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MVVDSCVAESRYGPVRGADDGRVKVWKGIRYAAPPLGDLRFRTPEPPERWTEVADATTFGPACPQPAIPN MPLDLGASQSEDCWSLNIWAPADTEPGDGKPVMVWLHGGAYILGSGSQPLYNGRRLAASGDVVVVTVNYR LGALGFLDLSSFNTSRRRFDSNIGLRDVLAVLRWVADNIAVFGGDPEKVTLFGESARESSRPCSPPRRPR VCSRRRSPRAHRRHRSTTR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1134 | - | - | 100% (229) | hypothetical protein Mb1134 |
| M. bovis AF2122 / 97 | Mb2071c | lipT | 3e-42 | 48.96% (192) | carboxylesterase LipT |
| M. bovis AF2122 / 97 | Mb1434c | lipH | 7e-09 | 33.33% (99) | lipase LipH |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3419 | - | 4e-75 | 67.89% (190) | carboxylesterase, type B |
| M. tuberculosis H37Rv | Rv1104 | - | 1e-136 | 100.00% (229) | hypothetical protein Rv1104 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2866c | - | 2e-43 | 46.67% (195) | carboxylesterase (LipT) |
| M. marinum M | MMAR_4363 | - | 3e-83 | 69.61% (204) | carboxylesterase |
| M. avium 104 | MAV_1226 | - | 3e-89 | 76.53% (196) | carboxylesterase superfamily protein |
| M. smegmatis MC2 155 | MSMEG_3667 | - | 8e-72 | 62.56% (195) | para-nitrobenzyl esterase |
| M. thermoresistible (build 8) | TH_3679 | - | 7e-78 | 66.49% (194) | PUTATIVE Carboxylesterase, type B |
| M. ulcerans Agy99 | MUL_2261 | lipT | 2e-41 | 49.21% (191) | carboxylesterase, LipT |
| M. vanbaalenii PYR-1 | Mvan_3172 | - | 5e-75 | 66.84% (190) | carboxylesterase, type B |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1134|M.bovis_AF2122/97 ---------------------------------MVVDSCVAESRYGPVRG
Rv1104|M.tuberculosis_H37Rv ---------------------------------MVVDSCVAESRYGPVRG
MMAR_4363|M.marinum_M --------------------------MTSDIRRMASDGYVVETAYGPVRG
MAV_1226|M.avium_104 ---------------------------------MAVDDLVVETGYGPVR-
Mflv_3419|M.gilvum_PYR-GCK ------------------------MTAEATPRSSA---PVVDTSTGPVRG
Mvan_3172|M.vanbaalenii_PYR-1 ------------------------MTADATTRSSAGGRPVVETTNGPVRG
MSMEG_3667|M.smegmatis_MC2_155 -------------------------MANAARIADG---PVAETGYGPVRG
TH_3679|M.thermoresistible__bu ----------MPSTTPPDDRTPDDAPTRPAPAHSAVGSPVVDTVHGPVRG
MUL_2261|M.ulcerans_Agy99 ---------------------------------MHERTVRARTATGVVEG
MAB_2866c|M.abscessus_ATCC_199 MYPEKTRGNFPAPPLRLCGPVTADRTTIRYVAVDVALPTVVRTPLGALRG
. : * :.
