTAWFLQERGVDVTVVDRSGVAAGASWGNAGWVSPALTAPLNSPSV LREGLRALADPAAPLHIPVRADTALARFLLRFAANCRPSAWERAVRANAILNDEAIETFDVLVSNGVDAP VTDTSLAVAFRDAGHAELFLTELNHLRSTGQQLHVETLTGAALHEQVPLASSNVAAVVNVSGQRFVDPGR FTHALGFAVAERGATMLSGEVCRVSGSRDGALLELRDRELLRGDAVVLATGAWLPALTGRRIRVGLQAGR GYSFTVPVDRALPGPVYLPEARVACTPYRGGLRVAGTMEFRRPSEPLAQRRIDAIIASATPLLDGVRWTE RTDAWVGPRPVTDDGKPLIGQLASAMYVAGGHGMWGLAHGPATGRLLAEQIVTGKQPEAVRPFDPLRGRG RATPTEVLTLPL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4780 | - | - | 100% (432) | D-amino-acid dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0708 | - | 9e-05 | 27.61% (163) | glycine oxidase ThiO |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_0955 | - | 1e-100 | 48.10% (420) | D-amino-acid dehydrogenase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4218c | - | 2e-08 | 26.90% (197) | thiamine biosynthesis oxidoreductase ThiO |
| M. marinum M | MMAR_0718 | thiO | 7e-05 | 26.39% (269) | thiamine biosynthesis oxidoreductase ThiO |
| M. avium 104 | MAV_4746 | thiO | 1e-06 | 29.56% (203) | glycine oxidase ThiO |
| M. smegmatis MC2 155 | MSMEG_6291 | - | 1e-154 | 64.27% (417) | D-amino-acid dehydrogenase |
| M. thermoresistible (build 8) | TH_2138 | - | 1e-146 | 61.80% (411) | D-amino-acid dehydrogenase |
| M. ulcerans Agy99 | MUL_2805 | thiO | 8e-05 | 26.39% (269) | thiamine biosynthesis oxidoreductase ThiO |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6291|M.smegmatis_MC2_155 MVD--GERIDGGPRGAVVVGAGIVGLSTAWFLQERGVDVTVVDRTGVAAG
TH_2138|M.thermoresistible__bu MSQRFAERVDGGPRSAIVIGAGIVGLSTAWFLQERGVDVCVVDRTGVAAG
Mvan_4780|M.vanbaalenii_PYR-1 MSG--GSGMDGGPRSVIVVGAGIVGLSTAWFLQERGVDVTVVDRSGVAAG
Mflv_0955|M.gilvum_PYR-GCK MES-MSERSGGRPQRVVVVGAGMVGLSTAWYLQEHGVEVTVVDSDGVAAG
MMAR_0718|M.marinum_M -------MSSPSMGSLAVIGGGVIGLSVARRAAQAGWAVRVHRRA--EPG
MUL_2805|M.ulcerans_Agy99 -------MSSPSMGSLAVIGGGVIGLSVARRAAQAGWAVRVHRRA--EPG
MAV_4746|M.avium_104 -------MPS-DCGSLAVVGGGVIGLAVARRAAQAGWSVRVHRSG--ERG
MAB_4218c|M.abscessus_ATCC_199 -------MMSSQKGSVAVIGGGVIGLSVAREAARTGWRVVIHDDG--AKG
. *:*.*::**:.* . * * : *
MSMEG_6291|M.smegmatis_MC2_155 ASWGNAGWVSPTLTIPLNDPAVLRYGLRSLASPTAPLHIPLTAGVGLWAF
TH_2138|M.thermoresistible__bu ASWGNAGWISPGLAIPLNEPGVLRYGLRNLLSPTAPLHLPLTRDLRQWAF
Mvan_4780|M.vanbaalenii_PYR-1 ASWGNAGWVSPALTAPLNSPSVLREGLRALADPAAPLHIPVRADTALARF
Mflv_0955|M.gilvum_PYR-GCK SSWGNAGWLTPSIATPLPEPAVLRYGVRALLSPSSPVYVPLTADPRLIGF
