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MSYVIAVPDLVAGAASELAGVGSTLSTATTAAAAQTTGVLAAAGDEVSAAIAAVFSAHGQSYQTLSAQAE TFHAQFVQALSAGASAYTQAEAASASPLAGLLAAINAPVQSLTGRPLIGNGANGTPGTGADGAPGGWLLG DGGAGGSGAPGLNGGAGGAAGLLGSGGAGGAGGSSTSTNGGAGGAGGAGGWLSGNAGVGGAGGASTVANG GAGGAGGAGGLLGGGGLGGAGGASTSATASGGAGGQGGAAGLLSGFVGADGGHGGAGGHGAAGGDGGAGG DGGPLAGAGGSGGTGGSGNAGGGAGGAGGNAGLLFGDGGVGGTGGTSGQGVGGIGGDGGSAGLLFSNGGA GGAGGAGTALISGNGGAGGNGGNGGWLFSNGGVGGAGGAGAPAMPSLGISAGSGGVGGAGGTGGLLLGNG GAGGAGGTSGNGGGTGGAGGAAGSGVLIGNGGNGGIGGAGPTPGGNGIGGTSGLLLGLDGFNAPTSTSPI HTLQQQALNAINAPIQAATGRPLIGNGTPGDAGSGTDGTPGGWLLGDGGAGGSGGTGLDGGDGGAAGLMG TGGTGGAGGWGGTDEITGGTGGAGGTGGGGGWLSGSGGIGGGGGAGGYGGAIIPGNGGAGGSAGAGGAGG LFGGGGTGGAGGTGGPAGLGVFVGVPTFGDGGGGGAGGAGGAGGLLSGLVGAGGGDGGAGGQGGIGFGGS GGSGGGGGVGGNAGLLGGPGGAGGSGGAAGPALFGIGVDGTAGVGGAGGNAGLLFGSGGAGGDGGFGPGA GGTGGRGGNAGLLFSSAGAGGFGGYGTTGGGTGGAGGDAGWLGCGGAGGAGGITIGGTGGTGGAGGTGGQ LLGAGGAGGAGGQTDPLGGSTGGSGGVGGNAVLIGTGGNGGNGGAGTAKGTPGTGGTGGLIGVDGLSGAS
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_4399 | - | - | 100% (910) | PE-PGRS family protein |
M. marinum M | MMAR_4398 | - | 0.0 | 72.49% (927) | PE-PGRS family protein, PE_PGRS9_3 |
M. marinum M | MMAR_2695 | - | 0.0 | 64.39% (924) | PE-PGRS family protein, PE_PGRS9_1 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0768 | PE_PGRS10 | 0.0 | 57.14% (966) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 1e-162 | 46.23% (822) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv0746 | PE_PGRS9 | 0.0 | 60.46% (870) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 5e-11 | 34.38% (96) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 6e-47 | 31.91% (517) | hypothetical protein MAB_4284c |
M. avium 104 | MAV_4827 | - | 2e-24 | 44.75% (181) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-135 | 37.62% (1074) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 6e-39 | 39.86% (291) | PUTATIVE - |
M. ulcerans Agy99 | MUL_3062 | - | 0.0 | 61.84% (925) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-162 | 44.46% (866) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_4399|M.marinum_M -------------------------------------------------- Rv0746|M.tuberculosis_H37Rv -------------------------------------------------- MUL_3062|M.ulcerans_Agy99 -------------------------------------------------- Mb0768|M.bovis_AF2122/97 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_4399|M.marinum_M -------------MSYVIAVPDLVAGAASELAGVGSTLSTATTAAAAQTT Rv0746|M.tuberculosis_H37Rv -------------MSFVLAMPEVLGSAATDLAALGSVLGAADAAAAATTT MUL_3062|M.ulcerans_Agy99 -------------MAFVLAVPDMVAEAAADLAGVGSVIDAANTAAAGSTT Mb0768|M.bovis_AF2122/97 -------------MSWVMVSPELVVAAAADLAGIGSAISSANAAAAVNTT Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------------MSIIDFILNLFRDPVEAASYVADPEAALANAGL MAV_4827|M.avium_104 -------------MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAIDVT MMAR_4399|M.marinum_M G-------------------------------------VLAAAGDEVSAA Rv0746|M.tuberculosis_H37Rv G-------------------------------------IVAAAQDEVSAA MUL_3062|M.ulcerans_Agy99 G-------------------------------------IVAAAEDEVSAA Mb0768|M.bovis_AF2122/97 G-------------------------------------LLTAGADEVSTA Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 S-------------------------------------AVSAAQVGAVMP MAV_4827|M.avium_104 G-----------------------------------------ADDAATAS MMAR_4399|M.marinum_M IAAVFSAHGQSYQTLSAQAETFHAQFVQALSAGASAYTQAEAASASPLAG Rv0746|M.tuberculosis_H37Rv IAALFSAHGRAYQVASAQAAAVHAQFVEALSAGAGAYASAEAAGAAVLAN MUL_3062|M.ulcerans_Agy99 IAALFSGHGQAYQQISTRVAEFHAQFERVFAAGVQAYSGAEAANASFLQD Mb0768|M.bovis_AF2122/97 IAALFGAQGQAYQAASAQAAAFYAQFVQALSAGGGAYAAAEAAAVSPLLA Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 VVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSPSLLS MAV_4827|M.avium_104 APDRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALRDALAARRIDN MMAR_4399|M.marinum_M --------------------------------------------LLAAIN Rv0746|M.tuberculosis_H37Rv PA------------------------------------QSVQQDLLAAVN MUL_3062|M.ulcerans_Agy99 P----------------------------------------LQTALNATN Mb0768|M.bovis_AF2122/97 P-----------------------------------------------IN Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 PR------------------------------------------DNDFLS MAV_4827|M.avium_104 ---------------------------------------------VMLVS MMAR_4399|M.marinum_M APVQSLTGRPLIGNGANGTPG-----TGADGAPGGWLLGDGGAGGSGAP- Rv0746|M.tuberculosis_H37Rv AQSVALTGRPLIGNGANGAPG-----TGANGAPGGWLLGNGGAGGSAAAG MUL_3062|M.ulcerans_Agy99 KPVQDLTGRPLVGNGANGVPG-----TGANGAAGGWLLGNGGAGGSGAA- Mb0768|M.bovis_AF2122/97 AQFVAATGRPLIGNGANGAPG-----TGANGGPGGWLIGNGGAGGSGAPG Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG TH_3810|M.thermoresistible__bu ------------------------------------------------VD MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 HNDTDFASHNPIASGNQVMSPSGNVDSFNRGPLLDLSFGDLQFGNRDTTA MAV_4827|M.avium_104 AFLAAAALAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGSIPDVYKQQ MMAR_4399|M.marinum_M --GLNGGAGGAAGLLGSGGAGGAGGSS--------------------TST Rv0746|M.tuberculosis_H37Rv S-GLPGGAGGAAGLFGTGGAGGAGGSS--------------------TVG MUL_3062|M.ulcerans_Agy99 --GQAGGDGGAAGLIGAGGAGGAGGNSP-----------------LRNTA Mb0768|M.bovis_AF2122/97 --AGAGGNGGAGGLFGSGGAGGAGGNAFGAGEVGGAGGAGGNAMLFGAGG Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG----------APGV Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG----------APGV MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGG--------TGGT TH_3810|M.thermoresistible__bu GDGGSGGRTGLFSKLSRGGDGGDGGLG---------------------GN MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 IGDGAVAVGGSNSGPIASGQGSTAVNGDVRDSNIIN------------AD MAV_4827|M.avium_104 IRAESYGDAAGQLSAMVAGLEKLESLPG------------------GLLL MMAR_4399|M.marinum_M NGGAGGAGGAGGWLSGNAGVGGAGGAST-VANGGAGGAGGAGG------L Rv0746|M.tuberculosis_H37Rv DGEAGGAGGSGGWLLGTGGVGGVGGLG--AGAGGAGGVGGAGG------L MUL_3062|M.ulcerans_Agy99 NGGNGGTGGAGGLLFGPGGVGGAGGAS--FLTGGTGGDGGAGG------L Mb0768|M.bovis_AF2122/97 AGGAGGAGGNAGMLFGAAGVGGVGGFSNGGATGGAGGAGGAGG------L Mflv_5091|M.gilvum_PYR-GCK AGATGATGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG------- Mvan_1264|M.vanbaalenii_PYR-1 AGATGATGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG------- MSMEG_0868|M.smegmatis_MC2_155 GGTGGGTGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYV TH_3810|M.thermoresistible__bu GGHGGGTGIIS--------------------LLSLAGNGGNGG------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 HGSNVGVDQSQTRVGGDYTNVSGHGSADIDKSVTVVDDHSQRN------- MAV_4827|M.avium_104 VGSGVDVAPLKQVLQTTTFLDVSVAEEPETALARGAALAAANAP------ MMAR_4399|M.marinum_M LGGGGLGGAGGASTSATASGGAGGQGGAAGLLSGFVGADGGHGGAG---- Rv0746|M.tuberculosis_H37Rv LGAGGHGGAGGLG---AVTGGVGGTGGAGGLLAGLLAGPGGAGGTG---- MUL_3062|M.ulcerans_Agy99 FGAGGLGGVGGSG----NVGGNGGAGGAGGLLAGLVGAGGGDGGSG---- Mb0768|M.bovis_AF2122/97 FTTGGVGGAGGAG-------GDGGDGGAGGLFG--AGGTGGAGGFGTAVL Mflv_5091|M.gilvum_PYR-GCK -------AVGSAG-----AAGEAGETGTWG--NAGLPGKAGDAGGAG--- Mvan_1264|M.vanbaalenii_PYR-1 -------AVGSAG-----TAGSAGAPGVWG--NAGLPGAAGAAGGAG--- MSMEG_0868|M.smegmatis_MC2_155 LIAGPNVTVGSET-----RGGTGGAGGTGGQSTAAGPGKGGGGGGGGG-- TH_3810|M.thermoresistible__bu --------NGYRT-----TDNNALDGGHGG-------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------TTNINDSFNTDRSTNIGSGNTTNTEIGSHNQANIGTS--- MAV_4827|M.avium_104 -------LFASST----AALAYAQDPGTGAVDQYSLPDYLYVPVDPE--- MMAR_4399|M.marinum_M -GHGAAGGDGGAGGDGGPLAGAGGSGGTGGSGNAGGGAGGAGGNAG-LLF Rv0746|M.tuberculosis_H37Rv -GRGFLNN---------------------------GGVGGAGGNAG-LLF MUL_3062|M.ulcerans_Agy99 -GLGAAGGDGGNGGRAGLFGGAGGAGGMGATGGHSGGDGGAGGDAG-LLF Mb0768|M.bovis_AF2122/97 AGTGGAGGPGGAGG----LFGAGGEGGSGGSGNLTGGAGGAGGNAGTLAT Mflv_5091|M.gilvum_PYR-GCK ------------------AVGAAGAAG------TVGTAGATGGTG----- Mvan_1264|M.vanbaalenii_PYR-1 ------------------AIGTAGVAG------AAGTAGATGGTG----- MSMEG_0868|M.smegmatis_MC2_155 ---GAILIGANGGTVDGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAE TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------------------TSAGGSAAVGGNAG---- MAV_4827|M.avium_104 ----------------------------------PGDDELAYSAVG---- MMAR_4399|M.marinum_M GDG------GVGGTGGTS-GQGVGGIGGDG----------------GSAG Rv0746|M.tuberculosis_H37Rv GAG------GTGGSGGAG-LGGDGGAGGAG----------------GNTG MUL_3062|M.ulcerans_Agy99 GTG------GAGGAGGHA-FDGDGGAGGAG----------------GNAG Mb0768|M.bovis_AF2122/97 GDG------GAGGTGGASRSGGFGGAGGAG----------------GDAG Mflv_5091|M.gilvum_PYR-GCK ----------TGANGGAGGVGGVGGTGAAG--------------AAGGAG Mvan_1264|M.vanbaalenii_PYR-1 ----------VGGNGGAGQAGGIGGTGAAG--------------AAGQAG MSMEG_0868|M.smegmatis_MC2_155 GTGSTAEGTATGGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRG TH_3810|M.thermoresistible__bu ----------NGGNVGFFSLFNLGG--------------------AGGWG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------LAGNAGLAGNAGLAGNAGLA----------------GNAG MAV_4827|M.avium_104 ---------EEDAESPTVVIEKLFLPEDSE----------------PRRR MMAR_4399|M.marinum_M LLFSNGGAGGAGGAGTA--LISGNGGAGGNGGNGGWLFSNGGVGGAGGAG Rv0746|M.tuberculosis_H37Rv VLFGNAGSGGTGGFG------DTDGGAGGAGGDAGWLGS-GGVGGAGGFG MUL_3062|M.ulcerans_Agy99 LMFSSGGSGGVGGAG------SIDGGAGGAGGDAGWLGG-GGAGGAGGFG Mb0768|M.bovis_AF2122/97 MFFGSGGSGGAGGAGGSGGFGLPSGGKGGAGGDAGMLFGSGGSGGAGGIS Mflv_5091|M.gilvum_PYR-GCK GLGETGTTGGAGGVGGQ--GTAGGTGGVGGIGGAGSTGAVGGVGGKG--- Mvan_1264|M.vanbaalenii_PYR-1 TAGETGVTGGVGGIGGQ--GTEGGTGGVGGVGGVGATGGAGGVGGKG--- MSMEG_0868|M.smegmatis_MC2_155 GDGIDGGTGGAGGMGEIYSGADGEATGISAGGDGGSATGADSLGGRGGTS TH_3810|M.thermoresistible__bu GSGVDG---------------------VDVVGGNP--------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGNAGLAG-----NAGLAGNAGLAGNAGLAGNAGLAGNAGLAG MAV_4827|M.avium_104 PVLLVGSGLAVVGISAVLALEIALAIGIRTTGTVALQPTPNQHLIVP--- MMAR_4399|M.marinum_M APAMPSL------------GISAGSGGVGGAGGTGGLLLGNGGA------ Rv0746|M.tuberculosis_H37Rv ---------------------ETGDGGVGGAGGKAGLLIGNGGA------ MUL_3062|M.ulcerans_Agy99 ---------------------TISDGGAGGRGGGGGQLLGNGGA------ Mb0768|M.bovis_AF2122/97 R--------------------SVGDGAAGGAGGAPG-LIGNGGN------ Mflv_5091|M.gilvum_PYR-GCK -IQGGQG-------------LQGGKGGDGGAGGKGGDADSMGS------- Mvan_1264|M.vanbaalenii_PYR-1 -IQGGQG-------------LQGGQGGDGGTGGTGGDATSMGE------- MSMEG_0868|M.smegmatis_MC2_155 WVQAGYGPTTGGKASGTAKAGHGGKASDGGKGGNGGDALVMAAGATGVAT TH_3810|M.thermoresistible__bu ---------------------------DGGTPG----------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------------NAGLAGNAGLAGNAGLAGNAG-------- MAV_4827|M.avium_104 --------------------TEQAPAPPPVQASAPQPKISVPEP------ MMAR_4399|M.marinum_M -----GGAGGTSGNGGGTGGAGGAAGSGVLIG------------------ Rv0746|M.tuberculosis_H37Rv -----GGAG---GQGAVTGGTGGAGGDGVLIG------------------ MUL_3062|M.ulcerans_Agy99 -----GGAG---GQGGNDGGAGGLGGNGVLIG------------------ Mb0768|M.bovis_AF2122/97 -----GGNGG-ASTGGGDGGPGGAGGTGVLIG------------------ Mflv_5091|M.gilvum_PYR-GCK -----------AGATGGKGGNGGNGGRGGLFG---------------KGG Mvan_1264|M.vanbaalenii_PYR-1 -----------AGATGGKGGNGGNGGRGSLFG---------------RGG MSMEG_0868|M.smegmatis_MC2_155 GNTAIGGNGGAASANGAVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGG TH_3810|M.thermoresistible__bu -------------AHGESHTPGVYTDRQ---------------------- MLBr_01183|M.leprae_Br4923 --------------------------MPLFLN------------------ MAB_4284c|M.abscessus_ATCC_199 -----------LAGNAGLAGNAGLAGNAGLAG------------------ MAV_4827|M.avium_104 -----------VAAPKPLSPPVAAPLPAAPPP------------------ MMAR_4399|M.marinum_M -------------------------------NGGNGGIGGAGPTPGGNGI Rv0746|M.tuberculosis_H37Rv -------------------------------NGGNAGIGGTGPTAGDTGA MUL_3062|M.ulcerans_Agy99 -------------------------------NGGNGGVGGVGETPGGDGG Mb0768|M.bovis_AF2122/97 -------------------------------NGGS---GGTGATLGKAGI Mflv_5091|M.gilvum_PYR-GCK NAGNGAD----------------------GGTGGAGGAGGTGG-TGGAGG Mvan_1264|M.vanbaalenii_PYR-1 NAGNGGN----------------------GGTGGNGGNGGTGG-TGGNGG MSMEG_0868|M.smegmatis_MC2_155 NGGNGGNGWVQAYDPNGPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGG TH_3810|M.thermoresistible__bu ---------------------------------GEDGEDGTGTGIGGRGG MLBr_01183|M.leprae_Br4923 --------------------------------AEPQALTAAANTLEGLSA MAB_4284c|M.abscessus_ATCC_199 ----------------------------NAGLAGNAGLAGNAAVAGNAAV MAV_4827|M.avium_104 ---------------------------------AAPPLPEAPPIPAAPPV MMAR_4399|M.marinum_M GGTSGLLLGLDG-----FNAPTSTSPIHTLQQQALNAINAPIQAATGRPL Rv0746|M.tuberculosis_H37Rv GGISGLLLGADG-----FNTPASASPLHTLKQQALAAINAPTQTLTGRPL MUL_3062|M.ulcerans_Agy99 GGISGLLLGADG-----FNAPAGSSPVHALQQQALAAINAPVQELTGRPL Mb0768|M.bovis_AF2122/97 GGTGGVLLGLDG-----FTAPASTSPLHTLQQDVINMVNDPFQTLTGRPL Mflv_5091|M.gilvum_PYR-GCK TGG-----------------TGGTGGIGGAGSTGGTGGTGGTGGTGGTGG Mvan_1264|M.vanbaalenii_PYR-1 TGG-----------------TGGTGGIGGAGSTGGTGGTGGTGGTGGTGG MSMEG_0868|M.smegmatis_MC2_155 DGAGASVWKANGQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGAGG TH_3810|M.thermoresistible__bu NGG----------------SSSGTHPMAEDG--------EHVKALDGRPG MLBr_01183|M.leprae_Br4923 ATV------------------ASNAAAAQLTTEIAPPAADDVSILLAHFF MAB_4284c|M.abscessus_ATCC_199 AGN---------------AAVAGNAAVGGVLNTGVSGAIGGSSHVGGAIN MAV_4827|M.avium_104 VPVPVVVPPVPVP---VPVRIPVPDPVSPPQLLAPPRLSVPQPVQPPVRV MMAR_4399|M.marinum_M IGNGTPGDAGSGTDGTPGG--WLLGDGGAGGSG----GTGLDGGDGGAAG Rv0746|M.tuberculosis_H37Rv IGNGTPGAVGSGATGAPGG--WLLGDGGAGGSGAA--GSGAPGGAGGAAG