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RAAIYHGREDVRIEELPDPSPRAGEVVIEVARAGICGTDLHEYIAGPMHAAPGVVIGHEYSGTVVGVGSG VREFTEGDRVCGVGVFGCGECGFCKQGAEALCGAVGFIGFAVNGALARYASLPTKALFRIPDEISLAEAA VVEPIASAYHAVRRSGLAAGGTVFIAGAGPIGLALVQFSLAQGATQVIVSEVSATRRVAAHRVGATRVID PLAEDAVEVVRTLTNGNGVDISFDAAGVQPALDAALGVLRPRGRLMVVAIWEAPAGIDINRSVMREANIG FSFCYEAQRQVPAILDLLATGAINLGELITDEIPLDAVVSQGLEELRVNRDAHVKILIDPSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0556 | - | - | 100% (343) | alcohol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0638 | - | 0.0 | 100.00% (343) | alcohol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0660 | - | 1e-75 | 41.35% (341) | alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3753 | - | 2e-26 | 25.96% (389) | putative dehydrogenase |
| M. tuberculosis H37Rv | Rv1895 | - | 3e-34 | 28.86% (350) | dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 1e-21 | 24.56% (338) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2084 | - | 3e-30 | 29.32% (365) | zinc-type alcohol dehydrogenase AdhD |
| M. marinum M | MMAR_0343 | - | 9e-37 | 29.79% (339) | zinc-dependent alcohol dehydrogenase |
| M. avium 104 | MAV_2804 | - | 7e-39 | 32.66% (349) | zinc-binding dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5021 | - | 2e-64 | 38.92% (352) | alcohol dehydrogenase, zinc-containing |
| M. thermoresistible (build 8) | TH_4349 | - | 1e-34 | 31.07% (338) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_4777 | - | 9e-38 | 30.38% (339) | zinc-dependent alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0527 | - | 0.0 | 99.71% (343) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0556|M.gilvum_PYR-GCK ----MRAAIYHGRED-VRIEELPDPSPRAGEVVIEVARAGICGTDLHEYI
Mvan_0527|M.vanbaalenii_PYR-1 ----MRAAIYHGRED-VRIEELPDPSPRAGEVVIEVARAGICGTDLHEYI
MSMEG_5021|M.smegmatis_MC2_155 ----MKAAVYHGPNK-LEIADLPEPQPGPGTVKVKVGFNGICGTDLHEYY
MMAR_0343|M.marinum_M MAATMRAERFYADSKTVVLEDVPIPEPGPGEVLVKVAYCGICHSDLSLIN
MUL_4777|M.ulcerans_Agy99 MAATMRAERFYADSKTVVLEDVPIPEPGPGEVLVKVAYCGICHSDLSLIN
Rv1895|M.tuberculosis_H37Rv ----MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLHFYE
MAV_2804|M.avium_104 ----MRTVVVDGPRSIRVDTRPDPVLPGPDGAIVEVSAAGICGSDLHFYE
TH_4349|M.thermoresistible__bu ----MKALRLMDWKSEPELVEVPDPTPGPGQVLVKIGGAGACHSDLHLMH
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE
MAB_2084|M.abscessus_ATCC_1997 --MKTRAAVLWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEHLVT
Mb3753|M.bovis_AF2122/97 ----MKAVTCT--NAKLEVVDRPSPAPAKGQLLLDVLRCGICGSDLHARL
: * . : : * * :*
Mflv_0556|M.gilvum_PYR-GCK AGPMHAAPG--------------VVIGHEYSGTVVGVGSGVREFTE-GDR
