For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. ulcerans Agy99 MUL_3062 (-)

annotation: PE-PGRS family protein
coordinates: 3394387 - 3396999
length: 870

MAFVLAVPDMVAEAAADLAGVGSVIDAANTAAAGSTTGIVAAAEDEVSAAIAALFSGHGQAYQQISTRVA
EFHAQFERVFAAGVQAYSGAEAANASFLQDPLQTALNATNKPVQDLTGRPLVGNGANGVPGTGANGAAGG
WLLGNGGAGGSGAAGQAGGDGGAAGLIGAGGAGGAGGNSPLRNTANGGNGGTGGAGGLLFGPGGVGGAGG
ASFLTGGTGGDGGAGGLFGAGGLGGVGGSGNVGGNGGAGGAGGLLAGLVGAGGGDGGSGGLGAAGGDGGN
GGRAGLFGGAGGAGGMGATGGHSGGDGGAGGDAGLLFGTGGAGGAGGHAFDGDGGAGGAGGNAGLMFSSG
GSGGVGGAGSIDGGAGGAGGDAGWLGGGGAGGAGGFGTISDGGAGGRGGGGGQLLGNGGAGGAGGQGGND
GGAGGLGGNGVLIGNGGNGGVGGVGETPGGDGGGGISGLLLGADGFNAPAGSSPVHALQQQALAAINAPV
QELTGRPLIGNGLPGSAGSGAAGAPGGWLLGDGGAGGSAAATPGAAGGAGGAAGLVGAGGAGGAGANTGI
SNPGFGGAGGAGGAGAGAGGGVGEAGGAGGLLGAGGTGGGGGVAPSLVDGGTGGAGGAGGAGGLFGGIFG
AGGGDGGAGGFTGGIDGAGGVGGAGGNTGLLGGPGGSGGSGGDGIAKLGFNVDGGAGGAGVNGGFLFGSG
GTGGFGGVGGVGTSTGIGGAGGRGGNAGLLFSDAGVGGFGGFGGTGGNAGWLGSGGSGGAGGGSNGDGGA
GGTGGSGGQIVGDGGAGGAGGQGDLLAAGGSGGDGGQGGDAVLIGTGGNGGNGASGVLAGIGGDGGSRGL
LLGEDGVNGEAAPPMTHIVLLGGDFPAAAS
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. ulcerans Agy99MUL_3062--100% (870)PE-PGRS family protein
M. ulcerans Agy99MUL_2485-0.062.86% (754) PE-PGRS family protein
M. ulcerans Agy99MUL_4280-0.057.29% (789) PE-PGRS family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0767PE_PGRS90.061.15% (870) PE-PGRS family protein
M. gilvum PYR-GCKMflv_5091-1e-14145.25% (811) triple helix repeat-containing collagen
M. tuberculosis H37RvRv0746PE_PGRS90.060.83% (840) PE-PGRS family protein
M. leprae Br4923MLBr_01183-2e-1038.04% (92) hypothetical protein MLBr_01183
M. abscessus ATCC 19977MAB_4284c-9e-4233.33% (468) hypothetical protein MAB_4284c
M. marinum MMMAR_2695-0.095.41% (893) PE-PGRS family protein, PE_PGRS9_1
M. avium 104MAV_4827-4e-2340.76% (184) hypothetical protein MAV_4827
M. smegmatis MC2 155MSMEG_0868-1e-12238.84% (865) hypothetical protein MSMEG_0868
M. thermoresistible (build 8)TH_3810-4e-4239.63% (328) PUTATIVE -
M. vanbaalenii PYR-1Mvan_1264-1e-14144.15% (804) triple helix repeat-containing collagen

