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MTAIFLGSSGTPGEDGGNGGAGGAGGAGGAHAGDGGAGGAGGNGGAGGAGGNGAHGFNAVLVSDGGNGGD GGAGGRGGDGGAGGAGGDAPAGRAGSQGVGGDGGAGGAGGAPGNGGSGGRGDMAFKDGDGGAGGDGGDPG AGGKGGAGGAGATEGVTGATGATVHSGGNGGKGGNGADATVAGANGGKGGAGGNGGLVGDGGAGGDGGSG AAGANGANVGEDGADGTLSGQPGEGSEANGGQGGVGGGGAGGAGGDGGAGSSALGSGGNGGRGDAGQAGG AGGAGGAGGAGGSVSGDGGPGGKGGAGGAGGAGASGGGGGKGASGADSAEAVGGAGGKGGDGGVGGVGGD GGPGGDGGAGGAAPAGQVGSHGVGGVGGDGGLGGAGGNGGDGGHGSDGGDGGDGGDPGAGGLGGLGGDSG NGTRAASGVDASDHGPGSGGNGGNGGNGAQASVAGGAGGNGGDGGNAGRVGDGGAGGNGGDGAAGANGAN SGAPGSDALALGQPGGNGGQGDAGQAGGAGGAGGAGGSVSGDGGAGGNGGAGGNGGVGASGGAGARGANG IDSIGGTGGAGGGGGDGGAGGVGGHGGDGGVGGAAPSGTVGSHGTGGVGGDGGLGGAGGVGGAGGNGGIG ITVGGAGGAGGNGGDPGAGGRGGLGGDSGNGTSAANGVDASKHGPLTGGDGGVGGNGAKAAAAGGDGGQG GDGGNAGLFGDGGAGGDGADGTAAEALGGDGGAGGAGGKGGDAGDIGDGGDGGKGGDGAHGALGGLTVAG GNGGAGGAGGAGGAGGAFLGDGGNGGAGGQGGAGRGGSPGGGGGVGGHGGAGGDAGMNGGGGTGGQGGNG AAGGAGWSPDSDLKGFDGFDGGSGGAGGDGGAGGAGGTQTGDGGDGGAGGLGGAGGVGGNGVDGFDINET TGRDGDGGDGGYGGWGGAGGNGGAGGSAPAGEVGNRGVGGDGGDGGSGGDAGNGGLGGDGFTYLADFDGE PGGDGGDGGDGGWGRPGGQGGFGSTSGAHGKAGFGAPGGDGGDGGNGGHGGDGNGSFADAGDGGPGGNGG NGGLGGAGRDGGAPGGDGGDGGTGGSGGFGAPPPRSIGGGDGGDGGRGGDGGRGAGGLTSGGVGSSGESG GSGNGRGDPGSGGSGGEGGEGGPSISVNVT
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2517c | PE_PGRS43b | - | 100% (1150) | hypothetical protein Mb2517c |
M. bovis AF2122 / 97 | Mb3541 | PE_PGRS55 | 0.0 | 48.54% (1298) | PE-PGRS family protein |
M. bovis AF2122 / 97 | Mb3538 | PE_PGRS54 | 0.0 | 47.88% (1320) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_5091 | - | 1e-179 | 45.21% (845) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv2490c | PE_PGRS43 | 0.0 | 99.65% (1154) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01556 | infB | 6e-10 | 46.91% (81) | translation initiation factor IF-2 |
M. abscessus ATCC 19977 | MAB_4284c | - | 3e-49 | 34.00% (450) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_2656 | - | 0.0 | 49.15% (1349) | PE-PGRS family protein, PE_PGRS50 |
M. avium 104 | MAV_4827 | - | 5e-25 | 44.71% (170) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-164 | 39.55% (1100) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 5e-46 | 42.95% (298) | PUTATIVE - |
M. ulcerans Agy99 | MUL_4367 | - | 0.0 | 50.19% (1034) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-177 | 46.30% (825) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 MMFLAPPGGPGPISAAIQLTSTGSEATEP--------------------W Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv -MSYVIATPEMMATAAFDLARIGSQVSAASAVAAMPTTEVVAAGADEVSA MMAR_2656|M.marinum_M -MSLVTVSPELVAGAASDLARIGSSLGAANAAAAGPTTTVLSAAADEVSV MUL_4367|M.ulcerans_Agy99 -MSFVSVGPGLLEAAARDLAGLGAGLREANLAAAGATVGVLPAAGDEVSA MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------------------------------------MSIID MAV_4827|M.avium_104 -MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAATASAPD MLBr_01556|M.leprae_Br4923 -----MAGKARVHELAKELGVTSKEVLARLNEQGEFVKSASSTVEAPVAR Mflv_5091|M.gilvum_PYR-GCK -MVTFGGGATPTPTSLGAAAVDLSG------TSCG--------------- Mvan_1264|M.vanbaalenii_PYR-1 YVVSFGGSGAPTPNNLAASLVDLSG------TSCG--------------- Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv GIAALFSAHAQEYQALSAQAAAFHDQFVHTLTAAARWYTATEIAN----- MMAR_2656|M.marinum_M AIATLFGTHAAEYQSLSARMAAFHEQFVQTLTSGAGIYVSTEATNASFIS MUL_4367|M.ulcerans_Agy99 AIAELFGGFGREYQAMGARVALLHDDFVRALTAGGSAYGQAEALN---MW MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTN------ TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 FILNLFRDPVEAASYVADPEAALANAGLSAVSAAQVG------------- MAV_4827|M.avium_104 RVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALR------------- MLBr_01556|M.leprae_Br4923 RLRESFGGIKPAADKGAEQVATKAQAKRLGESLDQTLDR----------- Mflv_5091|M.gilvum_PYR-GCK ------------------------LICNGQDGT------GQNGGIL-FGN Mvan_1264|M.vanbaalenii_PYR-1 ------------------------LICNGQDGT------GQNGGIL-FGN Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv --AAAMRVVLGAVNAPTQTLLGRPLIGDGAHGT-APGQPGGAGGLL-FGN MMAR_2656|M.marinum_M ALQLAEQNALNAINAPTQSWLGRPLIGNGVDATPGSGQAGGAGGLL-WGN MUL_4367|M.ulcerans_Agy99 PLQELEQQALGVVNAPSMALFGRPSIGNGVDGVAGTGQAGGAGGIL-WGN MSMEG_0868|M.smegmatis_MC2_155 ---TTDQPTSDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------AVMPVVAESVASNYGYQSQWVNTGNPIHDL