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MTHRASALISAQEWFSAGERVGYDAERPGINPRSPLRAFIRRAAGTGVTRTFLPGWPDGSYGWAKVEAFL SSRFHFPRIYLDYIGHGDSDKPRDYPYSTFERADLVEALWHAEGIAQTVVVAFDYSCIVSLELLARRIDR ERAGNDQRTRITACLLANGGIFADGHTHAWYTTPLLTSPLGAAITPIGQRSWRMFAPFLRPSSRADTH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3202c | mesTa | - | 100% (208) | epoxide hydrolase MesTa |
| M. bovis AF2122 / 97 | Mb1865 | - | 6e-11 | 27.84% (194) | hydrolase |
| M. bovis AF2122 / 97 | Mb2734 | - | 9e-05 | 40.79% (76) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3952 | - | 9e-05 | 39.44% (71) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3176c | mesT | 1e-119 | 100.00% (201) | epoxide hydrolase MesT |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4300 | - | 2e-13 | 29.95% (207) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_2711 | - | 7e-11 | 31.25% (128) | hydrolase |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_2777 | - | 4e-12 | 32.88% (146) | alpha/beta hydrolase fold |
| M. thermoresistible (build 8) | TH_4027 | - | 3e-12 | 33.33% (126) | PUTATIVE hydrolase |
| M. ulcerans Agy99 | MUL_3053 | - | 4e-11 | 31.25% (128) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_2445 | - | 0.0001 | 39.47% (76) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3202c|M.bovis_AF2122/97 -----------------MTHRASALISAQEWFSAGERVGYDAERPGINPR
Rv3176c|M.tuberculosis_H37Rv -----------------MTHRASALISAQEWFSAGERVGYDAERPGINPR
MMAR_2711|M.marinum_M ----------------------MTSPSVSDWRAGGGWINTAAG-------
MUL_3053|M.ulcerans_Agy99 MNCRPITLVTLLSWSSRWYARRVTSPSVSDWRAGGGWINTAAG-------
TH_4027|M.thermoresistible__bu ---------------------------VARWRAEGRWIRTGVG-------
MAB_4300|M.abscessus_ATCC_1997 -----------------------MDAELEEWKAAGHYFDYLGF-------
MSMEG_2777|M.smegmatis_MC2_155 -----------------------MHDELQRWKDAGQYFDYLGF-------
Mflv_3952|M.gilvum_PYR-GCK -----------------MTARTPNLRPVRELTPTLRYCTIHGY-------
Mvan_2445|M.vanbaalenii_PYR-1 -----------------MTERKPNLRPVRELTPTLKFCTIHGY-------
Mb3202c|M.bovis_AF2122/97 SPLRAFIRRA---AGTGVTRTFLPGWPDGSYGWAKVEAFLSSRFHFPRIY
Rv3176c|M.tuberculosis_H37Rv SPLRAFIRRA---AGTGVTRTFLPGWPDGSYGWAKVEAFLSSRFHFPRIY
MMAR_2711|M.marinum_M ---KVFVRSG---EGIAPTVLLLHGFPSSSFDFRSVIPYLAGQAWLT---
MUL_3053|M.ulcerans_Agy99 ---KVFVRSG---EGIAPTVLLLHGFPSSSFNFRSVIPYLAGQAWLT---
TH_4027|M.thermoresistible__bu ---SVFVRSA---SGRGSPVVLLHGYPSSSYDYRAVLPELGDRGWVT---
MAB_4300|M.abscessus_ATCC_1997 ---DIFYRVE----GSGPPLLLIHGYPFNSWDWALIWPTLVERFTVIAP-
MSMEG_2777|M.smegmatis_MC2_155 ---DIFYRVDGVAPGTGPNLLLIHGYPFNSWDWSLIWPTLTQRFTVIAP-
Mflv_3952|M.gilvum_PYR-GCK ---RRAYRIA----GSGPAILLIHGIGDNSTTWAGVQTQLAQRFTVIAP-
Mvan_2445|M.vanbaalenii_PYR-1 ---RRAFRVA----GSGPAILLIHGIGDNSTTWSTVQTQLAQRFTVIAP-
* * . :: * .* : : . * : .
