For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TGWLAGKRALIVGAGSGIGRATVDAFLNEDARVAVLEYDSGKCATLRQQLPDVPVIEGDGTTRTANDEAV QVAVDAFGGLDTLVNCVGIFDFYRRIQDIPAERIDQAFDEMFRINVLSHIHSVKAAVPALMGQDGASIVL TESASSFYPGRGGLLYVASKFAVRGVVTALAHELAPRIRVNGVAPGGTLNTDLRGLDSLDLGARRLDAAP DRARELAARTPLGVALSGEDHAWSYVFLASHRSRGLTGETIHPDGGFSLGPPPQRN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0592 | - | - | 100% (267) | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0682 | - | e-152 | 100.00% (267) | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0621 | - | 3e-51 | 44.57% (258) | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2788c | fabG | 2e-17 | 29.77% (262) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. tuberculosis H37Rv | Rv2766c | fabG | 2e-17 | 29.77% (262) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_01094 | - | 1e-11 | 25.91% (247) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4365c | - | 5e-36 | 37.74% (265) | putative dihydrodiol dehydrogenase |
| M. marinum M | MMAR_4765 | - | 4e-21 | 31.34% (268) | short chain dehydrogenase |
| M. avium 104 | MAV_3512 | - | 1e-109 | 74.90% (263) | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3367 | - | 5e-24 | 35.50% (262) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_3420 | - | 4e-21 | 32.20% (264) | PUTATIVE oxidoreductase, short chain dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_0336 | - | 9e-22 | 32.21% (267) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0466 | - | 1e-151 | 99.25% (267) | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0592|M.gilvum_PYR-GCK --MTG-WLAGKRALIVGAGSGIGRATVDAFLNEDARVAVLEYDSGKCATL
Mvan_0466|M.vanbaalenii_PYR-1 --MTG-WLAGKRALIVGGGSGIGRATVDAFLNEDARVAVLEYDSGKCATL
MAV_3512|M.avium_104 --MTG-WLDGKRALVVGAGSGIGRAVVDAFAAEGAKVAALERDSDKCDRL
MAB_4365c|M.abscessus_ATCC_199 --MSGGWLGGYVALITGGGSGIGRAVTERYLAEGASVTIVGHRPEQLDRV
Mb2788c|M.bovis_AF2122/97 --MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVLTARRQEAADEA
Rv2766c|M.tuberculosis_H37Rv --MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVLTARRQEAADEA
MSMEG_3367|M.smegmatis_MC2_155 --MSHKRLAGKTALITGGTSGIGLATARLFAAEGAKVAVIGRDADRVQAT
MMAR_4765|M.marinum_M ---MVDELAGKIAIVTGGASGIGRATVARFIAEGARVVIADVEEERGESL
MUL_0336|M.ulcerans_Agy99 ---MVDELAGKIAIVTGGASGIGRATVARFIAEGARVVIADVEEERGESL