CLUSTAL 2.0.9 multiple sequence alignment


MUL_3062|M.ulcerans_Agy99           --------------------------------------------------
MMAR_2695|M.marinum_M               --------------------------------------------------
Mb0767|M.bovis_AF2122/97            --------------------------------------------------
Rv0746|M.tuberculosis_H37Rv         --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MUL_3062|M.ulcerans_Agy99           ------------------MAFVLAVPDMVAEAAADLAGVGS---------
MMAR_2695|M.marinum_M               ------------------MAFVLAVPDMVAGAAADLAGVGS---------
Mb0767|M.bovis_AF2122/97            ------------------MSFVLAMPEVLGSAATDLAALGS---------
Rv0746|M.tuberculosis_H37Rv         ------------------MSFVLAMPEVLGSAATDLAALGS---------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155      PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -----------MSIIDFILNLFRDPVEAASYVADPEAALANAG-------
MAV_4827|M.avium_104                ------------------MNIVLGVSMAPSSIQMVVLEGEYADG------
                                                                                      

MUL_3062|M.ulcerans_Agy99           -----------------------------------VIDAANTAAAGSTTG
MMAR_2695|M.marinum_M               -----------------------------------VIDAANTAAAGSTTG
Mb0767|M.bovis_AF2122/97            -----------------------------------VLGAADAAAAATTTG
Rv0746|M.tuberculosis_H37Rv         -----------------------------------VLGAADAAAAATTTG
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1       ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155      SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ------------------------------------LSAVSAAQVGAVMP
MAV_4827|M.avium_104                ----------------------------------ATVEEDAIDVTGADDA
                                                                                      

MUL_3062|M.ulcerans_Agy99           IVAAAEDEVSAAIAALFSGHGQAYQQISTRVAEFHAQFERVFAAGVQAYS
MMAR_2695|M.marinum_M               IVAAAEDEVSAAIAALFSGHGQAYQQISARVAEFHAQFERVLAAGAQAYS
Mb0767|M.bovis_AF2122/97            IVAAVQDEVSAAIAALFSAHGRAYQVASAQAAAVHAQFVEALSAGAGAYA
Rv0746|M.tuberculosis_H37Rv         IVAAAQDEVSAAIAALFSAHGRAYQVASAQAAAVHAQFVEALSAGAGAYA
Mflv_5091|M.gilvum_PYR-GCK          ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155      PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      VVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSPSLLS
MAV_4827|M.avium_104                ATASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALRDALAAR
                                                                                      

MUL_3062|M.ulcerans_Agy99           G------------------------AEAANASFLQDPLQTALN----ATN
MMAR_2695|M.marinum_M               G------------------------AEAANASFLQDPLQTALN----AIN
Mb0767|M.bovis_AF2122/97            S------------------------AEAAGAAVLANPAQSVQQDLLAAVN
Rv0746|M.tuberculosis_H37Rv         S------------------------AEAAGAAVLANPAQSVQQDLLAAVN
Mflv_5091|M.gilvum_PYR-GCK          S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1       S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155      TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      P---------------------------RDNDFLSHNDTDFASHNPIASG
MAV_4827|M.avium_104                R------------------------------------------IDNVMLV
                                                                                      

MUL_3062|M.ulcerans_Agy99           KPVQDLTGRPLVGNGANGVPG-----TGANGAAGGWLLGNGGAGGSGAAG
MMAR_2695|M.marinum_M               TPVQDLTGRPLVGNGANGVPG-----TGANGAAGGWLLGNGGAGGSGAAG
Mb0767|M.bovis_AF2122/97            AQSVALTGRPLIGNGANGAPG-----TGANGAPGGWLLGNGGAGGSAAAG
Rv0746|M.tuberculosis_H37Rv         AQSVALTGRPLIGNGANGAPG-----TGANGAPGGWLLGNGGAGGSAAAG
Mflv_5091|M.gilvum_PYR-GCK          QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG
Mvan_1264|M.vanbaalenii_PYR-1       QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS
MSMEG_0868|M.smegmatis_MC2_155      DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG
TH_3810|M.thermoresistible__bu      ------------------------------------------------VD
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      NQVMSPSGNVDSFNRGPLLDLSFGDLQFGNRDTTAIGDGAVAVGGSNSGP
MAV_4827|M.avium_104                SAFLAAAALAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGSIPDVYKQ
                                                                                      

