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MSLVTVSPELVAGAASDLARIGSSLGAANAAAAGPTTTVLSAAADEVSVAIATLFGTHAAEYQSLSARMA AFHEQFVQTLTSGAGIYVSTEATNASFISALQLAEQNALNAINAPTQSWLGRPLIGNGVDATPGSGQAGG AGGLLWGNGGAGGSGAAGQSGGAGGSAGLFGNGGAGGAGGISAAGNGGSGGVGGRGGLVYGSGGAGGAGG QGALSGGAGGAGGGAWLWGAGGAGGSGGEGLASAGGVGGAGGNAGLIGTGGLGGAGGVGGQNGGAGGDGG NAPLLGRGGTGGVGGASDGGNGGAGGDGGVGGGLFGSGGAGGSGGAGGVLGTGGDGGSGGAAAGLWGAGG SGGAGGNGADGISGGIGESGGDGGNAGNGGAGGRGGRLIGAGGAGGFGGVGGLGGAGGAGANGIVAGSAG DGGGNGGSGGAGGVGGDGGKGGLIRFLGGRGAGGSGGEGGAGGAAGDGGDGAAGSFLTGTGAGGAGGQGG DPGLGGAGGAGGRGSVPGSHGVTGQSPTSGGDGGNGGRGADAIDPATTAGAGGVGGDGGRYGNGGVGGAG GDGYRGYDGMSVVGGDGTVGGDGGAGGAGGAGGMGGALAGHGGAGGAGGDGGTGGIGGDGGRGVDGTDLS LDGTDGGSGGMGGVGGAGGDGGAGGLAQAAGFSDGIRGVGGAGGDGGAGGGAGDGGDGANAPAASGLAGG SGGHGGDPGVGGAGGAGGTGSVTGAHGTEGLTQTTGGNGGDGGDGANASTVGASGGAGGAGGDGGRYGNG GVGGAGGDGYRGYDGMSVVGGDGTVGGDGGAGGAGGAGGMGGALAGHGGAGGAGGDGGTGGIGGDGGRGV DGTDLSLDGTDGGSGGMGGVGGAGGDGGAGGLAQAAGFSDGIRGVGGAGGDGGAGGGAGDGGDGANAPAA SGLAGGSGGHGGDPGVGGAGGAGGTGSVTGAHGTEGLTQTTGGNGGDGGDGANASTVGASGGAGGAGGDG GRYGNGGVGGAGGDGYRGYDGMSVVGGDGTVGGDGGAGGAGGAGGMGGALAGHGGAGGAGGDGGTGGIGG DGGRGVDGTDLSLDGTDGGSGGMGGVGGAGGDGGAGGLAQAAGFSDGIRGVGGAGGDGGAGGGAGDGGDG ANAAAGSGAVGGKGGDGGDPGVGGAGGAGGTGSVTGAHGTEGLTQTTGGNGGDGGNGGSGTTGTTGSKGG AGGAGGDGGRYGNGGNGGTGGTGSTGTAGSSDVMGANGGAGGSGWAGGDGGAGGMGGTLAGHGGDGGDGG SGGTGGTGGRGGNGFNGSTKAGLNGGDAGDGGAGGVGGAGGNGGAAGLAQAAGFSDGIQGAGGAGGDGGA GGGAGDGGDGANAAAGSGAVGGNGGDGGDPGLGGGGGAGGTGATTGAHGADGLSPTTGGNGGKGGNGGSG AIGVAGGAGGAGGDGGLYGDGGDGGSGGNGGAGKAGAAGVSAGSNGEAGGQAGAGGVGGAGGNGGANAGN GGTGGNGGDGGVGGTGGAGKVGTTGPAGGAGGEGGDGGKGGTGGRGGNGGAGGTAQAAGYSDGSQGVGGD GGAGGTGGTAGNGGKGGAGTWAVNNGIGGKGGNGGNAGTGGTGGSFGTGSQIGNHGSTGHLGDGGDGGTG GAGVNATAPGQDGAAGGVGGNGGIVGDGGVGGKGGDGAAGTTGSSGTASGEAGKDGGDGGKGGAGGAGGN GGTSRGDGGAGGAGGTGGVGGSGGDGADGTSGLFGGADGTAGGAGGDGGDGGAGGAGGAGGKAVSGVGQN GSQGAGGNGGAAGDGGDGGNGGNGHDGNNGSVPSGGTDRDGGDGQGGGDGGAGGAGGAGGNGGAAGAGGG GTRGAGGDGGDGGNGGFAGDGGLGMDGLDATLTNRAGDGGDGGGGGQAFAGGAGGAGGTGSTQGSAGTTG AWRAGGDGGSGGDGGDGFGLWNPGEGGRGGSGGDGGTGGDGGDGGNGRVEIWEGRGGNGGNGAIGPGGDG GDGGDAPNQQRVSSSSPGYEGADGGNGGNGTIGGNGGNGGTGGPGYDASLGGEATAGGEGGDGGDGGKGF NGAGGAGGDGGAGGAGGSGAPAPFGSGGAYGGTGGQGGTGGSGVIGGIGEGGKIGDAGFGGNPPNSQTGE GGSGGAGGAGGAGGDPSN
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_2656 | - | - | 100% (2118) | PE-PGRS family protein, PE_PGRS50 |
M. marinum M | MMAR_3763 | - | 0.0 | 63.32% (1843) | PE-PGRS family protein |
M. marinum M | MMAR_0806 | - | 0.0 | 53.85% (2208) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3541 | PE_PGRS55 | 0.0 | 50.37% (2019) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 1e-177 | 45.43% (843) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv3508 | PE_PGRS54 | 0.0 | 49.09% (1874) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 1e-10 | 32.97% (91) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 5e-50 | 34.41% (465) | hypothetical protein MAB_4284c |
M. avium 104 | MAV_4827 | - | 3e-23 | 46.79% (156) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-174 | 40.73% (1063) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 3e-44 | 39.93% (303) | PUTATIVE - |
M. ulcerans Agy99 | MUL_4367 | - | 0.0 | 50.26% (1136) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-178 | 48.07% (776) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment Rv3508|M.tuberculosis_H37Rv -MSFVLIAPEFVTAAAGDLTNLGSSISAANASAASATTQVLAAGADEVSA MUL_4367|M.ulcerans_Agy99 -MSFVSVGPGLLEAAARDLAGLGAGLREANLAAAGATVGVLPAAGDEVSA MMAR_2656|M.marinum_M -MSLVTVSPELVAGAASDLARIGSSLGAANAAAAGPTTTVLSAAADEVSV Mb3541|M.bovis_AF2122/97 -MSFVLISPEVVSAAAGDLANVGSTISAANKAAAAATTQVLAAGADEVSA Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ---------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAAQVGAVMPVVA MLBr_01183|M.leprae_Br4923 MPLFLNAEPQALTAAANTLEGLSAATVASNAAAAQLTTEIAPPAADDVSI MAV_4827|M.avium_104 -MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAATASAPD Rv3508|M.tuberculosis_H37Rv RIAALFGGFGLEYQAISAQVAAYHQRFVQALSTGAGAYASAEAA------ MUL_4367|M.ulcerans_Agy99 AIAELFGGFGREYQAMGARVALLHDDFVRALTAGGSAYGQAEALNM---W MMAR_2656|M.marinum_M AIATLFGTHAAEYQSLSARMAAFHEQFVQTLTSGAGIYVSTEATNASFIS Mb3541|M.bovis_AF2122/97 RIAALFGMYGLEYQAISAQVAAYHQQFVQTLRTGAASYMLAEATN----- Mflv_5091|M.gilvum_PYR-GCK --MVTFGGGA---TPTPTSLGAAAVDLSGTSCG----------------- Mvan_1264|M.vanbaalenii_PYR-1 