TH_3420|M.thermoresistible__bu VTERAGELAGKVAVVTGGAAGLGAGLARRFVAEGAKVLIGDVDTGNGAKL
MLBr_01094|M.leprae_Br4923 ----MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDGEGLAQT
: * *::.*. *:* . . .* :
Mflv_0592|M.gilvum_PYR-GCK RQQ---LPD-VPVIEGDGTTRTANDEAVQVAVDAFGGLDTLVNCVGIFDF
Mvan_0466|M.vanbaalenii_PYR-1 RHQ---LPD-VPVIEGDGTTRTANDEAVQVAVDAFGGLDTLVNCVGIFDF
MAV_3512|M.avium_104 RRQ---LPE-VAVAEGDATTREANERAVALAVDTFGGLDTLVNCVGVFDF
MAB_4365c|M.abscessus_ATCC_199 HAES-SAPDRLHTVVADTRESDQLHDAVVQTVSRFGQLDTLVANAGVWDY
Mb2788c|M.bovis_AF2122/97 AAQ---VGDRALGVGAHAVDEDAARRCVDLTLERFGSVDILINNAGTNPA
Rv2766c|M.tuberculosis_H37Rv AAQ---VGDRALGVGAHAVDEDAARRCVDLTLERFGSVDILINNAGTNPA
MSMEG_3367|M.smegmatis_MC2_155 QDE---LGDGSLALRADTTSPDDMTAVAGRIQDAFGGLDVFFANAG-IAY
MMAR_4765|M.marinum_M AAA---LGADAMFCRTDVSQPEQVAAVVAAAVENFGGLHVMVNNAGVSGV
MUL_0336|M.ulcerans_Agy99 AAA---LGADAMFCRTDVSQPEQVAAVVAAAVDNFGGLHVMVNNAGVSGA
TH_3420|M.thermoresistible__bu AAE---LGADAEFVEADVADLDQVSGLVSTAVERFGGLHVMVNNAGISGT
MLBr_01094|M.leprae_Br4923 EGQLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQIYNNAG--IA
. . . ** :. : .*
Mflv_0592|M.gilvum_PYR-GCK YRRIQDIPAERIDQAFDEMFRINVLSHIHSVKAAVPALMGQDGASIVLTE
Mvan_0466|M.vanbaalenii_PYR-1 YRRIQDIPAERIDQAFDEMFRINVLSHIHSVKAAVPALMGQDGASIVLTE
MAV_3512|M.avium_104 YRGVADIDAGALADAFDEMFRTNVLSHLQSVKAALPALRAAGASSIVLTE
MAB_4365c|M.abscessus_ATCC_199 QRPLTRLTASELTASFHEVFSVNVKGYLLAAEAAWRELVKTRG-SIIMTL
Mb2788c|M.bovis_AF2122/97 YGPLLEQDHAR----FAKIFDVNLWAPLMWTSLVVTAWMGEHGGAVVNTA
Rv2766c|M.tuberculosis_H37Rv YGPLLEQDHAR----FAKIFDVNLWAPLMWTSLVVTAWMGEHGGAVVNTA
MSMEG_3367|M.smegmatis_MC2_155 PTPLLETDEQR----YDEIMDINIKGVFFSMQAVAPILR--DGASVILNT
MMAR_4765|M.marinum_M MHRRFLDDDLAD---FHRVMAVNVLGVMAGTRDAARHMAAHGGGSIVNLT
MUL_0336|M.ulcerans_Agy99 MHRRFLDDDLAD---FHRVMAVNVLGVMAGTRDAARHMAAHGGGSIVNLT
TH_3420|M.thermoresistible__bu MHRSLLDDDLAD---FDRVMRINVRAVMAGTRDAARHMAEHGGGSIINLT
MLBr_01094|M.leprae_Br4923 FTGDVEVSHFKD---IERVMDVDYWGVVNGTKAFLPYLISSGDGHVINIS
.:: : . . ::
Mflv_0592|M.gilvum_PYR-GCK SASSFYPGRGGLLYVASKFAVRGVVTALAHELAPR---IRVNGVAPGGTL
Mvan_0466|M.vanbaalenii_PYR-1 SASSFYPGRGGLLYVASKFAVRGVVTALAHELAPR---IRVNGVAPGGTL
MAV_3512|M.avium_104 SASSFYPGRGGVLYVSSKFAVRGLVSALAHELAPG---IRVNGVAPGGTL
