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MNFMVLPPEVNSARIYAGAGPAPMLAAAVAWDGLAAELGMAAASFSLLISGLTAGPGSAWQGPAAAAMAA AAAPYLSWLNAATARAEGAAAGAKAAAAVYEAARAATAHPALVAANRNQLLSLVLSNLFGQNLPAIAATE ASYEQLWAQDVAAMVGYHGGASTVASQLTPWQQLLSVLPPVVTAAPAGAVGVPAALAIPALGVENIGVGN FLGIGNIGNNNVGSGNTGDYNFGIGNIGNANLGNGNIGNANLGSGNAGFFNFGNGNDGNTNFGSGNAGFL NIGSGNEGSGNLGFGNAGDDNTGWGNSGDTNTGGFNSGDLNTGIGSPVTQGVANSGFGNTGTGHSGFFNS GNSGSGFQNLGNGSSGFGNASDTSSGFQNAGTALTRASSTWADSPRAWPIRAPSRLQVWRTRATTARECS IRVIISRVSSTGAPPQKK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0902c | PPE13 | - | 100% (438) | PPE family protein |
| M. bovis AF2122 / 97 | Mb1166c | PPE16 | e-126 | 57.91% (430) | PPE family protein |
| M. bovis AF2122 / 97 | Mb3183c | PPE53 | e-123 | 57.70% (409) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0325 | - | 7e-25 | 35.03% (197) | PPE protein |
| M. tuberculosis H37Rv | Rv0878c | PPE13 | 0.0 | 100.00% (438) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 9e-30 | 37.20% (207) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 2e-27 | 38.76% (178) | PPE-family protein |
| M. marinum M | MMAR_4319 | - | 1e-134 | 59.48% (427) | PPE family protein |
| M. avium 104 | MAV_2914 | - | 1e-50 | 48.57% (245) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 7e-26 | 39.05% (169) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-26 | 37.16% (183) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_0964 | - | 1e-132 | 62.34% (401) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-27 | 37.50% (216) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0902c|M.bovis_AF2122/97 -------------MNFMVLPPEVNSARIYAGAGPAPMLAAAVAWDGLAAE
Rv0878c|M.tuberculosis_H37Rv -------------MNFMVLPPEVNSARIYAGAGPAPMLAAAVAWDGLAAE
MMAR_4319|M.marinum_M -------------MNFMMLPPEVNSALMFTGAGSAPTLAAATAWDGLAAE
MUL_0964|M.ulcerans_Agy99 -------------MNFMMLPPEVNSALMFTGAGSAPTLAAATAWDGLVAE
MAV_2914|M.avium_104 ------------MIDFAALPPEINSARIYAGPGSAPMMSAAAAWNTMAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_0669|M.abscessus_ATCC_1997 ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN
: .** :*: : *.*... ::*. * : :
Mb0902c|M.bovis_AF2122/97 LGMAAASFSLLISGLTAGPGSAWQGPAAAAMAAAAAPYLSWLNAATARAE
Rv0878c|M.tuberculosis_H37Rv LGMAAASFSLLISGLTAGPGSAWQGPAAAAMAAAAAPYLSWLNAATARAE
MMAR_4319|M.marinum_M LGEAAEAFSSVTSGLASG---SWQGPAAAAMAAAAAPYAGWLSAAATRAL
MUL_0964|M.ulcerans_Agy99 LGEAAEAFSSVTSGLASG---SWQGPAAAAMAAAAAPYAGWLSAAATRAL
MAV_2914|M.avium_104 MRSAAASYGAVISELTSA---DWFGPSSMSMLAAVTPYLTWLTDTATRAE
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT----FEGESAAALAERVTPYEKWLTQNAASAE
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSG---AWEGPSSQQYVAAHTPYLAWLAQQSAVSA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAG---AWEGPSSEQYVAAHTPYLAWLAQQSAAGA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAG---SWEGPSSEQYVAAHAPYLQWLAQQSANSA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAG---SWEGPSAERYVAAHAPYLAWLTQQSANSA
MAB_0669|M.abscessus_ATCC_1997 YANTAVELAQVLAGVRAG---SWQGPSASEYVAAHLPYLAWLEQAAAESS
:* : : : * :: ** ** :: .