Mvan_0527|M.vanbaalenii_PYR-1 AGPMHAAPG--------------VVIGHEYSGTVVGVGSGVREFTE-GDR
MSMEG_5021|M.smegmatis_MC2_155 AGPIFVPTEPHP----LTGQVMPLTMGHEFAGTITDVGAGVTGFAP-GDR
MMAR_0343|M.marinum_M G---TFP-----------TQAPVVTQGHEASGTIAKLGPEVDGWSE-GDR
MUL_4777|M.ulcerans_Agy99 G---TFP-----------TQAPVVTQGHEASGTIVKLGPEVDGWSE-GDR
Rv1895|M.tuberculosis_H37Rv G---EYP------------FTEPVALGHEAVGTIVEAGPQVRTVGV-GDL
MAV_2804|M.avium_104 A---DFP------------MPDPIALGHEAIGTVVEAGPQVRNVKV-GDQ
TH_4349|M.thermoresistible__bu D---FEPGM--------MPWQLPFTLGHENAGWVAAVGAGVGTVTE-GDA
MLBr_01784|M.leprae_Br4923 GG---------------INDRYPFLLGHEAAGTVEVVGPGVTAVEP-GDF
MAB_2084|M.abscessus_ATCC_1997 G---------------DLPIPLPVVGGHEGAGTVVECGEGVEDLSE-GDS
Mb3753|M.bovis_AF2122/97 HCDELADVMAESGYHAFMRSNQQVVFGHEFCGEVVDYGPGTRRTPRRGTP
. *** * : * . *
Mflv_0556|M.gilvum_PYR-GCK VCGVGVFGCGECGFCKQGAEALCGA---VGFIGFAV--------------
Mvan_0527|M.vanbaalenii_PYR-1 VCGVGVFGCGECGFCKQGAEALCGA---VGFIGFAV--------------
MSMEG_5021|M.smegmatis_MC2_155 VAIEPIYRCGHCAPCRAGNYNVCQQ---IGFHGLMC--------------
MMAR_0343|M.marinum_M VVVAAGRPCQSCPNCRRGDTVNCLR---IQLMAFAY--------------
MUL_4777|M.ulcerans_Agy99 VVVAAGRPCQSCPNCRRGDTVNCLR---IQLMAFAY--------------
Rv1895|M.tuberculosis_H37Rv VMVSSVAGCGVCPGCETHDPVMCFS--GPMIFGAGV--------------
MAV_2804|M.avium_104 VMVSSVAGCGSCAGCATRDPVLCHS--GFQIFGGGV--------------
TH_4349|M.thermoresistible__bu VAVYGPWGCGTCERCMGGAENYCENPAGAPVLSGGAG-------------
MLBr_01784|M.leprae_Br4923 VILNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTLIDGTE--------LT
MAB_2084|M.abscessus_ATCC_1997 VILTFLPSCGRCSYCARGMGNLCELG-AALMMGPQIDGTYRFHARGEDVG
Mb3753|M.bovis_AF2122/97 VVAMPLLRRGNKEVHGIGLSTMAPG-------------------------
* .
Mflv_0556|M.gilvum_PYR-GCK ----NGALARYASLPTKALF--RIPDEISLAEAAVVEP-IASAYHAVRR-
Mvan_0527|M.vanbaalenii_PYR-1 ----NGALARYASLPTKALF--RIPDEISLAEAAVVEP-IASAYHAVRR-
MSMEG_5021|M.smegmatis_MC2_155 ----DGGMAEYTVVPVDMLH--KLPDNVSLQLGALVEP-MSVAYHAATL-
MMAR_0343|M.marinum_M ----DGAWAEYTVAQAAGLT--RVPDNVSLDQAAILADAVSTPFGAVVR-
MUL_4777|M.ulcerans_Agy99 ----DGAWAEYTVAQAAGLT--RVPDNVSLDQAAILADAVSTPFGAVVR-
Rv1895|M.tuberculosis_H37Rv ---LGGAQADLLAVPAADFQVLKIPEGITTEQALLLTDNLATGWAAAQR-
MAV_2804|M.avium_104 ---LGGAQADLLAVPAADFQLLKIPEGISTEQALLLTDNLATGWAAAQR-
TH_4349|M.thermoresistible__bu -LGMDGGMAEYLLVP-AERLVVKLPESMTPVTAAALTDAGLTPYHAIRRS
MLBr_01784|M.leprae_Br4923 PALGIGAFADKTLVHSGQCT--KVDPAADPAVAGLLGCGVMAGLGAAIN-
MAB_2084|M.abscessus_ATCC_1997 QMCLLGTFSEYTVVPQASVV--KIDGGIPLDRAALIGCGVTTGYGSAVR-
Mb3753|M.bovis_AF2122/97 ------AYAERLVVEQSLTFP--VPNGLAPEIAALTEP-MAVGWHAVRR-
: : . :