WYVVSFGGSG---APTPNNLAASLVDLSGTSCG----------------- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTT---- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQP--------------- MLBr_01183|M.leprae_Br4923 LLAHFFSGHGRQYQAHASQGATNHQDLIQ--------------------- MAV_4827|M.avium_104 RVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALR------------- Rv3508|M.tuberculosis_H37Rv ---AAEQIVLGVINAPTQALLGRPLIGDGAN-ATTPGGAGGAGGLLFGN- MUL_4367|M.ulcerans_Agy99 PLQELEQQALGVVNAPSMALFGRPSIGNGVDGVAGTGQAGGAGGILWGN- MMAR_2656|M.marinum_M ALQLAEQNALNAINAPTQSWLGRPLIGNGVDATPGSGQAGGAGGLLWGN- Mb3541|M.bovis_AF2122/97 ----VEQNLLNLINAPTQTLLGRPLIGDGAN-ATTPGGAGGDGGLLFGS- Mflv_5091|M.gilvum_PYR-GCK ------------------------LICNGQD------GTGQNGGILFGN- Mvan_1264|M.vanbaalenii_PYR-1 ------------------------LICNGQD------GTGQNGGILFGN- MSMEG_0868|M.smegmatis_MC2_155 -----DQPTSDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------------------DGPSILSPSLLSPRDNDFLSHN- MLBr_01183|M.leprae_Br4923 -------------------------------------------SLLTSS- MAV_4827|M.avium_104 ---------------------------------DALAARRIDNVMLVSAF Rv3508|M.tuberculosis_H37Rv GGAGA-AGAPGQAGGPGGPAGLWGNGGPGGAGGS----GGGTGGAGGAGG MUL_4367|M.ulcerans_Agy99 GGNGG-LGAAGANGGAGGSAGLIGTGGVGGAGG----------------- MMAR_2656|M.marinum_M GGAGG-SGAAGQSGGAGGSAGLFGNGGAGGAGGISAAGNGGSGGVGGRGG Mb3541|M.bovis_AF2122/97 GGNGA-PGAPGQAGGAGGSAGLLGNGGSGGAGGT-----GAPGGNGGNAG Mflv_5091|M.gilvum_PYR-GCK GGSGWNSDVVGMDGGNGGNGGLFG--GNGGNGGN---------------- Mvan_1264|M.vanbaalenii_PYR-1 GGSGWNSEIAGVSGGNGGNAGLFG--GNGGNGGN---------------- MSMEG_0868|M.smegmatis_MC2_155 LGTTLIPNAPTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVP TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----DTDFASHNPIASGNQVMSPSGNVDSFNR----------------- MLBr_01183|M.leprae_Br4923 ------SAYAGTETANHDSL------------------------------ MAV_4827|M.avium_104 LAAAALAQNVGGAMGYERTAVLLVEPDTATLAVV---------------- Rv3508|M.tuberculosis_H37Rv WLFGVGGAGGVGGAGGGTGGAGGPGG--LIWGGGGAGGVGGAGGGTGGAG MUL_4367|M.ulcerans_Agy99 ----VGAAG----MTGGSGGAGGGGG--WLWGAGGSGGAAGAGG------ MMAR_2656|M.marinum_M LVYGSGGAGGAGGQGALSGGAGGAGGGAWLWGAGGAGGSGGEGLASAGGV Mb3541|M.bovis_AF2122/97 WLYGRGGVG---GAGGIGGGTGGAGGHAWLFGHGGTGGIGGGPGGNGG-- Mflv_5091|M.gilvum_PYR-GCK ------------GLGGGNGGNGGNAGAFALFGNGGNGGNG---------- Mvan_1264|M.vanbaalenii_PYR-1 ------------GLGSGDGGNGGDAGLFSLFGRGGNGGNG---------- MSMEG_0868|M.smegmatis_MC2_155 TVASAVLDPTQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISG--- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------GPLLDLSFGDLQFGNRDTTAIG---------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --------------------ETSDGSIPDVYKQQIR-------------- Rv3508|M.tuberculosis_H37Rv GRAELLFGAGGAGGAGTDGGPGATGGTGGHGGVGGDGG---WLAPGGAGG MUL_4367|M.ulcerans_Agy99 --------------------------------SGGSGG---WLWG----- MMAR_2656|M.marinum_M GGAG-----GNAGLIGTGGLGGAGGVGGQNGGAGGDGGNAPLLGRGGTGG Mb3541|M.bovis_AF2122/97 ------------WLLGNGGHGGAGGIGGGSGGAGGNGG--WLLGNGGIGG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv AG-----GQGGAGGAGSDGGALGGTGGTGGTGGAGGAGGRGALLLGAGGQ MUL_4367|M.ulcerans_Agy99 --------------------------NAGQTAGAG--------------- MMAR_2656|M.marinum_M VGGASDGGNGGAGGDGGVGGGLFGSGGAGGSGGAGGVLGTGGDGGSGGAA Mb3541|M.bovis_AF2122/97 AG-------GTGGGAGGTGGNAAWLLGGGGTGGAGGIG--GGNGGHGGNG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv GGLGGAGGQGGTGGAGGDGVLGGVGGTGGK-GGVGGVAGLGGAGGAAGQL MUL_4367|M.ulcerans_Agy99 --VGGAGGAGGAGDAGDQGVSG---------------------------- MMAR_2656|M.marinum_M AGLWGAGGSGGAGGNGADGISGGIGESGGD-G---GNAGNGGAGGRGGRL Mb3541|M.bovis_AF2122/97 GWLLGNGGNGGLGGDGDGGTGGGHGGNGGNPGWLLGTAGGGGNGGAGSTG Mflv_5091|M.gilvum_PYR-GCK ----GVGVVGATGAVGAPGVAG---------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ----GVGIAGATGAVGAPGVAG---------------------------- MSMEG_0868|M.smegmatis_MC2_155 -QYLIGNGINGTADNPNGGTGG---------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------DGAVAVGGSNSGPIAS---------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----AESYGDAAGQLSAMVAG---------------------------- Rv3508|M.tuberculosis_H37Rv FSAGGAAGAVGVGGTGGQGGAGGAGAAGADAPASTGLTGGTGF-AGGAGG MUL_4367|M.ulcerans_Agy99 --------------------------------VAPGEAGAVGF-AGGAGG MMAR_2656|M.marinum_M IGAGGAGGFGGVGGLGGAGGAGANG----IVAGSAGDGGGNGG-SGGAGG Mb3541|M.bovis_AF2122/97 