MMAR_0718|M.marinum_M ASWAAGGMLAPHSEGWPGEERLLRLGLESLR---------LWHESGFLDG
MUL_2805|M.ulcerans_Agy99 ASWAAGGMLAPHSEGWPGEERLLRLGLESLR---------LWHESGFLDG
MAV_4746|M.avium_104 ASWVAGGMLAPHSEGWPGEERLLRLGLESLR---------LWREGGFLDG
MAB_4218c|M.abscessus_ATCC_199 PSWVAGGMLAPYSEAWPGEDELLELGIESLG---------IWRD-GFIDD
.** .* ::* . :*. *:. * :
MSMEG_6291|M.smegmatis_MC2_155 LTRFALNCRLSSWTRAAKANLPLNEECIEAYDVLMANGVDAVTTDAPITA
TH_2138|M.thermoresistible__bu LTRFAANCRRSSWTRALLANKPLNDEAIEAYDVLTANGVDAPVTDAPITA
Mvan_4780|M.vanbaalenii_PYR-1 LLRFAANCRPSAWERAVRANAILNDEAIETFDVLVSNGVDAPVTDTSLAV
Mflv_0955|M.gilvum_PYR-GCK LLRFARNSTASRWQKAMKALIPLNRDALAAFDRMEVQSSEQSSPAEPFIA
MMAR_0718|M.marinum_M LPPQVVTARES-------------------------------------LV
MUL_2805|M.ulcerans_Agy99 LPPQVVTARES-------------------------------------LM
MAV_4746|M.avium_104 LPGRLVTARES-------------------------------------LV
MAB_4218c|M.abscessus_ATCC_199 VENPVITARGS-------------------------------------LT
: .. *
MSMEG_6291|M.smegmatis_MC2_155 LFETDRQAGHLLTELQRMADLGQDVKFTQLTSDEVREQVPLASPRITTAV
TH_2138|M.thermoresistible__bu VFRDPREAGRLRDELRRVAETGRDVEVTELSGADLRERVPLASAEITVGL
Mvan_4780|M.vanbaalenii_PYR-1 AFRDAGHAELFLTELNHLRSTGQQLHVETLTGAALHEQVPLASSNVAAVV
Mflv_0955|M.gilvum_PYR-GCK AYRTAADREVLLEEFAQIRAAGQSVNFEVLDGATARAQEPALSPEVDAAI
MMAR_0718|M.marinum_M VAVDRADVADLRTVADWLSEQGHPVSWESAA----RDVEPLLAQGIRHGF
MUL_2805|M.ulcerans_Agy99 VAVDRADVADLRTVADWLSEQGHPVSWESAA----RDVEPLLAQGIRHGF
MAV_4746|M.avium_104 VAVDRADVADLRTVADWLSAQGHPVVWESAA----RDVEPLLAQGIRHGF
MAB_4218c|M.abscessus_ATCC_199 VAVDTADVGELRTMTGWLAARGHPVTEIANA----RDVEPMLAQNVRRGF
. : : *: : : * : : .
MSMEG_6291|M.smegmatis_MC2_155 SVEGQRFVDPGRFVHALADAVVARGATIRT-GEVLDVQPSKPGVRIVLAD
TH_2138|M.thermoresistible__bu EIHGQRYVDPARFVQALADSVVDRGATIHR-MDITGVDSGPGGVTVHSAG
Mvan_4780|M.vanbaalenii_PYR-1 NVSGQRFVDPGRFTHALGFAVAERGATMLS-GEVCRVSGSRDGALLELRD
Mflv_0955|M.gilvum_PYR-GCK AIHDERFVNPSAYVDALAAQVLARGGRIEAGVDVDSVSDTGDGVRVAG--
MMAR_0718|M.marinum_M RATTELAVDNRALLDALAVDCERRGVTWAG-PVADLSDATGDAVVIAN--
MUL_2805|M.ulcerans_Agy99 RATTELAVDNRALLDALAVDCERRGVTWAG-PVADLSDATGDAVVIAN--
MAV_4746|M.avium_104 TAPTELAVDNRAVLEALDAACERLGVRWAP-PLHDLAEADADAVVIAN--
MAB_4218c|M.abscessus_ATCC_199 TAPEELSVDNRKVLQALTAECEALGVGRGP-AAVHTRDVDADQVVIAN--
: *: .** * . . :
MSMEG_6291|M.smegmatis_MC2_155 G-EIQSDAAVIATGAWLSRLVKAW-VPTPVRAGRGYSFTVPVDRPVPTPI
