For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MDFVVSAPEVNSLRMYLGAGSGPMLAAAAAWDGLADELAVAASWFGSVTSGLADAAWRGPAAVAMARAVA PYLGWLISATAQAEQAAAQARVAVATFEAARAATVHPAIVAANRAVLVSLVSSNLLGFNAPAIAATEAAY ERMWAQDVAAMVGYHAGASAAVSALMPFTQQLKKLAGLSERLTSAAAAAAGPPSAAGFNLGLANVGANNV GNGNVGVFNVGFGNLGSYNLGFANLGSDNLGLANLGGHNIGFANTGSNNVGFGNTGSNNVGIGLTGNGQI GFGSFNSGSHNIGLFNSGSGNVGLFNSGTGNFGIGNSGTGNFGLGNTGSTNTGWFNTGDVNTGGFNPGSY NTGNFNTGNYNTGSFNAGNYNTGYFNTGDYNTGVANTGNVNTGAFIAGNYSNGVLWRGDYQGLIGADIAL EIPAIPINAQLFSMPIHQVMVMPGSVMTIPGMRLPFTSIVPFVVYYGPVELPQSTLTLPTVTITVGGPTT TIDGNLTGMVGGVSIPLIKIPAAPGFGNSTTSPSSGFFNAGAGTASGFGNFGGGASGFWNLASATSGLSG FGNVGALGSGVANVGNTISGLYNTSTSNLATPAFNSGLLHHSVGTMTLNFGLANVGGNNVGGANAGIFNV GLANLGDYNIGFGNLGGDNLGFAHAGSYNIGFANTGSNNLGFANTGDNNIGFANIGSNNIGIGLTGSGQI GFGSLNSGSHNIGLFNSGDGNIGLFNSGSGNFGIGNAGTGNWGIGNSGAGNFGIGNAGSTNTGLFNSGDL NTGSLNPGSYNTGSVNTGSVNTGGFNAGNYNTGYFNTGDYNTGMANTGNINTGAFISGNHSNGLLWRGDN QGLIDLAIGVDIPEIPIVSVDVNIPIHIPITASFTDIVYSGLDLPPNTAVTVIFFGPVDIDPFTVPVIRI TGPTPVVMVGGPTTAINIGATVGVDAINIPIIHIPATPGFGNSTGGLSSGFFNSGAGSASGFGNFGGAAS GFMNLVSTTSGMSGFLNVGALGSGVANVGNTISGIYNVGTSDLSTPAVNSGLANIGTNIAGLLRDGAGTA AINLGLANHGNLNVGFASLGGFNFGGATIGHNNVGIGNTGIFDVGLANLGSYNIGFGNLGDDNLGFGNFG SYNIGFGNVGNDNLGFANAGGGNIGFANTGSNNVGFGNTGSNNVGIGLTGNGQIGFGSFNSGSGNIGLFN SGSNNIGFFNSGSGNFGIANSGSFNTGIGNTGNTNTGLFNSGDVNTGAFNPGSFNTGSFNTGSFNTGGFN PGNTNTGYLNIGNYNTGIANTGDVDTGAFITGNYSNGLFLSGDYQGLVGLNLVIDMPLPISLGVNIPIDI PITASAGNITLMGVTIPPTGDIVLSSIAGQRAHFGPITIPNITVVGPTTTVAIGGPNTAITITGGGAIRI PLISIPAAPGFGNSTTNPSSGFFNTGAGGASGFGNFGGANSGFWNLASATSGASGLLNVGALGSGLANVG TTVSGFYNTSTSDLATPAFNSGLANISTSIAGLLRDSTGTMVLNLGLANHGTLNVGIANLGDYNIGFANL GSANFGSANIGGNNIGGANTGIFDIGLANLGSYNIGFGNFGDDNLGFGNLGSYNVGFGNLGNDNLGFANT GSNNIGFANTGSNNIGIGLTGDGQIGFGSLNSGSGNIGLFNSGSGNIGFFNSGNGNVGIGNTGTANFGLG NTGSTNTGFFNSGDVNTGIGNTGSFNTGSFNPGDSNTGDFNPGSYNTGLGNTGDVDTGAFISGSYSNGFL WSGNYQGLIGLHAALAIPEIALTFGVDIPIHIPINIDAGVVTLQGFSIVAAENNIDFTPIIIPTINITLP TAAITVGGPTTSIGITASAGIGSITIPIIDIPATSGFGNSTTSPSSGFFNSGAGSASGFLNVVAGASGIS GYLNVGALGSGVTNVGHTVSGFYNASALDLVTPAFASGLMRDGMGTMTLNLGLANLGSNNAGFGNTGIFD VGVANLGNYNIGFGNFGDDNLALPT
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0313c | PPE6 | - | 100% (1985) | PPE family protein |
M. bovis AF2122 / 97 | Mb0362c | PPE8 | 0.0 | 50.96% (2074) | PPE family protein |
M. bovis AF2122 / 97 | Mb0312c | PPE5 | 0.0 | 56.99% (1302) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_0325 | - | 9e-23 | 34.90% (192) | PPE protein |
M. tuberculosis H37Rv | Rv0304c | PPE5 | 0.0 | 100.00% (999) | PPE family protein |
M. leprae Br4923 | MLBr_01182 | - | 3e-32 | 46.43% (168) | PPE-family protein |
M. abscessus ATCC 19977 | MAB_0047 | - | 2e-23 | 32.86% (210) | PPE family protein |
M. marinum M | MMAR_1639 | - | 0.0 | 52.00% (2054) | PPE family protein |
M. avium 104 | MAV_2910 | - | 2e-49 | 50.72% (207) | PPE family protein |
M. smegmatis MC2 155 | MSMEG_0868 | - | 2e-35 | 24.92% (1328) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3113 | - | 3e-25 | 41.85% (184) | PUTATIVE PPE protein |
M. ulcerans Agy99 | MUL_0782 | - | 1e-126 | 51.88% (478) | PPE family protein |
M. vanbaalenii PYR-1 | Mvan_0415 | - | 9e-26 | 37.86% (206) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment Rv0304c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1639|M.marinum_M -------------MNFAVLPPEINSARLFSGAGSGPVLAAATAWTGLAAE Mb0313c|M.bovis_AF2122/97 -------------MDFVVSAPEVNSLRMYLGAGSGPMLAAAAAWDGLADE MUL_0782|M.ulcerans_Agy99 -------------MNFSVLPPEVNSALIFTGPGAEPMRTAATAWGGMAVE Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE MAB_0047|M.abscessus_ATCC_1997 ----------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSTQ TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE MAV_2910|M.avium_104 ------------MLDFGAYPPEYNSGRMYVGAGSGPLLAAAAAWDELAAE MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE MSMEG_0868|M.smegmatis_MC2_155 ---------MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPK Rv0304c|M.tuberculosis_H37Rv -----MNLV------------STTSGMSG--------------------- MMAR_1639|M.marinum_M LRSAAAAFL------------AVTSGLTGNSWRGPAAAVMSDVAASYVGW Mb0313c|M.bovis_AF2122/97 LAVAASWFG------------SVTSGLADAAWRGPAAVAMARAVAPYLGW MUL_0782|M.ulcerans_Agy99 LESAADSFA------------SVTSGLVGGAWQGASSVAMGTAAASYLGW