TAGGGSGGTGGDGGTGGRGGLLMGAGAG--GHGGTGGAGGAGVDGGGAGG Mflv_5091|M.gilvum_PYR-GCK ------------------------------------ATGATGVTSGVVGG Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------ATGATGVTSNVTGG MSMEG_0868|M.smegmatis_MC2_155 ---------------------------------LLFGDGGHGYDGSAAGL TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv VGGQGGNA-----IAG-GINGSGGAGGTGGQGG-----AGGMGGSGADNA MUL_4367|M.ulcerans_Agy99 AGGAGGNG-----VGG-GVNGAGGAGGAGGVGG-----GGGAGASGVG-- MMAR_2656|M.marinum_M VGGDGGKGGLIRFLGGRGAGGSGGEGGAGGAAG-----DGGDGAAGSFLT Mb3541|M.bovis_AF2122/97 AGGAGGNGGAG--GQAALLFGRGGTGGAGGYGG-----DGGGGGDGFDGT Mflv_5091|M.gilvum_PYR-GCK NGED--------------AVGYGATGAAGAAGA-----AGAAG------- Mvan_1264|M.vanbaalenii_PYR-1 NGAD--------------AVGYGATGAAGAAGA-----AGAAG------- MSMEG_0868|M.smegmatis_MC2_155 AGGNGGNAGLFGNGGNGGVGWAGLDGGNGGSGGLLMGIGGAGGAGGVGAD TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------GQGSTAVNGDVRD----------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----------------LEKLESLPGGLLLVGS------GVDVAPLKQVL Rv3508|M.tuberculosis_H37Rv -SGIGADGGAGGTGGNAGAGGAGG-------------------------- MUL_4367|M.ulcerans_Agy99 ---AGVAGGDGGTGGAGGAAGVGG-------------------------- MMAR_2656|M.marinum_M GTGAGGAGGQGGDPGLGGAGGAGGRGSVPGSHGVTGQSPTSGGDGGNGGR Mb3541|M.bovis_AF2122/97 MAGLGGTGGSGGTGGDGGAPGNGG-------------------------- Mflv_5091|M.gilvum_PYR-GCK ---AAGAVGSAGAAGEAGETGTWG-------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ---KAGAVGSAGTAGSAGAPGVWG-------------------------- MSMEG_0868|M.smegmatis_MC2_155 GTSAHVDGGTGGTGGTGGGTGGTG-------------------------- TH_3810|M.thermoresistible__bu -----VD----GDGGSGGRTG----------------------------- MAB_4284c|M.abscessus_ATCC_199 --SNIINADHGSNVGVDQSQTRVG-------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 QTTTFLDVSVAEEPETALARG----------------------------- Rv3508|M.tuberculosis_H37Rv ---------AAGTGGTGGVVGAAGKAGIGGTGGQ---------------- MUL_4367|M.ulcerans_Agy99 ---------AAGTGGTG------GAAGVAGTGGD---------------- MMAR_2656|M.marinum_M GADAIDPATTAGAGGVGGDGGRYGNGGVGGAGGDGYRGYDGMSVVGGDGT Mb3541|M.bovis_AF2122/97 ---------AGGAGQLLSHSGVAGASGKGGAGGT---------------- Mflv_5091|M.gilvum_PYR-GCK ------------------------NAGLPGKAGD---------------- Mvan_1264|M.vanbaalenii_PYR-1 ------------------------NAGLPGAAGA---------------- MSMEG_0868|M.smegmatis_MC2_155 -------GIGGTGGGLFGLLGHSGSTGAAGAAGN---------------- TH_3810|M.thermoresistible__bu ---------------LFSKLSR---------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------------------------GDYTN---------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -GGAGGAGSAGTDATAT-GATGGTGFSGGAGGAGGAGGNTGVGG------ MUL_4367|M.ulcerans_Agy99 -GGDGGAGGAGSDASLA-GQAG---FAGGSGGAGGVGGSAGAGG------ MMAR_2656|M.marinum_M VGGDGGAGGAGGAGGMG-GALAGHGGAGGAGGDGGTGGIGGDGGRGVDGT Mb3541|M.bovis_AF2122/97 -GGNGGAGSAGADAPAGSGAMGSTGFAGGAGGDGGNGGGSGASQG----- Mflv_5091|M.gilvum_PYR-GCK ---AGGAGAVGAAGAAG--TVG----TAGATGGTGTGANGGAGG------ Mvan_1264|M.vanbaalenii_PYR-1 ---AGGAGAIGTAGVAG--AAG----TAGATGGTGVGGNGGAGQ------ MSMEG_0868|M.smegmatis_MC2_155 -GGDGGNGGFGYVLIAGPNVTVGSETRGGTGGAGGTGGQSTAAGP----- TH_3810|M.thermoresistible__bu -GGDGGDGGLG--------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---VSGHGSADIDKSVTVVDDHSQRNTTNINDSFNTDRSTNIGS------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ----AALAAANAPLFASSTAALAYAQDPGTGAVDQYSLPDYLYVP----- Rv3508|M.tuberculosis_H37Rv -------TNGSGGQGGTGGAGGAGGAGGVGADN--PTGIGGTGGTGGKGG MUL_4367|M.ulcerans_Agy99 -------VNGSGGDGGAGAAGGAGGASAT---------VAGSGGVGGDGG MMAR_2656|M.marinum_M DLSLDGTDGGSGGMGGVGGAGGDGGAGGLAQAAGFSDGIRGVGGAGGDGG Mb3541|M.bovis_AF2122/97 -------NGGNGGNGGTGGKGGTGGAGMNSLDPLLAAQDGGQGGTGGTGG Mflv_5091|M.gilvum_PYR-GCK -------VGGVGGTGAAGAAGGAGGLGET----------GTTGGAGGVGG Mvan_1264|M.vanbaalenii_PYR-1 -------AGGIGGTGAAGAAGQAGTAGET----------GVTGGVGGIGG MSMEG_0868|M.smegmatis_MC2_155 -------GKGGGGGGGGGGAILIGANGGTVDGH----AIGGNGGNGGNGS TH_3810|M.thermoresistible__bu ---------GNGGHGGGTGIISLLS-------------LAGNGGNGGNGY MAB_4284c|M.abscessus_ATCC_199 ---------GNTTNTEIGSHNQANIGTSTS--------AGGSAAVGGNAG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------VDPEPGDDELAYSAVGEEDAESPTVVIEKLFLPEDSEPRRRPV Rv3508|M.tuberculosis_H37Rv AGGAGGQGGSSG-----AGGTNGSGGAGGTGGQGGAGGAGGAGADN---- MUL_4367|M.ulcerans_Agy99 