MAB_4365c|M.abscessus_ATCC_199 SNASFYVNGGGPIYTASKHACLGLMRELAFELAPK---VRVNGVACGG-M
Mb2788c|M.bovis_AF2122/97 SIGGMHQSPAMGMYNATKAALIHVTKQLALELSPR---IRVNAICPG---
Rv2766c|M.tuberculosis_H37Rv SIGGMHQSPAMGMYNATKAALIHVTKQLALELSPR---IRVNAICPG---
MSMEG_3367|M.smegmatis_MC2_155 SFLNQVGRPGLSLLSASKAAVRSFARTWSAELLDRG--IRVNAISPG---
MMAR_4765|M.marinum_M SIGGIQAGGGVMTYRASKAAVIQFTKSAAIELAHYE--IRVNAIAPGN--
MUL_0336|M.ulcerans_Agy99 SIGGIQAGGGVMTYRASKGAVIQFTKSAAIELAHYE--IRVNAIAPGN--
TH_3420|M.thermoresistible__bu SIGGIQAGGGVQTYRASKAAVIQFTKSAAIELAHHE--IRVNALAPGN--
MLBr_01094|M.leprae_Br4923 SVFGLFSVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTTVYPGG--
* . . ::* * . *: :.*. : *
Mflv_0592|M.gilvum_PYR-GCK NTDLRGLDSLDLGARRLDAAPDRARELAAR--TPLGVALSG-EDHAWSYV
Mvan_0466|M.vanbaalenii_PYR-1 NTDLRGLDSLDLGARRLDAAPDRARELAAR--TPLGVALSG-EDHAWSYV
MAV_3512|M.avium_104 GTDLRGLASLRLQGTRLDDAPDRAAEVAAR--TPLRVALSG-ADHAWSFV
MAB_4365c|M.abscessus_ATCC_199 NTDLRGPEALSLADRSISTSFAKRGHDASAPLIPLHDSSTDPADFTGPYV
Mb2788c|M.bovis_AF2122/97 -----------VVRTRLAEALWKDHEDPLAATIALGRIGEP-ADIASAVA
Rv2766c|M.tuberculosis_H37Rv -----------VVRTRLAEALWKDHEDPLAATIALGRIGEP-ADIASAVA
MSMEG_3367|M.smegmatis_MC2_155 ------AIDTPLQRRGRTPEEAQAVLAALVARTPAGRAGAA-DDIAQAAL
MMAR_4765|M.marinum_M IPTPLLASSAAGMDQEQVERFTAQIRQTMREDRPLKREGTP-EDIAEAAL
MUL_0336|M.ulcerans_Agy99 IPTPLLASSAAGLDQEQVERFTAQIRQTMREDRPLKREGTP-EDIAEAAL
TH_3420|M.thermoresistible__bu IRTAIVRKSATGADLERLERFEARIRQQMRDDRPLKREGTV-EDVAEAAL
MLBr_01094|M.leprae_Br4923 -IKTAIARNATAAEGLDVSKIASRFDTWVAHTSPQHAARIILKAVRKKKA
.
Mflv_0592|M.gilvum_PYR-GCK FLASHRSRG-LTGETIHPDGGFSLG------PPPQRN---
Mvan_0466|M.vanbaalenii_PYR-1 FLASHRSRG-LTGETIHPDGGFSLG------PPPQRN---
MAV_3512|M.avium_104 FLASDRSRG-ITGETVRPDGGFGLG------TPR------
MAB_4365c|M.abscessus_ATCC_199 LLASREQSGPITGEAIAIDGGIGVRGFV---KPAGGEHL-
Mb2788c|M.bovis_AF2122/97 FLVSDAASW-ITGETMIIDGGLLLGNALGFRAAPSTEH--
Rv2766c|M.tuberculosis_H37Rv FLVSDAASW-ITGETMIIDGGLLLGNALGFRAAPSTEH--
MSMEG_3367|M.smegmatis_MC2_155 YLAGDESTF-ILGAELVVDGGISQL---------------
MMAR_4765|M.marinum_M YFAGERSRY-VTGTVLPVDGGTVAGKVIRRSR--------
MUL_0336|M.ulcerans_Agy99 YFAGERSRY-VTGTVLPVDGGTVAGKVIRRSR--------
TH_3420|M.thermoresistible__bu YFAGDRSRY-VTGTVLPIDGGTVAGKVIARKSHAE-----
MLBr_01094|M.leprae_Br4923 RVLVGPDAK-VANVVVRFSGGAGYQRLFAQVASRLILNQR
. : . : .**