MUL_3062|M.ulcerans_Agy99           --QAGGDGGAAGLIGAGGAGGAGGNSPLRNTANGGNGG--TGGAGGLLFG
MMAR_2695|M.marinum_M               --QAGGDGGAAGLIGAGGAGGAGGNSPLGNTANGGNGG--TGGAGGLLFG
Mb0767|M.bovis_AF2122/97            SGLPGGAGGAAGLFGTGGAGGAGGSSTVG---DGGAGG--AGGSGGWLLG
Rv0746|M.tuberculosis_H37Rv         SGLPGGAGGAAGLFGTGGAGGAGGSSTVG---DGEAGG--AGGSGGWLLG
Mflv_5091|M.gilvum_PYR-GCK          --GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGA
Mvan_1264|M.vanbaalenii_PYR-1       --GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGA
MSMEG_0868|M.smegmatis_MC2_155      --LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGG
TH_3810|M.thermoresistible__bu      --GDGGSGGRTGLFSKLSRGGDGGDGGLG-------------GNGGHGGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      IASGQGSTAVNGDVRDSNIINADHGSNVGVDQSQTRVGGDYTNVSGHGSA
MAV_4827|M.avium_104                QIRAESYGDAAGQLSAMVAGLEKLESLPG-----------GLLLVGSGVD
                                                                                      

MUL_3062|M.ulcerans_Agy99           PGGVGGAGGASFLTGGTGGDGGAGGLFGAGGLGGVGG-------------
MMAR_2695|M.marinum_M               PGGVGGAGGASFLTGGTGGDGGAGGLFGAGGLGGVGG-------------
Mb0767|M.bovis_AF2122/97            TGGVGGVGGLGAGAGGAGGVGGAGGLLGAGGHGGAGG-------------
Rv0746|M.tuberculosis_H37Rv         TGGVGGVGGLGAGAGGAGGVGGAGGLLGAGGHGGAGG-------------
Mflv_5091|M.gilvum_PYR-GCK          TGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG-------------
Mvan_1264|M.vanbaalenii_PYR-1       TGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG-------------
MSMEG_0868|M.smegmatis_MC2_155      TGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPN
TH_3810|M.thermoresistible__bu      TGIIS--------------------LLSLAGNGGNGG-------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      DIDKSVTVVDDHSQRNTTNINDSFNTDRSTNIGSGNTTN-----------
MAV_4827|M.avium_104                VAPLKQVLQTTTFLDVSVAEEPETALARGAALAAANAP------------
                                                                                      

MUL_3062|M.ulcerans_Agy99           ---SGNVGG-NGGAGGAGGLLAGLVGAGGGDGGSGGLGAAGGDGGNGGRA
MMAR_2695|M.marinum_M               ---SGNVGG-NGGAGGAGGLLAGLVGAGGGDGGSGGLGAAGGDGGNGGRA
Mb0767|M.bovis_AF2122/97            ---LGAVTGGVGGAGGAGGLLAGLLAGPGGAGGTGGRGFLN---------
Rv0746|M.tuberculosis_H37Rv         ---LGAVTGGVGGTGGAGGLLAGLLAGPGGAGGTGGRGFLN---------
Mflv_5091|M.gilvum_PYR-GCK          -AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG--------------
Mvan_1264|M.vanbaalenii_PYR-1       -AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG--------------
MSMEG_0868|M.smegmatis_MC2_155      VTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVD
TH_3810|M.thermoresistible__bu      --NGYRTTDNNALDGGHGG-------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      TEIGSHNQANIGTSTSAGG--SAAVGGNAGLAGNAG--------------
MAV_4827|M.avium_104                LFASSTAALAYAQDPGTGAVDQYSLPDYLYVPVDPE--------------
                                                                                      