AGGAAG-------------------------------------------- MMAR_2656|M.marinum_M AGGGAGDGGDGANAPAASGLAGGSGGHGGDPGVGGAGGAGGTGSVTGAHG Mb3541|M.bovis_AF2122/97 NAGAGG-----------TGFTQGADGNAGNGGDGGVGGNGGNGADN---- Mflv_5091|M.gilvum_PYR-GCK QGTAGG-------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 QGTEGG-------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 TTAAGGNGGTGG-------------------------------------- TH_3810|M.thermoresistible__bu RTTDNN-------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 LAGNAG-------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 LLVGSG-------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------PTGIGGAGGTGGTGGAAGAGGAGGAIGTGGTGGAVGSVGNAG- MUL_4367|M.ulcerans_Agy99 ------------------------------------------GGVGAAS- MMAR_2656|M.marinum_M TEGLTQTTGGNGGDGGDGANASTVGASGGAGGAGGDGGRYGNGGVGGAGG Mb3541|M.bovis_AF2122/97 ------------------TTTAAAGTTGGAGGAGGAGGTGGTGGAAGTG- Mflv_5091|M.gilvum_PYR-GCK -----------------------------------------TGGVGGIG- Mvan_1264|M.vanbaalenii_PYR-1 -----------------------------------------TGGVGGVG- MSMEG_0868|M.smegmatis_MC2_155 ------------------------TGRVIAEGTGSTAEGTATGGDGGHS- TH_3810|M.thermoresistible__bu ---------------------------------------ALDGGHGGN-- MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------LAGNAGLAG- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -----------IGGTGGTGGVGGAGGAGAAAAAG-----SSATGGAGFAG MUL_4367|M.ulcerans_Agy99 -----------LGGDGGHAGAGGAGGEGLSGGFN-----TGAAGGIGGAG MMAR_2656|M.marinum_M DGYRGYDGMSVVGGDGTVGGDGGAGGAGGAGGMGGALAGHGGAGGAGGDG Mb3541|M.bovis_AF2122/97 -----------TGGQQGNGGNGGNGGTGGKGGTGGAGMNSLDPLLAAQDG Mflv_5091|M.gilvum_PYR-GCK -------------GAGSTGAVGGVGGKGIQGGQG-------LQGGKGGDG Mvan_1264|M.vanbaalenii_PYR-1 -------------GVGATGGAGGVGGKGIQGGQG-------LQGGQGGDG MSMEG_0868|M.smegmatis_MC2_155 ----------TGTGIGGNGGIGSVYAYGNNGAVS-----GTATGGRGGDG TH_3810|M.thermoresistible__bu ---------------GGNVGFFSLFNLG-------------GAGGWGGSG MAB_4284c|M.abscessus_ATCC_199 -------------NAGLAGNAGLAGNAGLAGNAG--------LAGNAGLA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---------------LAVVGISAVLALEIALAIGIRTTGTVALQPTPNQH Rv3508|M.tuberculosis_H37Rv GAGGEGGAGGNSGVGGTN--------GSGGAGGAGGKGGTGGAGGSGADN MUL_4367|M.ulcerans_Agy99 GAGGTGGDSG--GVGGVN--------GDGGAGGGGGRGGDGGSSTS---- MMAR_2656|M.marinum_M GTGGIGGDGGR-GVDGTDLSLDGTDGGSGGMGGVGGAGGDGGAGGLAQAA Mb3541|M.bovis_AF2122/97 GQGGTGGTGGNAGAGGTG-----FTQGADGNAGNGGDGGVGGNGGNGADN Mflv_5091|M.gilvum_PYR-GCK GAGGKGGDADSMGSAGATG-------GKGGNGGNGGRGGLFGKGGN---- Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGDATSMGEAGATG-------GKGGNGGNGGRGSLFGRGGN---- MSMEG_0868|M.smegmatis_MC2_155 IDGGTGGAGGMGEIYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQ TH_3810|M.thermoresistible__bu VDG---------------------------------VDVVGGN------- MAB_4284c|M.abscessus_ATCC_199 GNAGLAGNAGLAGNAGLAG-----------NAGLAGNAGLAGN------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 LIVPTEQAPAPPPVQASAP-----------QPKISVPEPVAAPKPLS--- Rv3508|M.tuberculosis_H37Rv ---------------PTGAGFAGGAGGTGGAAGAGGAGG--ATGTGGTGG MUL_4367|M.ulcerans_Agy99 ---------------TSGVGGAGGAGGNGGNAGFGVSAG--GTG------ MMAR_2656|M.marinum_M G----------FSDGIRGVGGAGGDGGAGGGAGDGGDGANAPAASGLAGG Mb3541|M.bovis_AF2122/97 -------------TTTAAAGTTGGAGGAGGAGGTGGTGGAAGTGTGGQQG Mflv_5091|M.gilvum_PYR-GCK ----------------AGNGADGGTGGAGGAGGTG--------------- Mvan_1264|M.vanbaalenii_PYR-1 ----------------AGNGGNGGTGGNGGNGGTG--------------- MSMEG_0868|M.smegmatis_MC2_155 AGYGPTTGGKASGTAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNT TH_3810|M.thermoresistible__bu -----------------------PDGGTPG-------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------AGLAGNAGLAGNAGLAG----------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ----------------PPVAAPLPAAPPPAAPPLP--------------- Rv3508|M.tuberculosis_H37Rv VVGATGSAGIGGAGGRGGDGGDGASGLGLGLSGFDGGQGGQGGAGG---- MUL_4367|M.ulcerans_Agy99 -----GSAGDGGAGG----------------------------------- MMAR_2656|M.marinum_M SGGHGGDPGVGGAGGAGGTGSVTGAHGTEGLTQTTGGNGGDGGDGANAST Mb3541|M.bovis_AF2122/97 NGGNGGNGGTGGKGGTGGAGMNSLDPLLAAQDGGQGGTGGTGGNAG---- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 AIGGNGGAASANGAVGGNGGFTNI-------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv ---SAGAGGINGAGGAGGNGGDGGDGATGA--------AGLGDNGGVGGD