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VYSIQGMTQRMIFTLLVMDSIGHNFHGSWRHPAARNREFKGFDMWVDLARKAEQAKVDAFFFTDVMGVQG EYNGKRDIVFEMAMNVPIGDCTMLIPALAQQTRDLGFLYTSSVISHHPFVFARAASTLDNLSNGRIGWNI VTSANEKAFRNLGLPGNLSHDERYVWAQEYVDVTYKLWEGSWDVDAIVDDPASGVYADPSKVHDINHKGA RYSVEGFNLMEPSPQRTPVLAQAGGSPAGLAFAGKHAELMFLSAYSLETIAAQVGAVREQARTNGRRDGD ILFLQGMMFVIGSTDEEAYRKWGELEEWRSPEAQTAYFSSLSGMDLGRYDPGTPLENILDEIPGIQGAFL AVINAWPDGSKPTIKDFLTSLSLPQMVVGSPETIAGRLLEYQGAGVNGVQVMNALLPNSYAEFFEHLVPV LQDKGIMQKEYQPGTLRQKLFGSGPDISERHPAHGYRGMFC
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1269 | - | - | 100% (461) | putative monooxygenase |
| M. gilvum PYR-GCK | Mflv_0250 | - | 3e-56 | 32.22% (419) | hypothetical protein Mflv_0250 |
| M. gilvum PYR-GCK | Mflv_0214 | - | 5e-21 | 29.07% (258) | fmnh2-utilizing oxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3401 | - | 3e-85 | 37.36% (455) | putative monooxygenase |
| M. marinum M | MMAR_0703 | - | 5e-49 | 32.47% (425) | FMNH2-utilizing oxygenase |
| M. avium 104 | MAV_4059 | - | 2e-81 | 36.56% (454) | monoxygenase |
| M. smegmatis MC2 155 | MSMEG_2841 | - | 1e-117 | 46.41% (459) | putative monooxygenase |
| M. thermoresistible (build 8) | TH_4268 | - | 1e-89 | 38.51% (444) | PUTATIVE putative monooxygenase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_3887 | - | 1e-104 | 43.56% (450) | putative monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 MTLTSPAAASAGDLPARPGLRTVAAGSMIGTTIEWYDFYLYATASALVFK
MSMEG_2841|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0703|M.marinum_M --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 PLFFPNISPSAGTLASFATYAAGFGARPLGAVLSGHFGDRLGRKTVLVAA
MSMEG_2841|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0703|M.marinum_M --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 LLVMGLVTTAIGALPTYAEAGLAAPALLASLRVVQGLAVGAEWGGAAVLS
MSMEG_2841|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0703|M.marinum_M --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 VEHAPPGRRGLFGSFTQLGSPAGMLLATSVFFGVRKATGPAAFLGFGWRI
MSMEG_2841|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0703|M.marinum_M --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 PFLLSIFLVAVGLFVRLRLTDAEVFDRLRSRDELARLPIVQVLRTDARNV
MSMEG_2841|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0703|M.marinum_M --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 VITTGLRLSQIGLFVLLTTYSLSYLQDSFGKGSGVGLVAVLISSALGFLS
MSMEG_2841|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0703|M.marinum_M --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 TPGWALLSDRVGRRPPYLFGALASVVALVLFFVAAGTGSAVLVVVAIVFG