MAV_4827|M.avium_104 ----------------------DALAARRIDNVMLVSAFLAAAALAQNVG MLBr_01556|M.leprae_Br4923 ---------------------ALDKAVAGNGATTAAPVQVDHSAAVVPIV Mflv_5091|M.gilvum_PYR-GCK GGSGWNSDVVGMDGGNGGNG-GLFG------------------------- Mvan_1264|M.vanbaalenii_PYR-1 GGSGWNSEIAGVSGGNGGNA-GLFG------------------------- Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv GGNGA-AGAVGQVGGAGGAA-GLFGIGGAGGAGGAGAPGGTG-------- MMAR_2656|M.marinum_M GGAGG-SGAAGQSGGAGGSA-GLFGNGGAGGAGGISAAGNGGSGGVGGRG MUL_4367|M.ulcerans_Agy99 GGNGG-LGAAGANGGAGGSA-GLIGTGGVGGAGGVGAAGMTG-------- MSMEG_0868|M.smegmatis_MC2_155 LGTTLIPNAPTEPADMPGVW-AVMAWARRQPMYSDPAMRTTVN------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SGNLQNYYAAQPDGPSILSP-SLLS------------------------- MAV_4827|M.avium_104 GAMGYERTAVLLVEPDTATL-AVVET------------------------ MLBr_01556|M.leprae_Br4923 AGEGPSTAHREELAPPAGQPS----------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv -------------------------GTGGWLAGGGGVGGMGG----AGGG MMAR_2656|M.marinum_M GLVYGSGGAGGAGGQGALSGGAGGAGGGAWLWGAGGAGGSGGEGLASAGG MUL_4367|M.ulcerans_Agy99 ----GSGGAG---------------GGGGWLWGAGGSGGAAG-----AGG MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv AGGAGGNAGLFGNGGAGGAGGAGGGAGGAGGNAGWFGHGGAGGVGGVGAA MMAR_2656|M.marinum_M VGGAGGNAGLIGTGGLGGAGGVGGQNGGAGGDGGNAPLLGRGGTGGVGGA MUL_4367|M.ulcerans_Agy99 SGGSGG--WLWGN---------AGQTAGAG----------VGGAGGAGGA MSMEG_0868|M.smegmatis_MC2_155 ----------------------------------------PQAQLPVPTV TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv GANGATPGQDGAAGVAGSDDGAGGDGLAGSDGGDGGAGGVGGNGGRGGWL MMAR_2656|M.marinum_M SD-GGNGGAGGDGGVGGGLFGSGGAGGSGGAGGVLGTGGDGGSGGAAAGL MUL_4367|M.ulcerans_Agy99 GD-AGDQGVSG--------VAPGEAGAVGFAG------------------ MSMEG_0868|M.smegmatis_MC2_155 ASAVLDPTQIVNWLIYQPLHAAG--------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv LGNGGAGGVGGVG---------------------GAGG-------AGAAG MMAR_2656|M.marinum_M WGAGGSGGAGGNGADGISGGIGESGGDGGNAGNGGAGGRGGRLIGAGGAG MUL_4367|M.ulcerans_Agy99 -GAGGAGGAGGN----------------------GVGG------GVNGAG MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------Q TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv GAGGAGATGINGPAGISAAGGDGGAGGNGGAGGNGGVGGAGGAGGSAGLL MMAR_2656|M.marinum_M GFGGVGGLGGAGGAGANG-IVAGSAGDGGGNGGSGGAGGVGGDGGKGGLI MUL_4367|M.ulcerans_Agy99 GAGGAGGVGGGGGAGASG-VGAGVAGGDGGTGGAGGAAGVGG-------- MSMEG_0868|M.smegmatis_MC2_155 QFWVVSPIGSTLGGVINTISGQYLIGNGINGTADNPNGGTGG-------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv GYVGRAGDGGAGGGGGLGGAPGDGGAGGNGGSWLAAGDGGAGGHGGDPGL MMAR_2656|M.marinum_M RFLGGRGAGGSGGEGGAGGAAGDGGDGAAGSFLTGTGAGGAGGQGGDPGL MUL_4367|M.ulcerans_Agy99 -------AAGTGGTGGAAGVAGTGGD------------------------ MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2517c|M.bovis_AF2122/97 -------------------------------------------------- Rv2490c|M.tuberculosis_H37Rv GGAGGAGGASGGAGARAGANGLAAGNDGPVSGGNGGKGGNGAHAPVAGGH MMAR_2656|M.marinum_M GGAGGAGGRGSVPGSHG------VTGQSPTSGGDGGNGGRGADAIDPATT MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------------GNGG Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------------GNGG Mb2517c|M.bovis_AF2122/97 ---------------------------------MTAIFLGSSGTPGEDGG Rv2490c|M.tuberculosis_H37Rv GGNGGAGGNGGLVGDGGAGGHGGDGAAGAGYADMTAIFLGSSGTPGEDGG MMAR_2656|M.marinum_M AGAGGVGGDGGRYGNGGVGGAGGDGYRGY----DGMSVVGGDGTVGGDGG MUL_4367|M.ulcerans_Agy99 ---------------------------------------------GGDGG MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------LLFGDGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------------------------------------PRDND MAV_4827|M.avium_104 ----------------------------------------------SDGS MLBr_01556|M.leprae_Br4923 ----------------------------------------------EQPG Mflv_5091|M.gilvum_PYR-GCK NGGNG--------------------------------------LGGGNGG Mvan_1264|M.vanbaalenii_PYR-1 NGGNG--------------------------------------LGSGDGG Mb2517c|M.bovis_AF2122/97 NGGAGGAGGAGGAHAGDGGAGGAGGNGGAGGAGGNGAHGFN-AVLVSDGG Rv2490c|M.tuberculosis_H37Rv NGGAGGAGGAGGAHAGDGGAGGAGGNGGAGGAGGNGAHGFN-AVLVSDGG MMAR_2656|M.marinum_M AGGAGGAGGMGGALAGHGGAGGAGGDGGTGGIGGDGGRGVDGTDLSLDGT MUL_4367|M.ulcerans_Agy99 AGGAG-------------------------------------SDASLAGQ MSMEG_0868|M.smegmatis_MC2_155 