Mflv_0325|M.gilvum_PYR-GCK YASAAAELT------------SILAGVQSGAWEGPSSQQYVAAHTPYLAW Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELS------------SILADVQAGAWEGPSSEQYVAAHTPYLAW MAB_0047|M.abscessus_ATCC_1997 YATAATELT------------ELLGSTVAGSWQGPSAMQYAASHAPYLAW TH_3113|M.thermoresistible__bu YRAAAVELA------------AVVSQTCATAWEGVGADAYAAAHGPYLFW MAV_2910|M.avium_104 LQSVGASYG------------STVETLTTGPWTGPSSIAMAAAAAPYVAW MLBr_01182|M.leprae_Br4923 LTAAAQGLQ------------SAVEALLT-TFEGESAAALAERVTPYEKW MSMEG_0868|M.smegmatis_MC2_155 FPAALAPESPLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQAT Rv0304c|M.tuberculosis_H37Rv FLNVGALGSGVANVGNTISGIYNVGTSDLSTPAVNSG-----LANIGTNI MMAR_1639|M.marinum_M LSASGAHAEQAAEQAKTAAQVFEAARAVTVQPGLVAANRAQLVSLVGSNL Mb0313c|M.bovis_AF2122/97 LISATAQAEQAAAQARVAVATFEAARAATVHPAIVAANRAVLVSLVSSNL MUL_0782|M.ulcerans_Agy99 LNAAAAHAEQAAAQAEALVAEFAAAQSAMVQPFLLAANRSSLVSLVLSNL Mflv_0325|M.gilvum_PYR-GCK LAQQSAVSAATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNF Mvan_0415|M.vanbaalenii_PYR-1 LAQQSAAGAAAAAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNF MAB_0047|M.abscessus_ATCC_1997 LTQQSAMSATNAVLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNF TH_3113|M.thermoresistible__bu LTDTAAAAAAAGAQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNF MAV_2910|M.avium_104 LQATGAQAEQAGAQAKLAAAAYETAFAATVPPPVIAANRALLATLVATNI MLBr_01182|M.leprae_Br4923 LTQNAASAELTATQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNI MSMEG_0868|M.smegmatis_MC2_155 STNTTDQPTSDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVT . : : Rv0304c|M.tuberculosis_H37Rv AGLLR-------------------------DGAGTAAINLG--------- MMAR_1639|M.marinum_M FGQNAPAIATAEAQYEQMWAQDVVAMLDYHAGASSVAAALTPLSWPTQTL Mb0313c|M.bovis_AF2122/97 LGFNAPAIAATEAAYERMWAQDVAAMVGYHAGASAAVSALMP-------- MUL_0782|M.ulcerans_Agy99 FGQNAP-------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK LGINTIP------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 LGINTIP------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 FGINTIP------------------------------------------- TH_3113|M.thermoresistible__bu FGVNTIP------------------------------------------- MAV_2910|M.avium_104 LGQNTPA------------------------------------------- MLBr_01182|M.leprae_Br4923 FGQNSTA------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 LGTTLIPN------------------------------------------ * Rv0304c|M.tuberculosis_H37Rv ------------LANHGNLNVGFASLGGFNFGGATIGHNNVGIGNTGIFD MMAR_1639|M.marinum_M AGLAAPAAALGSVARSISFNVGFANAGQGNVGAANIGDFNLGLGNIGSGN Mb0313c|M.bovis_AF2122/97 ------------------FTQQLKKLAGLSERLTSAAAAAAGPPSAAGFN MUL_0782|M.ulcerans_Agy99 --------------------------------------------AIEAVE Mflv_0325|M.gilvum_PYR-GCK ---------------------------------------------IALNE Mvan_0415|M.vanbaalenii_PYR-1 ---------------------------------------------IAMTE MAB_0047|M.abscessus_ATCC_1997 ---------------------------------------------IALNE TH_3113|M.thermoresistible__bu ---------------------------------------------IAVNE MAV_2910|M.avium_104 ---------------------------------------------IAATE MLBr_01182|M.leprae_Br4923 ---------------------------------------------IAEKE MSMEG_0868|M.smegmatis_MC2_155 ---------------------------------------------APTEP Rv0304c|M.tuberculosis_H37Rv VGLANLGSYNIGFGNLGDDNLGFGNFGSYNIGFGNVGNDNLGFANAGGGN MMAR_1639|M.marinum_M VGSGNIGGINVGSGNRGSYNIGPGNLGDYNIGLGNLGDSSVGFGNAGDHN Mb0313c|M.bovis_AF2122/97 LGLANVGANNVGNGNVGVFNVGFGNLGSYNLGFANLGSDNLGLANLGGHN MUL_0782|M.ulcerans_Agy99 AEYEQMWALDVS------------TMATYHAG------------------ Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAAT------------TMATYQSVSG---------------- Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAAT------------TMATYQAVSG---------------- MAB_0047|M.abscessus_ATCC_1997 ADYIRMWIQAAT------------TMGVYQGVSS---------------- TH_3113|M.thermoresistible__bu ADYARMWIQAAT------------TMATYEAVAS---------------- MAV_2910|M.avium_104 AHYMEMWAQDAA------------AMYAYAASSA---------------- MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAA------------AMTSYQASVL---------------- MSMEG_0868|M.smegmatis_MC2_155 ADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLP--------------- : Rv0304c|M.tuberculosis_H37Rv