MSMEG_2841|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0703|M.marinum_M --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 VNVVHDAMYGPQAAWFAELFDTRVRYSGSSLGYHIGAVLSGGFAPLIAAS
MSMEG_2841|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3887|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1269|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0703|M.marinum_M --------------------------------------------------
MAB_3401|M.abscessus_ATCC_1997 -----------------------------------------MTRVIRFNA
TH_4268|M.thermoresistible__bu --------------------------------------------------
MAV_4059|M.avium_104 LLVAGGGRPWLIVGYFAVLAAITVGAACAGPGDARGADRMSAARRIYLNA
MSMEG_2841|M.smegmatis_MC2_155 ----------------------------MDATGTGPSVGVMTRPRLILNA
Mvan_3887|M.vanbaalenii_PYR-1 ----------------------------------------MTKRPLYYSA
Mflv_1269|M.gilvum_PYR-GCK ----------------------------------MYSIQGMTQR-MIFTL
MMAR_0703|M.marinum_M ----------------------------------------MIRKPVHLAA
MAB_3401|M.abscessus_ATCC_1997 FDMNCVAHQSPGLWRHPDDQSWRYKDLSYWTNLATLLERGRFDGLFIADV
TH_4268|M.thermoresistible__bu --MNCVAHQSPGLWKHPEDQSWRYKDLEYWTELARLLERGRFDGLFIADV
MAV_4059|M.avium_104 FDMACVGHQSAGLWRHPDDQGHRYRELSYWTELARTLEAGGFDALFLADV
MSMEG_2841|M.smegmatis_MC2_155 FTMNTATHVAYGAWRNPETRSVEFDQLDPWVELVKLLERGKFDSIFFADV
Mvan_3887|M.vanbaalenii_PYR-1 FVMNTASHVLHGLWRAPDAQNHRFNSLRHWTSLAAEVDKAGYDVLFFADV
Mflv_1269|M.gilvum_PYR-GCK LVMDSIGHNFHGSWRHPAARNREFKGFDMWVDLARKAEQAKVDAFFFTDV
MMAR_0703|M.marinum_M HFP---GVNNTTVWADPGAGS--QIEFESFVHLARTAERGLFDFFFLAEG
* * . : :. *. : . * :*:::
MAB_3401|M.abscessus_ATCC_1997 LGTYDIYGASDEAAIRQAAQIPVADPLLLVSAMALVTEHLGFGVTTGTGF
TH_4268|M.thermoresistible__bu LGTYDVYGAGDEAAIRQAAQIPVNDPMMLVSAMALVTEHLGFGITTGTGF
MAV_4059|M.avium_104 LGVYDIYGASRDAAVVDAAQFPVNEPSAAVSAMAAVTETLGFGITLSLTY
MSMEG_2841|M.smegmatis_MC2_155 VGLYDDYRGGWETYLREGLQIPNHDPSAIVSALALSTEHLGLVITSSVLQ
Mvan_3887|M.vanbaalenii_PYR-1 FGLRAPWNGNWRKAVEGGIQVPVNDPSVLASAIAAATENLGIVFTSSIVQ
Mflv_1269|M.gilvum_PYR-GCK MGVQGEYNGKRDIVFEMAMNVPIGDCTMLIPALAQQTRDLGFLYTSSVIS
MMAR_0703|M.marinum_M LRLREHRG-----RIHDLDVVGRPDTFTLLAALAGVTDRIGLTGTINTTF
. . . : .*:* * :*: * .
MAB_3401|M.abscessus_ATCC_1997 EHPYPFARRLSTLDHLTGGRVGWNVVTGYLPAAARNMGQTDQPAHDARYD
TH_4268|M.thermoresistible__bu EHPYPFARRMSTLDHLTKGRIGWNVVTGYLPAAARNMGQSDQPAHDARYD
MAV_4059|M.avium_104 EQPYALARRLSTLDHLTGGRVAWNIVTSYLDSAARNLGLDAQIPHDQRYE
MSMEG_2841|M.smegmatis_MC2_155 DHPFSFARKISTLDHASKGRIGWNVVTSALQNSARNFGLPEREEHDERYQ