TH_2138|M.thermoresistible__bu GQELSAGAVVIATGAWLHQLAQRW-VRVPVQAGRGYSFTVPVDRPVPAPV
Mvan_4780|M.vanbaalenii_PYR-1 RELLRGDAVVLATGAWLPALTGRR-IRVGLQAGRGYSFTVPVDRALPGPV
Mflv_0955|M.gilvum_PYR-GCK ---QRYDAAVVATGARLNKLLAPFGVRRTVQAGRGYSFTVKVDHLPRGPV
MMAR_0718|M.marinum_M ----GIDAPALWPGLPVRPVKGEV-LRLRWRKGCMPLLQRVVRARVHG--
MUL_2805|M.ulcerans_Agy99 ----GIDAPALWPGLPVRPVKGEV-LRLRWRKGCMPLLQRVVRARVHG--
MAV_4746|M.avium_104 ----GIDAPALWPGLPVRPVKGEV-LRLRWRKGCMPVPQRVIRARVHG--
MAB_4218c|M.abscessus_ATCC_199 ----GVQAAALA-GLPVRPVKGEV-LRLRQRPGAMPPPANVIRARVHG--
* .: * : : : : * :
MSMEG_6291|M.smegmatis_MC2_155 YLPDARVACTPYQGGLRVAGTMEFRSPDDPVQPARVDAIIASATPLLDGV
TH_2138|M.thermoresistible__bu YLPEVRVACTPCAAGLRVAGTMEFRDPDAPLISKRVDAIVAAARPLLDGV
Mvan_4780|M.vanbaalenii_PYR-1 YLPEARVACTPYRGGLRVAGTMEFRRPSEPLAQRRIDAIIASATPLLDGV
Mflv_0955|M.gilvum_PYR-GCK YFPTQRVACTPVGDRLRIAGMMEFRAVDAPLDPRRIEVLKNAAGELLTGA
MMAR_0718|M.marinum_M ----RQVYLVPRADGVVVGATQYEHGRDLAPVVSGVRDLLEDACAVMPAL
MUL_2805|M.ulcerans_Agy99 ----RQVYLVPRADGVVVGATQYEHGRDLAPVVSGVRDLLEDACAVMPAL
MAV_4746|M.avium_104 ----RQVYLVPRADGVVVGATQYEHGRDTAPVVSGVRDLLDDACAVLPAL
MAB_4218c|M.abscessus_ATCC_199 ----RHVYLVPRADGVVVGATQYEHGHDTAPAVAGVRDLLDDACALLPCL
:* .* : :.. : . . : : * ::
MSMEG_6291|M.smegmatis_MC2_155 RWDERTDVWVGPRPVTPDGRPLVG-EVAPGVYVAGGHGMWGLAHGPITGR
TH_2138|M.thermoresistible__bu RWDERGPSWVGPRPVTPDGRPLIG-AVAEDVYVAAGHGMWGLTHGPVTGR
Mvan_4780|M.vanbaalenii_PYR-1 RWTERTDAWVGPRPVTDDGKPLIG-QLASAMYVAGGHGMWGLAHGPATGR
Mflv_0955|M.gilvum_PYR-GCK HLDTREDEWVGARPCTADGLPLIGRTRSSRVFAAGGHGMWGITLGPVTGR
MMAR_0718|M.marinum_M GEYELAECTAGLRPMTPDNLPIVG-RLDARTLVAAGLGRSGFLLAPWTAE
MUL_2805|M.ulcerans_Agy99 GEYEFAECTAGLRPMTPDNLPIVG-RLDARTLVAAGLGRSGFLLAPWTAE
MAV_4746|M.avium_104 GEYELAECGAGLRPMTPDNLPLVG-RLDARTLVAAGHGRSGFLLAPWTAE
MAB_4218c|M.abscessus_ATCC_199 GEYEFAECAAGLRPMTDDNLPMVG-RIDERVVVAAGHGRSGFLLAPWTAK
.* ** * *. *::* .*.* * *: .* *..
MSMEG_6291|M.smegmatis_MC2_155 LLAEYLTTGKEPDALREFNPLR---------------
TH_2138|M.thermoresistible__bu LLAEQITTGKQPDVLDEFDPLR---------------
Mvan_4780|M.vanbaalenii_PYR-1 LLAEQIVTGKQPEAVRPFDPLRGRGRATPTEVLTLPL
Mflv_0955|M.gilvum_PYR-GCK LLAEQIVTGRTPDALRAVDPLR---------------
MMAR_0718|M.marinum_M QIVSEL------VPIG------AHS------------
MUL_2805|M.ulcerans_Agy99 QIVSEL------VPIG------AHS------------
MAV_4746|M.avium_104 QIVSEL------APVG------AHR------------
MAB_4218c|M.abscessus_ATCC_199 TIGAVLDGGESPAAVDPRRFEKAHSQEAR--------
: : :