HGYDG-------------------------------------SAAGLAGG TH_3810|M.thermoresistible__bu --------------------------------------------VDGDGG MAB_4284c|M.abscessus_ATCC_199 FLSHN------------------------------------DTDFASHNP MAV_4827|M.avium_104 IPDVY-------------------------------------KQQIRAES MLBr_01556|M.leprae_Br4923 VPLPG-------------------------------------QQGTPAAP Mflv_5091|M.gilvum_PYR-GCK NGGNAGAFALFGNGGNGGNGG-----------VGVVGAT----GAVGAPG Mvan_1264|M.vanbaalenii_PYR-1 NGGDAGLFSLFGRGGNGGNGG-----------VGIAGAT----GAVGAPG Mb2517c|M.bovis_AF2122/97 NGGDGGAGGRGGDGGAGGAGGDAPAG--RAGSQGVGGDG----GAGGAGG Rv2490c|M.tuberculosis_H37Rv NGGDGGAGGRGGDGGAGGAGGDAPAG--RAGSQGVGGDG----GAGGAGG MMAR_2656|M.marinum_M DGGSGGMGGVGGAGGDGGAGGLAQAAGFSDGIRGVGGAG----GDGGAGG MUL_4367|M.ulcerans_Agy99 AGFAGGSGGAGGVGGSAGAG-------------GVNGSG----GDGGAGA MSMEG_0868|M.smegmatis_MC2_155 NGGNAGLFGNGGNGGVGWAGLD----------GGNGGSGGLLMGIGGAGG TH_3810|M.thermoresistible__bu SGGRTGLFSKLSRGGD---------------------------------- MAB_4284c|M.abscessus_ATCC_199 IASGNQVMSPSGNVDSFNRGP----------------------------- MAV_4827|M.avium_104 YGDAAGQLSAMVAGLEKLESLP---------------------------- MLBr_01556|M.leprae_Br4923 HPGHPGMPTGPHPGPAPKPGGR--------------------PPRVGNNP Mflv_5091|M.gilvum_PYR-GCK VAGATG-------ATGVTSGVVGGNGED---------------------- Mvan_1264|M.vanbaalenii_PYR-1 VAGATG-------ATGVTSNVTGGNGAD---------------------- Mb2517c|M.bovis_AF2122/97 APGNGGSGGRGDMAFKDGDGGAGGDGGDPGAGGKGGAGGAGATEGVTGAT Rv2490c|M.tuberculosis_H37Rv APGNGGSGGRGDMAFKDGDGGAGGDGGDPGAGGKGGAGGAGATEGVTGAT MMAR_2656|M.marinum_M GAGDGGDGANAPAASGLAGG-SGGHGGDPGVGGAGGAGGTGSVTGAHGTE MUL_4367|M.ulcerans_Agy99 AGGAGG-------ASATVAG-SGGVGGD---------------------- MSMEG_0868|M.smegmatis_MC2_155 AGGVGADG-----TSAHVDGGTGGTGGTG--------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 FSSAQSVARPIPRPPAPRPSASPSSMS----------------------- Mflv_5091|M.gilvum_PYR-GCK ----------------------AVGYGATGAAGAAG-AAG---------- Mvan_1264|M.vanbaalenii_PYR-1 ----------------------AVGYGATGAAGAAG-AAG---------- Mb2517c|M.bovis_AF2122/97 GATVHSGGNGGKGGNGADATVAGANGGKGGAGGNGG-LVGDGGAGGDGGS Rv2490c|M.tuberculosis_H37Rv GATVHSGGNGGKGGNGADATVAGANGGKGGAGGNGG-LVGDGGAGGDGGS MMAR_2656|M.marinum_M GLTQTTGGNGGDGGDGANASTVGASGGAGGAGGDGG-RYGNGGVGGAGGD MUL_4367|M.ulcerans_Agy99 -------------------------GGAGGAAG--------GGVGAAS-- MSMEG_0868|M.smegmatis_MC2_155 ----------------------GGTGGTGGIGGTGGGLFGLLGHSGST-- TH_3810|M.thermoresistible__bu ----------------------------GGDGG----------------- MAB_4284c|M.abscessus_ATCC_199 --------------------LLDLSFGDLQFGN----------------- MAV_4827|M.avium_104 -------------------------GGLLLVGSGVD-------------- MLBr_01556|M.leprae_Br4923 ----------------------PRPGGAVGGGGPRP-------------- .. Mflv_5091|M.gilvum_PYR-GCK -------------------------------------AAGAAGAVGSAGA Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------AAGKAGAVGSAGT Mb2517c|M.bovis_AF2122/97 GAAGANG-------ANVGEDGADGTLSGQPGEGSE--ANGGQGGVGG-GG Rv2490c|M.tuberculosis_H37Rv GAAGANG-------ANVGEDGADGTLSGQPGEGSE--ANGGQGGVGG-GG MMAR_2656|M.marinum_M GYRGYDGMSVVGGDGTVGGDGGAGGAGGAGGMGGALAGHGGAGGAGGDGG MUL_4367|M.ulcerans_Agy99 ----------------LGGDG----------------GHAGAGGAGGEGL MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------GAAGAAGNGGDGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK AGEAGETG-------------TWGNAGLPGKAGDAGGAG----------- Mvan_1264|M.vanbaalenii_PYR-1 AGSAGAPG-------------VWGNAGLPGAAGAAGGAG----------- Mb2517c|M.bovis_AF2122/97 AGGAGGDGGAGSSALGSGGNGGRGDAGQAGGAGGAGGAGGAGGSVSGDGG Rv2490c|M.tuberculosis_H37Rv AGGAGGDGGAGSSALGSGGNGGRGDAGQAGGAGGAGGAGGAGGSVSGDGG MMAR_2656|M.marinum_M TGGIGGDGGRGVDGTDLSLDGTDGGSGGMGGVGGAGGDGGAGGLAQAAGF MUL_4367|M.ulcerans_Agy99 SGGFN-----------------TGAAGGIGGAGGAGGTGGDSG------- MSMEG_0868|M.smegmatis_MC2_155 NGGFGYVLIAGPN--------VTVGSETRGGTGGAGGTGGQST------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------------RDTTAIGDGAVAVGGSN----------- MAV_4827|M.avium_104 ----------------------VAPLKQVLQTTTFLDVSVAEE------- MLBr_01556|M.leprae_Br4923 -----------------------PRTGVPRPGGGRPGAP----------- Mflv_5091|M.gilvum_PYR-GCK -----AVGAAGAAGTVGTAGATGGTG---------------------TGA Mvan_1264|M.vanbaalenii_PYR-1 -----AIGTAGVAGAAGTAGATGGTG---------------------VGG Mb2517c|M.bovis_AF2122/97 