Mflv_0556|M.gilvum_PYR-GCK -SGLAAGGTVFIAGAGPIGLALVQFSLAQGATQVIVSEVSATRRVAAHRV
Mvan_0527|M.vanbaalenii_PYR-1 -SGLAAGGTVFIAGAGPIGLALVQFSLAQGATQVIVSEVSATRRVAAHRV
MSMEG_5021|M.smegmatis_MC2_155 -GDVGAGDTAVVFGAGPIGIGLWFALRGKGLESVYVAEPSPTRRAAIEAL
MMAR_0343|M.marinum_M TGKVAVGESVGVWGVGGVGTHIVQLARLVGAVPVIALDINPVVLDRALEL
MUL_4777|M.ulcerans_Agy99 TGKVAVGESVGVWGVGGVGTHIVQLARLVGAVPVIALDINPVVLDRALEL
Rv1895|M.tuberculosis_H37Rv -ADISFGSAVAVIGLGAVGLCALRSAFIHGAATVFAVDRVKGRLQRAATW
MAV_2804|M.avium_104 -ADIPFGGTVAVIGLGAVGLCALRSALFQGAATVFAVDQVDGRLARAARW
TH_4349|M.thermoresistible__bu WPKLTPTSTAVVIGVGGLGHVAVQLVKATTAARLIAVDNRSEALELAREM
MLBr_01784|M.leprae_Br4923 TAAVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTF
MAB_2084|M.abscessus_ATCC_1997 TGEVRAGDTVVVVGAGGIGMNAIQGARIAGALAIVAVDPVNFKREQASGF
Mb3753|M.bovis_AF2122/97 -GEVGKGDVAIVIGCGPIGLAVICMLKSRGVHTVIASDFSPGRRALATAC
: . : * * :* : . :
Mflv_0556|M.gilvum_PYR-GCK GATRVIDPLAEDAVEVVRTLTNGN--------------------------
Mvan_0527|M.vanbaalenii_PYR-1 GATRVIDPLAEDAVEVVRMLTNGN--------------------------
MSMEG_5021|M.smegmatis_MC2_155 GAQ-TLDPTQVDVPAFIADVTGGR--------------------------
MMAR_0343|M.marinum_M GADYAFDSRDDQLHDKLAEITGGR--------------------------
MUL_4777|M.ulcerans_Agy99 GADYAFDSRDDQLHDKLAEITGGR--------------------------
Rv1895|M.tuberculosis_H37Rv GATPIPSP----AAETILAATRGR--------------------------
MAV_2804|M.avium_104 GATPLKAP----ALEAILAATGGR--------------------------
TH_4349|M.thermoresistible__bu GADHVVRSDE-QAVEAIWELTGGR--------------------------
MLBr_01784|M.leprae_Br4923 GATHTVNALELEVVKTIQDLTSGF--------------------------
MAB_2084|M.abscessus_ATCC_1997 GATHTAASMD-EAWSLVSDMTRGK--------------------------
Mb3753|M.bovis_AF2122/97 GADSVVDPVQDSPYAVAAGLGQGNRHLQSILDAFDLAVGTVESLQRLRLP
** . *
Mflv_0556|M.gilvum_PYR-GCK ----------------GVDISFDAAGVQP--ALDAALGVLRPRGRLMVVA
Mvan_0527|M.vanbaalenii_PYR-1 ----------------GVDISFDAAGVQP--ALDAALGVLRPRGRLMVVA
MSMEG_5021|M.smegmatis_MC2_155 ----------------GADAAFDAAGVAP--AIEAATASVGSRRPTISVA
MMAR_0343|M.marinum_M ----------------MLDVAFDAVGLKA--TFEQALGSLTAGGRLVGVG
MUL_4777|M.ulcerans_Agy99 ----------------MLDVAFDAVGLKA--TFEQALGSLTAGGRLVGVG
Rv1895|M.tuberculosis_H37Rv ----------------GADSVIDAVGTDA--SMSDALNAVRPGGTVSVVG
MAV_2804|M.avium_104 ----------------GADAVIDAVATDA--SLTEALNAVRPGGTVSVVG
TH_4349|M.thermoresistible__bu ----------------GADVLLDFVGADA--TIELARAAARPLGDVTIVG
MLBr_01784|M.leprae_Br4923 ----------------GVDVVIDTVGRPE--TWKQAFYARDLAGTVVLVG
MAB_2084|M.abscessus_ATCC_1997 ----------------LADVCILTTDVAEGSYTAEALALVGKRGRVVVTA
Mb3753|M.bovis_AF2122/97 WWHLWRAAEAAGAATPKRPVIFECVGVPG--IIDGIIASAPLFSRVVVVG
: . ..
