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TADATTRSSAGGRPVVETTNGPVRGVDDGSVKSWKAVRYAAAPVGELRWRAPEPPQAWSEPVDAGRVGPV CPQPTDPRIPIDLGAPQGEDFLTLNIWAPSGTQPGDAKPVMVWIHGGAYILGSASQPLYHGGTLASGGDA VVVTVNYRLGALGFLELSTLGADPERFATNLGLRDVLAALEWVRDNIAAFGGDPGRVTVFGESAGGGIVA SLLASPAAAGLFSAAIAQSAPVTSTYELGRAQRVAERFLDVLGARPDDLHRLSEAPIDVLVEASRTVFDE VPVRTPGTLAFAPTVDGDLLPDYPVNLARQGRTHPVPLIIGTNKNEAALFRYMKSPLMPIAPASIKAMFA EIAAEQPGLQLPSEDILKGTYRGRGKTKGLGLTSDLGFRMPSLWFADGHRAVAPVYLYRFDFHTPLLRLV RLHAAHATELPFVWGNLVAGRRDPTFALGGRKSGAAVSERMRARWVSFAAHGAPTGPAGEPVWRPYGADD RATLVIDKQDTVVDDLDADVRRAWGDDVLSFL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3172 | - | - | 100% (523) | carboxylesterase, type B |
| M. vanbaalenii PYR-1 | Mvan_2609 | - | 1e-79 | 38.45% (515) | carboxylesterase, type B |
| M. vanbaalenii PYR-1 | Mvan_3408 | - | 1e-74 | 37.30% (504) | carboxylesterase, type B |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2071c | lipT | 3e-76 | 38.70% (509) | carboxylesterase LipT |
| M. gilvum PYR-GCK | Mflv_3419 | - | 0.0 | 80.31% (523) | carboxylesterase, type B |
| M. tuberculosis H37Rv | Rv2045c | lipT | 3e-76 | 38.70% (509) | carboxylesterase LipT |
| M. leprae Br4923 | MLBr_00314 | - | 3e-06 | 22.84% (232) | putative esterase |
| M. abscessus ATCC 19977 | MAB_2866c | - | 5e-83 | 39.77% (513) | carboxylesterase (LipT) |
| M. marinum M | MMAR_4363 | - | 0.0 | 61.58% (531) | carboxylesterase |
| M. avium 104 | MAV_1226 | - | 0.0 | 63.58% (508) | carboxylesterase superfamily protein |
| M. smegmatis MC2 155 | MSMEG_3667 | - | 0.0 | 66.40% (509) | para-nitrobenzyl esterase |
| M. thermoresistible (build 8) | TH_3679 | - | 0.0 | 65.84% (524) | PUTATIVE Carboxylesterase, type B |
| M. ulcerans Agy99 | MUL_2261 | lipT | 2e-75 | 38.84% (502) | carboxylesterase, LipT |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2071c|M.bovis_AF2122/97 ------------MALESATVGSMHERTVR-----------ARTATGIVEG
Rv2045c|M.tuberculosis_H37Rv ------------MALESATVGSMHERTVR-----------ARTATGIVEG
MUL_2261|M.ulcerans_Agy99 ----------------------MHERTVR-----------ARTATGVVEG
MAB_2866c|M.abscessus_ATCC_199 MYPEKTRGNFPAPPLRLCGPVTADRTTIRYVAVDVALPTVVRTPLGALRG
Mvan_3172|M.vanbaalenii_PYR-1 --------------------MTADATTRSSAGGR----PVVETTNGPVRG
Mflv_3419|M.gilvum_PYR-GCK --------------------MTAEATPRSSA-------PVVDTSTGPVRG
MSMEG_3667|M.smegmatis_MC2_155 ---------------------MANAARIADG-------PVAETGYGPVRG
TH_3679|M.thermoresistible__bu ------MPSTTPPDDRTPDDAPTRPAPAHSAVGS----PVVDTVHGPVRG
MMAR_4363|M.marinum_M --------------------MTSDIRRMASDG------YVVETAYGPVRG
MAV_1226|M.avium_104 ---------------------------MAVDD------LVVETGYGPVR-
MLBr_00314|M.leprae_Br4923 -------------------MAISAGAPVE----------IVESGPSIAAR
. : .
