For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
LIGNGGAGGSGAPGAIGGAGGPAGLIGVGGAGGAGGDSAVAGVIGGAGGAGGAALLFGAGGAGGAGGSGG SGAAGGAGGAGGAGGLFASGGSGGFGGFASTGTGGAGGTGGAGGLFASGGVGGTGGGAGSGGTGGVGGTG GAGGLFASGGAGGAGGSGGTGGAGGTGGAGGLFGAGGAGGLGGQGNHTGGHGGAGGSAGLLALGDGGAGG AGGAATTGTGGAGGAGGKAGLLFGSGGAGGSGGAAGTFGDTGNSGGAGGAGGKAGLLFGSGGAGGSGGAG GFANGSTGGAGGAGGGAGLIGNGGNGGSGGTSVATGGAGNGGAGGAGGGAGLIGNGGNGGSGGMGDAPGG TGVGGIGGLLLGLDGANAPASTNPLHTAQQQALAAVNAPIQAVTGRPLIGNGANGAPGSGAPGGHGGWLF GGGGTGGSGVSGGAGGDGGAGGILFGAGGAGGAGGAVTGTGATGGSGGAGGGALLFGAGGAGGAGGSSGI GGFAAGGAGGPGGAGGLFNGGGAGGAGGSGVSGGAGGEGGAGGAGGLFAGGGIGGAGGFGGFRGGEGGAG GAGGLFAGGGAGGAGGSGNNVGGAGGAGGVGGLFGAGGAGGSGGGGSVAGDGGAGGNAGLLAPGLAGGAG GGGGQGFDTGGAGGPGGDAGLLVGSGGVGGAGGFGLTTGGPGAAGGDAGLLFGSGGAGGAGGSGRTDLGG AGGAGGKAGLIGNGGNGGAGGAGGAGGPGGAAFGLGNGGNGGNGGTGTSAGSPGAGGAGGSLIGAEGLPG LLP
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0856 | PE_PGRS13 | - | 100% (773) | PE-PGRS family protein |
M. bovis AF2122 / 97 | Mb0768 | PE_PGRS10 | 0.0 | 63.04% (809) | PE-PGRS family protein |
M. bovis AF2122 / 97 | Mb1789c | wag22b | 0.0 | 61.69% (804) | hypothetical protein Mb1789c |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_5091 | - | 1e-166 | 48.33% (780) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv0833 | PE_PGRS13 | 0.0 | 87.69% (780) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01556 | infB | 7e-10 | 43.00% (100) | translation initiation factor IF-2 |
M. abscessus ATCC 19977 | MAB_4284c | - | 2e-51 | 39.12% (363) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_4399 | - | 0.0 | 59.07% (816) | PE-PGRS family protein |
M. avium 104 | MAV_4827 | - | 1e-26 | 46.34% (164) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-128 | 37.96% (1001) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 1e-40 | 40.38% (312) | PUTATIVE - |
M. ulcerans Agy99 | MUL_3062 | - | 0.0 | 57.92% (789) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-163 | 46.25% (800) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment Mb0856|M.bovis_AF2122/97 -------------------------------------------------- Rv0833|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4399|M.marinum_M -------------------------------------------------- MUL_3062|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mb0856|M.bovis_AF2122/97 -------------------------------------------------- Rv0833|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4399|M.marinum_M -------------MSYVIAVPDLVAGAASELAGVGSTLSTATTAAAAQTT MUL_3062|M.ulcerans_Agy99 -------------MAFVLAVPDMVAEAAADLAGVGSVIDAANTAAAGSTT Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------MAGKARVHELAKELGVTSKEVLARLNEQG-------- Mb0856|M.bovis_AF2122/97 -------------------------------------------------- Rv0833|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4399|M.marinum_M