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VVDGERIDGGPRGAVVVGAGIVGLSTAWFLQERGVDVTVVDRTGVAAGASWGNAGWVSPTLTIPLNDPAV LRYGLRSLASPTAPLHIPLTAGVGLWAFLTRFALNCRLSSWTRAAKANLPLNEECIEAYDVLMANGVDAV TTDAPITALFETDRQAGHLLTELQRMADLGQDVKFTQLTSDEVREQVPLASPRITTAVSVEGQRFVDPGR FVHALADAVVARGATIRTGEVLDVQPSKPGVRIVLADGEIQSDAAVIATGAWLSRLVKAWVPTPVRAGRG YSFTVPVDRPVPTPIYLPDARVACTPYQGGLRVAGTMEFRSPDDPVQPARVDAIIASATPLLDGVRWDER TDVWVGPRPVTPDGRPLVGEVAPGVYVAGGHGMWGLAHGPITGRLLAEYLTTGKEPDALREFNPLR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6291 | - | - | 100% (416) | D-amino-acid dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1129 | - | e-154 | 63.31% (417) | D-amino-acid dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0175 | - | 3e-14 | 27.10% (428) | FAD dependent oxidoreductase, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0423 | thiO | 2e-05 | 25.93% (162) | thiamine biosynthesis oxidoreductase ThiO |
| M. gilvum PYR-GCK | Mflv_0955 | - | 1e-105 | 48.67% (415) | D-amino-acid dehydrogenase |
| M. tuberculosis H37Rv | Rv0415 | thiO | 2e-05 | 25.93% (162) | thiamine biosynthesis oxidoreductase ThiO |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2283 | - | 1e-13 | 27.52% (258) | putative oxidoreductase |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_4746 | thiO | 3e-07 | 29.44% (180) | glycine oxidase ThiO |
| M. thermoresistible (build 8) | TH_2138 | - | 1e-169 | 69.49% (413) | D-amino-acid dehydrogenase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_4780 | - | 1e-154 | 64.27% (417) | D-amino-acid dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0423|M.bovis_AF2122/97 --------------------------MASDLHTGSLAVIGGGVIGLSVAR
Rv0415|M.tuberculosis_H37Rv --------------------------MASDLHTGSLAVIGGGVIGLSVAR
MAV_4746|M.avium_104 --------------------------MPSD--CGSLAVVGGGVIGLAVAR
MSMEG_6291|M.smegmatis_MC2_155 --------------------MVD--GERIDGGPRGAVVVGAGIVGLSTAW
TH_2138|M.thermoresistible__bu --------------------MSQRFAERVDGGPRSAIVIGAGIVGLSTAW
Mvan_4780|M.vanbaalenii_PYR-1 --------------------MSG--GSGMDGGPRSVIVVGAGIVGLSTAW
Mflv_0955|M.gilvum_PYR-GCK --------------------MES-MSERSGGRPQRVVVVGAGMVGLSTAW
MAB_2283|M.abscessus_ATCC_1997 MNGTEIGHLAETAPIWWPGSPESAAPITDGRHDVDVLVIGAGLAGLAAAY
. *:*.*: **:.*
Mb0423|M.bovis_AF2122/97 RAAQA--GWPVRVHRSD--ERGASWVAGGMLAPHSEGWPGEERLLRLGLQ
Rv0415|M.tuberculosis_H37Rv RAAQA--GWPVRVHRSD--ERGASWVAGGMLAPHSEGWPGEERLLRLGLQ
MAV_4746|M.avium_104 RAAQA--GWSVRVHRSG--ERGASWVAGGMLAPHSEGWPGEERLLRLGLE
MSMEG_6291|M.smegmatis_MC2_155 FLQER--GVDVTVVDRTGVAAGASWGNAGWVSPTLTIPLNDPAVLRYGLR
TH_2138|M.thermoresistible__bu FLQER--GVDVCVVDRTGVAAGASWGNAGWISPGLAIPLNEPGVLRYGLR
Mvan_4780|M.vanbaalenii_PYR-1 FLQER--GVDVTVVDRSGVAAGASWGNAGWVSPALTAPLNSPSVLREGLR
Mflv_0955|M.gilvum_PYR-GCK YLQEH--GVEVTVVDSDGVAAGSSWGNAGWLTPSIATPLPEPAVLRYGVR
MAB_2283|M.abscessus_ATCC_1997 FVTELRPELSVAVLEAKHVGAGATGRSTGIVSPGLSMPMAAFRRKYGDDA
: * * *:: * ::* .