MUL_3062|M.ulcerans_Agy99           GLFGGAGGAGGMGATGGHSGGDGGAGGDAGLLFG-----------TGGAG
MMAR_2695|M.marinum_M               GLFGGAGGAGGMGATGGHSGGDGGAGGDAGLLFG-----------TGGAG
Mb0767|M.bovis_AF2122/97            ------------------DGGVGGAGGNAGLLFG-----------AGGTG
Rv0746|M.tuberculosis_H37Rv         ------------------NGGVGGAGGNAGLLFG-----------AGGTG
Mflv_5091|M.gilvum_PYR-GCK          --AVGAAGAAG------TVGTAGATGGTG---------------TGANGG
Mvan_1264|M.vanbaalenii_PYR-1       --AIGTAGVAG------AAGTAGATGGTG---------------VGGNGG
MSMEG_0868|M.smegmatis_MC2_155      GHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGG
TH_3810|M.thermoresistible__bu      --------------------------------------------NGGNVG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------LAGNAG
MAV_4827|M.avium_104                ----------------------------------------------PGDD
                                                                                      

MUL_3062|M.ulcerans_Agy99           GAGGHAFDGDGGAG----------------GAGGNAGLMFSSGGSGGVGG
MMAR_2695|M.marinum_M               GAGGHAFDGDGGAG----------------GAGGNAGLMFSSGGSGGVGG
Mb0767|M.bovis_AF2122/97            GSGGAGLGGDGGAG----------------GAGGNAGVLFGNAGSGGTGG
Rv0746|M.tuberculosis_H37Rv         GSGGAGLGGDGGAG----------------GAGGNTGVLFGNAGSGGTGG
Mflv_5091|M.gilvum_PYR-GCK          AGGVGGVGGTGAAG--------------AAGGAGGLGETGTTGGAGGVGG
Mvan_1264|M.vanbaalenii_PYR-1       AGQAGGIGGTGAAG--------------AAGQAGTAGETGVTGGVGGIGG
MSMEG_0868|M.smegmatis_MC2_155      HSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGE
TH_3810|M.thermoresistible__bu      FFSLFNLGG--------------------AGGWGGSGVDG----------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      LAGNAGLAGNAGLAG-------------NAGLAGNAGLAGNAGLAGNAGL
MAV_4827|M.avium_104                ELAYSAVGEEDAES--------------------PTVVIEKLFLPEDSEP
                                                                                      

MUL_3062|M.ulcerans_Agy99           AG----SIDGGAGGAGGDAGWLGGGGAGGAGG------------------
MMAR_2695|M.marinum_M               AG----SIDGGAGGAGGDAGWLGGGGAGGAGG------------------
Mb0767|M.bovis_AF2122/97            FG----DTDGGAGGAGGDAGWLGSGGVGGAGG------------------
Rv0746|M.tuberculosis_H37Rv         FG----DTDGGAGGAGGDAGWLGSGGVGGAGG------------------
Mflv_5091|M.gilvum_PYR-GCK          Q--GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG---------
Mvan_1264|M.vanbaalenii_PYR-1       Q--GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG---------
MSMEG_0868|M.smegmatis_MC2_155      IYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASG
TH_3810|M.thermoresistible__bu      -----------VDVVGGNP-------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AG---NAGLAGNAGLAGNAGLAGNAGLAGNAG------------------
MAV_4827|M.avium_104                RRRPVLLVGSGLAVVGISAVLALEIALAIGIR------------------
                                                                                      

MUL_3062|M.ulcerans_Agy99           ------FGTISDGGAGGRGGGGGQLLG---------------------NG
MMAR_2695|M.marinum_M               ------FGTISDGGAGGRGGVGGQLLG---------------------NG
Mb0767|M.bovis_AF2122/97            ------FGETGDGGVGGAGGKAGLLIG---------------------NG
Rv0746|M.tuberculosis_H37Rv         ------FGETGDGGVGGAGGKAGLLIG---------------------NG
Mflv_5091|M.gilvum_PYR-GCK          ----LQGGKGGDGGAGGKGGDADSMGS------------------AGATG
Mvan_1264|M.vanbaalenii_PYR-1       ----LQGGQGGDGGTGGTGGDATSMGE------------------AGATG
MSMEG_0868|M.smegmatis_MC2_155      TAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANG
TH_3810|M.thermoresistible__bu      -----------DGGTPG------------------------------AHG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------LAGNAGLAGNAGLAGN-------------------------A
MAV_4827|M.avium_104                --------TTGTVALQPTPNQHLIVP----------------------TE
                                                                                      