MUL_3062|M.ulcerans_Agy99 IGNGLPGSAGSGAAGAPGG--WLLGDGGAGGSAAA--TPGAAGGAGGAAG Mb0768|M.bovis_AF2122/97 IGNGANGTPGTGADGGAGG--WLFGNGGNGGQGTIGGVNGGAGGAGGAGG Mflv_5091|M.gilvum_PYR-GCK TG-GTGGTGGTGGTGGKGGTGGTGGAGGTG----GDGGTGGTGGTGGTG- Mvan_1264|M.vanbaalenii_PYR-1 TG-GTGGTGGTGGTGGKGGTGGTGGDGGTG----GTGGTGGTGGTGGTG- MSMEG_0868|M.smegmatis_MC2_155 VSEGEGGTGGHGGDGGRGGDGALGGNGGTGGVGLGNGGKGGNGGNGGNGG TH_3810|M.thermoresistible__bu LD---GGNGSHGGNGGHGGRGGFLGIGGSG-------GWGGHGGNGGD-- MLBr_01183|M.leprae_Br4923 SGHG-RQYQAHASQGATNHQDLIQSLLTSS---------SAYAG------ MAB_4284c|M.abscessus_ATCC_199 ESLGGSGSVGGSTAVGGGAHTGVGGGVSTG------VGVGSHVGGGISES MAV_4827|M.avium_104 PQPPSPPQVGGTVPQSPPQHQTPPGEGTPP-------KPDGPGNYGGGHV . . . . MMAR_4399|M.marinum_M ------LMGTGGTGGAGGWGGTDE-----ITGGTGGAGGTGGGGGWLSGS Rv0746|M.tuberculosis_H37Rv ------LWGTGGAGGAGGS-----------SAGGGGAGGAGGAGGWLLGD MUL_3062|M.ulcerans_Agy99 ------LVGAGGAGGAGANTGIS-------NPGFGGAGGAGGAG------ Mb0768|M.bovis_AF2122/97 I-----LFGTGGTGGSGGPG----------ATGLGGIGGAGGAA-LLFGS Mflv_5091|M.gilvum_PYR-GCK --------GTGGTGGTGGAG-----------DGTGGTGGTGG----TGGQ Mvan_1264|M.vanbaalenii_PYR-1 --------GTGGTGGTGGAG-----------DGLGGTGGTGG----TGGF MSMEG_0868|M.smegmatis_MC2_155 TYVDPSHTGAGGNGGNGGAGRIRVNNGTATGTATGGNGGNGGNGDADGHR TH_3810|M.thermoresistible__bu ---------TDADGGNGGDG---------------GNGGSAG-------- MLBr_01183|M.leprae_Br4923 ----------TETANHDSL------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------LGGSGSVGGST------------AVGGGAHTG--------- MAV_4827|M.avium_104 P--------TPGAGGSGGSG--------------GGHVPTPG-------- .. .. MMAR_4399|M.marinum_M GGIGGGGGAGGYGGAIIPGN---GGAGGSAGAGG-AGGLFGGG------- Rv0746|M.tuberculosis_H37Rv GGAGGIGGAS-------------TVLGGTGGGGG-VGGLWGAG------- MUL_3062|M.ulcerans_Agy99 ------AGAG----------------GGVGEAGG-AGGLLGAG------- Mb0768|M.bovis_AF2122/97 GGAGGSGGAG--------------AVGGNGGAGGNAGALLGAA------- Mflv_5091|M.gilvum_PYR-GCK GGQGGQGG-----------------TGGTGGQGG-LGGGGGTG------- Mvan_1264|M.vanbaalenii_PYR-1 GGQGGQGG-----------------TGGTGGQGG-LGGVGGTG------- MSMEG_0868|M.smegmatis_MC2_155 GGKGGDGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVA TH_3810|M.thermoresistible__bu -------------------------RGGTGGLRGVFGINGGNG------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------VGGGVSTGVGVGSHVGGG------- MAV_4827|M.avium_104 -------------------------AGGSGGSGGGHVPTPGTG------- MMAR_4399|M.marinum_M ----------------GTGGAGGTGGPAGLGVFVGVPTFGDGGGGGAGGA Rv0746|M.tuberculosis_H37Rv ----------------GAGGAGGTG-------LV-------GGDGGAGGA MUL_3062|M.ulcerans_Agy99 ----------------GTGGGGGVAPS-----LVD------GGTGGAGGA Mb0768|M.bovis_AF2122/97 ----------------GAGGAGGAG-----------------AVGGNGGA