Mb0423|M.bovis_AF2122/97 SLR------------------------------LWREGSFLDG-LGPQLV
Rv0415|M.tuberculosis_H37Rv SLR------------------------------LWREGSFLDG-LGPQLV
MAV_4746|M.avium_104 SLR------------------------------LWREGGFLDG-LPGRLV
MSMEG_6291|M.smegmatis_MC2_155 SLASPTAPLHIPLTAGVGLWAFLTRFALNCRLSSWTRAAKANLPLNEECI
TH_2138|M.thermoresistible__bu NLLSPTAPLHLPLTRDLRQWAFLTRFAANCRRSSWTRALLANKPLNDEAI
Mvan_4780|M.vanbaalenii_PYR-1 ALADPAAPLHIPVRADTALARFLLRFAANCRPSAWERAVRANAILNDEAI
Mflv_0955|M.gilvum_PYR-GCK ALLSPSSPVYVPLTADPRLIGFLLRFARNSTASRWQKAMKALIPLNRDAL
MAB_2283|M.abscessus_ATCC_1997 AIASFDATFHG---------------------VGLLRDLVAKENIDCDAR
: . :
Mb0423|M.bovis_AF2122/97 TAHESLVVAVDRADVADLRTVADWLSAQGHPVIWES--------------
Rv0415|M.tuberculosis_H37Rv TAHESLVVAVDRADVADLRTVADWLSAQGHPVIWES--------------
MAV_4746|M.avium_104 TARESLVVAVDRADVADLRTVADWLSAQGHPVVWES--------------
MSMEG_6291|M.smegmatis_MC2_155 EAYDVLMANGVDAVTTDAPITALFETDRQAGHLLTELQRMADLGQDVKFT
TH_2138|M.thermoresistible__bu EAYDVLTANGVDAPVTDAPITAVFRDPREAGRLRDELRRVAETGRDVEVT
Mvan_4780|M.vanbaalenii_PYR-1 ETFDVLVSNGVDAPVTDTSLAVAFRDAGHAELFLTELNHLRSTGQQLHVE
Mflv_0955|M.gilvum_PYR-GCK AAFDRMEVQSSEQSSPAEPFIAAYRTAADREVLLEEFAQIRAAGQSVNFE
MAB_2283|M.abscessus_ATCC_1997 DEPHTLVALTDRSLARMVTHLENLAELGREVPWLSS--------------
. : .
Mb0423|M.bovis_AF2122/97 -----AARDVEPLLAQGIRHGFRAPTELAVDNRALLDVLCRDCERLGVRW
Rv0415|M.tuberculosis_H37Rv -----AARDVEPLLAQGIRHGFRAPTELAVDNRALLDALCRDCERLGVRW
MAV_4746|M.avium_104 -----AARDVEPLLAQGIRHGFTAPTELAVDNRAVLEALDAACERLGVRW
MSMEG_6291|M.smegmatis_MC2_155 QLTSDEVREQVPLASPRITTAVSVEGQRFVDPGRFVHALADAVVARGATI
TH_2138|M.thermoresistible__bu ELSGADLRERVPLASAEITVGLEIHGQRYVDPARFVQALADSVVDRGATI
Mvan_4780|M.vanbaalenii_PYR-1 TLTGAALHEQVPLASSNVAAVVNVSGQRFVDPGRFTHALGFAVAERGATM
Mflv_0955|M.gilvum_PYR-GCK VLDGATARAQEPALSPEVDAAIAIHDERFVNPSAYVDALAAQVLARGGRI
MAB_2283|M.abscessus_ATCC_1997 -------QEVVQWAGAGYKAGFAYRDAMVVDPYRLVTGMADILRRRGAPV
: . . *: : *
Mb0423|M.bovis_AF2122/97 SS--QVSSLSDVDAHTVVIAN-----GIDAPALWPG--LPIRPVKGEV--
Rv0415|M.tuberculosis_H37Rv SS--QVSSLSDVDAHTVVIAN-----GIDAPALWPG--LPIRPVKGEV--
MAV_4746|M.avium_104 AP--PLHDLAEADADAVVIAN-----GIDAPALWPG--LPVRPVKGEV--
MSMEG_6291|M.smegmatis_MC2_155 RT-GEVLDVQPSKPGVRIVLADG-EIQSDAAVIATG--AWLSRLVKAW--
TH_2138|M.thermoresistible__bu HR-MDITGVDSGPGGVTVHSAGGQELSAGAVVIATG--AWLHQLAQRW--
Mvan_4780|M.vanbaalenii_PYR-1 LS-GEVCRVSGSRDGALLELRDRELLRGDAVVLATG--AWLPALTGRR--
Mflv_0955|M.gilvum_PYR-GCK EAGVDVDSVSDTGDGVRVAG-----QRYDAAVVATG--ARLNKLLAPFG-
MAB_2283|M.abscessus_ATCC_1997 YEHSPVISIEADATGVCVFTARAQVRARHAFLATDGYSGTLNPLKSSVIP
: : . : * * : :
Mb0423|M.bovis_AF2122/97 LRLRWRPG-----CMPLPQRVIR-ARVRGRQVYLVPR----SDGVVVGAT
Rv0415|M.tuberculosis_H37Rv LRLRWRPG-----CMPLPQRVIR-ARVRGRQVYLVPR----SDGVVVGAT
MAV_4746|M.avium_104 LRLRWRKG-----CMPVPQRVIR-ARVHGRQVYLVPR----ADGVVVGAT
MSMEG_6291|M.smegmatis_MC2_155 VPTPVRAGRGYSFTVPVDRPVPTPIYLPDARVACTPY----QGGLRVAGT
TH_2138|M.thermoresistible__bu VRVPVQAGRGYSFTVPVDRPVPAPVYLPEVRVACTPC----AAGLRVAGT
Mvan_4780|M.vanbaalenii_PYR-1 IRVGLQAGRGYSFTVPVDRALPGPVYLPEARVACTPY----RGGLRVAGT
Mflv_0955|M.gilvum_PYR-GCK VRRTVQAGRGYSFTVKVDHLPRGPVYFPTQRVACTPV----GDRLRIAGM
MAB_2283|M.abscessus_ATCC_1997 LRTHLLATAPLTEGQLAELGWSGRGAIIDQRTFFNYYRMSADKRVVFGGG
: . :. : ...