Mb1134|M.bovis_AF2122/97 -----ADDG---RVKVWKGIRYAAPPLGDLRFRTPEPPERWTEVADATTF
Rv1104|M.tuberculosis_H37Rv -----ADDG---RVKVWKGIRYAAPPLGDLRFRTPEPPERWTEVADATTF
MMAR_4363|M.marinum_M AEDGIAAAGSGVRTKSWKGIRYGAPPVGELRFRAPQPPQPWTEIADATAF
MAV_1226|M.avium_104 ---GVPVDG----VKAWKGIRYAAPPIGDLRFRAPQPPERWTEVADATVF
Mflv_3419|M.gilvum_PYR-GCK -----LDDG---IIKSWKGVPYAAAPVGELRWRAPEPPPAWTEPRDATRV
Mvan_3172|M.vanbaalenii_PYR-1 -----VDDG---SVKSWKAVRYAAAPVGELRWRAPEPPQAWSEPVDAGRV
MSMEG_3667|M.smegmatis_MC2_155 -----TDDG---TAKAWLGIRYARAPIGELRWRAPEPPASWHDVFDATRV
TH_3679|M.thermoresistible__bu -----RDDG---VVKVWRGIRYAAAPVGGLRWRAPEPPQPWREPMDAIRV
MUL_2261|M.ulcerans_Agy99 ----FTRDG----VHRWRSIPYARAPIGLLRFRAPRPPQPWSGVRHCHGF
MAB_2866c|M.abscessus_ATCC_199 -----AIEG---GVSVWRGVPYAQQPVEQLRFLAPVPLEPWEGVRDAIEH
* * .: *. *: **: :* * * ..
Mb1134|M.bovis_AF2122/97 GPACPQPAIPNMP-LDLGASQSEDCWSLNIWAPADTEPGDGKPVMVWLHG
Rv1104|M.tuberculosis_H37Rv GPACPQPAIPNMP-LDLGASQSEDCWSLNIWAPADTEPGDGKPVMVWLHG
MMAR_4363|M.marinum_M GPVCPQPVLANMP-IDLGAPQDEDCLRLNIWAPANTAPGAAKPVMVWLHG
MAV_1226|M.avium_104 GPACPQPVFPNMP-LDLGAPQGEDCLRLNVWASADTQPGDAKPVMVWLHG
Mflv_3419|M.gilvum_PYR-GCK GPVCPQPTDPKIP-LDLGAPQGEDFLSLNVWAPSGTQPGDRKPVMVWVHG
Mvan_3172|M.vanbaalenii_PYR-1 GPVCPQPTDPRIP-IDLGAPQGEDFLTLNIWAPSGTQPGDAKPVMVWIHG
MSMEG_3667|M.smegmatis_MC2_155 GAVCPQATDARIP-IDLGGKQDEDSLVLNVWAPSGCRPGDRRPVMVWVHG
TH_3679|M.thermoresistible__bu GPACPQPADPRIP-LDLGAAIGEDCLNLNVWASSDTEPGDRKPVLVWVHG
MUL_2261|M.ulcerans_Agy99 THCSPQQRRYTMLGLGKYQPMSEDCLTLNVVAPEAPTHR-PLPVMVFIHG
MAB_2866c|M.abscessus_ATCC_199 APLPPQGKSFVGAGRDDPKIRGEECLTVTVWSP---DVHASLPVMVWIPG
** . .*: :.: :. **:*:: *
Mb1134|M.bovis_AF2122/97 GAYILGSGSQPLYNGRRLAASGDVVVVTVNYRLGALGFLDLSSFNTSRRR
Rv1104|M.tuberculosis_H37Rv GAYILGSGSQPLYNGRRLAASGDVVVVTVNYRLGALGFLDLSSFNTSRRR
MMAR_4363|M.marinum_M GAYMLGSASQALYDGRRLASSGEVIVVTVNYRLGALGFLDLSSLSHAGRS
MAV_1226|M.avium_104 GAYVLGSSSQTLYDGRRLVSHGDVVVVTVNYRLGALGFLDLSSLNSAGRS
Mflv_3419|M.gilvum_PYR-GCK GAYVLGSASQPLYHGRAMAGAGDVIVVTVNYRLGALGFLELSTLD-DSGR
Mvan_3172|M.vanbaalenii_PYR-1 GAYILGSASQPLYHGGTLASGGDAVVVTVNYRLGALGFLELSTLGADPER
MSMEG_3667|M.smegmatis_MC2_155 GAYVLGSASQPLCRGRVLASEGDVVVVTVNYRLGPFGFLDLSEYSSRAMR
TH_3679|M.thermoresistible__bu GAYVIGAASQPLYHGRELVRRGDVVLVTLNYRLGAFGFLELTALSSGRRR
MUL_2261|M.ulcerans_Agy99 GGYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTPDIA
MAB_2866c|M.abscessus_ATCC_199 GAFVFGAGQLELYSGARLAANGNVVVVNVTYRLGALGGLELSALG---EG
*.:::*:. : * :. * : *.:.****.:* *:*: .