IGFANTGSNNVGFGNTGSNNVGIGLTGNGQIGFGSFNSGSGNIGLFNSGS MMAR_1639|M.marinum_M VGVANAGFNNFGFANTGSNNIGIGLSGDGQVGIGALNSGTGNIGLFNSGT Mb0313c|M.bovis_AF2122/97 IGFANTGSNNVGFGNTGSNNVGIGLTGNGQIGFGSFNSGSHNIGLFNSGS MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Rv0304c|M.tuberculosis_H37Rv NNIGFFNSGSGNFGIANSGSFNTGIGNTGNTNTGLFNSGDVNTGAFNPGS MMAR_1639|M.marinum_M DNIGLFNSGTGNFGIGNSGDYNTGIGNAGATNTGLLNAGLVNTGVGNAGN Mb0313c|M.bovis_AF2122/97 GNVGLFNSGTGNFGIGNSGTGNFGLGNTGSTNTGWFNTGDVNTGGFNPGS MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Rv0304c|M.tuberculosis_H37Rv FNTGSFNTGSFNTGGFNPGNTNTGYLNIGNYNTGIANTGDVDTGAFITGN MMAR_1639|M.marinum_M YNSGGFNAGHTNTGSFNSGDYNTGYLNPGNYNTGLANSGDVNTGAFISGN Mb0313c|M.bovis_AF2122/97 YNTGNFNTGNYNTGSFNAGNYNTGYFNTGDYNTGVANTGNVNTGAFIAGN MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Rv0304c|M.tuberculosis_H37Rv YSNGLFLSGDYQGLVGLNLVIDM-PLPISLGVN-IPIDIPITASAGNITL MMAR_1639|M.marinum_M YSNGAFWRGDHQGTGISYSVTIP-AIPININET-YSLDIPFTEDIGPRSI Mb0313c|M.bovis_AF2122/97 YSNGVLWRGDYQGLIGADIALEIPAIPINAQLFSMPIHQVMVMPGSVMTI MUL_0782|M.ulcerans_Agy99 ------------------------------------------ASAAAASL Mflv_0325|M.gilvum_PYR-GCK ------------------------------------------AALAATPT Mvan_0415|M.vanbaalenii_PYR-1 ------------------------------------------AALAATPT MAB_0047|M.abscessus_ATCC_1997 ------------------------------------------AALAATTP TH_3113|M.thermoresistible__bu ------------------------------------------AAVSATPR MAV_2910|M.avium_104 ------------------------------------------SAAQLTPF MLBr_01182|M.leprae_Br4923 ------------------------------------------EAVGATKA MSMEG_0868|M.smegmatis_MC2_155 ------------------------------------VPTVASAVLDPTQI Rv0304c|M.tuberculosis_H37Rv MGVTIPPTGDIVLSSIAGQRAHFGPITIPNITVVGPTTTVAIGGPNTAIT MMAR_1639|M.marinum_M ASFVIPRQ---SVTVIGIDLLYLGPITIPQINITGPVLSFEIGPATLRLH Mb0313c|M.bovis_AF2122/97 PGMRLPFT------SIVPFVVYYGPVELPQSTLTLPTVTITVGGPTTTID MUL_0782|M.ulcerans_Agy99 T------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK SA------------------------------------------------ Mvan_0415|M.vanbaalenii_PYR-1 AT------------------------------------------------ MAB_0047|M.abscessus_ATCC_1997 TQ------------------------------------------------ TH_3113|M.thermoresistible__bu TV------------------------------------------------ MAV_2910|M.avium_104 TE------------------------------------------------ MLBr_01182|M.leprae_Br4923 FT------------------------------------------------ MSMEG_0868|M.smegmatis_MC2_155 VNWLIYQP------------------------------------------ Rv0304c|M.tuberculosis_H37Rv --ITGG-GAIRIPLISIPAAPGFGNSTTNPSSGFFNTGAGGASGFGNFGG MMAR_1639|M.marinum_M --ATGEIGPVEVPIIDIPATPGFGNTTTNPSSGFFNTGDGSVSGFGNFAA Mb0313c|M.bovis_AF2122/97 GNLTGMVGGVSIPLIKIPAAPGFGNSTTSPSSGFFNAGAGTASGFGNFGG MUL_0782|M.ulcerans_Agy99 --------PLAQPLQNLSELP--GRVIAAFGNGAPATTVTAAVTALRLPA Mflv_0325|M.gilvum_PYR-GCK ----------PAPSVLLPGVGEAGRAAADMSAFAAQPMAAQAGAAFDVSN Mvan_0415|M.vanbaalenii_PYR-1 ----------PAPFVLAPGVGEAGRAAADVTAFAAQAQAAEAGSALDLSN MAB_0047|M.abscessus_ATCC_1997 ----------PSPMIMAPG-GEMSRMSADMMSMAAQPQAAESGSALDSSN TH_3113|M.thermoresistible__bu ----------APPPILGAGTGESATAAITGAHVTAELRAAESRTLLDEIN MAV_2910|M.avium_104 -----------PPRTTNESAGPLQSAAVAQSAAQSGSNTAAHLSQLSAT- MLBr_01182|M.leprae_Br4923 -----------APPLGVNEVGLAQEVVEEVVEEVVEEVVEAEQAISQAAL MSMEG_0868|M.smegmatis_MC2_155 ------LHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTADNPNG Rv0304c|M.tuberculosis_H37Rv ANSGFWNLASATSGASGLLNVGALGSGLANVGTTVSGFYNTSTSDLATPA MMAR_1639|M.marinum_M RTSGFLNVG---SGSSGVQNLGALQSGLANLGDTVSGAFNTG---LGVPA Mb0313c|M.bovis_AF2122/97 GASGFWNLASATSGLSGFGNVGALGSGVANVGNTISGLYNTSTSNLATPA MUL_0782|M.ulcerans_Agy99 DAS----------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK IIADIIRLYGE--------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 IIADLIRAYGE--------------------------------------- MAB_0047|M.abscessus_ATCC_1997 NIMDQL-------------------------------------------- TH_3113|M.thermoresistible__bu ELIDRLFAP----------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 DQAVNEGMEAT--------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GTGGLLFGDGG--------------------------------------- Rv0304c|M.tuberculosis_H37Rv