Mflv_5091|M.gilvum_PYR-GCK ----------------GQGGTGGTGGQ--------------GGTGGTGGT Mvan_1264|M.vanbaalenii_PYR-1 ----------------GTGGTGGTGGQ--------------GGTGGTGGT MSMEG_0868|M.smegmatis_MC2_155 YNVVQANPQASGTATDGHGGSGINGGH--------------GGNGGQGTI TH_3810|M.thermoresistible__bu -----------------RAGLGGRGXX--------------XXGGGVGAA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------ISESLGGSGSVG-----------------GSTAVGGG MAV_4827|M.avium_104 ----------------GPGGTGGSGGG-------------HVPTPGAGTP MMAR_4399|M.marinum_M GGAGGLLS-------GLVGAGGGDGGAGGQGGIGFGGSGGSGGGGGVGGN Rv0746|M.tuberculosis_H37Rv GGTGGLLA-------GLIGAGGGHGGTGGLS------TNGDGGVGGAGGN MUL_3062|M.ulcerans_Agy99 GGAGGLFG-------GIFGAGGGDGGAGGFTG----GIDGAGGVGGAGGN Mb0768|M.bovis_AF2122/97 GGNGGLFANGGAGGPGGFGSPAGAGGIGGAGGNG--GLFGAGGTGGAGGG Mflv_5091|M.gilvum_PYR-GCK GGTG---------GTGGAGGDGGLGGLGGFGGSG--GTGGQGGLGGPGGS Mvan_1264|M.vanbaalenii_PYR-1 GGTG---------GTGGAGGDGGLGGLGGFGGVG--GTGGQGGQGGPGGS MSMEG_0868|M.smegmatis_MC2_155 EANGPSAVASGI-GAGGNGGDGIDGGLGGNGGDG--VVNTTANAANPGSA TH_3810|M.thermoresistible__bu VRSG----------------NGVFSGGGGTPSAG--FGVPTTIQFPAGSC MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AHTG--------------VGGGVNTGVGVGSHVGGGISESLGGSGSVGGS MAV_4827|M.avium_104 GGSG--------------GGHLPFPGAGSTPGGSGGGHLPTPGAGTPGGG MMAR_4399|M.marinum_M AGLLGGPGGAGG------SGGAAGPALFGIGVDGTAGVGGAGGNAGLLFG Rv0746|M.tuberculosis_H37Rv AGMLAGPGGAGG------AGGD------GENLD-TGGDGGAGGSAGLLFG MUL_3062|M.ulcerans_Agy99 TGLLGGPGGSGG------SGGDG---IAKLGFNVDGGAGGAGVNGGFLFG Mb0768|M.bovis_AF2122/97 STLAGGAGGAGGNGGLFGAGGTGGAGSHSTAAGVSGGAGGAGGDAGLLSL Mflv_5091|M.gilvum_PYR-GCK TGGAGGAGG--QAGTAGKGGLFG----GSGSAGKAGATGAAGASGGKGAQ Mvan_1264|M.vanbaalenii_PYR-1 TGGAGGAGG--QAGVAGKGGLFG----GSGSAGTAGVTGASGASGGKGAQ MSMEG_0868|M.smegmatis_MC2_155 TGTATGGDGGKATGTASQGGNGGPSWVQSGYGSTLGGNATGTATAGKGGE TH_3810|M.thermoresistible__bu TSRAVSREG------------------------IMPSSRAASARAG---- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 TAVGGGAHT-------------------SAINDALGGSGSVGGSTAVGGG MAV_4827|M.avium_104 LGGFGGGHAP----------------------APGGGLGGGGGHAP---- MMAR_4399|M.marinum_M --SGGAGGDGGFGP-----GAGGTGGRGGNAGLLFSSAGAGGFGGYGTTG Rv0746|M.tuberculosis_H37Rv --SGGAGGAGGFG------FLGGDGGAGGNAGLLLSSGGAGGFGGFGTAG MUL_3062|M.ulcerans_Agy99 --SGGTGGFGGVGGVGTSTGIGGAGGRGGNAGLLFSDAGVGGFGGFG--- Mb0768|M.bovis_AF2122/97 GASGGAGGSGGSSLT----AAGVVGGIGGAGGLLFGSGGAGGSGGFSNSG Mflv_5091|M.gilvum_PYR-GCK GATGAQGATG------AQGATG-ATGAAGKAGATGAAGAAGAAGSAG--- Mvan_1264|M.vanbaalenii_PYR-1 GATGAQGATG------AQGATG-ATGASGAQGSAGSAGSAGVAGSAG--- MSMEG_0868|M.smegmatis_MC2_155 ASNGGVAGNGGNALVMAAGTTGVATGNTATGGDGGAATTAGATGGAGGFS