Mb1134|M.bovis_AF2122/97 FDSNIGLRDVLAVLRWVADNIAVFGGDPEKVTLFGESARE----------
Rv1104|M.tuberculosis_H37Rv FDSNIGLRDVLAVLRWVADNIAVFGGDPEKVTLFGESARE----------
MMAR_4363|M.marinum_M FDSNVGLRDVLAALHWVRENIAAFGGDPANITLFGESAGAGLVTTLLVTP
MAV_1226|M.avium_104 FDSNVGLRDVLAALEWVRDNITAFGGDPRRVTLFGESAGAGIVTTLLASP
Mflv_3419|M.gilvum_PYR-GCK FASNLGLRDVLAALGWVRDNIAAFGGDPGRVTVFGESAGGGIVTSLLGSP
Mvan_3172|M.vanbaalenii_PYR-1 FATNLGLRDVLAALEWVRDNIAAFGGDPGRVTVFGESAGGGIVASLLASP
MSMEG_3667|M.smegmatis_MC2_155 FDTNLGLRDVIFALQWVRDNIAAFGGDPSRVTLFGESAGGGMITTLLASP
TH_3679|M.thermoresistible__bu FDTNVGLRDVLFALAWVRDNIAAFGGDPDRVTLFGESAGGGIVTTLLGSP
MUL_2261|M.ulcerans_Agy99 IDGNLYLRDLVMALQWIQDNIAEFGGDPDNVTIFGESAGAHITATLLAVP
MAB_2866c|M.abscessus_ATCC_199 FDDNLALRDQMAALTWVRDNIAAFGGDPDHVTIFGESAGATSVLALLASP
: *: *** : .* *: :**: ***** .:*:*****
Mb1134|M.bovis_AF2122/97 -----------SSRPCS---------------------------------
Rv1104|M.tuberculosis_H37Rv -----------SSRPCS---------------------------------
MMAR_4363|M.marinum_M AARGLFSRAIAQSSPATSVYDRERAQRVAVHLLDKLGVAASDVD-KLTQL
MAV_1226|M.avium_104 AAAGLFAAAIAQSSPATSVYDRDRAARVAEAFLGKLGITASESR-RLIDM
Mflv_3419|M.gilvum_PYR-GCK AAAGLFHAAIAQSSPATSMYDVGRARRVATRFLEVIGVDRADMS-ALTTA
Mvan_3172|M.vanbaalenii_PYR-1 AAAGLFSAAIAQSAPVTSTYELGRAQRVAERFLDVLGARPDDLH-RLSEA
MSMEG_3667|M.smegmatis_MC2_155 AAEGLFSAAIAQSSPATSVYDAERSRRVARALLERLLIEPDDAA-RLAHV
TH_3679|M.thermoresistible__bu AAAGLFHRAIAQSSPATSCYGTERAIDVAEQFLGHLGLSPRDVD-RLPDV
MUL_2261|M.ulcerans_Agy99 AAKGLFARAISESPAAGMVRPREIAAEFATRFARLLGARKHDAASALMRA
MAB_2866c|M.abscessus_ATCC_199 AAEGLFGRAIAQSPALPLIADKALRDKRAHRYLELLDVTDPS---RLKVL
.* .