MUL_4367|M.ulcerans_Agy99 -----GAGGVDGVGGASGNGGAAGAGGAGG--------SGIG----AGID MMAR_2656|M.marinum_M VGASGGAGGAGGDGGRYGNGGVGGAGGDGYRGYD--GMSVVGGDGTVGGD Mb3541|M.bovis_AF2122/97 ---AGGTGFTQGADGNAGNGGDGGVGGNGGNGADNTTTAAAGTTGGAGGA Mflv_5091|M.gilvum_PYR-GCK -----GTGGAGGTGGTGGTGGIGGAGSTGG----------------TGGT Mvan_1264|M.vanbaalenii_PYR-1 -----GTGGNGGTGGTGGTGGIGGAGSTGG----------------TGGT MSMEG_0868|M.smegmatis_MC2_155 ---AAIHGSITDSSATSGHGGAAQGGNGGN---------------GGNGW TH_3810|M.thermoresistible__bu -----AHG------------------------------------------ MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------------NAGL MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---------------------------------------------EAPPI Rv3508|M.tuberculosis_H37Rv GGAGGAAGNGGNAGVGLTAKAGDGGAAGNGGNGGAGGAGGAGDN------ MUL_4367|M.ulcerans_Agy99 GGAGGAGGTGGAAGF-----PGGGGTTGAWGTGGAGGAGGAG-------- MMAR_2656|M.marinum_M GGAGGAGGAGGMGGALAG-HGGAGGAGGDGGTGGIGGDGGRGVDGTDLSL Mb3541|M.bovis_AF2122/97 GGAGGTGGTGGAAGTGTGGQQGNGGNGGNGGTGGKGGTGGDGALAG---- Mflv_5091|M.gilvum_PYR-GCK GGTGGTGGTGG-----------TGGTGGTGGTGGTGGKGGTG-------- Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTGGTGG-----------TGGTGGTGGTGGTGGKGGTG-------- MSMEG_0868|M.smegmatis_MC2_155 VQAYDPNGPAGTTIDKGKAAGGNGGDGGFNGTG--GATGGRG-------- TH_3810|M.thermoresistible__bu -ESHTP----GVYTDRQ-------GEDGEDGTG--TGIGGRG-------- MAB_4284c|M.abscessus_ATCC_199 AGNAGLAGNAG-----------LAGNAGLAGNAGLAGNAAVA-------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 PAAPPVVPVPVVVPPVPVPVPVRIPVPDPVSPPQLLAPPRLS-------- Rv3508|M.tuberculosis_H37Rv ----NFNGGQGGAGGQGGQGGLGGASTTS--------INANGGAGGNGGT MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2656|M.marinum_M DGTDGGSGGMGGVGGAGGDGGAGGLAQAAGFSDGIRGVGGAGGDGGAGGG Mb3541|M.bovis_AF2122/97 -----SSGGAGGKGGNGGDAGKAGTGSAPG-------TAGTGGDGGKGGN Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv GGKGGAGGAGTLGVGGSGGTGGDGGDAGSGGGGGFG--GAAGKAGGGGNG MUL_4367|M.ulcerans_Agy99 ------------GAGDHGGVGVNPGDSGTAG------------------- MMAR_2656|M.marinum_M AGDGGDGANAAAGSGAVGGKGGDGGDPGVGGAGGAG--GTGSVTGAHGTE Mb3541|M.bovis_AF2122/97 GGIGAAGTTGPVGTGASGGTGGSGGAGGTGGDGGAANGGTAGAGGAGGNG Mflv_5091|M.gilvum_PYR-GCK ------------GTGGAGGTGGDGGTGGTGG------------------- Mvan_1264|M.vanbaalenii_PYR-1 ------------GTGGDGGTGGTGGTGGTGG------------------- MSMEG_0868|M.smegmatis_MC2_155 ------------GDGAGASVWKANGQHSTGQTD----------------- TH_3810|M.thermoresistible__bu ------------GNGG-----SSSGTHPMAE------------------- MAB_4284c|M.abscessus_ATCC_199 ------------GNAAVAGNAAVAGNAAVGG------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ------------VPQPVQPPVRVPQPPSPPQ------------------- Rv3508|M.tuberculosis_H37Rv GRGGDGGDGASGLGLGLSGFDGGQGGQGGAGGSAGAGGINGAGGAGGNGG MUL_4367|M.ulcerans_Agy99 -------------------WAGGAGGAGGAGGSAAFNGVNGAGGAGGNGG MMAR_2656|M.marinum_M GLTQTTGGNGGDGGNGGSGTTGTTGSKGGAGGAGGDGGRYGNGGNGGTGG Mb3541|M.bovis_AF2122/97 GKGGDGGAGVTSSTAGNSGGAGGSGGKGGDAGAGGAGATPGANGIAGNGG Mflv_5091|M.gilvum_PYR-GCK --------------------TGGTGGTGGTGGTGGAG--DGTGGTGGTGG Mvan_1264|M.vanbaalenii_PYR-1 --------------------TGGTGGTGGTGGTGGAG--DGLGGTGGTGG MSMEG_0868|M.smegmatis_MC2_155 --------------------TGGNGGRGGDGGTFVNAGANGNGGAGGAGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv DGGDGATGAA-----------GLGDNGGVGGDGGAGGAAGNGGNAGVGLT MUL_4367|M.ulcerans_Agy99 AGGGGGAGAS-----------GIG-AGVAGGDGGTGGTGG---------- MMAR_2656|M.marinum_M TGSTGTAGSSDVMGAN----GGAGGSGWAGGDGGAGGMGG----TLAGHG Mb3541|M.bovis_AF2122/97 DGGDGAAGAVGISGATGAGDGGHGGTGGAGGNGGTGGAGG-----SGIDG Mflv_5091|M.gilvum_PYR-GCK TGGQG----------------GQGGQGGTGGTGGQGGLGG---------- Mvan_1264|M.vanbaalenii_PYR-1 TGGFG----------------GQGGQGGTGGTGGQGGLGG---------- MSMEG_0868|M.smegmatis_MC2_155 VSEGEGGTG------------GHGGDGGRGGDGALGGNGG-------TGG TH_3810|M.thermoresistible__bu -----------------------DGEHVKALDGRPGLDG----------- MAB_4284c|M.abscessus_ATCC_199 ----------------------VLNTGVSGAIGGSSHVGG---------A MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------VGGTVPQSPPQHQTP---------- Rv3508|M.tuberculosis_H37Rv AKAGDGGAAGNGGNGGAGG-----------AGGAGDNNFNGGQGGAGGQG MUL_4367|M.ulcerans_Agy99 -AAGTGGAAGTGGTGGAAG-----------AAGS---------------- MMAR_2656|M.marinum_M GDGGDGGSGGTGGTGGRGGNGFNGSTKAGLNGGDAGDGGAGGVGGAGGNG Mb3541|M.bovis_AF2122/97 