MUL_3062|M.ulcerans_Agy99           GAGGAGGQGGNDGGAGGLGGNG----------------------------
MMAR_2695|M.marinum_M               GAGGAGGQGGNDGGAGGLGGNG----------------------------
Mb0767|M.bovis_AF2122/97            GAGGAG--------------------------------------------
Rv0746|M.tuberculosis_H37Rv         GAGGAGGQGAVTGGTGGAGGDG----------------------------
Mflv_5091|M.gilvum_PYR-GCK          GKGGNGGNGGRGGLFG---------------KGGNAGNGAD---------
Mvan_1264|M.vanbaalenii_PYR-1       GKGGNGGNGGRGSLFG---------------RGGNAGNGGN---------
MSMEG_0868|M.smegmatis_MC2_155      AVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPN
TH_3810|M.thermoresistible__bu      ESHTPGVYTDRQ--------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GLAGNAGLAGNAGLAGN---------------------------------
MAV_4827|M.avium_104                QAPAPPPVQASAPQPK----------------------------------
                                                                                      

MUL_3062|M.ulcerans_Agy99           -----------VLIGNGGNGGVGGVGETPGGDGGGGISGLLLGADG----
MMAR_2695|M.marinum_M               -----------VLIGNGGNGGVGGVGETPGGDGGGGISGLLLGADG----
Mb0767|M.bovis_AF2122/97            -----------VLIGNGGNAGIGGTGPTAGDTGAGGISGLLLGADG----
Rv0746|M.tuberculosis_H37Rv         -----------VLIGNGGNAGIGGTGPTAGDTGAGGISGLLLGADG----
Mflv_5091|M.gilvum_PYR-GCK          -------------GGTGGAGGAGGTGG-TGGAGGTGG-------------
Mvan_1264|M.vanbaalenii_PYR-1       -------------GGTGGNGGNGGTGG-TGGNGGTGG-------------
MSMEG_0868|M.smegmatis_MC2_155      GPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHST
TH_3810|M.thermoresistible__bu      -----------------GEDGEDGTGTGIGGRGGNGG-------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -------------AGLAGNAGLAGNAAVAGNAAVAGN-------------
MAV_4827|M.avium_104                ------------ISVPEPVAAPKPLSPPVAAPLPAAP-------------
                                                                                      

MUL_3062|M.ulcerans_Agy99           -FNAPAGSSPVHALQQQALAAINAPVQELTGRPLIGNGLPGSAGSGAAGA
MMAR_2695|M.marinum_M               -FNAPASSSPVHALQQQALAAINAPVQELTGRPLIGNGLPGSAGSGVAGA
Mb0767|M.bovis_AF2122/97            -FNAPASASPLHTLKQQALAAINAPTQTLTGRPLIGNGTPGAVGSGATGA
Rv0746|M.tuberculosis_H37Rv         -FNTPASASPLHTLKQQALAAINAPTQTLTGRPLIGNGTPGAVGSGATGA
Mflv_5091|M.gilvum_PYR-GCK          ----TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGG
Mvan_1264|M.vanbaalenii_PYR-1       ----TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGG
MSMEG_0868|M.smegmatis_MC2_155      GQTDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDGG
TH_3810|M.thermoresistible__bu      ---SSSGTHPMAEDG--------EHVKALDGRPGLD---GGNGSHGGNGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --AAVAGNAAVGGVLNTGVSGAIGGSSHVGG--AINESLGGSGSVGGSTA
MAV_4827|M.avium_104                ----PPAAPPLPEAPPIPAAPPVVPVPVVVPPVPVPVPVRIPVPDPVSPP
                                                                                      