G-------------------------------------VLAAAGDEVSAA MUL_3062|M.ulcerans_Agy99 G-------------------------------------IVAAAEDEVSAA Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mb0856|M.bovis_AF2122/97 -----------------------------------------MIGNGGAGG Rv0833|M.tuberculosis_H37Rv -----------------------------------------MIGNGGAGG MMAR_4399|M.marinum_M IAAVFSAHG-------------QSYQTLSAQAETFHAQFVQALSAGASAY MUL_3062|M.ulcerans_Agy99 IAALFSGHG-------------QAYQQISTRVAEFHAQFERVFAAGVQAY Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------MSIIDFILNL MAV_4827|M.avium_104 ---------------------------------------MNIVLGVSMAP MLBr_01556|M.leprae_Br4923 -------------------------------------EFVKSASSTVEAP Mb0856|M.bovis_AF2122/97 SG---------------------APGAIGG-------------------- Rv0833|M.tuberculosis_H37Rv SG---------------------APGAIGG-------------------- MMAR_4399|M.marinum_M TQ---------------------AEAASAS----------PLAGLLAAIN MUL_3062|M.ulcerans_Agy99 SG---------------------AEAANASFL------QDPLQTALNATN Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 FR---------------------DPVEAAS-------------------- MAV_4827|M.avium_104 SS------------------------------------------------ MLBr_01556|M.leprae_Br4923 VAR--------------------RLRESFG-------------------- Mb0856|M.bovis_AF2122/97 ------------AGGPAGLIG-----VGGAGGAG------GDSAVAGVIG Rv0833|M.tuberculosis_H37Rv ------------AGGPAGLIG-----VGGAGGAG------GDSAVAGVIG MMAR_4399|M.marinum_M APVQSLTGRPLIGNGANGTPG-----TGADGAPGGWLLGDGGAGGSGAPG MUL_3062|M.ulcerans_Agy99 KPVQDLTGRPLVGNGANGVPG-----TGANGAAGGWLLGNGGAGGSGAAG Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG TH_3810|M.thermoresistible__bu ------------------------------------------------VD MAB_4284c|M.abscessus_ATCC_199 -----YVADPEAALANAGLSAVSAAQVGAVMPVVAESVASNYGYQSQWVN MAV_4827|M.avium_104 ------IQMVVLEGEYADGATVEEDAIDVTGADDAATASAPDRVISAILG MLBr_01556|M.leprae_Br4923 -------GIKPAADKGAEQVATKAQAKRLGESLDQTLDRALDKAVAGNGA Mb0856|M.bovis_AF2122/97 GAGGAGGAAL---LFGAGGAGGAGGSG--GSGAAGG--AGGAGGAGG-LF Rv0833|M.tuberculosis_H37Rv GAGGAGGAAL---LFGAGGAGGAGGSG--GSGAAGG--AGGAGGAGG-LF MMAR_4399|M.marinum_M LNGGAGGAAG---LLGSGGAGGAGGSS---TSTNGG--AGGAGGAGGWLS MUL_3062|M.ulcerans_Agy99 QAGGDGGAAG---LIGAGGAGGAGGNSPLRNTANGG--NGGTGGAGGLLF Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGATG MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG TH_3810|M.thermoresistible__bu GDGGSGGRTGLFSKLSRGGDGGDGGLG-------------GNGGHGG--- MAB_4284c|M.abscessus_ATCC_199 TGNPIHDLSGNLQNYYAAQPDGPSILSPSLLSPRDN----DFLSHNDTDF MAV_4827|M.avium_104 TREGAADAGLQLSSIGVTWTDQLEAAALRDALAARR--IDNVMLVSAFLA MLBr_01556|M.leprae_Br4923 TTAAPVQVDHSAAVVPIVAGEGPSTAHREELAPPAGQPSEQPGVPLPGQQ Mb0856|M.bovis_AF2122/97 ASGGSGGFGGFASTGTGGAGGTGGAGGLFASGGVGGTGG----------G Rv0833|M.tuberculosis_H37Rv ASGGSGGFGGFASTGTGGAGGTGGAGGLFASGGVGGTGG----------G