Mvan_3887|M.vanbaalenii_PYR-1 DHPFNFARRMSSLDHYTDGRLGWNIVTSFNANMFRSFGHEGTLAHDQRYE
Mflv_1269|M.gilvum_PYR-GCK HHPFVFARAASTLDNLSNGRIGWNIVTSANEKAFRNLGLPGNLSHDERYV
MMAR_0703|M.marinum_M NEPFEVARQFATLDHLSEGRAGWNIVTSSDAFTGANFRRGGYLDHADRYQ
..*: .** ::**: : ** .**:**. .: * **
MAB_3401|M.abscessus_ATCC_1997 HADEYLEVLYKLWEGSWEDDAVVRDAARGVFTDPDKVHHIGHEGTHFTVP
TH_4268|M.thermoresistible__bu HADEYLEVLYKLWEGSWEDDAVIRDRERGVFTDPDKVHHIGHRGRHFSVP
MAV_4059|M.avium_104 IADEYLEVCYKLWEGSWEAGAVLRDRQRGVFTDPAKVHDIEHKGRYFSVP
MSMEG_2841|M.smegmatis_MC2_155 WAEEYTEVVYKLWEGSWDDGALLRDRERGIHADPDKVHKIHHIGKRYRVE
Mvan_3887|M.vanbaalenii_PYR-1 WANEYVDVTYKLWEGSWDDDALVQDKERSVHSDPSKIHKINHVGRRYTVE
Mflv_1269|M.gilvum_PYR-GCK WAQEYVDVTYKLWEGSWDVDAIVDDPASGVYADPSKVHDINHKGARYSVE
MMAR_0703|M.marinum_M RAEEFLTVARKFWD-SWAPGAVLADIENGDYVDPERIRSVEHSGPQFEVR
*:*: * *:*: ** .*:: * . . ** ::: : * * : *
MAB_3401|M.abscessus_ATCC_1997 GVHLVEPSPQRTPVIYQAGSSPRGVRFAAENAEAVFTAAPTKELLRQTVT
TH_4268|M.thermoresistible__bu GVHLSEPSPQRTPVIYQAGSSPRGVRFAAENAEAIFTASPTKEILRRTVS
MAV_4059|M.avium_104 GPFLCEPSPQRTPVLFQAGASPRGIRFAAAHAEAVFVSGPTAQVVREPVR
MSMEG_2841|M.smegmatis_MC2_155 GPHLSFPSPQRTPVLFQAGTSTAGRAFAARHAEGVFINAASPKGARVVID
Mvan_3887|M.vanbaalenii_PYR-1 GPHFTSPSPQRTPVLFQAGSSPAGQLFSARNAEGVYISSPTPADAHKLTG
Mflv_1269|M.gilvum_PYR-GCK GFNLMEPSPQRTPVLAQAGGSPAGLAFAGKHAELMFLSAYSLETIAAQVG
MMAR_0703|M.marinum_M GFATLPAGPQGHPVLLQAGDSEQGRAFGARHADAMFTLHSSLRDGQRYYA
* ..** **: *** * * *.. :*: :: :
MAB_3401|M.abscessus_ATCC_1997 TIRRELELAGRDPYSAKIFNLTTVVTGENSEAAHAKHAELLGYGSA-EGA
TH_4268|M.thermoresistible__bu TIRQELEIAGRDPYSVKIFNLTTIITAETDEEAHARHAEYLAYGDP-EGA
MAV_4059|M.avium_104 ALRTAAAQLGRDPRAVKVFTMVTPVVAETHDAAVAKLAEYRRFVSP-RGA
MSMEG_2841|M.smegmatis_MC2_155 DTRDRAVAAGRRREDIKFFQGLSFVVGSTEVEARARAAELDEYLSV-DAL
Mvan_3887|M.vanbaalenii_PYR-1 ETRALAAANGRDPQDITFAQGLSFVIGDTHAEAVRRNDELKRYLDV-EGV
Mflv_1269|M.gilvum_PYR-GCK AVREQARTNGRRDGDILFLQGMMFVIGSTDEEAYRKWGELEEWRSP-EAQ
MMAR_0703|M.marinum_M DVKGRARSYGRDPDQLKVFPAATFVIGDTPDQAGEKARQISYQQVSGATA
: ** . : ... * : :
MAB_3401|M.abscessus_ATCC_1997 LVFMSGWMGVDLARYGLDEPIGNVD--SNAILSA----------VAAFQA
TH_4268|M.thermoresistible__bu LTFMSGWMGVDLARYGLDEPVGNVD--SNAILSA----------VAAFQS
MAV_4059|M.avium_104 LALFGGWTGVDLAELDPDEPLTYVE--TDANRSA----------LASFTT
MSMEG_2841|M.smegmatis_MC2_155 IAHRSGGIGVDLGGLDHHTPIGDLAPTVQGTRST----------IEALIA
Mvan_3887|M.vanbaalenii_PYR-1 ALHALGDAGIDAGNLPLDTPISALG-EFTGIQS-----------FSRWAA
Mflv_1269|M.gilvum_PYR-GCK TAYFSSLSGMDLGRYDPGTPLENILDEIPGIQGA----------FLAVIN
MMAR_0703|M.marinum_M IAMLEQVWGRDLSDYDPDGPLPDIDPIADAAISQGRVRHADPVAVARRYR
* * . *: : . . .