MUL_3062|M.ulcerans_Agy99           PGG--WLLGDGGAGGS--AAATPGAAGGAGGAAG---------LVGAGGA
MMAR_2695|M.marinum_M               PGG--WLLGDGGAGGS--AAATPGAAGGAGGAAG---------LVGAGGA
Mb0767|M.bovis_AF2122/97            PGG--WLLGDGGAGGS--GAAGSGAPGGAGGAAG---------LWGTGGA
Rv0746|M.tuberculosis_H37Rv         PGG--WLLGDGGAGGS--GAAGSGAPGGAGGAAG---------LWGTGGA
Mflv_5091|M.gilvum_PYR-GCK          KGGTGGTGGAGGTG----GDGGTGGTGGTGGTG---------GTGGTGGT
Mvan_1264|M.vanbaalenii_PYR-1       KGGTGGTGGDGGTG----GTGGTGGTGGTGGTG---------GTGGTGGT
MSMEG_0868|M.smegmatis_MC2_155      RGGDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGN
TH_3810|M.thermoresistible__bu      HGGRGGFLGIGGSG-------GWGGHGGNGGD-----------TDADGGN
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      VGGGAHTGVGGGVSTG----VGVGSHVGGGISES---------LGGSGSV
MAV_4827|M.avium_104                QLLAPPRLSVPQPVQPPVRVPQPPSPPQVGGTVPQ-------SPPQHQTP
                                                                                      

MUL_3062|M.ulcerans_Agy99           GGAGANT----GISNPGFG----------------GAGGAGG--------
MMAR_2695|M.marinum_M               GGAGANT----GISNPGFGGAGGDGGAGGFLLGDGGAGGAGG--------
Mb0767|M.bovis_AF2122/97            G------------------------GAGGWLLGDGGAGGIGG--------
Rv0746|M.tuberculosis_H37Rv         GGAGG--------SSAGGGGAGGAGGAGGWLLGDGGAGGIGG--------
Mflv_5091|M.gilvum_PYR-GCK          GGAG-----------DGTGGTGGTGG----TGGQGGQGGQGG--------
Mvan_1264|M.vanbaalenii_PYR-1       GGAG-----------DGLGGTGGTGG----TGGFGGQGGQGG--------
MSMEG_0868|M.smegmatis_MC2_155      GGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEALIRATV
TH_3810|M.thermoresistible__bu      GGDG---------------GNGGSAG------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GGSTAVG-------------------------------------------
MAV_4827|M.avium_104                PGEGTPP-------------------------------------------
                                                                                      

MUL_3062|M.ulcerans_Agy99           -AGAGAGGGVGEAGGAGGLLGAGGTGG-----------------------
MMAR_2695|M.marinum_M               -AGAGAGGGVGGAGGAGGLLGAGGTGG-----------------------
Mb0767|M.bovis_AF2122/97            -ASTVLGG-TGGGGGVGGLWGAGGAGG-----------------------
Rv0746|M.tuberculosis_H37Rv         -ASTVLGG-TGGGGGVGGLWGAGGAGG-----------------------
Mflv_5091|M.gilvum_PYR-GCK          ---------TGGTGGQGG-LGGGGGTG-----------------------
Mvan_1264|M.vanbaalenii_PYR-1       ---------TGGTGGQGG-LGGVGGTG-----------------------
MSMEG_0868|M.smegmatis_MC2_155      IGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATD
TH_3810|M.thermoresistible__bu      ---------RGGTGGLRGVFGINGGNG-----------------------
MLBr_01183|M.leprae_Br4923          ---------------MPLFLNAEPQAL-----------------------
MAB_4284c|M.abscessus_ATCC_199      ---------GGAHTGVGGGVSTGVGVG-----------------------
MAV_4827|M.avium_104                --------KPDGPGNYGGGHVPTPGAG-----------------------
                                                                                      

MUL_3062|M.ulcerans_Agy99           -GGGVAPSLVDGGTGGAGGAGGAG------------GLFGGIFGAGGGDG
MMAR_2695|M.marinum_M               -GGGVAPSLVDGGTGGAGGAGGAG------------GLFGGIFGAGGGDG
Mb0767|M.bovis_AF2122/97            -AGGTG---LVGGDGGAGGAGGTG------------GLLAGLIGAGGGHG
Rv0746|M.tuberculosis_H37Rv         -AGGTG---LVGGDGGAGGAGGTG------------GLLAGLIGAGGGHG
Mflv_5091|M.gilvum_PYR-GCK          GQGGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFG
Mvan_1264|M.vanbaalenii_PYR-1       GTGGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFG
MSMEG_0868|M.smegmatis_MC2_155      GHGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNG
TH_3810|M.thermoresistible__bu      -RAGLGGRGXXXXGGGVGAAVRSG---------------NGVFSGGGGTP
MLBr_01183|M.leprae_Br4923          ---TAAANTLEGLSAATVASNAAA---------------AQLTTEIAPPA
MAB_4284c|M.abscessus_ATCC_199      SHVGGGISESLGGSGSVGGSTAVG---------------GGAHTGVGGGV
MAV_4827|M.avium_104                --GSGGSGGGHVPTPGAGGSGGSG----------------GGHVPTPGTG
                                         .         .       .                          