Mb1134|M.bovis_AF2122/97 ----------------PPRRP-------------------RVCSRRRSP-
Rv1104|M.tuberculosis_H37Rv ----------------PPRRP-------------------RVCSRRRSP-
MMAR_4363|M.marinum_M PTAAIVAASTEVFNEVPVRNPGTLAFVPIVDGDVLTDYPVKVAQEGRSHP
MAV_1226|M.avium_104 PMAAILAASQQVFDEVPVRNPGTLAFVPIVDGDVLADYPVKVAQQGCSHP
Mflv_3419|M.gilvum_PYR-GCK PISALVEASRTVFNEVPVRTPGTLAFAPTIDGDLLPDYPVNLARNGKTHP
Mvan_3172|M.vanbaalenii_PYR-1 PIDVLVEASRTVFDEVPVRTPGTLAFAPTVDGDLLPDYPVNLARQGRTHP
MSMEG_3667|M.smegmatis_MC2_155 PIPAILGASQQIFNEVPAQSPGTLAFAPIVDGDVVPDYPVQAARAGRTHR
TH_3679|M.thermoresistible__bu PVAAIVEVSKHVFDDVPARRPGTLAFAPIVDGDIVPDYPVALARAGRTLP
MUL_2261|M.ulcerans_Agy99 TAAQLVQTQHRLIDQGMQKRLGAFPIGPTFGDDCLPLDPVEAMRAGQSHK
MAB_2866c|M.abscessus_ATCC_199 PQRELRRGAAKLQIESATETP-VLGYGLAHGTELLPYHPIEAARRGEVHQ
.
Mb1134|M.bovis_AF2122/97 --------------------------------------------------
Rv1104|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4363|M.marinum_M VPLLIGTNKHEAALFRLMRSPLMPITPRAITSMFTQIAAEQPDLQLPTEE
MAV_1226|M.avium_104 VPLIIGTNQHEAALFRLMRSALMPITPHAITSMFNQIAAEQPDLQLPTEK
Mflv_3419|M.gilvum_PYR-GCK VPLLIGTNKNEAALFRYMKSPLMPVAPESVRAMFAEISAEQPTLQLPSED
Mvan_3172|M.vanbaalenii_PYR-1 VPLIIGTNKNEAALFRYMKSPLMPIAPASIKAMFAEIAAEQPGLQLPSED
MSMEG_3667|M.smegmatis_MC2_155 VPLIIGTNKHEASLFRWMKSPLMPITPEAIRAMFEGIASEQPGLALPTEE
TH_3679|M.thermoresistible__bu VPLVIGTNKDEASLFRWMKSPLLPITPDAIKKMFADIAAEQPGLRLPTET
MUL_2261|M.ulcerans_Agy99 VPLIVGTNADEGRLFTRFLK-MLPTNKAMIDELLADTEP-------ATRE
MAB_2866c|M.abscessus_ATCC_199 VPLIIGSNSHEASMFARVKPPMLPTTEPTVNGYFNRIGP-------EYQD
Mb1134|M.bovis_AF2122/97 ---RAHRRHRSTTR------------------------------------
Rv1104|M.tuberculosis_H37Rv ---RAHRRHRSTTR------------------------------------
MMAR_4363|M.marinum_M EIGLAYSRLRRRARPLSIATDVGFRMPSVWLAEGHSRVAPVYLYRFDYST
MAV_1226|M.avium_104 QIGSAYSRFRRRARYLSIATDVGFRMPSVWLAEGHARVAPVYLYRFDYST
Mflv_3419|M.gilvum_PYR-GCK HLRGIYRG-RGKNHALGLTSDLGFRMPSIWFADGHRAVAPVYLYRFDFAT
Mvan_3172|M.vanbaalenii_PYR-1 ILKGTYRG-RGKTKGLGLTSDLGFRMPSLWFADGHRAVAPVYLYRFDFHT
MSMEG_3667|M.smegmatis_MC2_155 EIRAAYSGMRTKAIGMGVARDIGFRMPTLWFADGHSTSAPVYLYRFDFAT