PGGKGGAGGAGGAGASGGGGGKGASGADSAEAVG---GAGGKGGDGGVGG Rv2490c|M.tuberculosis_H37Rv PGGKGGAGGAGGAGASGGGGGKGASGADSAEAVG---GAGGKGGDGGVGG MMAR_2656|M.marinum_M SDGIRGVGGAGGDGGAGGGAGDGGDGANAPAASGLAGGSGGHGGDPGVGG MUL_4367|M.ulcerans_Agy99 -----GVGGVNGDGGAGGGGGRGGDGGSSTSTS-------------GVGG MSMEG_0868|M.smegmatis_MC2_155 -----AAGPGKGGGGGGGGGGAILIGANGGTVDG--------HAIGGNGG TH_3810|M.thermoresistible__bu -----------------------------------------------LGG MAB_4284c|M.abscessus_ATCC_199 ------------------------------------------------SG MAV_4827|M.avium_104 -----------------------------------------------PET MLBr_01556|M.leprae_Br4923 -----------------------------------------------VGG Mflv_5091|M.gilvum_PYR-GCK NGGAG-------------------GVGGVGGTGAAGAAGGAGGLGETGTT Mvan_1264|M.vanbaalenii_PYR-1 NGGAG-------------------QAGGIGGTGAAGAAGQAGTAGETGVT Mb2517c|M.bovis_AF2122/97 VGGDG-------------------GPGGDGGAGGAAPAGQVGSHGVGGVG Rv2490c|M.tuberculosis_H37Rv VGGDG-------------------GPGGDGGAGGAAPAGQVGSHGVGGVG MMAR_2656|M.marinum_M AGGAGGTGSVTGAHGTEGLTQTTGGNGGDGGDG-ANASTVGASGGAGGAG MUL_4367|M.ulcerans_Agy99 AGGAG-------------------GNGGNAGFG-VSAGGTGGSAGDGGAG MSMEG_0868|M.smegmatis_MC2_155 NGGNGS-------------TTAAGGNGGTGGTGRVIAEGTGSTAEGTATG TH_3810|M.thermoresistible__bu NGGHG------------------------GGTGIISLLSLAG-------- MAB_4284c|M.abscessus_ATCC_199 PIASG--------------------QGSTAVNGDVRDSNIINADHGSNVG MAV_4827|M.avium_104 ALARG------------------AALAAANAPLFASSTAALAYAQDPGTG MLBr_01556|M.leprae_Br4923 RSDAGG------------------GNYRGGGVGALPGGGSGGFRGRPGGG * Mflv_5091|M.gilvum_PYR-GCK G-----GAGGVGGQGTAG--------------GTGGVGGIGGAGSTGAVG Mvan_1264|M.vanbaalenii_PYR-1 G-----GVGGIGGQGTEG--------------GTGGVGGVGGVGATGGAG Mb2517c|M.bovis_AF2122/97 GDGGLGGAGGNGGDGGHG--------------SDGGDGGDGGDPGAGGLG Rv2490c|M.tuberculosis_H37Rv GDGGLGGAGGNGGDGGHG--------------SDGGDGGDGGDPGAGGLG MMAR_2656|M.marinum_M GDGGRYGNGGVGGAGGDGYRGYDGMSVVGGDGTVGGDGGAGGAGGAGGMG MUL_4367|M.ulcerans_Agy99 G-----GAGGVDGVGG-----------------ASGNGGAAGAGGAGGSG MSMEG_0868|M.smegmatis_MC2_155 GDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAG TH_3810|M.thermoresistible__bu ---------------------------------NGGNGGNGYRTTDNNAL MAB_4284c|M.abscessus_ATCC_199 VDQSQTRVGGDYTN-------------------VSGHGSADIDKSVTVVD MAV_4827|M.avium_104 AVDQYSLPDYLYVPVD------------------PEPGDDELAYSAVGEE MLBr_01556|M.leprae_Br4923 GHGGGGRPGQRGGAAG----------------AFGRPGGAPRRGRKSKRQ *. Mflv_5091|M.gilvum_PYR-GCK G-------------VGG--------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 G-------------VGG--------------------------------- Mb2517c|M.bovis_AF2122/97 G-------------------LGGDSGNGTR-------------------A Rv2490c|M.tuberculosis_H37Rv G-------------------LGGDSGNGTR-------------------A MMAR_2656|M.marinum_M GALAGHGGAGGAGGDGGTGGIGGDGGRGVDGTDLSLDGTDGGSGGMGGVG MUL_4367|M.ulcerans_Agy99 --------------------IG---------------------------- MSMEG_0868|M.smegmatis_MC2_155 G---------------------------------------------MGEI TH_3810|M.thermoresistible__bu D------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 D------------------------------------------------- MAV_4827|M.avium_104 D------------------------------------------------- MLBr_01556|M.leprae_Br4923 K------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -KGIQGGQGLQ----------------GGKGGDGG--------------- Mvan_1264|M.vanbaalenii_PYR-1 -KGIQGGQGLQ----------------GGQGGDGG--------------- Mb2517c|M.bovis_AF2122/97 ASGVDASDHGP--------------GSGGNGGNGGNG----------AQA Rv2490c|M.tuberculosis_H37Rv ASGVDASDHGP--------------GSGGNGGNGGNG----------AQA MMAR_2656|M.marinum_M GAGGDGGAGGLAQAAGFSDGIRGVGGAGGDGGAGGGAGDGGDGANAAAGS MUL_4367|M.ulcerans_Agy99 -AGIDGGAG----------------GAGGTGGAAG--------------- MSMEG_0868|M.smegmatis_MC2_155 YSGADGEATGIS--------------AGGDGGSATG-------------A TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK --AGGKGGDADSMGSAGATGGKG--------------------------- Mvan_1264|M.vanbaalenii_PYR-1 --TGGTGGDATSMGEAGATGGKG--------------------------- Mb2517c|M.bovis_AF2122/97 SVAGGAGGNGGDGGNAGRVGDG---------------------------- Rv2490c|M.tuberculosis_H37Rv SVAGGAGGNGGDGGNAGRVGDG---------------------------- MMAR_2656|M.marinum_M GAVGGKGGDGGDPGVGGAGGAGGTGSVTGAHGTEGLTQTTGGNGGDGGNG MUL_4367|M.ulcerans_Agy99 --FPGGGGTTGAWGTGGAGGAG---------------------------- MSMEG_0868|M.smegmatis_MC2_155 DSLGGRGGTSWVQAGYGPTTGGKASG------------------------ TH_3810|M.thermoresistible__bu ---GGHGGNGGNVGFFSLFNLG---------------------------- MAB_4284c|M.abscessus_ATCC_199 ---HSQRNTTNINDSFNTDRSTN--------------------------- MAV_4827|M.avium_104 ----AESPTVVIEKLFLPEDSEPRRR------------------------ MLBr_01556|M.leprae_Br4923 RQEYDSMQAPVVGGVRLPHGNGETIR------------------------ Mflv_5091|M.gilvum_PYR-GCK ------------GNGGNGGRGGLFGKGGNAGN------------------ Mvan_1264|M.vanbaalenii_PYR-1 ------------GNGGNGGRGSLFGRGGNAGN------------------ Mb2517c|M.bovis_AF2122/97 ------------GAGGNGGDGAAGANGANSGAPGSDALALGQP----GGN Rv2490c|M.tuberculosis_H37Rv ------------GAGGNGGDGAAGANGANSGAPGSDALALGQP----GGN MMAR_2656|M.marinum_M GSGTTGTTGSKGGAGGAGGDGGRYGNGGNGGTGGTGSTGTAGSSDVMGAN MUL_4367|M.ulcerans_Agy99 ------------GAGGAGDHGGVGVNPGDSGT------------------ MSMEG_0868|M.smegmatis_MC2_155 --------TAKAGHGGKASDGGKGGNGGDALVMAAGATGVATG-----NT TH_3810|M.thermoresistible__bu ------------GAGGWGGSG----------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------IGSGNTTNTEIGSHNQANIGTS----------------- MAV_4827|M.avium_104 --------PVLLVGSGLAVVGISAVLALEIALAIG--------------- MLBr_01556|M.leprae_Br4923 ------------LARGASLSDFAEKIDANPAALVQALFNLG--------- . Mflv_5091|M.gilvum_PYR-GCK ------GADGGTGGAGGAG------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ------GGNGGTGGNGGNG------------------------------- Mb2517c|M.bovis_AF2122/97 GGQGDAGQAGGAGGAGGAG---GSVSGDGGAGGNGGAGGNGGVGASGGAG Rv2490c|M.tuberculosis_H37Rv GGQGDAGQAGGAGGAGGAGGAGGSVSGDGGAGGNGGAGGNGGVGASGGAG MMAR_2656|M.marinum_M GGAGGSGWAGGDGGAGGMG---GTLAGHGGDGGDGGSGGTGGTGGRGGNG MUL_4367|M.ulcerans_Agy99 -----AGWAGGAGGAGGAG---GSAA------------------------ MSMEG_0868|M.smegmatis_MC2_155 AIGGNGGAASANGAVGGNGGFTNIAAIHG--------------------- TH_3810|M.thermoresistible__bu --------VDGVDVVGGNP------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------TSAGGSAAVGGNAG------------------------------ MAV_4827|M.avium_104 ------IRTTGTVALQPTPN------------------------------ MLBr_01556|M.leprae_Br4923 ------EMVTATQSVGDETLELLGSEMN---------------------- . Mflv_5091|M.gilvum_PYR-GCK ------------------------------------------GTGGTGGA Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------------GTGGTGGN Mb2517c|M.bovis_AF2122/97 ARGANGIDSIG-------------------------------GTGGAGGG Rv2490c|M.tuberculosis_H37Rv ARGANGIDSIG-------------------------------GTGGAGGG MMAR_2656|M.marinum_M FNGSTKAGLNGGDAGDGGAGGVGGAGGNGGAAGLAQAAGFSDGIQGAGGA MUL_4367|M.ulcerans_Agy99 FN----------------------------------------GVNGAGGA MSMEG_0868|M.smegmatis_MC2_155 ------------------------------------------SITDSSAT TH_3810|M.thermoresistible__bu -------------------------------------------DGGTPGA MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------LAGNAGL MAV_4827|M.avium_104 ------------------------------------------QHLIVPTE MLBr_01556|M.leprae_Br4923 -----------------------------------------YNVQVVSPE Mflv_5091|M.gilvum_PYR-GCK GGTGGTGG-----------------------------TGGIGGAG----- Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTGG-----------------------------TGGIGGAG----- Mb2517c|M.bovis_AF2122/97 GGDGGAGG-----------------------------VGGHGGDGGVGGA Rv2490c|M.tuberculosis_H37Rv GGDGGAGG-----------------------------VGGHGGDGGVGGA MMAR_2656|M.marinum_M GGDGGAGGGAGDGGDGANAAAGSGAVGGNGGDGGDPGLGGGGGAGGTGAT MUL_4367|M.ulcerans_Agy99 GGNGGAGG------------------------------GGGAGASGIGAG MSMEG_0868|M.smegmatis_MC2_155 SGHGGAAQG---------------------------GNGGNGGNGWVQAY TH_3810|M.thermoresistible__bu HGESHTPG------------------------------------------ MAB_4284c|M.abscessus_ATCC_199 AGNAGLAG------------------------------------------ MAV_4827|M.avium_104 QAPAPPP------------------------------------------- MLBr_01556|M.leprae_Br4923 DEDRELLEP-------------------------FDLTYGEDQGDEDELQ Mflv_5091|M.gilvum_PYR-GCK -----------STGGTGGTGGTGGTGGTGGTGGTGGT----GGTGGTGGK Mvan_1264|M.vanbaalenii_PYR-1 -----------STGGTGGTGGTGGTGGTGGTGGTGGT----GGTGGTGGK Mb2517c|M.bovis_AF2122/97 APSGTVG--SHGTGGVGGDGGLGGAGGVGGAGGNGGIGITVGGAGGAGGN Rv2490c|M.tuberculosis_H37Rv APSGTVG--SHGTGGVGGDGGLGGAGGVGGAGGNGGIGITVGGAGGAGGN MMAR_2656|M.marinum_M TGAHGADGLSPTTGGNGGKGGNGGSGAIGVAGGAGGA----GGDGGLYGD