FNSGLANISTSIAGLLRDSTGTMVLNLGL----------ANHGTLNVGIA MMAR_1639|M.marinum_M HVSGVGNVGSELAGFFRDAAGQAPFNLGLGNIGFGNVGSANVGSFNVGPA Mb0313c|M.bovis_AF2122/97 FNS----------GLLHHSVGTMTL------------------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Rv0304c|M.tuberculosis_H37Rv NLGDYNIG------------------------------FANLGSANFGSA MMAR_1639|M.marinum_M NMGDYNIGPGNLGNYNVGLGNLGDSSVGLANAGDLNVGVANAGSNNFGLA Mb0313c|M.bovis_AF2122/97 ---------------------------------------------NFGLA MUL_0782|M.ulcerans_Agy99 -------------------------------------------TVNFGLA Mflv_0325|M.gilvum_PYR-GCK ----------------------------------------VLRFLFEPIF Mvan_0415|M.vanbaalenii_PYR-1 ----------------------------------------LLRFLFEPIF MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------M TH_3113|M.thermoresistible__bu -------------------------------------------------L MAV_2910|M.avium_104 -------------------------------------------------A MLBr_01182|M.leprae_Br4923 ---------------------------------------------VVPQV MSMEG_0868|M.smegmatis_MC2_155 ------------------------------------------HGYDGSAA Rv0304c|M.tuberculosis_H37Rv NIGGNNIGG----------------------------------------- MMAR_1639|M.marinum_M NTGSNNIGIGLSGDGQVGFGALNSGTGNIGLFNSGADNIGLFNSGTGNFG Mb0313c|M.bovis_AF2122/97 NVGGNNVGG----------------------------------------- MUL_0782|M.ulcerans_Agy99 NIGSGNVGN----------------------------------------- Mflv_0325|M.gilvum_PYR-GCK NFLRDPIGN----------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 DFLRDPLGN----------------------------------------- MAB_0047|M.abscessus_ATCC_1997 RFMTNPLGT----------------------------------------- TH_3113|M.thermoresistible__bu FPPGFADAL----------------------------------------- MAV_2910|M.avium_104 QPAAQAAGN----------------------------------------- MLBr_01182|M.leprae_Br4923 DQQVN--------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GLAGGNGGNAG--------------------------------------- Rv0304c|M.tuberculosis_H37Rv ----------------ANTGIFDIGLAN---------------------- MMAR_1639|M.marinum_M IGNSGDYNTGIGNAGATNTGLLNAGLVNTGVSNAGNYNSGGFNAGHTNTG Mb0313c|M.bovis_AF2122/97 ----------------ANAGIFNVGLAN---------------------- MUL_0782|M.ulcerans_Agy99 ----------------ANNGIG---------------------------- Mflv_0325|M.gilvum_PYR-GCK -----------------TFALITDFLTN---------------------- Mvan_0415|M.vanbaalenii_PYR-1 -----------------TIKLITDFLTN---------------------- MAB_0047|M.abscessus_ATCC_1997 -----------------LQDMIEDFMRN---------------------- TH_3113|M.thermoresistible__bu -----------------PDGLLGTLLAP---------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 --------------LFGNGGNGGVGWAG---------------------- Rv0304c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1639|M.marinum_M SFNSGDYNTGYLNPGNYNTGLVNSGDVNTGAFISGDYSNGAFWRGDHQGL Mb0313c|M.bovis_AF2122/97 -------------------------------------------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Rv0304c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1639|M.marinum_M ADISYGITIPEIPAHIEGTIPLAVPVTMTSTNTVIHAVTIPVFDAGFLGI Mb0313c|M.bovis_AF2122/97 -------------------------------------------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Rv0304c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1639|M.marinum_M PIDAGPVTIPAIVITGPTLTGIIGGPTSAININTGQHVGPIRLSFLDIPA Mb0313c|M.bovis_AF2122/97 -------------------------------------------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Rv0304c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1639|M.marinum_M APGFGNSTTNPSSGFFNLGQGTVSGFGNLGARTSGFLNVGSGISGVQNVG Mb0313c|M.bovis_AF2122/97 -------------------------------------------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Rv0304c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1639|M.marinum_M ALQSGLANLGDTVSGAFNTGLGVPAHVSGLGNAGSELAGFFRDATGHARF Mb0313c|M.bovis_AF2122/97 -------------------------------------------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Rv0304c|M.tuberculosis_H37Rv --------------------------LGSYNIGFGNFGDDNLGFGNLGSY MMAR_1639|M.marinum_M NLGLGNIGSGNVGSGNIGGANVGSGNIGDYNIGPANLGDYNIGLGNLGDS Mb0313c|M.bovis_AF2122/97 --------------------------LGDYNIGFGNLGGDNLGFAHAGSY MUL_0782|M.ulcerans_Agy99 ----------------------------------------NLGSGNLGNF