Mb0423|M.bovis_AF2122/97 QYEHGRDTAPVVSG-----VRDLLDDACTVLPALGEYELAECEAGLRPMT
Rv0415|M.tuberculosis_H37Rv QYEHGRDTAPVVSG-----VRDLLDDACTVLPALGEYELAECEAGLRPMT
MAV_4746|M.avium_104 QYEHGRDTAPVVSG-----VRDLLDDACAVLPALGEYELAECGAGLRPMT
MSMEG_6291|M.smegmatis_MC2_155 MEFRSPDDPVQPAR-----VDAIIASATPLLDGVRWDERTDVWVGPRPVT
TH_2138|M.thermoresistible__bu MEFRDPDAPLISKR-----VDAIVAAARPLLDGVRWDERGPSWVGPRPVT
Mvan_4780|M.vanbaalenii_PYR-1 MEFRRPSEPLAQRR-----IDAIIASATPLLDGVRWTERTDAWVGPRPVT
Mflv_0955|M.gilvum_PYR-GCK MEFRAVDAPLDPRR-----IEVLKNAAGELLTGAHLDTREDEWVGARPCT
MAB_2283|M.abscessus_ATCC_1997 PAFVPSRIPSRDIKRSRVIQQRVRRELTERFPVLADVEIDAAWSGITASS
. : : * . :
Mb0423|M.bovis_AF2122/97 PDNLPLVQ-RLDSR-TLVAAGHGRSGFLLAPWTAEQIVSELVSVGAAS--
Rv0415|M.tuberculosis_H37Rv PDNLPLVQ-RLDSR-TLVAAGHGRSGFLLAPWTAEQIVSELVSVGAAS--
MAV_4746|M.avium_104 PDNLPLVG-RLDAR-TLVAAGHGRSGFLLAPWTAEQIVSELAPVGAHR--
MSMEG_6291|M.smegmatis_MC2_155 PDGRPLVG-EVAPG-VYVAGGHGMWGLAHGPITGRLLAEYLTTGKEPDAL
TH_2138|M.thermoresistible__bu PDGRPLIG-AVAED-VYVAAGHGMWGLTHGPVTGRLLAEQITTGKQPDVL
Mvan_4780|M.vanbaalenii_PYR-1 DDGKPLIG-QLASA-MYVAGGHGMWGLAHGPATGRLLAEQIVTGKQPEAV
Mflv_0955|M.gilvum_PYR-GCK ADGLPLIGRTRSSR-VFAAGGHGMWGITLGPVTGRLLAEQIVTGRTPDAL
MAB_2283|M.abscessus_ATCC_1997 FDRNPVVGPVPGMDGLWFAGSWCGHGFSTSVDTGWRFAKTLVGEPLPANI
* *:: *.. *: . *. :.. :.
Mb0423|M.bovis_AF2122/97 --------------------------------------------------
Rv0415|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4746|M.avium_104 --------------------------------------------------
MSMEG_6291|M.smegmatis_MC2_155 REFNP---------LR----------------------------------
TH_2138|M.thermoresistible__bu DEFDP---------LR----------------------------------
Mvan_4780|M.vanbaalenii_PYR-1 RPFDP---------LRGRGRATPTEVLTLPL-------------------
Mflv_0955|M.gilvum_PYR-GCK RAVDP---------LR----------------------------------
MAB_2283|M.abscessus_ATCC_1997 PWFRSGAQRVPTTLLRNVATGAYLKALDAADALDAKTSNPPQVARPTAGR
Mb0423|M.bovis_AF2122/97 --------------
Rv0415|M.tuberculosis_H37Rv --------------
MAV_4746|M.avium_104 --------------
MSMEG_6291|M.smegmatis_MC2_155 --------------
TH_2138|M.thermoresistible__bu --------------
Mvan_4780|M.vanbaalenii_PYR-1 --------------
Mflv_0955|M.gilvum_PYR-GCK --------------
MAB_2283|M.abscessus_ATCC_1997 QTSRGTTTLAEADK