Mb2071c|M.bovis_AF2122/97 ----FTRDG----VHRWRSIPYARAPVGSLRFRAPQPAQPWPGVRHCHTF
Rv2045c|M.tuberculosis_H37Rv ----FTRDG----VHRWRSIPYARAPVGSLRFRAPQPAQPWPGVRHCHTF
MUL_2261|M.ulcerans_Agy99 ----FTRDG----VHRWRSIPYARAPIGLLRFRAPRPPQPWSGVRHCHGF
MAB_2866c|M.abscessus_ATCC_199 ----AIEGG----VSVWRGVPYAQQPVEQLRFLAPVPLEPWEGVRDAIEH
Mvan_3172|M.vanbaalenii_PYR-1 -----VDDGS---VKSWKAVRYAAAPVGELRWRAPEPPQAWSEPVDAGRV
Mflv_3419|M.gilvum_PYR-GCK -----LDDGI---IKSWKGVPYAAAPVGELRWRAPEPPPAWTEPRDATRV
MSMEG_3667|M.smegmatis_MC2_155 -----TDDGT---AKAWLGIRYARAPIGELRWRAPEPPASWHDVFDATRV
TH_3679|M.thermoresistible__bu -----RDDGV---VKVWRGIRYAAAPVGGLRWRAPEPPQPWREPMDAIRV
MMAR_4363|M.marinum_M AEDGIAAAGSGVRTKSWKGIRYGAPPVGELRFRAPQPPQPWTEIADATAF
MAV_1226|M.avium_104 ---GVPVDG----VKAWKGIRYAAPPIGDLRFRAPQPPERWTEVADATVF
MLBr_00314|M.leprae_Br4923 --------------LASLTSRLTIRPILAVGSYVPQLPWPFGLIDHAARV
*: : .* : ..
Mb2071c|M.bovis_AF2122/97 ANCAPQQRRYTVMGIGRYQTRSEDCLTLNVVTPEEP-ATQPLPVMVFIHG
Rv2045c|M.tuberculosis_H37Rv ANCAPQQRRYTVMGIGRYQTRSEDCLTLNVVTPEEP-ATQPLPVMVFIHG
MUL_2261|M.ulcerans_Agy99 THCSPQQRRYTMLGLGKYQPMSEDCLTLNVVAPEAP-THRPLPVMVFIHG
MAB_2866c|M.abscessus_ATCC_199 APLPPQGKSFVGAGRDDPKIRGEECLTVTVWSPD---VHASLPVMVWIPG
Mvan_3172|M.vanbaalenii_PYR-1 GPVCPQP-TDPRIPIDLGAPQGEDFLTLNIWAPSGTQPGDAKPVMVWIHG
Mflv_3419|M.gilvum_PYR-GCK GPVCPQP-TDPKIPLDLGAPQGEDFLSLNVWAPSGTQPGDRKPVMVWVHG
MSMEG_3667|M.smegmatis_MC2_155 GAVCPQA-TDARIPIDLGGKQDEDSLVLNVWAPSGCRPGDRRPVMVWVHG
TH_3679|M.thermoresistible__bu GPACPQP-ADPRIPLDLGAAIGEDCLNLNVWASSDTEPGDRKPVLVWVHG
MMAR_4363|M.marinum_M GPVCPQP-VLANMPIDLGAPQDEDCLRLNIWAPANTAPGAAKPVMVWLHG
MAV_1226|M.avium_104 GPACPQP-VFPNMPLDLGAPQGEDCLRLNVWASADTQPGDAKPVMVWLHG
MLBr_00314|M.leprae_Br4923 LLPVTNA---ARAEVNLSNTSAQLVRAAGVRPADGS-----GRIVLYLHG
.: . : : .. ::::: *
Mb2071c|M.bovis_AF2122/97 GGYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTPQIT
Rv2045c|M.tuberculosis_H37Rv GGYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTPQIT
MUL_2261|M.ulcerans_Agy99 GGYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTPDIA
MAB_2866c|M.abscessus_ATCC_199 GAFVFGAGQLELYSGARLAANGNVVVVNVTYRLGALGGLELSALG---EG
Mvan_3172|M.vanbaalenii_PYR-1 GAYILGSASQPLYHGGTLASGGDAVVVTVNYRLGALGFLELSTLGADPER
Mflv_3419|M.gilvum_PYR-GCK GAYVLGSASQPLYHGRAMAGAGDVIVVTVNYRLGALGFLELSTLD-DSGR
MSMEG_3667|M.smegmatis_MC2_155 GAYVLGSASQPLCRGRVLASEGDVVVVTVNYRLGPFGFLDLSEYSSRAMR
TH_3679|M.thermoresistible__bu GAYVIGAASQPLYHGRELVRRGDVVLVTLNYRLGAFGFLELTALSSGRRR
MMAR_4363|M.marinum_M GAYMLGSASQALYDGRRLASSGEVIVVTVNYRLGALGFLDLSSLSHAGRS
MAV_1226|M.avium_104 GAYVLGSSSQTLYDGRRLVSHGDVVVVTVNYRLGALGFLDLSSLNSAGRS
MLBr_00314|M.leprae_Br4923 GAFLGCGANSHRRLVETLSKLADSPILVVNYRLLPK--------------
*.:: .. : . : :.*** .