Mflv_0325|M.gilvum_PYR-GCK ------------------------------------PVQALITWGPFLLA Mvan_0415|M.vanbaalenii_PYR-1 ------------------------------------PAQALITWGPFLAA MAB_0047|M.abscessus_ATCC_1997 ------------------------------------PVAAFFAWFPLLFF TH_3113|M.thermoresistible__bu ------------------------------------LLPGATGDGPPMAT MAV_2910|M.avium_104 -----------------------------------------AASTTAAST MLBr_01182|M.leprae_Br4923 ---------------------------------------VDVATPQTAVP MSMEG_0868|M.smegmatis_MC2_155 -------------------------------LDGGNGGSGGLLMGIGGAG Rv0304c|M.tuberculosis_H37Rv NVGFGNLGNDNLGFANTGSNNIGFANTGSNNIGIGLTGDGQIGFGSLNSG MMAR_1639|M.marinum_M SIGLANAGDHNLGVANAGFNNFGFANTGNNNIGIGLSGDGQVGFGALNSG Mb0313c|M.bovis_AF2122/97 NIGFANTGSNNLGFANTGDNNIGFANIGSNNIGIGLTGSGQIGFGSLNSG MUL_0782|M.ulcerans_Agy99 NLGSGNLGSSNAGWANLGSNNIGGANSGGNNLGWG--------------- Mflv_0325|M.gilvum_PYR-GCK VVYQAVSWVGASILYPSLFLLPLLATTLAIVAGVGQHLLSLLNTPPAEEA Mvan_0415|M.vanbaalenii_PYR-1 VAYQAVSWVGASILYPSLLLLPLVATTLAIVLGVGAYLLENLPAPAEDAP MAB_0047|M.abscessus_ATCC_1997 IAYEAFFIPFGFTFWGVLLSAP---AWLPIVLGLALSALVPPAGIEEPGQ TH_3113|M.thermoresistible__bu IMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAVSGMLAQLVPLMPALLP MAV_2910|M.avium_104 QLTTPSFITNWNEFWSVVTGVYSPQSWTTIPGGPFLSFGQAYAWGQ---- MLBr_01182|M.leprae_Br4923 DSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNG------ MSMEG_0868|M.smegmatis_MC2_155 GAGGVGADGTSAHVDGGTGGTGGTGGGTGGTGGIGGTGGGLFGLLGHSGS . Rv0304c|M.tuberculosis_H37Rv SGNIGLFNSGSGNIGFFNSGNGNVGIGNTGT----------ANFGLGNTG MMAR_1639|M.marinum_M TGNIGLFNSGTDNIGLFNSGTGNFGIGNSGD----------YNTGIGNAG Mb0313c|M.bovis_AF2122/97 SHNIGLFNSGDGNIGLFNSGSGNFGIGNAGTGNWGIGNSGAGNFGIGNAG MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK AEEPAP-------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 AEEPAA-------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 EDEPGR-------------------------------------------- TH_3113|M.thermoresistible__bu VAVAAL-------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 TGAAGAAGNG---------------------------------------- Rv0304c|M.tuberculosis_H37Rv STNTGFFNSGDVNTGIG----------NTGSFNTGSFNPGDSNTGDFNPG MMAR_1639|M.marinum_M ATNTGLLNAGLVNTGVGNAGNYNSGGFNTGSTNTGSFNSGDYNTGYLNPG Mb0313c|M.bovis_AF2122/97 STNTGLFNSGDLNTGSLNPGSYNTGSVNTGSVNTGGFNAGNYNTGYFNTG MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Rv0304c|M.tuberculosis_H37Rv SYNTGLGNTGDVDTGAFISGSYSNGFLWSGNYQGLIGLHAALAIPEIALT MMAR_1639|M.marinum_M NYNTGLANSGDVNTGAFISGDYSNGAFWRGDHQGLVGFSYAINIPETPGH Mb0313c|M.bovis_AF2122/97 DYNTGMANTGNINTGAFISGNHSNGLLWRGDNQGLIDLAIGVDIPEIPIV MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Rv0304c|M.tuberculosis_H37Rv -FGVDIPIHIPIN-----IDAGVVTLQGFSIVAAENN----IDFTPIIIP MMAR_1639|M.marinum_M -AEISIPIDIPINGTIGDINTPRVRIPEFPLNVYVFTPIHVGDVGPIVLP Mb0313c|M.bovis_AF2122/97 SVDVNIPIHIPITASFTDIVYSGLDLPPNTAVTVIFFG--PVDIDPFTVP MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Rv0304c|M.tuberculosis_H37Rv TINITLPTAAITVGGPTTSIGITASAGIGSITIPIIDIPATSGFGNSTTS MMAR_1639|M.marinum_M PIRITGPTLTGNIGGPTTSIDIGIGGTLGPAKITIIDIPAAPGFGNSTTS Mb0313c|M.bovis_AF2122/97 VIRITGPTPVVMVGGPTTAINIGATVGVDAINIPIIHIPATPGFGNSTGG MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Rv0304c|M.tuberculosis_H37Rv PSSGFFNSGAGSASGFLN----------VVAGASGISGYLNVGALGSGVT MMAR_1639|M.marinum_M PSSGFFNSGDGSVSGFGNFGDHTS---GLVNFGSGNSGAQNVGALQSGLA Mb0313c|M.bovis_AF2122/97 LSSGFFNSGAGSASGFGNFGGAASGFMNLVSTTSGMSGFLNVGALGSGVA MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Rv0304c|M.tuberculosis_H37Rv NVGHTVSGFYN-----------ASALDLVTPAFASGLMRDGMGTMTLNLG MMAR_1639|M.marinum_M NLGDTVSGAFNT---GLGVPAHVSGVGNVGSELAG-FFRDATGHAPFNLG Mb0313c|M.bovis_AF2122/97 NVGNTISGIYNVGTSDLSTPAVNSGLANIGTNIAG-LLRDGAGTAAINLG MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Rv0304c|M.tuberculosis_H37Rv LAN--------------------LGSNNAGFGNTGIFDVGVANLGNYNIG MMAR_1639|M.marinum_M LGN--------------------IGFGNVGSANAGNFNVGSANIGDYNIG Mb0313c|M.bovis_AF2122/97 LANHGNLNVGFASLGGFNFGGATIGHNNVGIGNTGIFDVGLANLGSYNIG MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Rv0304c|M.tuberculosis_H37Rv ----------FGNFG----------DDNLGFANLGSYNIGVANTGSNNIG MMAR_1639|M.marinum_M