Mb3202c|M.bovis_AF2122/97 LDYIGHGDSDKPRDYPYSTFERADLVEALWHAEGIAQTVVVAFDYSCIVS
Rv3176c|M.tuberculosis_H37Rv LDYIGHGDSDKPRDYPYSTFERADLVEALWHAEGIAQTVVVAFDYSCIVS
MMAR_2711|M.marinum_M MDFLGFGLSDKPRPHRYSLLEQADLVQNVVAQNVTGPVVVLAHDMGTSVT
MUL_3053|M.ulcerans_Agy99 MDFLGFGLSDKPRPHRYSLLEQADLVQNVVAQNVTGPVVVLAHDMGTSVT
TH_4027|M.thermoresistible__bu FDFLGFGLSDKPRPHRYSLFEQADLVQTVVRSVTDEPVLLIAHDMGTSVA
MAB_4300|M.abscessus_ATCC_1997 -DMIGMGFSDKPVQYGYSVLDHADMHEALLSYLGIERFHLLTHDLGNSVG
MSMEG_2777|M.smegmatis_MC2_155 -DMIGMGFSDKPVAYEYRVTDHADIHEALLAHLGITSTHILAHDLGDSVG
Mflv_3952|M.gilvum_PYR-GCK -DLLGHGKSDKPR-ADYSVAAYANGMRDLLSVLNIDSATVVGHSLGGGVA
Mvan_2445|M.vanbaalenii_PYR-1 -DLLGHGRSDKPR-ADYSVAAYANGMRDLLSVLDIDDVTVIGHSLGGGVA
* :* * **** * *: . : :: .. . *
Mb3202c|M.bovis_AF2122/97 LELLARRIDRERAGNDQ----RTRITACLLANGGIFADGHTHAWYTTPLL
Rv3176c|M.tuberculosis_H37Rv LELLARRIDRERAGNDQ----RTRITACLLANGGIFADGHTHAWYTTPLL
MMAR_2711|M.marinum_M TELLARDLEGRLP---------FELQRAVLSNGSVILE-RASLRPIQKVL
MUL_3053|M.ulcerans_Agy99 TELLARDLEGRLP---------FELQRVVLSNGSVILE-RASLRLIQKVL
TH_4027|M.thermoresistible__bu TELMARDLQGQLP---------FRLQRVVLSNGSVLLD-RASLRPIQKVL
MAB_4300|M.abscessus_ATCC_1997 QEMLARFEFEQQSRG------RVPIDSVTWLNGGLFIEAYRPRIAQTLMS
MSMEG_2777|M.smegmatis_MC2_155 QEMLARHEFGGQAYG------GFQIESVTWLNGGLFNEAYRPRLMQKVMS
Mflv_3952|M.gilvum_PYR-GCK MQFAYQFPQLVDRLILVGAGGVTKDVNIALRAASLPMGTEALALLRLPLL
Mvan_2445|M.vanbaalenii_PYR-1 MQFAYQFPQLVNRLILVGAGGVTKDVNIALRLASLPMGSEALALLRLPLV
:: : ..: :
Mb3202c|M.bovis_AF2122/97 T---SPLGAAITPIGQRSW--RMFAPFLRPS-SR----------------
Rv3176c|M.tuberculosis_H37Rv T---SPLGAAITPIGQRSW--RMFAPFLRPVFSRGYPLSAAEMKELHDAI
MMAR_2711|M.marinum_M R---GPLGPIAARLVNR----GGFTRGFGKLFSAQHPLSAQEAEAQWELL
MUL_3053|M.ulcerans_Agy99 R---GPLGPIAARLVNR----GGFTRGFGKLFSAQHPLSAQEPEAQWELL
TH_4027|M.thermoresistible__bu R---GRFGPVVSQLVNE----PMFIRGLGKVFSKQRPLSAAEGAAQWALM
MAB_4300|M.abscessus_ATCC_1997 R---TPLGDLVSRFQGTPVTRRIMDAAVSEMFGPDTKPSPRLLSLFQQVL
MSMEG_2777|M.smegmatis_MC2_155 R---TPLGDILSPLQGSPLSRRVFESTLDQMFGVNTKPSREMIEKFHQIL
Mflv_3952|M.gilvum_PYR-GCK LPTLRLLGRVGGPLLGNTRIGRDIPNMLRILADLPEPTASSAFARTLRSV
Mvan_2445|M.vanbaalenii_PYR-1 LPALQVLGRVSGTVFGSTGVGRDIPDMLRILADLPEPTASSAFARTLRAV
:* . : . .