Mb2071c|M.bovis_AF2122/97 LDSNVYLRDLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITATLLAVP
Rv2045c|M.tuberculosis_H37Rv LDSNVYLRDLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITATLLAVP
MUL_2261|M.ulcerans_Agy99 IDGNLYLRDLVMALQWIQDNIAEFGGDPDNVTIFGESAGAHITATLLAVP
MAB_2866c|M.abscessus_ATCC_199 FDDNLALRDQMAALTWVRDNIAAFGGDPDHVTIFGESAGATSVLALLASP
Mvan_3172|M.vanbaalenii_PYR-1 FATNLGLRDVLAALEWVRDNIAAFGGDPGRVTVFGESAGGGIVASLLASP
Mflv_3419|M.gilvum_PYR-GCK FASNLGLRDVLAALGWVRDNIAAFGGDPGRVTVFGESAGGGIVTSLLGSP
MSMEG_3667|M.smegmatis_MC2_155 FDTNLGLRDVIFALQWVRDNIAAFGGDPSRVTLFGESAGGGMITTLLASP
TH_3679|M.thermoresistible__bu FDTNVGLRDVLFALAWVRDNIAAFGGDPDRVTLFGESAGGGIVTTLLGSP
MMAR_4363|M.marinum_M FDSNVGLRDVLAALHWVRENIAAFGGDPANITLFGESAGAGLVTTLLVTP
MAV_1226|M.avium_104 FDSNVGLRDVLAALEWVRDNITAFGGDPRRVTLFGESAGAGIVTTLLASP
MLBr_00314|M.leprae_Br4923 HSIGMALDDCHDGYQWLRR----LGYDPEQIVLAGDSAGGYLALALAQRL
.: * * . *:: :* ** .:.: *:***. :*
Mb2071c|M.bovis_AF2122/97 AAKGLFARAISESPAAGMVRSREVAAEFAARFANLIGARTQDAANALMQA
Rv2045c|M.tuberculosis_H37Rv AAKGLFARAISESPAAGMVRSREVAAEFAARFANLIGARTQDAANALMQA
MUL_2261|M.ulcerans_Agy99 AAKGLFARAISESPAAGMVRPREIAAEFATRFARLLGARKHDAASALMRA
MAB_2866c|M.abscessus_ATCC_199 AAEGLFGRAIAQSPALPLIADKALRDKRAHRYLELLDVTDPSRLKVLPQR
Mvan_3172|M.vanbaalenii_PYR-1 AAAGLFSAAIAQSAPVTSTYELGRAQRVAERFLDVLGARPDD-LHRLSEA
Mflv_3419|M.gilvum_PYR-GCK AAAGLFHAAIAQSSPATSMYDVGRARRVATRFLEVIGVDRAD-MSALTTA
MSMEG_3667|M.smegmatis_MC2_155 AAEGLFSAAIAQSSPATSVYDAERSRRVARALLERLLIEPDD-AARLAHV
TH_3679|M.thermoresistible__bu AAAGLFHRAIAQSSPATSCYGTERAIDVAEQFLGHLGLSPRD-VDRLPDV
MMAR_4363|M.marinum_M AARGLFSRAIAQSSPATSVYDRERAQRVAVHLLDKLGVAASD-VDKLTQL
MAV_1226|M.avium_104 AAAGLFAAAIAQSSPATSVYDRDRAARVAEAFLGKLGITASE-SRRLIDM
MLBr_00314|M.leprae_Br4923 QDVGEEPAALVAISPLLQLAKKGKQAHPNAKTDAMFPP------------
* *: .. :
Mb2071c|M.bovis_AF2122/97 SPAQLVEAQHHLIRQGMRKRLGAFPIGPVFGDDYLPMDPVEAMRSGRVHA
Rv2045c|M.tuberculosis_H37Rv SPAQLVEAQHHLIRQGMRKRLGAFPIGPVFGDDYLPMDPVEAMRSGRVHA
MUL_2261|M.ulcerans_Agy99 TAAQLVQTQHRLIDQGMQKRLGAFPIGPTFGDDCLPLDPVEAMRAGQSHK
MAB_2866c|M.abscessus_ATCC_199 ---ELRRGAAKLQIESATETP-VLGYGLAHGTELLPYHPIEAARRGEVHQ
Mvan_3172|M.vanbaalenii_PYR-1 PIDVLVEASRTVFDEVPVRTPGTLAFAPTVDGDLLPDYPVNLARQGRTHP