PGNLGDYNIGLGNLG----------DSSIGLANAGDHNLGVANAGFNNFG Mb0313c|M.bovis_AF2122/97 FGNLGDDNLGFGNFGSYNIGFGNVGNDNLGFANAGGGNIGFANTGSNNVG MUL_0782|M.ulcerans_Agy99 --------------------------------NLGGLNTGFANAGSGNFR Mflv_0325|M.gilvum_PYR-GCK ---------------------------AQSAPSR--PDQQSFPATMSAPP Mvan_0415|M.vanbaalenii_PYR-1 ---------------------------SSPAPTR--ADQPSPAIAVSAPP MAB_0047|M.abscessus_ATCC_1997 ---------------------------EPTRIERRSPQQDLQLAHVPSGS TH_3113|M.thermoresistible__bu ---------------------------GGLAGVWAGLSGLAGLAGLTAVP MAV_2910|M.avium_104 --------------------------------NGQGAAAYLAGPKAISGA MLBr_01182|M.leprae_Br4923 -----------------------------------------MGSAMKSLA MSMEG_0868|M.smegmatis_MC2_155 --------------------------GDGGNGGFGYVLIAGPNVTVGSET Rv0304c|M.tuberculosis_H37Rv FANTGSNNIGIGLTGTGQIGIGALNSGSGNIGLFNSGDGNIGFFNSGTGN MMAR_1639|M.marinum_M FANTGNNNIGIGLSGDGQVGIGALNSGTGNIGLFNSGTDNIGLFNSGTGN Mb0313c|M.bovis_AF2122/97 FGNTGSNNVGIGLTGNGQIGFGSFNSGSGNIGLFNSGSNNIGFFNSGSGN MUL_0782|M.ulcerans_Agy99 FANTGNNNIGIGLTGDNQVGIGGLNSGVGNFGLFNSGTGNVGLFNSGTGN Mflv_0325|M.gilvum_PYR-GCK PPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYEGFSPTVRD Mvan_0415|M.vanbaalenii_PYR-1 PPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDPGTGFSPTVRD MAB_0047|M.abscessus_ATCC_1997 PTPGGSTTTTVTSGGSAPPAPAPATATPAYMVYAVQEDPPAARFGPTLNE TH_3113|M.thermoresistible__bu AADGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAG MAV_2910|M.avium_104 LAPLASGGNAVKPMLSSAVGAGQVSGSMGKAALVGSMSVPQGWTEAAPAI MLBr_01182|M.leprae_Br4923 PTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVP MSMEG_0868|M.smegmatis_MC2_155 RGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDGHAIGGN . . Rv0304c|M.tuberculosis_H37Rv FGIGNTGTGNFGIGNSGSTSTGLFNSGDGNTGGFNPGNFNTGNFNTGSFN MMAR_1639|M.marinum_M FGIGNSGDYNTGIGNAGATNTGLLNAGLVNTGVGNAGNYNSGGLNAGHTN Mb0313c|M.bovis_AF2122/97 FGIANSGSFNTGIGNTGNTNTGLFNSGDVNTGAFNPGSFNTGSFNTGSFN MUL_0782|M.ulcerans_Agy99 FGIGNSGAYGTGLFNSGQANTGLLNAGSFNTGLLDVGNANTGSLNTGSFN Mflv_0325|M.gilvum_PYR-GCK STGAKAPAGTIPAAASG----IAASAAERRKRRRRQKEEIKGRGYADAYA Mvan_0415|M.vanbaalenii_PYR-1 STSAKAPASGIPAAASG----VAASAAERRKRRRRQKDEIAGRAYADAYA MAB_0047|M.abscessus_ATCC_1997 GSGAKAPAAGISAAAA-----AAASARSRARRKRAARIKDPAPQFMDMNS TH_3113|M.thermoresistible__bu HSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSA MAV_2910|M.avium_104 RTLAQVLPGNMAAAPAAMAGEEGVFSQMALSSLAGRAVAAAATRPVGGAA MLBr_01182|M.leprae_Br4923 QTWTTASQPVTAATRALSPARVAVATESESAPLLGGGLPMAPMVPGGGSG MSMEG_0868|M.smegmatis_MC2_155 GGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHSTGTGI . Rv0304c|M.tuberculosis_H37Rv TGGFNAGNTNTGHFNTGNYNTGIANTGDVSTGAFISGNYSNGILWRGDYQ MMAR_1639|M.marinum_M TGSFNSGDYNTGYLNPGNYNTGMVNSGDVNTGAFISGDYSNGAFWRGDHQ Mb0313c|M.bovis_AF2122/97 TGGFNPGNTNTGYLNIGNYNTGIANTGDVDTGAFITGNYSNGLFLSGDYQ MUL_0782|M.ulcerans_Agy99 MGSFNPGPSNTGALNTGTANTGWFNTGSLNTGPFNIGDMNN--------- Mflv_0325|M.gilvum_PYR-GCK DYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGD------------ Mvan_0415|M.vanbaalenii_PYR-1 DYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDA------------ MAB_0047|M.abscessus_ATCC_1997 SVAPDFSES-AARQTTGVGASARGAGRLGFAGTAPAAAGT---------- TH_3113|M.thermoresistible__bu AAAAAARESAPIRRRRGQKDGLHGHRHEHQQPASMSAATA---------- MAV_2910|M.avium_104 SAASSLGGVAAEADPAAATIIVIPCIEE---------------------- MLBr_01182|M.leprae_Br4923 TGGVNTALRLQPRAFVMPRNPAAG-------------------------- MSMEG_0868|M.smegmatis_MC2_155 GGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIYSGADG Rv0304c|M.tuberculosis_H37Rv GLIGYSYALTIPEIPAHLDVNIPIDIPITGSFTDLVVDNFTIPIIGFESF MMAR_1639|M.marinum_M GLVGFSYGFTIPALPAQLEAQIPVNIPATATAGDTTIHSATFPAIHFDTF Mb0313c|M.bovis_AF2122/97 GLVGLNLVIDMP-LPISLGVNIPIDIPITASAGNITLMGVTIPPTGDIVL MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 EATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTAKAGHG Rv0304c|M.tuberculosis_H37Rv AFSFHIHTEPDIGPIIVPSFVLSVPTFAIAVGGPTTAINISATAGLGPIT MMAR_1639|M.marinum_M G--LLPQSNGTFGPVTLPDITLSGPTFSLLMGGPDTVVGIKAGGVAGPVT Mb0313c|M.bovis_AF2122/97 S--SIAGQRAHFGPITIPNITVVGPTTTVAIGGPNTAITITGG---GAIR MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAVGGNGG Rv0304c|M.tuberculosis_H37Rv IPIIDIPAAPGIGNSTTSPSSGFFNTGAGTASGFGNVGGNTSGLWNLASA