Mb0902c|M.bovis_AF2122/97 GAAAGAKAAAAVYEAARAATAHPALVAANRNQLLSLVLSNLFGQNLPAIA
Rv0878c|M.tuberculosis_H37Rv GAAAGAKAAAAVYEAARAATAHPALVAANRNQLLSLVLSNLFGQNLPAIA
MMAR_4319|M.marinum_M GAATQAKAAAAVFESAQAATVHPELVLANRNQLVSLVLSNLFGQNAPAIA
MUL_0964|M.ulcerans_Agy99 GAATQAKAAAAVFESAQAATVHPELVLANRNQLVSLVLSNLFGQNAPAIA
MAV_2914|M.avium_104 EAAAQANSAATAYEAAFAMTVPPAVVAANRAQLATLVATNVFGQNTPAIA
MLBr_01182|M.leprae_Br4923 LTATQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIA
Mflv_0325|M.gilvum_PYR-GCK ATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIA
Mvan_0415|M.vanbaalenii_PYR-1 AAAAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIA
MSMEG_0619|M.smegmatis_MC2_155 AAAVQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIA
TH_3569|M.thermoresistible__bu ATAGRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIA
MAB_0669|M.abscessus_ATCC_1997 VIAAQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIA
* :* .: :* : : *: *: :*.:* * .**
Mb0902c|M.bovis_AF2122/97 ATEASYEQLWAQDVAAMVGYHGGASTVASQLTPWQQLLSVLPPVVTAAPA
Rv0878c|M.tuberculosis_H37Rv ATEASYEQLWAQDVAAMVGYHGGASTVASQLTPWQQLLSVLPPVVTAAPA
MMAR_4319|M.marinum_M ATESTYEELWAQDVAAMVGYHGGASAVAAQLAPWQQAIQALPGRVAAMAT
MUL_0964|M.ulcerans_Agy99 ATESTYEELWAQDVAATVGYHGGASAVAAQLAPWQQAIQALPGRVAAMAT
MAV_2914|M.avium_104 ATEAEYGQMWAQDAAAMNGYA-VASTAATRLTPMTAPRSNTSPEGVAAQA
MLBr_01182|M.leprae_Br4923 EKEAEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEV
Mflv_0325|M.gilvum_PYR-GCK LNEADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR
Mvan_0415|M.vanbaalenii_PYR-1 MTEADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR
MSMEG_0619|M.smegmatis_MC2_155 LNEADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS
TH_3569|M.thermoresistible__bu LNEADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD
MAB_0669|M.abscessus_ATCC_1997 LNEADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG-GEARS
.*: * .:* * .:: *
Mb0902c|M.bovis_AF2122/97 GAVGVPAALAIP-----ALGVENIGVGNFLGIGNIGNNNVGSGNTGDYNF
Rv0878c|M.tuberculosis_H37Rv GAVGVPAALAIP-----ALGVENIGVGNFLGIGNIGNNNVGSGNTGDYNF
MMAR_4319|M.marinum_M TGPAASAAAALASGPAAALGIGNNGSGNFLSIGNIGNNNLGSGNTGSANL
MUL_0964|M.ulcerans_Agy99 TGPAASAAAALASGPAAALDIGNNGSGNFLSIGNIGNNNLGSGNTGSANL
MAV_2914|M.avium_104 TSVTNAAQAPAG-----------------TVQSTVSSSGLAGLLSGSDNS
MLBr_01182|M.leprae_Br4923 VEEVVEEVVEEV----VEAEQAISQAALDQAVNEGMEATVVPQVDQQVNV
Mflv_0325|M.gilvum_PYR-GCK AAADMSAFAAQPM--AAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNF
Mvan_0415|M.vanbaalenii_PYR-1 AAADVTAFAAQAQ--AAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDF
MSMEG_0619|M.smegmatis_MC2_155 ASASVQQMSAQAT--AAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDF
TH_3569|M.thermoresistible__bu AMATTQQIGSQAT--AADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDF
MAB_0669|M.abscessus_ATCC_1997 DQSDVPGSPDQ-----------------IMKMLQGFQQWFEKMG--FNPA
.