MMAR_4399|M.marinum_M GNAGVGGAGGASTVANGGAGGAGGAGGLLGGGGLGGAGG----------A MUL_3062|M.ulcerans_Agy99 GPGGVGGAGGASFLT-GGTGGDGGAGGLFGAGGLGGVGG----------S Mflv_5091|M.gilvum_PYR-GCK VTSGVVGGNGEDAVGYGATGAAGAAG-AAGAAGAAG-------------- Mvan_1264|M.vanbaalenii_PYR-1 VTSNVTGGNGADAVGYGATGAAGAAG-AAGAAGKAG-------------- MSMEG_0868|M.smegmatis_MC2_155 GTGGIGGTGGGLFGLLGHSGSTGAAG-AAGNGGDGGNGGFGYVLIAGPNV TH_3810|M.thermoresistible__bu ------GTGIISLLSLAGNGGNGGNGYRTTDN------------------ MAB_4284c|M.abscessus_ATCC_199 ASHNPIASGNQVMSPSGNVDSFNRGPLLDLSFGDLQFGN----------- MAV_4827|M.avium_104 AAALAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGSIP---------- MLBr_01556|M.leprae_Br4923 GTPAAPHPGHPGMPTGPHPGPAPKPGGRPPRVGNNPFSS---------AQ . Mb0856|M.bovis_AF2122/97 AGSG-GTGGVGGTGGAGG-LFA--SGGAGGAGGSGGTGGAGGTGGAGG-- Rv0833|M.tuberculosis_H37Rv AGSG-GTGGVGGTGGAGG-LFA--SGGAGGAGGSGGTGGAGGTGGAGG-- MMAR_4399|M.marinum_M STSATASGGAGGQGGAAG-LLSGFVGADGGHGGAGGHGAAGGDGGAGGDG MUL_3062|M.ulcerans_Agy99 GN----VGGNGGAGGAGG-LLAGLVGAGGGDGGSGGLGAAGGDGGNGGRA Mflv_5091|M.gilvum_PYR-GCK AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG----AVGAAG----- Mvan_1264|M.vanbaalenii_PYR-1 AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG----AIGTAG----- MSMEG_0868|M.smegmatis_MC2_155 TVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDG TH_3810|M.thermoresistible__bu ---NALDGGHGGNGGNVGFFSLFNLGGAGGWGGSG--------------- MAB_4284c|M.abscessus_ATCC_199 RDTTAIGDGAVAVGGSNSGPIASGQGSTAVNGDVRDSNIINADHGSN--- MAV_4827|M.avium_104 -DVYKQQIRAESYGDAAGQLSAMVAGLEKLESLPGGLLLVGSGVDVAPLK MLBr_01556|M.leprae_Br4923 SVARPIPRPPAPRPSASPSSMSPRPGGAVGGGGPRPPRTGVPRPGGGRPG . * . Mb0856|M.bovis_AF2122/97 --LFGAGGAGGLGGQGNHTGGHGGAGGSAGLLALGDGGAGGAGGAATTG- Rv0833|M.tuberculosis_H37Rv --LFGAGGAGGLGGQGNHTGGHGGAGGSAGLLALGDGGAGGAGGAATTG- MMAR_4399|M.marinum_M GPLAGAGGSGGTGGSGNAGGGAGGAGGNAGLL-FGDGGVGGTGGTSGQG- MUL_3062|M.ulcerans_Agy99 GLFGGAGGAGGMGATGGHSGGDGGAGGDAGLL-FGTGGAGGAGGHAFDG- Mflv_5091|M.gilvum_PYR-GCK --AAGTVGTAGATG-GTGTGANGGAGGVG-----GVGGTGAAGAAGGAGG Mvan_1264|M.vanbaalenii_PYR-1 --VAGAAGTAGATG-GTGVGGNGGAGQAG-----GIGGTGAAGAAGQAGT MSMEG_0868|M.smegmatis_MC2_155 HAIGGNGGNGGNGS-TTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGG TH_3810|M.thermoresistible__bu ------------------VDGVDVVGGNP------DGGTPGAHGESHTP- MAB_4284c|M.abscessus_ATCC_199 --VGVDQSQTRVGGDYTNVSGHGSADIDKSVTVVDDHSQRNTTNINDSFN MAV_4827|M.avium_104 QVLQTTTFLDVSVAEEPETALARGAALAAANAPLFASSTAALAYAQDPG- MLBr_01556|M.leprae_Br4923 APVGGRSDAGGGNYRGGGVGALPGGGSGGFRGRPGGGGHGGGGRPGQRG- . Mb0856|M.bovis_AF2122/97 ------TGGAGGAG-------------------GKAGLLFGSGGAGGSGG Rv0833|M.tuberculosis_H37Rv ------TGGAGGAG-------------------GKAGLLFGSGGAGGSGG MMAR_4399|M.marinum_M ------VGGIGGDG-------------------GSAGLLFSNGGAGGAGG MUL_3062|M.ulcerans_Agy99 ------DGGAGGAG-------------------GNAGLMFSSGGSGGVGG