TH_3810|M.thermoresistible__bu -----------------------AACASSTSRSRRSFCCSRA-------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AHTSAINESMNSSIN--------ASHSSSMNESFGSSMGSHGAAGTG--- MAV_4827|M.avium_104 -------------------------APGGGLGGFGGGHSGGGLGGLG--- MMAR_4399|M.marinum_M GG------TGGAGGDAG-WLGCGGAGGAGGITIGGTGGTGGAGGTGGQLL Rv0746|M.tuberculosis_H37Rv G-------VGGAGGNAG-WLGFGGAG------------------------ MUL_3062|M.ulcerans_Agy99 ----------GTGGNAG-WLGSGGSGGAGGGS-NGDGGAGGTGGSGGQIV Mb0768|M.bovis_AF2122/97 NGG-----AGGAGGDAGLLVGSGGAGGAGASATGAATGGDGGAGGKSGAF Mflv_5091|M.gilvum_PYR-GCK --------TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG----- Mvan_1264|M.vanbaalenii_PYR-1 --------TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG----- MSMEG_0868|M.smegmatis_MC2_155 NIAAIHGAITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSKIAN TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------FEAQGHAQGHASETAHTTLPGAEHH---------------- MAV_4827|M.avium_104 ------------GGHK---------------------------------- MMAR_4399|M.marinum_M GAGGAGGAGGQTDPLGGS-TGGSGGVGGN-----------AVLIGTGGNG Rv0746|M.tuberculosis_H37Rv ------------------------GVGGS-----------AGLIGTGGNG MUL_3062|M.ulcerans_Agy99 GDGGAGGAGGQGDLLAAGGSGGDGGQGGD-----------AVLIGTGGNG Mb0768|M.bovis_AF2122/97 GLGGDGGAGGATGLSGAFHIGGKGGVGGS-----------AVLIGNGGNG Mflv_5091|M.gilvum_PYR-GCK ---AAGEDGDAGSGGSG-INGGAGGAGG-----------AGGEGGEGGDG Mvan_1264|M.vanbaalenii_PYR-1 ---AAGDAGDPGSEAVD-INGGAGGAGG-----------AGGEGGEGGAG MSMEG_0868|M.smegmatis_MC2_155 SSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTGGNG TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_4399|M.marinum_M GNGG-----------AGTAKGTPGTGGTGG-LIGVDGLSGAS-------- Rv0746|M.tuberculosis_H37Rv GNGG-----------TGANAGSPGTGGAGGLLLGQNGLNGLP-------- MUL_3062|M.ulcerans_Agy99 GNGA-----------SGVLAGIGGDGGSRGLLLGEDGVNGEAAPPMTHIV Mb0768|M.bovis_AF2122/97 GNGGNSGNAGK----SGGAPGPSGAGGAGGLLLGENGLNGLM-------- Mflv_5091|M.gilvum_PYR-GCK GKGGAGAE--------GGAGGGGGAGGSGAGGAG--GAGGSGGSGGSGGS Mvan_1264|M.vanbaalenii_PYR-1 GAGGDGSE--------GGAGGSGGAGGSGTGGAG--GAGGSGGSGGSGGA MSMEG_0868|M.smegmatis_MC2_155 GNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGT TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_4399|M.marinum_M ------------ Rv0746|M.tuberculosis_H37Rv ------------ MUL_3062|M.ulcerans_Agy99 LLGGDFPAAAS- Mb0768|M.bovis_AF2122/97 ------------ Mflv_5091|M.gilvum_PYR-GCK GGSGGAAGDSDD Mvan_1264|M.vanbaalenii_PYR-1 GGSGGAAGDSD- MSMEG_0868|M.smegmatis_MC2_155 PGTAGTTGANNP TH_3810|M.thermoresistible__bu ------------ MLBr_01183|M.leprae_Br4923 ------------ MAB_4284c|M.abscessus_ATCC_199 ------------ MAV_4827|M.avium_104 ------------