Mb3202c|M.bovis_AF2122/97 ---------------ADTH-------------------------------
Rv3176c|M.tuberculosis_H37Rv SRRDGVRVLPATAGFVDEHREHAARWDLARIISALGDEVAFGVVGSAEDP
MMAR_2711|M.marinum_M THNNGHRIAHLLISYLEERERYAQRWHN----AVRDWPKPLGFVWGLDDP
MUL_3053|M.ulcerans_Agy99 THNNGHRIAHLLISYLEERERYAQRWNN----AVRDWPKPLGFVWGLDDP
TH_4027|M.thermoresistible__bu SYHDGHRIMHLLTAYLNERVRYADRWHG----AVADWPKPLGLLWGTDDP
MAB_4300|M.abscessus_ATCC_1997 EYNDGARVTHQVGRFINDRYDNRSRWVR----AMRETAVPMRMIDGPIDP
MSMEG_2777|M.smegmatis_MC2_155 DHNDGKRVLHKVGRFVTDRYTHRNRWVR----AMRETSVPMRLIDGPSDP
Mflv_3952|M.gilvum_PYR-GCK VDWRGQVVTMLDRCYLTQSVPVQLIWGS----QDSVIPVSHAEMAHTAMP
Mvan_2445|M.vanbaalenii_PYR-1 VDWRGQVVTMLDRCYLTQSVPVQLIWGD----CDAVIPVSHGEMAHAAMP
Mb3202c|M.bovis_AF2122/97 --------------------------------------------------
Rv3176c|M.tuberculosis_H37Rv FEGEQLRLARERLADSVEITELAG-G-HLTTAEQPDRLAEVIAALPERS-
MMAR_2711|M.marinum_M VATTNVLNGLRELRPNAGVIELPG-LGHYPQVEDPKAYTQAALDLL----
MUL_3053|M.ulcerans_Agy99 VATTNVLNGLRELRPNAGVIELPG-LGHYPQVEDPKAYTQPALDLL----
TH_4027|M.thermoresistible__bu VATTDVLAGLRELRSDAEVIELAG-VGHYPQIEVPEVFARAALELLGLNR
MAB_4300|M.abscessus_ATCC_1997 NSGLHMAERYLEVIHDPDVVLLDDNIGHWPQIEAPEAVLTHFLEHIDRIT
MSMEG_2777|M.smegmatis_MC2_155 NSGRHMAQRYLEVIPDPDVVMLADDIAHWPQIEAPDAVLAHFLEHIDRVV
Mflv_3952|M.gilvum_PYR-GCK GSRLEIFEGAGHFPFHDEPDRFVELVEKFIDSTEPAVYDQEYLRTLLRTG
Mvan_2445|M.vanbaalenii_PYR-1 GSRLEVFEGSGHFPFHDDPDRFVEVVEKFIDTSEPAVYDHEYLRGLLRAG
Mb3202c|M.bovis_AF2122/97 ----------------------------
Rv3176c|M.tuberculosis_H37Rv ----------------------------
MMAR_2711|M.marinum_M -VG-------------------------
MUL_3053|M.ulcerans_Agy99 -VG-------------------------
TH_4027|M.thermoresistible__bu TIG-------------------------
MAB_4300|M.abscessus_ATCC_1997 P---------------------------
MSMEG_2777|M.smegmatis_MC2_155 AL--------------------------
Mflv_3952|M.gilvum_PYR-GCK TSENTLSGDVDTQVAVLDAIGADERSAT
Mvan_2445|M.vanbaalenii_PYR-1 ISEGTISGPADTRVAVLDAMGADERSAT