Mb0902c|M.bovis_AF2122/97 GIGNIGNANLGNGNIGNANLGSGNAGFFNFGNGNDGNTNFGSGNAGFLNI
Rv0878c|M.tuberculosis_H37Rv GIGNIGNANLGNGNIGNANLGSGNAGFFNFGNGNDGNTNFGSGNAGFLNI
MMAR_4319|M.marinum_M GGGNIGNGNLGSGNTGNVNLGNGNNGFFNFGNGNLGDTNFGSGNSGNLNL
MUL_0964|M.ulcerans_Agy99 GGGNIGNGNLGSGNTGNVNLGNGNNGFFNFGNGNLGDTNFGSGNSGNLNL
MAV_2914|M.avium_104 AFGTFTNGNFFSTAVVNGSLAGG----------PFNPQFIISSVQGVLAA
MLBr_01182|M.leprae_Br4923 DVATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMAN-AGL
Mflv_0325|M.gilvum_PYR-GCK LRDPIGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSL
Mvan_0415|M.vanbaalenii_PYR-1 LRDPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSL
MSMEG_0619|M.smegmatis_MC2_155 LKDPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMI
TH_3569|M.thermoresistible__bu LRDPIGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMI
MAB_0669|M.abscessus_ATCC_1997 TSAVLAVIMLFLYDLLWYPY-----YASYLLPFLIPALSGLSG-LAALMH
.
Mb0902c|M.bovis_AF2122/97 GSGN-EGSGNLGFG-----------NAGDDNTGWGNSGDTNTGGFNSGDL
Rv0878c|M.tuberculosis_H37Rv GSGN-EGSGNLGFG-----------NAGDDNTGWGNSGDTNTGGFNSGDL
MMAR_4319|M.marinum_M GSGNRFGSGNIGFGNRFGDGNFGSGNAGSYNFGTGNNGSFNIGSGNNGDS
MUL_0964|M.ulcerans_Agy99 GSGNRFGSGNIGFGNRFGDGNFGSGNAGSYNFGTGNNGSFNIGSGNNGDS
MAV_2914|M.avium_104 QHATTLGG------------------LGDFAADAEGAATADLAASTGGS-
MLBr_01182|M.leprae_Br4923 SLVNGMGSAMKSLAP-------TTTKAAESAFKAMGSAVQSTGRGLLGSS
Mflv_0325|M.gilvum_PYR-GCK FLLPLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQ
Mvan_0415|M.vanbaalenii_PYR-1 LLLPLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQP
MSMEG_0619|M.smegmatis_MC2_155 FASPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQ
TH_3569|M.thermoresistible__bu LASPVLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP----
MAB_0669|M.abscessus_ATCC_1997 LRPAAPGPVPAAALSPGDRPIRRPTQHVEPNLAALPLPTSSVVPSGG---
.
Mb0902c|M.bovis_AF2122/97 NTGIG-----------------------------SPVTQGVANSGFGNTG
Rv0878c|M.tuberculosis_H37Rv NTGIG-----------------------------SPVTQGVANSGFGNTG
MMAR_4319|M.marinum_M NIGFGNFGTNNLGFGNNGSNNIGFGLSGSNQIGIGGLNAGIGNMGFGNAG
MUL_0964|M.ulcerans_Agy99 NIGFGNLGTNNLGFGNNGSNNIGFGLSGSNQIGIGGLNAGIGNMGFGNAG
MAV_2914|M.avium_104 ----------------------------------APVAAGMGRAQLVGSL
MLBr_01182|M.leprae_Br4923 SG--------------------------------GHVTAQLGRAASIGSL
Mflv_0325|M.gilvum_PYR-GCK SFPAT--------------------MSAPPPPSGAPIAANTVSAGSPPAP
Mvan_0415|M.vanbaalenii_PYR-1 SPAIA--------------------VSAPPPPSSAAATVGTVATGTAPAP
MSMEG_0619|M.smegmatis_MC2_155 PLAVG--------------------ISPAGVPGSAATAAAPAPAPAGTTV
TH_3569|M.thermoresistible__bu -----------------------------------VRAEPQNPLPLTXXX
MAB_0669|M.abscessus_ATCC_1997 --------------------------------SSVPVSTPTAPAHTVSSV
Mb0902c|M.bovis_AF2122/97 TGHSGFFNSGNSGSGFQNL-GNGSSGFGNASDTSSGFQNAG---------
Rv0878c|M.tuberculosis_H37Rv TGHSGFFNSGNSGSGFQNL-GNGSSGFGNASDTSSGFQNAG---------
MMAR_4319|M.marinum_M DNNVGFFNSGSNNIGFFNS-GDGNFGFANAGSTNTGFWNSGGTNTGFGNG
MUL_0964|M.ulcerans_Agy99 DNNVGFFNSGSNNIGFFNS-GDGNFGFAHAGSTNTGFWNSGGTNTGFGNG
MAV_2914|M.avium_104 SVPQGWANAATINPGQAAVPATGVTGLTDAASAAGGPGGVAG--------
MLBr_01182|M.leprae_Br4923 RVPQTWTTASQPVTAATRALSPARVAVATESESAPLLGGGLPMAP-----
Mflv_0325|M.gilvum_PYR-GCK GAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPAAASG---