Mflv_3419|M.gilvum_PYR-GCK PISALVEASRTVFNEVPVRTPGTLAFAPTIDGDLLPDYPVNLARNGKTHP
MSMEG_3667|M.smegmatis_MC2_155 PIPAILGASQQIFNEVPAQSPGTLAFAPIVDGDVVPDYPVQAARAGRTHR
TH_3679|M.thermoresistible__bu PVAAIVEVSKHVFDDVPARRPGTLAFAPIVDGDIVPDYPVALARAGRTLP
MMAR_4363|M.marinum_M PTAAIVAASTEVFNEVPVRNPGTLAFVPIVDGDVLTDYPVKVAQEGRSHP
MAV_1226|M.avium_104 PMAAILAASQQVFDEVPVRNPGTLAFVPIVDGDVLADYPVKVAQQGCSHP
MLBr_00314|M.leprae_Br4923 ----------KAFDALGRLVASSAAKNKVDDKPEELYEPLDHIAPGLPRT
. *: *
Mb2071c|M.bovis_AF2122/97 VPLIVGTNAEEGRLFTRFLG-MLPTNEPMVEELLSGMKPAD-------RE
Rv2045c|M.tuberculosis_H37Rv VPLIVGTNAEEGRLFTRFLG-MLPTNEPMVEELLSGMKPAD-------RE
MUL_2261|M.ulcerans_Agy99 VPLIVGTNADEGRLFTRFLK-MLPTNKAMIDELLADTEPAT-------RE
MAB_2866c|M.abscessus_ATCC_199 VPLIIGSNSHEASMFARVKPPMLPTTEPTVNGYFNRIGPEY-------QD
Mvan_3172|M.vanbaalenii_PYR-1 VPLIIGTNKNEAALFRYMKSPLMPIAPASIKAMFAEIAAEQPGLQLPSED
Mflv_3419|M.gilvum_PYR-GCK VPLLIGTNKNEAALFRYMKSPLMPVAPESVRAMFAEISAEQPTLQLPSED
MSMEG_3667|M.smegmatis_MC2_155 VPLIIGTNKHEASLFRWMKSPLMPITPEAIRAMFEGIASEQPGLALPTEE
TH_3679|M.thermoresistible__bu VPLVIGTNKDEASLFRWMKSPLLPITPDAIKKMFADIAAEQPGLRLPTET
MMAR_4363|M.marinum_M VPLLIGTNKHEAALFRLMRSPLMPITPRAITSMFTQIAAEQPDLQLPTEE
MAV_1226|M.avium_104 VPLIIGTNQHEAALFRLMRSALMPITPHAITSMFNQIAAEQPDLQLPTEK
MLBr_00314|M.leprae_Br4923 LIHVSGS------------------------------------------E
: : *:
Mb2071c|M.bovis_AF2122/97 RITAAYPNYPAPSACIQLGGDFAFSSAAWQIAEAHGANAPTYLYRYDYAP
Rv2045c|M.tuberculosis_H37Rv RITAAYPNYPAPSACIQLGGDFAFSSAAWQIAEAHGANAPTYLYRYDYAP
MUL_2261|M.ulcerans_Agy99 RITAAYPNYPESAACIQLGGDFAFNAAAWQIAEAQGVHAPTYLYRYDYAP
MAB_2866c|M.abscessus_ATCC_199 AIIAAYPGYPSRQALVAVGSDAMFAAPMWAFADAYSAFVDTYMYRFDHTA
Mvan_3172|M.vanbaalenii_PYR-1 ILKGTYRG-RGKTKGLGLTSDLGFRMPSLWFADGHRAVAPVYLYRFDFHT
Mflv_3419|M.gilvum_PYR-GCK HLRGIYRG-RGKNHALGLTSDLGFRMPSIWFADGHRAVAPVYLYRFDFAT
MSMEG_3667|M.smegmatis_MC2_155 EIRAAYSGMRTKAIGMGVARDIGFRMPTLWFADGHSTSAPVYLYRFDFAT
TH_3679|M.thermoresistible__bu QISAAYRRQRGKRLGVGVASDIGFRMPSVWFAEGHTAVAPTYLYRFDWST
MMAR_4363|M.marinum_M EIGLAYSRLRRRARPLSIATDVGFRMPSVWLAEGHSRVAPVYLYRFDYST
MAV_1226|M.avium_104 QIGSAYSRFRRRARYLSIATDVGFRMPSVWLAEGHARVAPVYLYRFDYST
MLBr_00314|M.leprae_Br4923 VLLHDAQLAATKLAAVGVPAEIRVWPGQVHVFQAAAPMVPEATLSLRQIS
: : : : . . :. . .