MUL_3062|M.ulcerans_Agy99           GAGGFTGGIDGAGGVGGAGGNTGLLGGPGGSGGSGGDGIAKLGFNVD-GG
MMAR_2695|M.marinum_M               GAGGFTGGIDGAGGVGGAGGNAGLLGGPGGSGGSGGDGIAKLGLNAD-GG
Mb0767|M.bovis_AF2122/97            GTGGLN--TNGDGGVGGAGGNAGMLAGPGGAGGAGGD-----GENLDTGG
Rv0746|M.tuberculosis_H37Rv         GTGGLS--TNGDGGVGGAGGNAGMLAGPGGAGGAGGD-----GENLDTGG
Mflv_5091|M.gilvum_PYR-GCK          GSGGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGLFG----GSGSAG
Mvan_1264|M.vanbaalenii_PYR-1       GVGGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGGLFG----GSGSAG
MSMEG_0868|M.smegmatis_MC2_155      GDGVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPSWVQSGYGS
TH_3810|M.thermoresistible__bu      SAGFGVPTTIQFPAGSCTSRAVSREG------------------------
MLBr_01183|M.leprae_Br4923          ADDVSILLAHFFSGHGRQYQAHASQG------------------------
MAB_4284c|M.abscessus_ATCC_199      NTGVGVGSHVGGGISESLGGSGSVGG------------------STAVGG
MAV_4827|M.avium_104                GPGGTGGSGGGHVPTPGAGTPGGSGG-----------------------G
                                      .                   .  .                        

MUL_3062|M.ulcerans_Agy99           AGGAGVNGGFLFGSGGTGGFGGVGGVG---------TSTGIGGAGGRGGN
MMAR_2695|M.marinum_M               AGGAGGNGGFLFGSGGTGGFGGVGGVG---------TSTGIGGAGGRGGN
Mb0767|M.bovis_AF2122/97            DGGAGGSAGLLFGSGGAGGAGGFG---------------FLGGDGGAGGN
Rv0746|M.tuberculosis_H37Rv         DGGAGGSAGLLFGSGGAGGAGGFG---------------FLGGDGGAGGN
Mflv_5091|M.gilvum_PYR-GCK          KAGATGAAGASGGKGAQGATGAQGATG------AQGATG-ATGAAGKAGA
Mvan_1264|M.vanbaalenii_PYR-1       TAGVTGASGASGGKGAQGATGAQGATG------AQGATG-ATGASGAQGS
MSMEG_0868|M.smegmatis_MC2_155      TLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTATGGD
TH_3810|M.thermoresistible__bu      IMPSSRAASARAG---------------------------AACASSTSRS
MLBr_01183|M.leprae_Br4923          ---ATNHQDLIQS--------------------------LLTSSSAYAGT
MAB_4284c|M.abscessus_ATCC_199      GAHTSAINDALGGSGSVGGSTAVG-----------------GGAHTSAIN
MAV_4827|M.avium_104                HLPFPGAGSTPGGSGGGHLPTPGAGTP-------------GGGLGGFGGG
                                                .                                     