MMAR_1639|M.marinum_M FSFIDIPAAPGFGNTTATPSSGFFNSGAGSASGFGNSGADNSGLLNLAFG Mb0313c|M.bovis_AF2122/97 IPLISIPAAPGFGNSTTNPSSGFFNTGAGGASGFGNFGGANSGFWNLASA MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 FTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPN------- Rv0304c|M.tuberculosis_H37Rv ASGVSGLLNVGALGSGVANVGNTISGIYNTSPLDLGTPAFGSGLANI--- MMAR_1639|M.marinum_M SS---GYQNVGALQSGIANLGNTMSGVYNTG---LAVPAHVSGIGNIGHN Mb0313c|M.bovis_AF2122/97 TSGASGLLNVGALGSGLANVGTTVSGFYNTSTSDLATPAFNSGLANISTS MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Rv0304c|M.tuberculosis_H37Rv -AGLLQGGAGTT--ILDLAGLGNLNVGLA--------------------N MMAR_1639|M.marinum_M LAGLLRGTAGQVPVNVGFANNGAGNVGFG--------------------N Mb0313c|M.bovis_AF2122/97 IAGLLRDSTGTMVLNLGLANHGTLNVGIANLGDYNIGFANLGSANFGSAN MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Rv0304c|M.tuberculosis_H37Rv LGGSNFGIGNTGIFNVGFANVGNHNIG----------LANLGNYSVGFAN MMAR_1639|M.marinum_M VGFSNVGSGNIGSFNVGSGNIGDYNIGPGNLGDYNIGLGNLGDSSIGFGN Mb0313c|M.bovis_AF2122/97 IGGNNIGGANTGIFDIGLANLGSYNIGFGNFGDDNLGFGNLGSYNVGFGN MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Rv0304c|M.tuberculosis_H37Rv SGNYHIGIANTGSANIGFANTGSGNIGIGLTGTGQIGFGSFNSGSHNIGL MMAR_1639|M.marinum_M AGDHNVGVANAGFNNFGFANTGSNNIGIGLNGDGQVGFGALNSGTGNIGL Mb0313c|M.bovis_AF2122/97 LGNDNLGFANTGSNNIGFANTGSNNIGIGLTGDGQIGFGSLNSGSGNIGL MUL_0782|M.ulcerans_Agy99 ------------------------------------------------GL Mflv_0325|M.gilvum_PYR-GCK --------------------------------------------EQAGGL Mvan_0415|M.vanbaalenii_PYR-1 --------------------------------------------AQAGGL MAB_0047|M.abscessus_ATCC_1997 --------------------------------------------TAAAGL TH_3113|M.thermoresistible__bu --------------------------------------------PSAAGI MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ----------------------------GPAGTTIDKGKAAGGNGGDGGF Rv0304c|M.tuberculosis_H37Rv FNSGDGNVGFFNSGTGNVGIGNTGTANFGIANSGSFNTGLGNTGSTNTGL MMAR_1639|M.marinum_M FNSGTDNIGLFNSGTG----------NFGIGNSGDYNTGIGNAGATNTGL Mb0313c|M.bovis_AF2122/97 FNSGSGNIGFFNSGNG----------NVGIGNTGTANFGLGNTGSTNTGF MUL_0782|M.ulcerans_Agy99 FNTGEMNNGIFYRGVG-----------------------QGN-------- Mflv_0325|M.gilvum_PYR-GCK TTLA---GDSFGGGPR---------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 TTLP---GDPFGGGPK---------------------------------- MAB_0047|M.abscessus_ATCC_1997 VERDSGTAEALDGART---------------------------------- TH_3113|M.thermoresistible__bu RVLG-GAGRISRTRGS---------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 NGTGGATGGRGGDGAG---------------------------------- Rv0304c|M.tuberculosis_H37Rv FNPGNVNTGVGNTGSINTGSINTGSFNTGSTNTGSFNLGDHNTGSFNSGD MMAR_1639|M.marinum_M LNAGLVNTGVG-----NAGNYNSGGFNTGSTNTGSFNPGDYNTGGLNQGD Mb0313c|M.bovis_AF2122/97 FNSGDVNTGIG--------------------NTGSFN-----TGSFNPGD MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Rv0304c|M.tuberculosis_H37Rv YNTGYFNAGDYNTGVANTGNVNTGAFISGNYSNGFFWRGDYQGLIGLSTT MMAR_1639|M.marinum_M YNTGYLNSGDYNTGFVNAGDVNTGAFISGNYSNGFFARGDYQNLIGWSYS Mb0313c|M.bovis_AF2122/97 SNTGDFNPGSYNTGLGNTGDVDTGAFISGSYSNGFLWSGNYQGLIGLHAA MUL_0782|M.ulcerans_Agy99 ----------------------------------------------FYFS Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ------------------------------------------------AS Rv0304c|M.tuberculosis_H37Rv ITIPEIPYRYDLSVPIDIPITGTVVATTPNSFTIPGFQIRVLLGP--AAV MMAR_1639|M.marinum_M ITVSEFPAYGTLDIPVYIPFTGAIGPITIQEFTIPSLPLDALVYINGTPI Mb0313c|M.bovis_AF2122/97 LAIPEIALTFGVDIPIHIPINIDAGVVTLQGFSIVAAENNIDFTP----- MUL_0782|M.ulcerans_Agy99 ITTPDLTLP-----PLEIPG------ITIPNLSLPPITMRR--------- Mflv_0325|M.gilvum_PYR-GCK --EPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP--------------- Mvan_0415|M.vanbaalenii_PYR-1 --APMLPGTWDPDTEPD------ERHNHHDGKDSQ--------------- MAB_0047|M.abscessus_ATCC_1997 --VPMLPTSWGTDSEHG-------PDRPAEGGSST--------------- TH_3113|M.thermoresistible__bu --VPHAEITPGDPTEPSS-----PTDRAHRPAEPN--------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 VWKANGQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEG Rv0304c|M.tuberculosis_H37Rv LVNEMIGPITIDVN--QVIAIDSPIQQTIS-MVGTGGFGPIPIGIS-IGG MMAR_1639|M.marinum_M PIFYDFGPITVDETTTDPIALNFVWDQLYHYEVGPRTFGPYEIPLF-SFP Mb0313c|M.bovis_AF2122/97 ---IIIPTINITLP---TAAITVGGPTTSIGITASAGIGSITIPIIDIPA MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GTGGHGGDGGRGGDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPS Rv0304c|M.tuberculosis_H37Rv TPGFGNSTTGPSSGFFHTGAGHVSGFGNFGAGNMSGSGNFGAGNSGFFN- MMAR_1639|M.marinum_M GPGFANSTTSPSSGFFNSGTGPTSGFFNSGAGSLSGLINLGANNSGFANT Mb0313c|M.bovis_AF2122/97 TSGFGNSTTSPSSGFFNSGAGSASGFLNVVAG------------------ MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 HTGAGGNGGNGGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGD Rv0304c|M.tuberculosis_H37Rv -AGGLGNSGLLNFGALQSGLANLGNTISGVYNTSTLDLATPAFGSGIANI MMAR_1639|M.marinum_M GIGGLGNSGFINDGALQSGMANVGNTISGIYNSTTLDPTAVANVSGIANT Mb0313c|M.bovis_AF2122/97 ---ASGISGYLNVGALGSGVTNVGHTVSGFYNASALDLVTPAFAS----- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GGEALIRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQA Rv0304c|M.tuberculosis_H37Rv GANLAGLFLDNTGNLTLNFGVANQGGLNAGIGNLGSVNIGFVNTGDSNLG MMAR_1639|M.marinum_M GVDLAGVFRG--ASRIHNLGFANLGIANLGSANIGDLNLGGANFGSANIG Mb0313c|M.bovis_AF2122/97 -----GLMRDGMGTMTLNLGLAN--------------------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 NPQASGTATDGHGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGD Rv0304c|M.tuberculosis_H37Rv IGNLGDLNFGGVNIGGNNIGIANTGIFD--IGLANLGSYNIGLANLGDDN MMAR_1639|M.marinum_M SGNIGFGNVGGGNVGSLNLGFGNLGDHN--IGPGNLGDYNIGLGNLGDSN Mb0313c|M.bovis_AF2122/97 -------------LGSNNAGFGNTGIFD--VGVANLGNYNIGFGNFGDDN MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GIDGGLGGNGGDGVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGG Rv0304c|M.tuberculosis_H37Rv LGFGNAGSYNIGFANFGSDNLGFANTGSYNIGFANTGNNNIGVGLTGNGQ MMAR_1639|M.marinum_M VGFGNAGDHNVGVG----------NAGFNNFGFANTGSNNIGIGLSGDGQ Mb0313c|M.bovis_AF2122/97 LALPT--------------------------------------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 PSWVQSGYGSTLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGV Rv0304c|M.tuberculosis_H37Rv IGIGSLNSGSNNIGLFNSGSGNIGFFNSGTGNVGIFNTGTGNFGLANSGG MMAR_1639|M.marinum_M VGFGALNSGTGNIGLFNSGTDNIGLFNSGTGNIGLFNSGTGSFGIGNSGN Mb0313c|M.bovis_AF2122/97 -------------------------------------------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ATGNTATGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGN Rv0304c|M.tuberculosis_H37Rv FNTGIGNAGSTNTGVFNP----------GDLNTGSFNPGSFNTGGFNPGS MMAR_1639|M.marinum_M YNTGIGNAGATNTGLFNTGLVNTGVGNAGNYNSGGFNTGSTNTGSFNSGD Mb0313c|M.bovis_AF2122/97 -------------------------------------------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GGNGGKGADGWVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGD Rv0304c|M.tuberculosis_H37Rv GNTGYLNTGDYNTGVANTGDVDTGAFITGSYSNGFLVSGDYQGLIGLPLL MMAR_1639|M.marinum_M HNTGYLNSGDYNTGLANSGDVNTGAFISGNYSNGFFVDGDHQGLIDG--- Mb0313c|M.bovis_AF2122/97 -------------------------------------------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GGNGGNTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNG Rv0304c|M.tuberculosis_H37Rv GIPVTPGYFNLTGGPSSGFFNSGAGSVSGFVN--------------SGAG MMAR_1639|M.marinum_M ----TPGFFNSTTNPSSGLLNSGEGSESGVGNYGVGNSGFLNFASVTGAG Mb0313c|M.bovis_AF2122/97 -------------------------------------------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GTGGTTAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP----------- Rv0304c|M.tuberculosis_H37Rv LSGYLNTGALGSGVANVGNTISGWLNASALDLATPGFLSGIGNFGTNLAG MMAR_1639|M.marinum_M SSGLLNVGALQSGILNLGSTISGFGNTGS---VTPAFVSGVANAGTRLSG Mb0313c|M.bovis_AF2122/97 -------------------------------------------------- MUL_0782|M.ulcerans_Agy99 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_0047|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3113|M.thermoresistible__bu -------------------------------------------------- MAV_2910|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Rv0304c|M.tuberculosis_H37Rv -FFRG--- MMAR_1639|M.marinum_M FFFRGTGP Mb0313c|M.bovis_AF2122/97 -------- MUL_0782|M.ulcerans_Agy99 -------- Mflv_0325|M.gilvum_PYR-GCK -------- Mvan_0415|M.vanbaalenii_PYR-1 -------- MAB_0047|M.abscessus_ATCC_1997 -------- TH_3113|M.thermoresistible__bu -------- MAV_2910|M.avium_104 -------- MLBr_01182|M.leprae_Br4923 -------- MSMEG_0868|M.smegmatis_MC2_155 --------