Mflv_5091|M.gilvum_PYR-GCK LGETGTTGGAGGVG--------------------GQGTAGGTGGVGGIGG Mvan_1264|M.vanbaalenii_PYR-1 AGETGVTGGVGGIG--------------------GQGTEGGTGGVGGVGG MSMEG_0868|M.smegmatis_MC2_155 HSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGE TH_3810|M.thermoresistible__bu ------------------------------------GVYTDRQGEDGEDG MAB_4284c|M.abscessus_ATCC_199 ------TDRSTNIG--------------------SGNTTNTEIGSHNQAN MAV_4827|M.avium_104 ------TGAVDQYS-------------------LPDYLYVPVDPEPGDDE MLBr_01556|M.leprae_Br4923 -------GAAGAFG-------------------RPGGAPRRGRKSKRQKR Mb0856|M.bovis_AF2122/97 AAGTFGDTGNSGGAGGAGGKAGLLFGSGGAGG----SGGAGG-------- Rv0833|M.tuberculosis_H37Rv AAGTFGDTGNSGGAGGAGGKAGLLFGSGGAGG----SGGAGG-------- MMAR_4399|M.marinum_M AGTAL--ISGNGGAGGNGGNGGWLFSNGGVGG----AGGAGAP-----AM MUL_3062|M.ulcerans_Agy99 AG------SIDGGAGGAGGDAGWLGG-GGAGG----AGGFGT-------- Mflv_5091|M.gilvum_PYR-GCK AG----------STGAVGG-------VGGKG----IQGGQG--------- Mvan_1264|M.vanbaalenii_PYR-1 VG----------ATGGAGG-------VGGKG----IQGGQG--------- MSMEG_0868|M.smegmatis_MC2_155 IYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASG TH_3810|M.thermoresistible__bu TG-----------TG----------------------------------- MAB_4284c|M.abscessus_ATCC_199 IG----------TSTSAGG------------------------------- MAV_4827|M.avium_104 LAYS---------------------------------------------- MLBr_01556|M.leprae_Br4923 QEYDSMQAPVVGGVRLPHGNGETIRLARGASLS----------------- Mb0856|M.bovis_AF2122/97 ---FANGSTGGAGGAGGGAG-LIGNGGN-----------GGSGGTSVATG Rv0833|M.tuberculosis_H37Rv ---FANGSTGGAGGAGGGAG-LIGNGGN-----------GGSGGTSVATG MMAR_4399|M.marinum_M PSLGISAGSGGVGGAGGTGGLLLGNGGA-----------GGAGGTSGNGG MUL_3062|M.ulcerans_Agy99 ----ISD--GGAGGRGGGGGQLLGNGGA-----------GGAGGQGGNDG Mflv_5091|M.gilvum_PYR-GCK ----LQGGKGGDGGAGGKGGDADSMGS------------------AGATG Mvan_1264|M.vanbaalenii_PYR-1 ----LQGGQGGDGGTGGTGGDATSMGE------------------AGATG MSMEG_0868|M.smegmatis_MC2_155 TAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----SAAVGGNAGLAGNAG------------------------LAGNAG MAV_4827|M.avium_104 ----AVGEEDAESPTVVIEKLFLPEDSE-----------------PRRRP MLBr_01556|M.leprae_Br4923 ---DFAEKIDANPAALVQALFNLGEMVT--------------ATQSVGDE Mb0856|M.bovis_AF2122/97 GAGNGGAGGAGGGAGLIG---------------NGGNGGSGGM------- Rv0833|M.tuberculosis_H37Rv GAGNGGAGGAGGGAGLIG---------------NGGNGGSGGM------- MMAR_4399|M.marinum_M GTG--GAGGAAGSGVLIG---------------NGGNGGIGGA------- MUL_3062|M.ulcerans_Agy99 GAG--GLG---GNGVLIG---------------NGGNGGVGGV------- Mflv_5091|M.gilvum_PYR-GCK GKG--GNGGNGGRGGLFG---------------KGGNAGNGAD------- Mvan_1264|M.vanbaalenii_PYR-1 GKG--GNGGNGGRGSLFG---------------RGGNAGNGGN------- MSMEG_0868|M.smegmatis_MC2_155 AVG--GNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYD TH_3810|M.thermoresistible__bu ---------------------------------IGGRGGNGGS------- MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGNAGLAGNAG---------------LAGNAGLAGN------- MAV_4827|M.avium_104 VLLVGSGLAVVGISAVLA---------------LEIALAIGIR------- MLBr_01556|M.leprae_Br4923 TLELLGSEMNYNVQVVSP---------------EDEDRELLEP------- Mb0856|M.bovis_AF2122/97 ---------------GDAPGGTGVGGIGGLLLGLDGANA----------- Rv0833|M.tuberculosis_H37Rv ---------------GDAPGGTGVGGIGGLLLGLDGANA----------- MMAR_4399|M.marinum_M ---------------GPTPGGNGIGGTSGLLLGLDGFNA----------- MUL_3062|M.ulcerans_Agy99 ---------------GETPGGDGGGGISGLLLGADGFNA----------- Mflv_5091|M.gilvum_PYR-GCK ---------------GGTGGAGGAGGTGG-TGGAGGTGG----------- Mvan_1264|M.vanbaalenii_PYR-1 ---------------GGTGGNGGNGGTGG-TGGNGGTGG----------- MSMEG_0868|M.smegmatis_MC2_155 PNGPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQH TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------AGLAGNAGLAGNAGLAGNAGLAGNAG--------- MAV_4827|M.avium_104 -----------------TTGTVALQPTPNQHLIVPTEQA----------- MLBr_01556|M.leprae_Br4923 ----------FDLTYGEDQGDEDELQVRPPVVTVMGHVDHG--------- Mb0856|M.bovis_AF2122/97 ------PASTNPLHTAQQQALAAVNAPIQAVTGRPLIGNGANGAPGSGAP Rv0833|M.tuberculosis_H37Rv ------PASTNPLHTAQQQALAAVNAPIQAVTGRPLIGNGANGAPGSGAP MMAR_4399|M.marinum_M ------PTSTSPIHTLQQQALNAINAPIQAATGRPLIGNGTPGDAGSGTD MUL_3062|M.ulcerans_Agy99 ------PAGSSPVHALQQQALAAINAPVQELTGRPLIGNGLPGSAGSGAA Mflv_5091|M.gilvum_PYR-GCK ------TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGT Mvan_1264|M.vanbaalenii_PYR-1 ------TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGT MSMEG_0868|M.smegmatis_MC2_155 STGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGD TH_3810|M.thermoresistible__bu ------SSGTHPMAEDG--------EHVKALDGRPGLDGGNGSHGGNGGH MAB_4284c|M.abscessus_ATCC_199 ------LAGNAGLAGNAGLAGNAGLAGNAGLAG----NAGLAGNAGLAGN MAV_4827|M.avium_104 ------PAPPPVQASAPQPKISVPEPVAAPKPLSPPVAAPLPAAPPPAAP MLBr_01556|M.leprae_Br4923 -------KTRLLDTIRKANVREAEAGGITQHIGAYQVGVDLDGSERLITF . Mb0856|M.bovis_AF2122/97 GGHGG--WLFGGGGTG----GSGVS--GGAGGDGGAGGI--------LFG Rv0833|M.tuberculosis_H37Rv GGHGG--WLFGGGGTG----GSGVS--GGAGGDGGAGGI--------LFG MMAR_4399|M.marinum_M GTPGG--WLLGDGGAG----GSGGT--GLDGGDGGAAG---------LMG MUL_3062|M.ulcerans_Agy99 GAPGG--WLLGDGGAG----GSAAATPGAAGGAGGAAG---------LVG Mflv_5091|M.gilvum_PYR-GCK GGKGGTGGTGGAGGTG----GDGGT--GGTGGTGGTG---------GTGG Mvan_1264|M.vanbaalenii_PYR-1 GGKGGTGGTGGDGGTG----GTGGT--GGTGGTGGTG---------GTGG MSMEG_0868|M.smegmatis_MC2_155 GGRGGDGALGGNGGTGGVGLGNGGK--GGNGGNGGNGGTYVDPSHTGAGG TH_3810|M.thermoresistible__bu GGRGG---FLGIGGSG---------------------------------G MAB_4284c|M.abscessus_ATCC_199 AGLAGNAGLAGNAGLAG---NAAVAGNAAVAGNAAVAGN---------AA MAV_4827|M.avium_104 PLPEAPPIPAAPPVVPVPVVVPPVPVPVPVRIPVPDPVS--------PPQ MLBr_01556|M.leprae_Br4923 IDTPGHEAFTAMRARG--AKATDIAILVVAADDGVMPQT--------VEA . . Mb0856|M.bovis_AF2122/97 AGGAGGAG-----GAVTGTGATGGSGGAGGG-ALLFGAGGAGGAGGSSGI Rv0833|M.tuberculosis_H37Rv AGGAGGAG-----GAVTGTGATGGSGGAGGG-ALLFGAGGAGGAGGSSGI MMAR_4399|M.marinum_M TGGTGGAGGW--GGTDEITGGTGGAGGTGGGGGWLSGSGGIGGGGGAGGY MUL_3062|M.ulcerans_Agy99 AGGAGGAG----ANTGISNPGFGGAGGAGG--------AGAGAGGGVG-- Mflv_5091|M.gilvum_PYR-GCK TGGTGGAG-----------DGTGGTGGTGG----TGGQGGQGGQGG---- Mvan_1264|M.vanbaalenii_PYR-1 TGGTGGAG-----------DGLGGTGGTGG----TGGFGGQGGQGG---- MSMEG_0868|M.smegmatis_MC2_155 NGGNGGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEALI TH_3810|M.thermoresistible__bu WGGHGGNG-----------GDTDADGGNGG-------------------- MAB_4284c|M.abscessus_ATCC_199 VGGVLNTG---------VSGAIGGSSHVGG--AINESLGGSGSVGGSTAV MAV_4827|M.avium_104 LLAPPRLSVPQPVQPPVRVPQPPSPPQVGGTVPQSPPQHQTPPGEGTPPK MLBr_01556|M.leprae_Br4923 INHAQAADVPIVVAVNKIDKEGADPAKIRGQLTEYGLVAEDFGGDTMFID . * Mb0856|M.bovis_AF2122/97 GG------FAAGGAGGPGGAGG-LFNGGGAG------------------- Rv0833|M.tuberculosis_H37Rv GG------FAAGGAGGPGGAGG-LFNGGGAG------------------- MMAR_4399|M.marinum_M GGAIIPGNGGAGGSAGAGGAGG-LFGGGGTG------------------- MUL_3062|M.ulcerans_Agy99 ---------------EAGGAGG-LLGAGGTG------------------- Mflv_5091|M.gilvum_PYR-GCK -------------TGGTGGQGG-LGGGGGTG------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------TGGTGGQGG-LGGVGGTG------------------- MSMEG_0868|M.smegmatis_MC2_155 RATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASG TH_3810|M.thermoresistible__bu ----------------DGGNGG---------------------------- MAB_4284c|M.abscessus_ATCC_199 GG------------GAHTGVGGGVSTGVGVG------------------- MAV_4827|M.avium_104 PD-------------GPGNYGGGHVPTPGAG------------------- MLBr_01556|M.leprae_Br4923 ISAKVGTNIEALLEAVLLTADAALDLRANSG------------------- .. Mb0856|M.bovis_AF2122/97 ----GAGGSG--------------VSGGAGGEGGAGGAGGLFAGGGIGGA Rv0833|M.tuberculosis_H37Rv ----GAGGSG--------------VSGGAGGEGGAGGAGGLFAGG----- MMAR_4399|M.marinum_M ----GAGGTGGPAGLGVFVGVPTFGDGGGGGAGGAGGAGGLLSGLVG--- MUL_3062|M.ulcerans_Agy99 ----GGGGVA-----------PSLVDGGTGGAGGAGGAGGLFGGIFG--- Mflv_5091|M.gilvum_PYR-GCK ----GQGGTG--------------GTGGQGGTGGTGGTGGTG-------- Mvan_1264|M.vanbaalenii_PYR-1 ----GTGGTG--------------GTGGQGGTGGTGGTGGTG-------- MSMEG_0868|M.smegmatis_MC2_155 TATDGHGGSG--------------INGGHGGNGGQGTIEANGPSAVA--- TH_3810|M.thermoresistible__bu -------------------------SAGRGGTGGLRGVFGIN-------- MAB_4284c|M.abscessus_ATCC_199 ----SHVGGG--------------ISESLGGSGSVGGSTAVGGGAHT--- MAV_4827|M.avium_104 ----GSGGSG----------------GGHVPTPGAGGSGGSG-------- MLBr_01556|M.leprae_Br4923 -----MEAQG--------VAIEAHLDRGRGPVATVLVQRGTLRIGDS--- . . Mb0856|M.bovis_AF2122/97 GGFGGFRGGEGGAGGAGGLFAGGGAGGAGGSG----NNVGGAGGAGGVGG Rv0833|M.tuberculosis_H37Rv -----------------------GAGGAGGSG----NNVGGAGGAGGVGG MMAR_4399|M.marinum_M --------------------AGGGDGGAGGQGGIGFGGSGGSGGGGGVGG MUL_3062|M.ulcerans_Agy99 --------------------AGGGDGGAGGFT----GGIDGAGGVGGAGG Mflv_5091|M.gilvum_PYR-GCK -----------------------GTGGAGGDGG--LGGLGGFGGSGGTGG Mvan_1264|M.vanbaalenii_PYR-1 -----------------------GTGGAGGDGG--LGGLGGFGGVGGTGG MSMEG_0868|M.smegmatis_MC2_155 --------------------SGIGAGGNGGDGI--DGGLGGNGGDGVVNT TH_3810|M.thermoresistible__bu -------------------------GGNGRAG------LGGRGXXX---- MAB_4284c|M.abscessus_ATCC_199 -----------------------GVGGGVSTG----VGVGSHVGGGISES MAV_4827|M.avium_104 -------------------------GGHVPTP-----GTGGPGGTGGSGG MLBr_01556|M.leprae_Br4923 -----------------------VVAGDAYGRVRRMVDEHGVDIEAALPS .* . Mb0856|M.bovis_AF2122/97 ----LFGAGGAGGSGGG----------GSVAGDGGAGGN--AGLLAPGLA Rv0833|M.tuberculosis_H37Rv ----LFGAGGAGGSGGG----------GSVAGDSGAGGN--AGLLAPGLA MMAR_4399|M.marinum_M NAGLLGGPGGAGGSGGAAGPALFGIGVDGTAGVGGAGGN--AGLLFG--S MUL_3062|M.ulcerans_Agy99 NTGLLGGPGGSGGSGGD-GIAKLGFNVDG--GAGGAGVN--GGFLFG--S Mflv_5091|M.gilvum_PYR-GCK QGG-LGGPGGSTGGAGG----AGG--QAGTAGKGGLFG----GSGSAGKA Mvan_1264|M.vanbaalenii_PYR-1 QGG-QGGPGGSTGGAGG----AGG--QAGVAGKGGLFG----GSGSAGTA MSMEG_0868|M.smegmatis_MC2_155 TAN-AANPGSATGTATG----GDGGKATGTASQGGNGGPSWVQSGYGSTL TH_3810|M.thermoresistible__bu -------XGGGVGAAVR--------------------------------- MAB_4284c|M.abscessus_ATCC_199 LGG-SGSVGGSTAVGGG---------------------------AHTGVG MAV_4827|M.avium_104 GHVPTPGAGTPGGSGGG--------------------------------- MLBr_01556|M.leprae_Br4923 SPVQVIGFTSVPGAGDNFLVVDEDRIARQIADRRSARKRNALAARSRKRI . . Mb0856|M.bovis_AF2122/97 GGAGGGGGQG-----FDTGGAGGPG--------GDAGLLVGSGGVGGAGG Rv0833|M.tuberculosis_H37Rv GGAGGGGGQG-----FDTGGAGGPG--------GDAGLLVGSGGVGGAGG MMAR_4399|M.marinum_M GGAGGDGGFG-----PGAGGTGGRG--------GNAGLLFSSAGAGGFGG MUL_3062|M.ulcerans_Agy99 GGTGGFGGVGGVGTSTGIGGAGGRG--------GNAGLLFSDAGVGGFGG Mflv_5091|M.gilvum_PYR-GCK GATGAAGASGGKGAQGATGAQGATG------AQGATG-ATGAAGKAGATG Mvan_1264|M.vanbaalenii_PYR-1 GVTGASGASGGKGAQGATGAQGATG------AQGATG-ATGASGAQGSAG MSMEG_0868|M.smegmatis_MC2_155 GGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTATGGDGG TH_3810|M.thermoresistible__bu ---------------------SGNG-------------VFSGGGGTPSAG MAB_4284c|M.abscessus_ATCC_199 GGVNTGVGVGSHVGGGISESLGGSG---------------SVGGSTAVGG MAV_4827|M.avium_104 -----------------HLPFPGAG-----------------STPGGSGG MLBr_01556|M.leprae_Br4923 SLEDLDSALKETSQLNLILKGDNAG--------TVEALEEALMGIQVDDE * Mb0856|M.bovis_AF2122/97 FGLTTGGPGAAGGDAGL------LFGSGGAGGAGGSGRTDLGGAGGAGGK Rv0833|M.tuberculosis_H37Rv FGLTTGGPGAAGGDAGL------LFGSGGAGGAGGSGRTDLGGAGGAGGK MMAR_4399|M.marinum_M YGTTGGGTGGAGGDAG-------WLGCGGAGGAGGITIGGTGGTGGAGGT MUL_3062|M.ulcerans_Agy99 FG-------GTGGNAG-------WLGSGGSGGAGGGSNG-DGGAGGTGGS Mflv_5091|M.gilvum_PYR-GCK AAGAAGAAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAGKA Mvan_1264|M.vanbaalenii_PYR-1 SAGSAGVAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAGKA MSMEG_0868|M.smegmatis_MC2_155 AATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADGWV TH_3810|M.thermoresistible__bu FGVPTTIQFPAG------------SCTSRAVSREGIMPSSRAASARAG-- MAB_4284c|M.abscessus_ATCC_199 GAHTSAINDALG-------------GSGSVGGSTAVGGGAHTSAINESMN MAV_4827|M.avium_104 GHLPTPGAGTPG---------------GGLGGFGGGHAPAPGGGLGGGGG MLBr_01556|M.leprae_Br4923 VALRVIDRGVGGITETN-----VNLASASDAIIIGFNVRAEGKATELASR * . . Mb0856|M.bovis_AF2122/97 AG--LIGNGG---------NGGAGG-----AGG----AGGPGG------- Rv0833|M.tuberculosis_H37Rv AG--LIGNGG---------NGGAGG-----AGGNGGGDGGPGG------- MMAR_4399|M.marinum_M GGQ-LLGAGG---------AGGAGGQTDPLG-GSTGGSGGVGG------- MUL_3062|M.ulcerans_Agy99 GGQ-IVGDGG---------AGGAGGQGDLLAAGGSGGDGGQGG------- Mflv_5091|M.gilvum_PYR-GCK GATGTTGATG--------AAGEDGDAGSGGSG-INGGAGGAGG------- Mvan_1264|M.vanbaalenii_PYR-1 GATGTTGATG--------AAGDAGDPGSEAVD-INGGAGGAGG------- MSMEG_0868|M.smegmatis_MC2_155 QAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKS TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SSINASHSSS---------------------------------------- MAV_4827|M.avium_104 HAP----------------------------------------------- MLBr_01556|M.leprae_Br4923 EGVEIRYYLVIYQAIDDIEKALRGMLKPIYEENQLGRAEIRALFRSSKVG Mb0856|M.bovis_AF2122/97 ----AAFGLGNGGNGGNGGTGTS--------AGSPGAGGAGGSLIGAEGL Rv0833|M.tuberculosis_H37Rv ----AAFGLGNGGNGGNGGTGTS--------AGSPGAGGAGGSLIGAEGL MMAR_4399|M.marinum_M ----NAVLIGTGGNGGNGGAGTA--------KGTPGTGGTGG-LIGVDGL MUL_3062|M.ulcerans_Agy99 ----DAVLIGTGGNGGNGASGVL--------AGIGGDGGSRGLLLGEDGV Mflv_5091|M.gilvum_PYR-GCK ----AGGEGGEGGDGGKGGAGAE--------GGAGGGGGAGGSGAGGAG- Mvan_1264|M.vanbaalenii_PYR-1 ----AGGEGGEGGAGGAGGDGSE--------GGAGGSGGAGGSGTGGAG- MSMEG_0868|M.smegmatis_MC2_155 GGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGSGN TH_3810|M.thermoresistible__bu ----AACASSTSRSRRSFCCSRA--------------------------- MAB_4284c|M.abscessus_ATCC_199 -----MNESFGSSMGSHGAAGTG--------FEAQGHAQGHASETAHTTL MAV_4827|M.avium_104 --------APGGGLGGFGGGHSG--------GGLGGLGGGHK-------- MLBr_01556|M.leprae_Br4923 IIAGCIISSGVVRRNAKVRLLRDNIVVTDNLTVTSLRREKDDVTEVREGF Mb0856|M.bovis_AF2122/97 PGLLP----------------------- Rv0833|M.tuberculosis_H37Rv PGLLP----------------------- MMAR_4399|M.marinum_M SGAS------------------------ MUL_3062|M.ulcerans_Agy99 NGEAAPPMTHIVLLGGDFPAAAS----- Mflv_5091|M.gilvum_PYR-GCK -GAGGSGGSGGSGGSGGSGGAAGDSDD- Mvan_1264|M.vanbaalenii_PYR-1 -GAGGSGGSGGSGGAGGSGGAAGDSD-- MSMEG_0868|M.smegmatis_MC2_155 GGNGGNGGNGGADGTPGTAGTTGANNP- TH_3810|M.thermoresistible__bu ---------------------------- MAB_4284c|M.abscessus_ATCC_199 PGAEHH---------------------- MAV_4827|M.avium_104 ---------------------------- MLBr_01556|M.leprae_Br4923 ECGMTLGYSDIKEGDVIESYELVEKQRA