MUL_3062|M.ulcerans_Agy99           AGLLFSDAGVGGFGGFGGTGG-------NAGWLGSGGSGGAGG-GSNGDG
MMAR_2695|M.marinum_M               AGLLFSDAGVGGFGGFGGTGGGTGGTGGNAGWLGSGGSGGAGG-GSNGDG
Mb0767|M.bovis_AF2122/97            AGLLLSSGGAGGFGGFGTAGG-VGGAGGNAGWLGFGGAGGIGGIGGNANG
Rv0746|M.tuberculosis_H37Rv         AGLLLSSGGAGGFGGFGTAGG-VGGAGGNAGWLGFGGAG-----------
Mflv_5091|M.gilvum_PYR-GCK          TGAAGAAGAAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAG
Mvan_1264|M.vanbaalenii_PYR-1       AGSAGSAGVAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAG
MSMEG_0868|M.smegmatis_MC2_155      GGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADG
TH_3810|M.thermoresistible__bu      RRSFCCSRA-----------------------------------------
MLBr_01183|M.leprae_Br4923          ETANHDSL------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ESMNSSINAS----------------------------------------
MAV_4827|M.avium_104                HAPAPGGGLGGGGG------------------------------------
                                                                                      

MUL_3062|M.ulcerans_Agy99           GAGGTGGSGGQIVGDGGAGGAGGQGDLLAAGGSGGDGGQGGDAVLIG---
MMAR_2695|M.marinum_M               GAGGTGGSGGQIVGDGGAGGAGGQGDLLAAGGSGGDGGQGGDAVLIG---
Mb0767|M.bovis_AF2122/97            GAGGNGGTGGQLWGSGGAGGEGGAA--LSVGDTGGAGGVGGSAGLIG---
Rv0746|M.tuberculosis_H37Rv         -------------------------------------GVGGSAGLIG---
Mflv_5091|M.gilvum_PYR-GCK          KAGATGTTGATG--------AAGEDGDAGSGGSG-INGGAGGAGG-----
Mvan_1264|M.vanbaalenii_PYR-1       KAGATGTTGATG--------AAGDAGDPGSEAVD-INGGAGGAGG-----
MSMEG_0868|M.smegmatis_MC2_155      WVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVW
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MUL_3062|M.ulcerans_Agy99           ------------TGGNGGNGASGVLAGIGGDGGSRGLLLGEDGVNGEAAP
MMAR_2695|M.marinum_M               ------------TGGNGGNGASGVLAGIGGDAGSGGLLLGEDGINGEAAP
Mb0767|M.bovis_AF2122/97            ------------TGGNGGNGGTGANAGSPGTGGAGGLLLGQNGLNGLP--
Rv0746|M.tuberculosis_H37Rv         ------------TGGNGGNGGTGANAGSPGTGGAGGLLLGQNGLNGLP--
Mflv_5091|M.gilvum_PYR-GCK          ------AGGEGGEGGDGGKGGAGAEGGAGGGGGAGGSGAGGAG-------
Mvan_1264|M.vanbaalenii_PYR-1       ------AGGEGGEGGAGGAGGDGSEGGAGGSGGAGGSGTGGAG-------
MSMEG_0868|M.smegmatis_MC2_155      KSGGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGS
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -------------HSSSMNESFGSSMGSHGAAGTGFEAQGHAQGHASETA
MAV_4827|M.avium_104                -------------HAPAPGGGLGGFGGGHSGGGLGGLGGGHK--------
                                                                                      

MUL_3062|M.ulcerans_Agy99           PMTHIVLLGGDFPAAAS------------
MMAR_2695|M.marinum_M               PMTHIVLLGGDFPAAAS------------
Mb0767|M.bovis_AF2122/97            -----------------------------
Rv0746|M.tuberculosis_H37Rv         -----------------------------
Mflv_5091|M.gilvum_PYR-GCK          GAGGSGGSGGSGGSGGSGGAAGDSDD---
Mvan_1264|M.vanbaalenii_PYR-1       GAGGSGGSGGSGGAGGSGGAAGDSD----
MSMEG_0868|M.smegmatis_MC2_155      GNGGNGGNGGNGGADGTPGTAGTTGANNP
TH_3810|M.thermoresistible__bu      -----------------------------
MLBr_01183|M.leprae_Br4923          -----------------------------
MAB_4284c|M.abscessus_ATCC_199      HTTLPGAEHH-------------------
MAV_4827|M.avium_104                -----------------------------