VGGGTGGTGGNGGNGAIGG----------AGGDAGGSGNSGGNGGTGGKG Mflv_5091|M.gilvum_PYR-GCK -GGGTGGQGGTGGTGGQGG------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -VGGTGGTGGTGGTGGQGG------------------------------- MSMEG_0868|M.smegmatis_MC2_155 VGLGNGGKGGNGGNGGNGGT------------------------------ TH_3810|M.thermoresistible__bu ---GNGSHGGNGGHGGRGG------------------------------- MAB_4284c|M.abscessus_ATCC_199 INESLGGSGSVGGSTAVGG------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --PGEGTPPKPDGPGNYGG------------------------------- Rv3508|M.tuberculosis_H37Rv GQGGLGGAS--TTSINANGGAGGNGGTGGKGGAGGAGT---LGVGGSGGT MUL_4367|M.ulcerans_Agy99 ---------------------AGDGGAGGAGGAGDDGS---AGVVS---- MMAR_2656|M.marinum_M GAAGLAQAAGFSDGIQGAGGAGGDGGAGGGAGDGGDGANAAAGSGAVGGN Mb3541|M.bovis_AF2122/97 GNAGAGGAAGSNGGTVGANGTGGDGGNGGAAGAATAGSNGGAGTGSAGGN Mflv_5091|M.gilvum_PYR-GCK -----------------------TGGTGGTGGTG---------------- Mvan_1264|M.vanbaalenii_PYR-1 -----------------------TGGTGGTGGTG---------------- MSMEG_0868|M.smegmatis_MC2_155 ---------------YVDPSHTGAGGNGGNGGAGRIRVNNGTATGTA--- TH_3810|M.thermoresistible__bu --------------------FLGIGGSGGWG------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------------GAHTGVGGGVSTG---------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ----------------------------GHVPTP---------------- Rv3508|M.tuberculosis_H37Rv GGDGGDAGSGGGGGFGGAAGKAGGGGNGGVGGDGGEGASGLGLGLSGFDG MUL_4367|M.ulcerans_Agy99 ----GDPG---------TAGKAGGAG------------------------ MMAR_2656|M.marinum_M GGDGGDPGLGGGGGAGGTGATTGAHGADGLSPTTGGNGGKGGNGGSGAIG Mb3541|M.bovis_AF2122/97 GGTGGRGGSGGAGG-DGIGGVGGGKGGNGADGEVGGAGGAGGSGPNTSPG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv GQGGQGGAGGSAGAGG-INGAGGAGGTGGAGGDGAPATLIG--GPDGGDG MUL_4367|M.ulcerans_Agy99 ---GAGGVGGNGVAGG-VNGSGGAGGAG---------------------- MMAR_2656|M.marinum_M VAGGAGGAGGDGGLYG-DGGDGGSGGNGGAGKAGAAGVSAGSNGEAGGQA Mb3541|M.bovis_AF2122/97 GNGGQGGQGGSGGAGG-AAGAGGAGGGANGTAGNGGQGGAGGTGGAGAAS Mflv_5091|M.gilvum_PYR-GCK ---GTGGAGGDGGLGG-LGGFGGSGGTG---------------------- Mvan_1264|M.vanbaalenii_PYR-1 ---GTGGAGGDGGLGG-LGGFGGVGGTG---------------------- MSMEG_0868|M.smegmatis_MC2_155 -TGGNGGNGGNGDADGHRGGKGGDGGEALIRATVIGSNASG--------- TH_3810|M.thermoresistible__bu ---GHGGNGGDTDADGGNGGDGGNGG------------------------ MAB_4284c|M.abscessus_ATCC_199 --VGVGSHVGGGISES-LGGSGSVGGST---------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---GAGGSGGSGGGHVPTPGAGGSGGSG---------------------- Rv3508|M.tuberculosis_H37Rv GQGGIGGDGGNAGFGAGVPGDGGDGGNAGFGAGVPGDGGIGGTGGAGGAG MUL_4367|M.ulcerans_Agy99 --------------------------------------------GAGGTG MMAR_2656|M.marinum_M GAGGVGGAGGNGGANAGNGGTGGNGGDGGVG-GTGGAGKVGTTGPAGGAG Mb3541|M.bovis_AF2122/97 SATNGGSGGAGGTGGAGGTGGAGGDGVGGAGGGNGGHGGDAGDGGNGANG Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------GQGGLG Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------GQGGQG MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------TATGGDG TH_3810|M.thermoresistible__bu ---------------------------------------------SAGRG MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------AVGGGA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv GAGADGDPSIDGGQGGAGGHGGQGGKGGLNSTGLASAASGDGGNGGAGGA MUL_4367|M.ulcerans_Agy99 GAGASGVP-----------------------------ASVDGGDGGAGGA MMAR_2656|M.marinum_M GEGGDGGKGGTGGRGGNGGAGG-----TAQAAGYSDGSQGVGGDGGAGGT Mb3541|M.bovis_AF2122/97 NNRSSGSFLAAGGTGGAAGDGG-----QGGQGGAGGGAGGQGGAGGAGGT Mflv_5091|M.gilvum_PYR-GCK GPG--------------------------------------GSTGGAGGA Mvan_1264|M.vanbaalenii_PYR-1 GPG--------------------------------------GSTGGAGGA MSMEG_0868|M.smegmatis_MC2_155 GNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGHGGSGINGGHGGN TH_3810|M.thermoresistible__bu GTGGLRGVF--------------------------------GINGGNGR- MAB_4284c|M.abscessus_ATCC_199 HTGVGGG---------------------------------VSTGVGVGSH MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----------------------------------------GGHVPTPGT Rv3508|M.tuberculosis_H37Rv GGNGGDGDGFIGGSGGTGGTGGDAGVGGLANTGGTAGNAG----IGGAGG MUL_4367|M.ulcerans_Agy99 GG-----------AAGTGGSG------------GSAGNTG----AGGAGG MMAR_2656|M.marinum_M GG--------TAGNGGKGGAGTWAVNNGIGGKGGNGGNAG----TGGTGG Mb3541|M.bovis_AF2122/97 GGNGGNITGGTAGTAGAAGNGGAAGKGGAGGQGGTGGGTGGQGGAGGDGG