Mvan_0415|M.vanbaalenii_PYR-1 GAPAAATASFVPYAVAGRDPGTGFSPTVRDSTSAKAPASGIPAAASG---
MSMEG_0619|M.smegmatis_MC2_155 AAPAPAAATFVPYAVANRDPGEGFTPTLGNKSQVAAPASGVPAAASG---
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 PAPSAAISYAIPGLVP---PGVSFGPKSTEKSSESAVDTVAAVAAAR---
Mb0902c|M.bovis_AF2122/97 --------------------------------------------TALTRA
Rv0878c|M.tuberculosis_H37Rv --------------------------------------------TALTRA
MMAR_4319|M.marinum_M GSLNFGFGNGGVENMGHGNAGSFNMGFGNGGGGNTGFYNSGTYNTGFSNA
MUL_0964|M.ulcerans_Agy99 GSLNFGFGNGGVENMGHGNAGSFNMGFGNGGGGNTGFYNSGTYNTGFSNA
MAV_2914|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK --------------------------------------------IAASAA
Mvan_0415|M.vanbaalenii_PYR-1 --------------------------------------------VAASAA
MSMEG_0619|M.smegmatis_MC2_155 --------------------------------------------VAASLA
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 --------------------------------------------GAVAAQ
Mb0902c|M.bovis_AF2122/97 SST---WADSPRAWP-----------IRAP--------------------
Rv0878c|M.tuberculosis_H37Rv SST---WADSPRAWP-----------IRAP--------------------
MMAR_4319|M.marinum_M GETNTGWENSGNVNTGGYNSGGLNTGIGSPDTQAGPNSGFGHSGSGNSGF
MUL_0964|M.ulcerans_Agy99 AETNTGWENSGNVNTGGYNSGGLNTGIGSPDTQAGPNSGFGHSGSGNSGF
MAV_2914|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK ERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPA------------
Mvan_0415|M.vanbaalenii_PYR-1 ERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQE------------
MSMEG_0619|M.smegmatis_MC2_155 SRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPE------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 ARRRLRGKNKAEAGGR--RHEYLEETAGMGAT-ATADV------------
Mb0902c|M.bovis_AF2122/97 -------SRLQVWRTRATTARECSIR------------------------
Rv0878c|M.tuberculosis_H37Rv -------SRLQVWRTRATTARECSIR------------------------
MMAR_4319|M.marinum_M FNSGDGNSGFQNSNTGVSANGHSGVRNSGDATNVGFSNSGSNNTGIFNTG
MUL_0964|M.ulcerans_Agy99 FNSGDGNSGFENSNTCVSANGHSGVRNSGDATNVGFSNSGSNNTGIFNTG
MAV_2914|M.avium_104 -------PVGGTGRRLRRAIPKYGFR------------------------
MLBr_01182|M.leprae_Br4923 -----MVPGGGSGTGGVNTALRLQPR------------------------
Mflv_0325|M.gilvum_PYR-GCK -------PRVTASTRGAGPMGFAGTVSRGDEQAGGLTT------------
Mvan_0415|M.vanbaalenii_PYR-1 -------PRIAATERGAGPMGFAGTVSRDAAQAGGLTT------------
MSMEG_0619|M.smegmatis_MC2_155 -------PRVRASERGSDAMGFTGTVTRHDVTAAGLTT------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 -------PAYAATGRGTGPLGFAGTAPAAASTHVAATVR-----------
Mb0902c|M.bovis_AF2122/97 ---------------VIISRVSSTGAPPQKK-------------------
Rv0878c|M.tuberculosis_H37Rv ---------------VIISRVSSTGAPPQKKVGNSG--------------
MMAR_4319|M.marinum_M TFNTGIANSGSDSSGLLISGTNSSGALNSGDDQSGFNN------------
MUL_0964|M.ulcerans_Agy99 TFNTGIANSGSDSSGLLISGTNSSGALNSGDDQSGFNN------------
MAV_2914|M.avium_104 --------------PVVMPRPPAAG-------------------------
MLBr_01182|M.leprae_Br4923 --------------AFVMPRNPAAG-------------------------
Mflv_0325|M.gilvum_PYR-GCK ------LAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 ------LPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 ------LTGDTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 ------LSSD--EARQVIPMLPSTWDAD-----------------GGDQN