MUL_4367|M.ulcerans_Agy99 -----------VAGGDGGTGGTGGAAGTGGAAGTGGT----GGAAGAAGS MSMEG_0868|M.smegmatis_MC2_155 DPNGPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGG----DGAGASVWK TH_3810|M.thermoresistible__bu ----------VYTDRQGEDGEDGTGTGIGGRGGNGGS------------- MAB_4284c|M.abscessus_ATCC_199 ------------NAGLAGNAGLAGNAGLAGNAGLAGN----AGLAGNAGL MAV_4827|M.avium_104 ---------VQASAPQPKISVPEPVAAPKPLSPPVAAPLPAAPPPAAPPL MLBr_01556|M.leprae_Br4923 VRPPVVTVMGHVDHGKTRLLDTIRKANVREAEAGGITQHIGAYQVGVDLD Mflv_5091|M.gilvum_PYR-GCK GGTGGTGGAGGTGGDGGTGGTGGTGGTGG-----TGGTGGTGGAG----- Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTGGDGGTGGTGGTGGTGGTGGTGG-----TGGTGGTGGAG----- Mb2517c|M.bovis_AF2122/97 GGDPGAGGRGGLGGDSGNGTSAANGVDASKHGPLTGGDGGVGGNG----- Rv2490c|M.tuberculosis_H37Rv GGDPGAGGRGGLGGDSGNGTSAANGVDASKHGPLTGGDGGVGGNG----- MMAR_2656|M.marinum_M GGDGGSGGNGGAGKAGAAGVSAGSNGEAGGQAG-AGGVGGAGGNGGANAG MUL_4367|M.ulcerans_Agy99 AGDGGAGGAGGAGDDGSAGVVSGDPGTAGKAGG-AGGAGGVGGNG----- MSMEG_0868|M.smegmatis_MC2_155 ANGQHSTGQTDTGGNGGRGGDGGTFVNAG-----ANGNGGAGGAG----- TH_3810|M.thermoresistible__bu -----SSGTHPMAEDGEHVKALD------------GRPGLDGGNG----- MAB_4284c|M.abscessus_ATCC_199 AGNAGLAGNAGLAGNAGLAGNAGLAGNAG----LAGNAGLAGNAG----- MAV_4827|M.avium_104 PEAPPIPAAPPVVPVPVVVPPVPVPVPVRIPVPDPVSPPQLLAPP----- MLBr_01556|M.leprae_Br4923 GSERLITFIDTPGHEAFTAMRARGAKATDIAILVVAADDGVMPQT----- Mflv_5091|M.gilvum_PYR-GCK ----------------------------DGTGGTGGTGGTGGQGGQGGQG Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------DGLGGTGGTGGTGGFGGQGGQG Mb2517c|M.bovis_AF2122/97 ----------------------AKAAAAGGDGGQGGDGGNAGLFGDGGAG Rv2490c|M.tuberculosis_H37Rv ----------------------AKAAAAGGDGGQGGDGGNAGLFGDGGAG MMAR_2656|M.marinum_M NGGTGGNGGDGGVGGTGGAGKVGTTGPAGGAGGEGGDGGKGGTGGRGGNG MUL_4367|M.ulcerans_Agy99 --------------------------VAGGVNGSGGAGGAGGAGGTGGAG MSMEG_0868|M.smegmatis_MC2_155 -------------------------GVSEGEGGTGGHGGDGGRGGDGALG TH_3810|M.thermoresistible__bu -----------------------------SHGGNGGHGGRGGFLGIGGSG MAB_4284c|M.abscessus_ATCC_199 ------------------------------LAGNAGLAGNAGLAGNAGLA MAV_4827|M.avium_104 -----------------------------RLSVPQPVQPPVRVPQPPSPP MLBr_01556|M.leprae_Br4923 -----------------------------VEAINHAQAADVPIVVAVNKI Mflv_5091|M.gilvum_PYR-GCK GTGGT-------------GGQGGLGGG------GGTGGQGGTGGT----- Mvan_1264|M.vanbaalenii_PYR-1 GTGGT-------------GGQGGLGGV------GGTGGTGGTGGT----- Mb2517c|M.bovis_AF2122/97 GDGADGTAAEALGGDGGAGGAGGKGGD------AGDIGDGGDGGKGGDGA Rv2490c|M.tuberculosis_H37Rv GDGADGTAAEALGGDGGAGGAGGKGGD------AGDIGDGGDGGKGGDGA MMAR_2656|M.marinum_M GAGGTAQAAGYSDGSQGVGGDGGAGGT------GGTAGNGGKGGAGTWAV MUL_4367|M.ulcerans_Agy99 ASGVPASVD---------GGDGGAGGA------GGAAGTGGSGGS----- MSMEG_0868|M.smegmatis_MC2_155 GNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGNGGAGRIRV TH_3810|M.thermoresistible__bu G----------------WGGHGGNGGD-----TDADGGNGGDGGN----- MAB_4284c|M.abscessus_ATCC_199 GNAG-------------LAGNAGLAGN------AAVAGNAAVAGN----- MAV_4827|M.avium_104 QVGGTVPQS--------PPQHQTPPGE------GTPPKPDGPGNYG---- MLBr_01556|M.leprae_Br4923 DKEGADPAKIRGQLTEYGLVAEDFGGDTMFIDISAKVGTNIEALLEAVLL * . Mflv_5091|M.gilvum_PYR-GCK ----------GGQGGTGGTGG----------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ----------GGQGGTGGTGG----------------------------- Mb2517c|M.bovis_AF2122/97 HGALGGLTVAGGNGGAGGAGG----------------------------- Rv2490c|M.tuberculosis_H37Rv HGALGGLTVAGGNGGAGGAGG----------------------------- MMAR_2656|M.marinum_M NNGIGGKGGNGGNAGTGGTGGSFGTGSQIGNHGSTGHLGDGGDGGTGGAG MUL_4367|M.ulcerans_Agy99 ----------AGNTGAGGAGG----------------------------- MSMEG_0868|M.smegmatis_MC2_155 NNGTATGTATGGNGGNGGNGDADG-------------------------- TH_3810|M.thermoresistible__bu ----------GGSAGRGGTGG----------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------AAVAGNAAVGG----------------------------- MAV_4827|M.avium_104 ----------GGHVPTPGAGG----------------------------- MLBr_01556|M.leprae_Br4923 TADAALDLRANSGMEAQGVAIEAH-------------------------- . . . Mflv_5091|M.gilvum_PYR-GCK -----------TGGTGG--------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -----------TGGTGG--------------------------------- Mb2517c|M.bovis_AF2122/97 -----------AGGAGG--AFLGDGGNGGAGGQGGAGRGGSP-------- Rv2490c|M.tuberculosis_H37Rv -----------AGGAGG--AFLGDGGNGGAGGQGGAGRGGSP-------- MMAR_2656|M.marinum_M VNATAPGQDGAAGGVGGNGGIVGDGGVGGKGGDGAAGTTGSSGTASGEAG MUL_4367|M.ulcerans_Agy99 -----------AGGAGG-----------------SAASTGVN-------- MSMEG_0868|M.smegmatis_MC2_155 ----------HRGGKGG----------DGGEALIRATVIGSN-------- TH_3810|M.thermoresistible__bu -----------LRGVFG--------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------VLNTGVSG--------------------------------- MAV_4827|M.avium_104 -----------SGGSGG--------------------------------- MLBr_01556|M.leprae_Br4923 ----------LDRGRGP--------------------------------- * Mflv_5091|M.gilvum_PYR-GCK ----TGGAGGDGGLGGLGG----FGGSGGTGGQGGLGGPGGS-------- Mvan_1264|M.vanbaalenii_PYR-1 ----TGGAGGDGGLGGLGG----FGGVGGTGGQGGQGGPGGS-------- Mb2517c|M.bovis_AF2122/97 -----GGGGGVGGHGGAGG-DAGMNGGGGTGGQGGNGAAGGAGWSPDSDL Rv2490c|M.tuberculosis_H37Rv -----GGGGGVGGHGGAGG-DAGMNGGGGTGGQGGNGAAGGAGWSPDSDL MMAR_2656|M.marinum_M KDGGDGGKGGAGGAGGNGGTSRGDGGAGGAGGTGGVGGSGGDGADGTSGL MUL_4367|M.ulcerans_Agy99 ---GDGGAGGAGGVGGLGGDSAATAGGGGAGGDGGKGGAGGAGVNGVG-- MSMEG_0868|M.smegmatis_MC2_155 -----ASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTAT TH_3810|M.thermoresistible__bu ----INGGNGRAGLGGRGX----XXXGGGVGAAVR--------------- MAB_4284c|M.abscessus_ATCC_199 ------AIGGSSHVGGAIN-----ESLGGSGSVGGSTAVGGG-------- MAV_4827|M.avium_104 ---GHVPTPGAGGSGGSGGGHVPTPGTGGPGGTGGSG------------- MLBr_01556|M.leprae_Br4923 ----VATVLVQRGTLRIGDSVVAGDAYGRVRRMVDEHGVDIEAALP---- * Mflv_5091|M.gilvum_PYR-GCK ----------TGGAGGAGGQAGTAGKGG----------LFGGSGSAGKAG Mvan_1264|M.vanbaalenii_PYR-1 ----------TGGAGGAGGQAGVAGKGG----------LFGGSGSAGTAG Mb2517c|M.bovis_AF2122/97 KG----FDGFDGGSGGAGGDGGAGGAGG----------TQTGDGGDGGAG Rv2490c|M.tuberculosis_H37Rv KG----FDGFDGGSGGAGGDGGAGGAGG----------TQTGDGGDGGAG MMAR_2656|M.marinum_M FGGADGTAGGAGGDGGDGGAGGAGGAGGKAVSG-VGQNGSQGAGGNGGAA MUL_4367|M.ulcerans_Agy99 -----------GGDGGKGGTGGAGGAG--------------GAGSDGIIP MSMEG_0868|M.smegmatis_MC2_155 DG--------HGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDG TH_3810|M.thermoresistible__bu -----------SGNGVFSGGGGTPSAG------------------FGVPT MAB_4284c|M.abscessus_ATCC_199 -----------AHTGVGGGVSTGVGVGS--------------HVGGGISE MAV_4827|M.avium_104 -----------GGHVPTPGAGTPGGSGG------------------GHLP MLBr_01556|M.leprae_Br4923 -----------SSPVQVIGFTSVPGAGDN----------FLVVDEDRIAR . * . * Mflv_5091|M.gilvum_PYR-GCK ATGAAGASGGKGAQG--------------ATGAQGATGAQGATGATGAAG Mvan_1264|M.vanbaalenii_PYR-1 VTGASGASGGKGAQG--------------ATGAQGATGAQGATGATGASG Mb2517c|M.bovis_AF2122/97 GLGGAGGVGGNGVDGFDINETTG---RDG-DGGDGGYGGWGGAGGNGGAG Rv2490c|M.tuberculosis_H37Rv GLGGAGGVGGNGVDGFDINETTG---RDGGDGGDGGYGGWGGAGGNGGAG MMAR_2656|M.marinum_M GDGGDGGNGGNGHDGNNGSVPSGGTDRDGGDGQGGGDGGAGGAGGAGGNG MUL_4367|M.ulcerans_Agy99 SNGGLGGNGGNGGNG----------------GQAFGDG-VGGAGGIGGKG MSMEG_0868|M.smegmatis_MC2_155 IDGGLGGNGGDGVVNTTANAANPG--SATGTATGGDGGKATGTASQGGNG TH_3810|M.thermoresistible__bu TIQFPAGSCTSRAVS--------------------REGIMPSSRAASARA MAB_4284c|M.abscessus_ATCC_199 SLGGSGSVGGSTAVG------------------GGAHTGVGGGVSTGVGV MAV_4827|M.avium_104 FPGAGSTPGGS----------------------GGGHLPTPGAGTPGGGL MLBr_01556|M.leprae_Br4923 QIADRRSARKRNALAARSRKRIS----LEDLDSALKETSQLNLILKGDNA . Mflv_5091|M.gilvum_PYR-GCK K------------AGATGAAGAAGAAGSAGTTGAQGSAGTN--------- Mvan_1264|M.vanbaalenii_PYR-1 A------------QGSAGSAGSAGVAGSAGTTGAQGSAGTN--------- Mb2517c|M.bovis_AF2122/97 G------------SAPAGEVGNRGVGGDGGDGGSGGDAGNGGLGGDGFTY Rv2490c|M.tuberculosis_H37Rv G------------SAPAGEVGNRGVGGDGGDGGSGGDAGNGGLGGDGFTY MMAR_2656|M.marinum_M G------------AAGAGGGGTRGAGGDGGDGGNGGFAGDGGLGMDGLDA MUL_4367|M.ulcerans_Agy99 G------------NAAIGTIVIN--GGVGGAGGSGGLGG----------- MSMEG_0868|M.smegmatis_MC2_155 GPSWVQSGYGSTLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTG TH_3810|M.thermoresistible__bu G-------------AACASSTSRSRRSFCCSRA----------------- MAB_4284c|M.abscessus_ATCC_199 G-------------SHVGGGISESLGGSGSVGGSTAVGG----------- MAV_4827|M.avium_104 G-------------GFGGGHAPAPGGGLGGGGGHAPAPG----------- MLBr_01556|M.leprae_Br4923 G------TVEALEEALMGIQVDDEVALRVIDRGVGGITETN--------- . . Mflv_5091|M.gilvum_PYR-GCK --------GANGANGS-QGAAGKAGATGTTG-------------ATGAAG Mvan_1264|M.vanbaalenii_PYR-1 --------GANGANGS-QGAAGKAGATGTTG-------------ATGAAG