Mflv_5091|M.gilvum_PYR-GCK GG-----------QAGTAGKG------------GLFGGSG------SAGK Mvan_1264|M.vanbaalenii_PYR-1 GG-----------QAGVAGKG------------GLFGGSG------SAGT MSMEG_0868|M.smegmatis_MC2_155 GG-----------QGTIEANGPSAVASGIGAGGNGGDGID-----GGLGG TH_3810|M.thermoresistible__bu ---------------------------------------------AGLGG MAB_4284c|M.abscessus_ATCC_199 VG----------------------------------GGIS-----ESLGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 GG------------------------------------------PGGTGG Rv3508|M.tuberculosis_H37Rv RGGDG---GAGDSGALSQDGNGFAGGQGGQ-----GGVGGNAGAGGINGA MUL_4367|M.ulcerans_Agy99 AGGAG---GSAASTGVNGDG----------------------------GA MMAR_2656|M.marinum_M SFGTGSQIGNHGSTGHLGDGGDGGTGGAGVNATAPGQDGAAGGVGGNGGI Mb3541|M.bovis_AF2122/97 AGGTGGDRTVGGGTVPAGSGGQGGNAGGGGAGGQGGADGGSGGDGGDAGT Mflv_5091|M.gilvum_PYR-GCK AGATG-------------------------------------------AA Mvan_1264|M.vanbaalenii_PYR-1 AGVTG-------------------------------------------AS MSMEG_0868|M.smegmatis_MC2_155 NGGDGVVNTTANAANPGSATGTATGG----------------------DG TH_3810|M.thermoresistible__bu RGXX--------------------------------------------XX MAB_4284c|M.abscessus_ATCC_199 SGSVG-------------------------------------------GS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 SGG---------------------------------------------GH Rv3508|M.tuberculosis_H37Rv GGTGG----------TGGAGGDGQNGTTGVASEGG--AGGQGGDGGQG-G MUL_4367|M.ulcerans_Agy99 GGAGG----------VGGLGGDS-------AATAG--GGGAGGDGGKG-G MMAR_2656|M.marinum_M VGDGG----------VGGKGGDGAAGTTGSSGTASGEAGKDGGDGGKG-G Mb3541|M.bovis_AF2122/97 GGNGGNGGNRNSGNGTGGAGGNGGGGANGGAGGAGGSGGGTGGNGGAG-G Mflv_5091|M.gilvum_PYR-GCK GASGG--------------------------------KGAQGATGAQG-A Mvan_1264|M.vanbaalenii_PYR-1 GASGG--------------------------------KGAQGATGAQG-A MSMEG_0868|M.smegmatis_MC2_155 GKATG--------------------------------TASQGGNGGPSWV TH_3810|M.thermoresistible__bu GGGVG--------------------------------AAVRSGNG----V MAB_4284c|M.abscessus_ATCC_199 TAVGG---------------------------------GAHTGVGGGVNT MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 VPTPG--------------------------------AGTPGGSGGGHLP Rv3508|M.tuberculosis_H37Rv IGGAGGNAGFGAGVPGDGGIGGTGGAGGAGGAGADGDP-------SIDGG MUL_4367|M.ulcerans_Agy99 AGGAGVNGVGG----GDGGKGGTGGAGGAGGAGSDGII-------PSNGG MMAR_2656|M.marinum_M AGGAGGNGGTSRGDGGAGGAGGTGGVGGSGGDGADGTSGLFGGADGTAGG Mb3541|M.bovis_AF2122/97 DAGDAGNGGNGNG-TGNGGNGGNGGIAGMGGNGGAGTG-------SGNGG Mflv_5091|M.gilvum_PYR-GCK TGAQGATGATG----AAGKAGATGAAGAAGAAGSAGTT-------GAQGS Mvan_1264|M.vanbaalenii_PYR-1 TGAQGATGATG----ASGAQGSAGSAGSAGVAGSAGTT-------GAQGS MSMEG_0868|M.smegmatis_MC2_155 QSGYGSTLGGNATGTATAGKGGEASNGGVAGNGGNALV-------MAAGT TH_3810|M.thermoresistible__bu FSGGG--------GTPSAGFGVPTT---IQFPAGSCTS-------RAVSR MAB_4284c|M.abscessus_ATCC_199 GVGVGSHVGGG----ISESLGGSGSVGGSTAVGGGAHTS------AINDA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 FPGAGSTPGGS--------GGGHLPTPGAGTPGG------------GLGG Rv3508|M.tuberculosis_H37Rv QGGAGGHGGQGGKGGLNSTGLA-------------SAASGDGGNGGAGGA MUL_4367|M.ulcerans_Agy99 LGGNGGNGGNGGQ------------------------AFGDG-------- MMAR_2656|M.marinum_M AGGDGGDGGAGGAGGAGGKAVSGVGQNGSQGAGGNGGAAGDGGDGGNGGN Mb3541|M.bovis_AF2122/97 NGGSGGNGGNAGMGGNSGTGSG------------DGGAGGNGGAAGTGGT Mflv_5091|M.gilvum_PYR-GCK AGTNGANGANGSQ------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 AGTNGANGANGSQ------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 TGVATGNTATGGDG------------------------------------ TH_3810|M.thermoresistible__bu EGIMPSSRAASARA------------------------------------ MAB_4284c|M.abscessus_ATCC_199 LGGSGSVGGSTAVG------------------------------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 FGGGHAPAPGGGLG------------------------------------ Rv3508|M.tuberculosis_H37Rv GGNGGDGDGFIGGSGGTGGTG---GDAGVGGLANTGGTAGNAGIGGAGGR MUL_4367|M.ulcerans_Agy99 ----------VGGAGGIGGKG---GNAAIGTIVING-------------- MMAR_2656|M.marinum_M GHDGNNGSVPSGGTDRDGGDGQGGGDGGAGGAGGAGGNGGAAGAGGGGTR Mb3541|M.bovis_AF2122/97 GGDGGLTG--TGGTGGSGGTG---GDGGNGGNGGNGADNTANMTAQAG-- Mflv_5091|M.gilvum_PYR-GCK -----------GAAGKAGATG---TTGATGAAGEDG-------------- Mvan_1264|M.vanbaalenii_PYR-1 -----------GAAGKAGATG---TTGATGAAGDAG-------------- MSMEG_0868|M.smegmatis_MC2_155 -----------GAATTAGATG---GAGGFSNIAAIHG------------- TH_3810|M.thermoresistible__bu -----------GAACASSTSR---SRRSFCCSRA---------------- MAB_4284c|M.abscessus_ATCC_199 -----------GGAHTSAINESMNSSINASHSSSMNES------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----------GGGGHAPAPG----------------------------- Rv3508|M.tuberculosis_H37Rv GGDGGAGDSGALSQDGNGFAGGQGGQGGVGGNAGAGGINGAGGTGGTGGA MUL_4367|M.ulcerans_Agy99 ------------------------------------GVGGAGGSGGLGGA MMAR_2656|M.marinum_M GAGGDGGDGGNGGFAGDGGLGMDGLDATLTNRAGDGGDGGGGGQAFAGGA Mb3541|M.bovis_AF2122/97 ---GDGGNGGDGGFGGGAGAGGGGLTAGANGTGGQGGAGGDGGNGAIGGH Mflv_5091|M.gilvum_PYR-GCK -------------------------------------DAGSGGSGINGGA Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------DPGSEAVDINGGA MSMEG_0868|M.smegmatis_MC2_155 --------------------------------------AITDSTAISGHG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------FGSSMGSHGAAGT MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv G-------GDGQNGTTGVASEGGAGGQGGDGGQGGIGGAGGNAGFGAGVP MUL_4367|M.ulcerans_Agy99 T-------EDG--------------------------------------- MMAR_2656|M.marinum_M G-------GAGGTGSTQGSAGTTGAWRAGGDGGSGGDGGDGFGLWNPGEG Mb3541|M.bovis_AF2122/97 GPLTDDPGGNGGTGGNGGTGGTGGAGIGSLGGGTGGDGGNGGTGGNGGTG Mflv_5091|M.gilvum_PYR-GCK G------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 G------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 G------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 G------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv GDGG-IGGTGGAGGAGGAGADGDPSIDGGQGGAGGH-----GGQGGKGGL MUL_4367|M.ulcerans_Agy99 -----VGGVGCAGGAG--------------------------GNGGRGDM MMAR_2656|M.marinum_M GRGG-SGGDGGTGGDGGDGGNGRVEIWEGRGGNGGNGAIGPGGDGGDGGD Mb3541|M.bovis_AF2122/97 GEGGEVGGAGGTGGAAGNGGDGGTGGTGGGDGGAGG----TGGTGGTGGL Mflv_5091|M.gilvum_PYR-GCK -------GAGGAGGEGG--------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------GAGGAGGEGG--------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ------AGNGGNGGKGADGWVQAYDPAGPVGSKIAN-------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv NSTGLASAASGDGGNGGAGGAGGNGGAGGLGGGGGTGGT------NGNGG MUL_4367|M.ulcerans_Agy99 LFT-----------VGGSGGTGGDGGGGGSASGSGTGGS------GGTGG MMAR_2656|M.marinum_M APNQQRVSSSSPGYEGADGGNGGNGTIGGNGGNGGTGGPGYDASLGGEAT Mb3541|M.bovis_AF2122/97 GDPR----VGGSGGDGGTGGSGGAAGNGGNGGNAGAGGNGN----GGTGG Mflv_5091|M.gilvum_PYR-GCK --------------EGGDGGKGGAGAEGGAGGGGGAGGS-------GAGG Mvan_1264|M.vanbaalenii_PYR-1 --------------EGGAGGAGGDGSEGGAGGSGGAGGS-------GTGG MSMEG_0868|M.smegmatis_MC2_155 --------------SSAVAGNGGDGGVNGTGGASGGDGGN-----GGNTS TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------FEAQGHAQGHASETAHTTLPGAEHH----------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---------------GGLGGFGGGHSGGGLGGLGGGHK------------ Rv3508|M.tuberculosis_H37Rv LGGGGGNGGAGGAGGTPTGSGTEGTGGDGGDAGAGGNGGSATGVGNGGNG MUL_4367|M.ulcerans_Agy99 VGGIGGDGKLG------------------------------------GFG MMAR_2656|M.marinum_M AGGEGGDGGDGGKGFNGAG----GAGGDGGAGGAGGSGAPAPFGSGGAYG Mb3541|M.bovis_AF2122/97 AGGIGGTGGNGGDAEPGVPPGAGGAGGAGTTGGKGGTGGNGSGTGSGGTG Mflv_5091|M.gilvum_PYR-GCK AGGAGGS------------------------------------------G Mvan_1264|M.vanbaalenii_PYR-1 AGGAGGS------------------------------------------G MSMEG_0868|M.smegmatis_MC2_155 VWKSGGQTADG----------------------------------EHNTG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv GDGGNGGDGGNGAPGGFGGGA--GAGGLGG-------SGAGGGTDGDDGN MUL_4367|M.ulcerans_Agy99 GDGGDGGDGGFGVIGGQGGGG--GFGGLGG-------TGAGG-APSDKGI MMAR_2656|M.marinum_M GTGGQGGTGGSGVIGGIGEGGKIGDAGFGGN-PPNSQTGEGG-SGGAGGA Mb3541|M.bovis_AF2122/97 GDGGTGGGGGNGGTGWNGGKGDTGSGGGAGD-GGKAPAGGTGGAGGDGGA Mflv_5091|M.gilvum_PYR-GCK GSGGSGGSGGSGGAAGDSDD------------------------------ Mvan_1264|M.vanbaalenii_PYR-1 GSGGSGGAGGSGGAAGDSD------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GNGGNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv GGSPGTDGS------ MUL_4367|M.ulcerans_Agy99 NGEPGNPG------- MMAR_2656|M.marinum_M GGAGGDPSN------ Mb3541|M.bovis_AF2122/97 GGKGGSGGV------ Mflv_5091|M.gilvum_PYR-GCK --------------- Mvan_1264|M.vanbaalenii_PYR-1 --------------- MSMEG_0868|M.smegmatis_MC2_155 DGTPGTAGTTGANNP TH_3810|M.thermoresistible__bu --------------- MAB_4284c|M.abscessus_ATCC_199 --------------- MLBr_01183|M.leprae_Br4923 --------------- MAV_4827|M.avium_104 ---------------