MAB_3401|M.abscessus_ATCC_1997 ATADGREWKVRDIAEWGEIGGMGPRIVGSGTEVADTLQEWVEETDVDGFN
TH_4268|M.thermoresistible__bu ADPDGREWAVRDIAEWGKIGGMGPRIVGSGFTVADTLQEWVEETDVDGFN
MAV_4059|M.avium_104 A---GRAWTVAELAAEIGIGGRGPVLVGSPTEVADELERWVDDADVDGFN
MSMEG_2841|M.smegmatis_MC2_155 AAPPGTNPTIADLVRQQQES---TRIVGTPEQIADALEEWQDAG-VDGLN
Mvan_3887|M.vanbaalenii_PYR-1 EISGNDEPTIRDMAWALEGA---NRVVGTPKEIADRLEEWREAG-VDGIN
Mflv_1269|M.gilvum_PYR-GCK AWPDGSKPTIKDFLTSLSLP---QMVVGSPETIAGRLLEYQGAG-VNGVQ
MMAR_0703|M.marinum_M ERSQAENLSIRELVIAVTSR---QQFVGTPSHIADEIDRYVQADACDGFI
: :: .**: :*. : .: :*.
MAB_3401|M.abscessus_ATCC_1997 LAYAITPGTFEDFIEYVVPVLTERGAYQSSYTPGTLRHKLLGHGDRLPEE
TH_4268|M.thermoresistible__bu LAYAITPGSFAQFIEHVVPVLTERGAYQPAYTPGTLRHKLFGKGDRLPDD
MAV_4059|M.avium_104 VAYVTTPGTFVDFAKFVVPELRRRGHVPEQVPGSTLRERLGAAGPLLGDD
MSMEG_2841|M.smegmatis_MC2_155 IRYITTPGSFADFIDHVVPELQSRGLAQTEYAPGTLREKLFGNGPHLPER
Mvan_3887|M.vanbaalenii_PYR-1 VYHATLPASFREVADRLFPTLRERGLIGTDKS-GTLRHKLLGRGDRLPDT
Mflv_1269|M.gilvum_PYR-GCK VMNALLPNSYAEFFEHLVPVLQDKGIMQKEYQPGTLRQKLFGSGPDISER
MMAR_0703|M.marinum_M LVPHLTPHGLDEFVDRVVPLLQERGAFRTAYTGQTLRDHLGLAG--LPS-
: * :. . :.* * :* ***.:* * : .
MAB_3401|M.abscessus_ATCC_1997 HRGAKYRIGGPLSTIIDRPSTVPSSSGSTAPAPTPGR
TH_4268|M.thermoresistible__bu HRGSRYRVGGPLSTIIDRPSTLPSSPASAASQPISGR
MAV_4059|M.avium_104 HPGAAYRLRR------DR-------------------
MSMEG_2841|M.smegmatis_MC2_155 HPARHWRGRFREADVAARAVSESV-------------
Mvan_3887|M.vanbaalenii_PYR-1 HPAARYRGAFSDNSLADR-VPETVGSV----------
Mflv_1269|M.gilvum_PYR-GCK HPAHGYRGMFC--------------------------
MMAR_0703|M.marinum_M -------------------------------------