Mb2517c|M.bovis_AF2122/97 LADFDGEPGGDGGDGG-DGGWGRPGGQGGFGSTSGAHGKAGFGAPGGDGG Rv2490c|M.tuberculosis_H37Rv LADFDGEPGGDGGDGG-DGGWGRPGGQGGFGSTSGAHGKAGFGAPGGDGG MMAR_2656|M.marinum_M TLTNRAGDGGDGGGGG-QAFAGGAGGAGGTGSTQGSAGTTGAWRAGGDGG MUL_4367|M.ulcerans_Agy99 --------ATEDGVGG-VGCAGGAGGNGGRG--------DMLFTVGGSGG MSMEG_0868|M.smegmatis_MC2_155 VATGNTATGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------GAHTGVGGGVNTGVGVGSHVGGG---------ISESLGGSGS MAV_4827|M.avium_104 ------------------GGLGGFG------------------------- MLBr_01556|M.leprae_Br4923 ------VNLASASDAIIIGFNVRAEGKATELASREGVEIRYYLVIYQAID Mflv_5091|M.gilvum_PYR-GCK EDGDAGSG-------------------GSGINGGAGGAGGAGG------- Mvan_1264|M.vanbaalenii_PYR-1 DAGDPGSE-------------------AVDINGGAGGAGGAGG------- Mb2517c|M.bovis_AF2122/97 DGGNGGHG---------------GDGNGSFADAGDGGPGGNGGNG----- Rv2490c|M.tuberculosis_H37Rv DGGNGGHG---------------GDGNGSFADAGDGGPGGNGGNG----- MMAR_2656|M.marinum_M SGGDGGDGFG-------LWNPGEGGRGGSGGDGGTGGDGGDGGNGRVEIW MUL_4367|M.ulcerans_Agy99 TGGDGGG-------------------GGSASGSGTGGSGGTGG------- MSMEG_0868|M.smegmatis_MC2_155 NGGNGGKGADGWVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTG----- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 VGGSTAVG------------------GGAHTSAINDALGGSGS------- MAV_4827|M.avium_104 ---------------------------GGHSGGGLGGLGGGHK------- MLBr_01556|M.leprae_Br4923 DIEKALRG-----------------MLKPIYEENQLGRAEIRALFR---- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------E Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------E Mb2517c|M.bovis_AF2122/97 --------------------------------------GLGGAGRDGGAP Rv2490c|M.tuberculosis_H37Rv --------------------------------------GLGGAGRDGGAP MMAR_2656|M.marinum_M EGRGGNGGNGAIGPGGDGGDGGDAPNQQRVSSSSPGYEGADGGNGGNGTI MUL_4367|M.ulcerans_Agy99 -------------------------------------------------V MSMEG_0868|M.smegmatis_MC2_155 -----------------------------------------------GAS TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------V MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------S Mflv_5091|M.gilvum_PYR-GCK GGEGGDGG------KGGAG---------AEGGAGGGGGAGG--------- Mvan_1264|M.vanbaalenii_PYR-1 GGEGGAGG------AGGDG---------SEGGAGGSGGAGG--------- Mb2517c|M.bovis_AF2122/97 GGDGGDGG------TGGSGGFGAPPPRSIGGGDGGDGGRGGDGGRGAGG- Rv2490c|M.tuberculosis_H37Rv GGDGGDGG------TGGSGGFGAPPPRSIGGGDGGDGGRGGDGGRGAGG- MMAR_2656|M.marinum_M GGNGGNGG------TGGPGYDASLGGEATAGGEGGDGGDGGKGFNGAGGA MUL_4367|M.ulcerans_Agy99 GGIGGDGK------LGG------------FGGDGGDGGDGG--------- MSMEG_0868|M.smegmatis_MC2_155 GGDGGNGGNTSVWKSGGQTADG----EHNTGGNGGNGGDGSEPGPGGNG- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GGSTAVGG-------GAHTSAINESMNSSINASHSSSMNES--------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 SKVGIIAGCIISSGVVRRNAKVRLLRDNIVVTDNLTVTSLR--------- Mflv_5091|M.gilvum_PYR-GCK ------------------------SGAGGAGGAGGSG-------GSGGSG Mvan_1264|M.vanbaalenii_PYR-1 ------------------------SGTGGAGGAGGSG-------GSGGSG Mb2517c|M.bovis_AF2122/97 ---------------------LTSGGVGSSGESGGSGN-GRGDPGSGGSG Rv2490c|M.tuberculosis_H37Rv ---------------------LTSGGVGSSGESGGSGN-GRGDPGSGGSG MMAR_2656|M.marinum_M GGDGGAGGAGGSGAPAPFGSGGAYGGTGGQGGTGGSG--VIGGIGEGGKI MUL_4367|M.ulcerans_Agy99 -----------------------FGVIGGQGGGGGFG--GLGGTGAGGAP MSMEG_0868|M.smegmatis_MC2_155 -----------------------AGGAGGNGGTGGTTAGGSGNGGNGGNG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------------------FGSSMGSHGAAGTG--FEAQGHAQGHA MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 ------------------------REKDDVTEVREGFECGMTLGYSDIKE Mflv_5091|M.gilvum_PYR-GCK GSGGSGGAAGDSDD-------------------- Mvan_1264|M.vanbaalenii_PYR-1 GAGGSGGAAGDSD--------------------- Mb2517c|M.bovis_AF2122/97 GEGGEGGPSISVNVT------------------- Rv2490c|M.tuberculosis_H37Rv GEGGEGGPSISVNVT------------------- MMAR_2656|M.marinum_M GDAGFGGNPPNSQTGEGGSGGAGGAGGAGGDPSN MUL_4367|M.ulcerans_Agy99 SDKGINGEPGNPG--------------------- MSMEG_0868|M.smegmatis_MC2_155 GNGGADGTPGTAGTTGANNP-------------- TH_3810|M.thermoresistible__bu ---------------------------------- MAB_4284c|M.abscessus_ATCC_199 SETAHTTLPGAEHH-------------------- MAV_4827|M.avium_104 ---------------------------------- MLBr_01556|M.leprae_Br4923 GDVIESYELVEKQRA-------------------