TH_3679|M.thermoresistible__bu QISAAYRRQRGKRLGVGVASDIGFRMPSVWFAEGHTAVAPTYLYRFDWST
MUL_2261|M.ulcerans_Agy99 RITAAYPNYPESAACIQLGGDFAFNAAAWQIAEAQGVHAPTYLYRYDYAP
MAB_2866c|M.abscessus_ATCC_199 AIIAAYPGYPSRQALVAVGSDAMFAAPMWAFADAYSAFVDTYMYRFDHTA
:
Mb1134|M.bovis_AF2122/97 --------------------------------------------------
Rv1104|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4363|M.marinum_M PLLKLLLVRAAHATELPYVWGNLGG-PQDPTLRLGGAKTAKAVSKRMRTR
MAV_1226|M.avium_104 PLLRLLMVKAAHATELPYVWGTLGA-PKDPTLKLGGSKTAKAVSKRVRTR
Mflv_3419|M.gilvum_PYR-GCK PLLRVARLHAAHATELPFVWGNLGSGRKDPTFALGGRKSGTAVSQRMQSR
Mvan_3172|M.vanbaalenii_PYR-1 PLLRLVRLHAAHATELPFVWGNLVAGRRDPTFALGGRKSGAAVSERMRAR
MSMEG_3667|M.smegmatis_MC2_155 PMLRLLRLGAAHATELPYVWGNLAAGPKDPTFKMGGLKQGRKVSQRIRRR
TH_3679|M.thermoresistible__bu PTLRLLRLGAAHATELPYVFGNLDT-PKDPTFTLGGRRTGRQVSQRIRTR
MUL_2261|M.ulcerans_Agy99 RTLRWSGFGATHATELFAVFDIYRTRFGALLTAAADRRHALRVSDEVIRR
MAB_2866c|M.abscessus_ATCC_199 WGLKLLGLGATHGSEIVHVQHSYGSFVGMLLSPLG-ARMMPSVGRRMQRA
Mb1134|M.bovis_AF2122/97 --------------------------------------------------
Rv1104|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4363|M.marinum_M WINFATQDNPAGPAGEPDWPAYQDGDRACLVID-KSDRVARDIDAPIRAA
MAV_1226|M.avium_104 WTNFAAHAKPAGPAGSPEWAPYQEQDRACLIIG-KNDVLAHDVDAKARAA
Mflv_3419|M.gilvum_PYR-GCK WTNFAANGDPSAPG-APTWRPYDAS-RATLVID-KHDSVVDDLDAHVRRA
Mvan_3172|M.vanbaalenii_PYR-1 WVSFAAHGAPTGPAGEPVWRPYGADDRATLVID-KQDTVVDDLDADVRRA
MSMEG_3667|M.smegmatis_MC2_155 WVNFATTGEPTGALGEPVWRRYRREDRAALVID-KQDKTVTDLDQQLQAA
TH_3679|M.thermoresistible__bu WINFAVHGRPDGPPGEPRWHAYDRAERPCLLID-RRDRVVRDVDEPIRLT
MUL_2261|M.ulcerans_Agy99 WRSFSQTGTP-----GEDWPAYTHTRRAVMVID-RKSRVEIDPHRHRRLA
MAB_2866c|M.abscessus_ATCC_199 WLDFATGAGP------EDWPTYGADGRRTRIIRSRSDVTVEDPDSVRRIA
Mb1134|M.bovis_AF2122/97 ---------
Rv1104|M.tuberculosis_H37Rv ---------
MMAR_4363|M.marinum_M WGREVVGFR
MAV_1226|M.avium_104 WGSEMVSFR
Mflv_3419|M.gilvum_PYR-GCK WGDDVLSFL
Mvan_3172|M.vanbaalenii_PYR-1 WGDDVLSFL
MSMEG_3667|M.smegmatis_MC2_155 WGDQVLNFR
TH_3679|M.thermoresistible__bu WGSEVLSFR
MUL_2261|M.ulcerans_Agy99 WDGFSLAR-
MAB_2866c|M.abscessus_ATCC_199 WAQVH----