Mflv_0556|M.gilvum_PYR-GCK IWEAPAGIDINRSVMREA-----NIGFSFCYEAQRQVPAILDLLATGAIN
Mvan_0527|M.vanbaalenii_PYR-1 IWEAPAGIDINRSVMREA-----NIGFSFCYEAQRQVPAILDLLATGAIN
MSMEG_5021|M.smegmatis_MC2_155 IYEKPLTTPLLNLVMNES-----RIQGSLCYTSA-DFEAVIALMADGVYD
MMAR_0343|M.marinum_M MSAESPTVGPTSMFGLTH-----KQVLGHLGYQNVDIETLAKLVSLGRLD
MUL_4777|M.ulcerans_Agy99 TSAESPTVGPTSMFGLTH-----KQVLGHLGYQNVDIETLAKLVSLGRLD
Rv1895|M.tuberculosis_H37Rv VHDLQPFPVPALTCLLRS-----ITLRMTMAPVQRTWPELIPLLQSGRLD
MAV_2804|M.avium_104 VHDMNPFPLNALGCLIRS-----ITLRMTTAPVQRTWPELIPLLQSGRLD
TH_4349|M.thermoresistible__bu IAGGS----VPLSFFSQP-----YEVSIQTTYWG-TRPELVELLDLAARG
MLBr_01784|M.leprae_Br4923 VPTPDMRLDMPLLDFFSHGG-SLKSSWYGDCLPERDFPTLVDLYLQGRLP
MAB_2084|M.abscessus_ATCC_1997 IGHPDESSISGSLLEMTLYEKQIRGALYGSSNAPHDIPRLVELYSAGLLK
Mb3753|M.bovis_AF2122/97 VCMGSDHIRPAMAINKEIN------LRFVLGYTPLEFRDTLHMLADGKVN
: .
Mflv_0556|M.gilvum_PYR-GCK LGELITDEIPLDAVVSQGLEELRVNRDAHVKILIDPSA------------
Mvan_0527|M.vanbaalenii_PYR-1 LGELITDEIPLDAVVSQGLEELRVNRDAHVKILIDPSA------------
MSMEG_5021|M.smegmatis_MC2_155 TTGWVT-TIGIDDVIDEGFEALHAGR--KMKVLIDPAI------------
MMAR_0343|M.marinum_M LSRSISEIVPLEDLP-LGIEKLERQDGNPIRILVQP--------------
MUL_4777|M.ulcerans_Agy99 LSRSISEIVPLEDLS-LGIEKLERQDGNPIRILVQP--------------
Rv1895|M.tuberculosis_H37Rv VDGIFTTTLPLDEAA-KGYATARARSGEELRFCLRPDSRDVLGAHETVDL
MAV_2804|M.avium_104 VDGIFTTTMPLDEAA-IGYATAGSRSGDDVKILLKP--------------
TH_4349|M.thermoresistible__bu LVHVESTTYPLDDAL-QAYRDLRAGRVRGRAVIVP---------------
MLBr_01784|M.leprae_Br4923 LGKFVSERIGLGDVE-EAFHKIHGGKVLRSVVML----------------
MAB_2084|M.abscessus_ATCC_1997 LDELVTREYSLDQIN-EGYQDMRSGRNIRGLVRF----------------
Mb3753|M.bovis_AF2122/97 AAPLITGTVGLPGVA--AAFDALGDPEAHAKIMIDPKSNAASPQPFRVE-
: : . . .
Mflv_0556|M.gilvum_PYR-GCK -----------------------------
Mvan_0527|M.vanbaalenii_PYR-1 -----------------------------
MSMEG_5021|M.smegmatis_MC2_155 -----------------------------
MMAR_0343|M.marinum_M -----------------------------
MUL_4777|M.ulcerans_Agy99 -----------------------------
Rv1895|M.tuberculosis_H37Rv YVHVRRCQSVADLQLEGAADGVDGPSMLN
MAV_2804|M.avium_104 -----------------------------
TH_4349|M.thermoresistible__bu -----------------------------
MLBr_01784|M.leprae_Br4923 -----------------------------
MAB_2084|M.abscessus_ATCC_1997 -----------------------------
Mb3753|M.bovis_AF2122/97 -----------------------------