Mb2071c|M.bovis_AF2122/97 RTLRWSGFGATHATELFAVFDIYRTRFGALLTAAADRRAALRVSNEVQRR
Rv2045c|M.tuberculosis_H37Rv RTLRWSGFGATHATELFAVFDIYRTRFGALLTAAADRRAALRVSNEVQRR
MUL_2261|M.ulcerans_Agy99 RTLRWSGFGATHATELFAVFDIYRTRFGALLTAAADRRHALRVSDEVIRR
MAB_2866c|M.abscessus_ATCC_199 WGLKLLGLGATHGSEIVHVQHSYGSFVGMLLSPLGAR-MMPSVGRRMQRA
Mvan_3172|M.vanbaalenii_PYR-1 PLLRLVRLHAAHATELPFVWGNLVAGRRDPTFALGGRKSGAAVSERMRAR
Mflv_3419|M.gilvum_PYR-GCK PLLRVARLHAAHATELPFVWGNLGSGRKDPTFALGGRKSGTAVSQRMQSR
MSMEG_3667|M.smegmatis_MC2_155 PMLRLLRLGAAHATELPYVWGNLAAGPKDPTFKMGGLKQGRKVSQRIRRR
TH_3679|M.thermoresistible__bu PTLRLLRLGAAHATELPYVFGNLDT-PKDPTFTLGGRRTGRQVSQRIRTR
MMAR_4363|M.marinum_M PLLKLLLVRAAHATELPYVWGNLGG-PQDPTLRLGGAKTAKAVSKRMRTR
MAV_1226|M.avium_104 PLLRLLMVKAAHATELPYVWGTLGA-PKDPTLKLGGSKTAKAVSKRVRTR
MLBr_00314|M.leprae_Br4923 QYIREATASKASRDRQSL--------------------------------
:: : .
Mb2071c|M.bovis_AF2122/97 WRCFSQIGVPG-----DDWPAYTQDDRAVLVFDRRCRIEF-DPHQHRRIA
Rv2045c|M.tuberculosis_H37Rv WRCFSQIGVPG-----DDWPAYTQDDRAVLVFDRRCRIEF-DPHQHRRIA
MUL_2261|M.ulcerans_Agy99 WRSFSQTGTPG-----EDWPAYTHTRRAVMVIDRKSRVEI-DPHRHRRLA
MAB_2866c|M.abscessus_ATCC_199 WLDFATGAGP------EDWPTYGADGRRTRIIRSRSDVTVEDPDSVRRIA
Mvan_3172|M.vanbaalenii_PYR-1 WVSFAAHGAPTGPAGEPVWRPYGADDRATLVIDKQDTVVD-DLDADVRRA
Mflv_3419|M.gilvum_PYR-GCK WTNFAANGDPSAPG-APTWRPYDAS-RATLVIDKHDSVVD-DLDAHVRRA
MSMEG_3667|M.smegmatis_MC2_155 WVNFATTGEPTGALGEPVWRRYRREDRAALVIDKQDKTVT-DLDQQLQAA
TH_3679|M.thermoresistible__bu WINFAVHGRPDGPPGEPRWHAYDRAERPCLLIDRRDRVVR-DVDEPIRLT
MMAR_4363|M.marinum_M WINFATQDNPAGPAGEPDWPAYQDGDRACLVIDKSDRVAR-DIDAPIRAA
MAV_1226|M.avium_104 WTNFAAHAKPAGPAGSPEWAPYQEQDRACLIIGKNDVLAH-DVDAKARAA
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mb2071c|M.bovis_AF2122/97 WDGFSLAN-
Rv2045c|M.tuberculosis_H37Rv WDGFSLAN-
MUL_2261|M.ulcerans_Agy99 WDGFSLAR-
MAB_2866c|M.abscessus_ATCC_199 WAQVH----
Mvan_3172|M.vanbaalenii_PYR-1 WGDDVLSFL
Mflv_3419|M.gilvum_PYR-GCK WGDDVLSFL
MSMEG_3667|M.smegmatis_MC2_155 WGDQVLNFR
TH_3679|M.thermoresistible__bu WGSEVLSFR
MMAR_4363|M.marinum_M WGREVVGFR
MAV_1226|M.avium_104 WGSEMVSFR
MLBr_00314|M.leprae_Br4923 ---------