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MSFVIAAPEVIAAAATDLASLESSIAAANAAAAANTTALLAAGADEVSTAVAALFGAHGQAYQALSAQAQ AFHAQFTQALTSGGGAYAAAEAAATSPLLAPINEFFLANTGRPLIGNGANGAPGTGADGAPGGWLIGNGG AGGSGAANNAVGGTGGTGGAGGASGLLGSGGAGGAGGVATNTGGIGGAGGTGGNAVLFGAGGAGGASTNT TGGAGGAGGDGGNAGLLFGAAGVGGAGGFALATTASGGAGGAGGAGGMFTDGGVGGVGGKGGFGGAGGAG GNGGLFGAGGTGGAGGTIGAGVAGMGGAGGAGGAGGLFGAGGTGGSGGGGATTGGDGGAGGAGGFGRTTG GIGGTGGNAGLLNGSGGAGGAGGAAITGPGGTGGAGGIPGLIGNGGNGGDGGASVTGTGGNGGAGGNGVQ IGNGGNGGSGGTGAAAGKAGLGGLGGQLIGLDGSNAPVSTSVHTLQQAALNVVNEPFQTLTGRPLIGNGA NGTPGTGAAGGAGGWLFGNGGNGGHGATNTAATATGGAGGAGGILFGTGGNGGTGGIATGAGGIGGAGGA GGVSLLIGSGGTGGNGGNSIGVAGIGGAGGRGGDAGLLFGAAGTGGHGAAGGVPAGVGGAGGNGGLFANG GAGGAGGFNAAGGNGGNGGLFGTGGTGGAGTNFGAGGNGGNGGLFGAGGTGGAAGSGGSGITTGGGGHGG NAGLLSLGASGGAGGSGGASSLAGGAGGTGGNGALLFGFGGAGGAGGHGGAALTSIQQGGAGGAGGNGGL LFGSAGAGGAGGSGANALGAGTGGTGGDGGHAGVFGNGGDGGAGGFGAGTGGSGGVGGNAVLIGNGGNGG NAGKAGATPGAGGTGGLLLGENGLNGLP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0285c | PE_PGRS3a | - | 100% (868) | hypothetical protein Mb0285c |
| M. bovis AF2122 / 97 | Mb0286c | PE_PGRS3 | 0.0 | 71.55% (907) | PE-PGRS family protein |
| M. bovis AF2122 / 97 | Mb0768 | PE_PGRS10 | 0.0 | 65.36% (947) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5091 | - | 1e-156 | 43.82% (842) | triple helix repeat-containing collagen |
| M. tuberculosis H37Rv | Rv0278c | PE_PGRS3 | 0.0 | 80.18% (888) | PE-PGRS family protein |
| M. leprae Br4923 | MLBr_01183 | - | 9e-13 | 39.56% (91) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 1e-45 | 32.79% (491) | hypothetical protein MAB_4284c |
| M. marinum M | MMAR_4399 | - | 0.0 | 57.58% (950) | PE-PGRS family protein |
| M. avium 104 | MAV_4827 | - | 2e-24 | 40.68% (177) | hypothetical protein MAV_4827 |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-126 | 36.63% (1002) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3810 | - | 4e-40 | 40.34% (295) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_3062 | - | 0.0 | 54.13% (883) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-151 | 45.24% (778) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0285c|M.bovis_AF2122/97 --------------------------------------------------
Rv0278c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
TH_3810|M.thermoresistible__bu --------------------------------------------------
MMAR_4399|M.marinum_M --------------------------------------------------
MUL_3062|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Mb0285c|M.bovis_AF2122/97 --------------------MSFVIAAPEVIAAAATDLASLESSIAAANA
Rv0278c|M.tuberculosis_H37Rv --------------------MSFVIAAPEVIAAAATDLASLGSSISAANA
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
TH_3810|M.thermoresistible__bu --------------------------------------------------
MMAR_4399|M.marinum_M --------------------MSYVIAVPDLVAGAASELAGVGSTLSTATT
MUL_3062|M.ulcerans_Agy99 --------------------MAFVLAVPDMVAEAAADLAGVGSVIDAANT
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------MSIIDFILNLFRDPVEAASYVADPEAALAN
MAV_4827|M.avium_104 --------------------MNIVLGVSMAPSSIQMVVLEGEYADGATVE
Mb0285c|M.bovis_AF2122/97 AAAANTTALLAAGADEVSTAVAALFGAHGQAYQALSAQAQAFHAQFTQAL
Rv0278c|M.tuberculosis_H37Rv AAAANTTALMAAGADEVSTAIAALFGAHGQAYQALSAQAQAFHAQFVQAL
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
TH_3810|M.thermoresistible__bu --------------------------------------------------
MMAR_4399|M.marinum_M AAAAQTTGVLAAAGDEVSAAIAAVFSAHGQSYQTLSAQAETFHAQFVQAL
MUL_3062|M.ulcerans_Agy99 AAAGSTTGIVAAAEDEVSAAIAALFSGHGQAYQQISTRVAEFHAQFERVF
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 AGLSAVSAAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYY
MAV_4827|M.avium_104 EDAIDVTGADDAATASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQL
Mb0285c|M.bovis_AF2122/97 TSG-----------------------------------GGAYAAAEAAAT
Rv0278c|M.tuberculosis_H37Rv TSG-----------------------------------GGAYAAAEAAAV
Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
TH_3810|M.thermoresistible__bu --------------------------------------------------
MMAR_4399|M.marinum_M SAG-----------------------------------ASAYTQAEAASA
MUL_3062|M.ulcerans_Agy99 AAG-----------------------------------VQAYSGAEAANA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 AAQ--------------------------------------PDGPSILSP
MAV_4827|M.avium_104 EAA--------------------------------------ALRDALAAR
Mb0285c|M.bovis_AF2122/97 S------------------------------------------PLLAPIN
Rv0278c|M.tuberculosis_H37Rv S------------------------------------------PLLDPIN
Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
TH_3810|M.thermoresistible__bu --------------------------------------------------
MMAR_4399|M.marinum_M S---------------------------------------PLAGLLAAIN
MUL_3062|M.ulcerans_Agy99 SFL-----------------------------------QDPLQTALNATN
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 S-------------------------------------------LLSPRD
MAV_4827|M.avium_104 R------------------------------------------IDNVMLV
Mb0285c|M.bovis_AF2122/97 EFFLANTGRPLIGNGANGAPG-----TGADGAPGGWLIGNGGAGGSGAA-
Rv0278c|M.tuberculosis_H37Rv EFFLANTGRPLIGNGANGAPG-----TGANGGDGGWLIGNGGAGGSGAAG
Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLG-
Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLG-
MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWA-
TH_3810|M.thermoresistible__bu ------------------------------------------------V-
MMAR_4399|M.marinum_M APVQSLTGRPLIGNGANGTPG-----TGADGAPGGWLLGDGGAGGSGAP-
MUL_3062|M.ulcerans_Agy99 KPVQDLTGRPLVGNGANGVPG-----TGANGAAGGWLLGNGGAGGSGAA-
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 NDFLSHNDTDFASHNPIASGNQVMSPSGNVDSFNRGPLLDLSFGDLQFG-
MAV_4827|M.avium_104 SAFLAAAALAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGSIPDVYK-
Mb0285c|M.bovis_AF2122/97 -NNAVGGTGGTGGAGGASGLLGSGGAGGAGGVATN---------TGGIGG
Rv0278c|M.tuberculosis_H37Rv VNGGAGGNGGAGGNGGAGGLIGNGGAGGAGGVAS-----------SGIGG
Mflv_5091|M.gilvum_PYR-GCK -----GGNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAG
Mvan_1264|M.vanbaalenii_PYR-1 -----SGDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAG
MSMEG_0868|M.smegmatis_MC2_155 -----GLDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGG
TH_3810|M.thermoresistible__bu -----DGDGGSGGRTGLFSKLSRGGDGGDGGLG-------------GNGG
MMAR_4399|M.marinum_M -----GLNGGAGGAAG---LLGSGGAGGAGGSS---TSTNGG--AGGAGG
MUL_3062|M.ulcerans_Agy99 -----GQAGGDGGAAG---LIGAGGAGGAGGNSPLRNTANGG--NGGTGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------NRDTTAIGDGAVAVGGSNSGPIASGQ------------GSTA
MAV_4827|M.avium_104 ---QQIRAESYGDAAGQLSAMVAGLEKLESLPGG-----------LLLVG
Mb0285c|M.bovis_AF2122/97 A-GGTGGNAVLFGAGGAGGAS---TNTTGGAGGAGGDGGNA---------
Rv0278c|M.tuberculosis_H37Rv S-GGAGGNAMLFGAGGAGGAGGGVVALTGGAGGAGGAGGNA---------
Mflv_5091|M.gilvum_PYR-GCK ATGATGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG---------
Mvan_1264|M.vanbaalenii_PYR-1 ATGATGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG---------
MSMEG_0868|M.smegmatis_MC2_155 TGGGTGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLI
TH_3810|M.thermoresistible__bu HGGGTGIIS--------------------LLSLAGNGGNGG---------
MMAR_4399|M.marinum_M AGGWLSGNAGVGGAGGASTVANGGAGGAGGAGGLLGGGGLGG--------
MUL_3062|M.ulcerans_Agy99 AGGLLFGPGGVGGAGGASFLT-GGTGGDGGAGGLFGAGGLGG--------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 VNGDVRDSNIINADHGSNVGVDQSQTRVGGDYTNVSGHGSAD--------
MAV_4827|M.avium_104 SGVDVAPLKQVLQTTTFLDVSVAEEPETALARGAALAAANAP--------
Mb0285c|M.bovis_AF2122/97 -------GLLFGAAGVGGAGGFALATTASGGAGGAGGAGG----------
Rv0278c|M.tuberculosis_H37Rv -------GLLFGAAGVGGAGGFTNG-SALGGAGGAGGAGG----------
Mflv_5091|M.gilvum_PYR-GCK -----AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG----------
Mvan_1264|M.vanbaalenii_PYR-1 -----AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG----------
MSMEG_0868|M.smegmatis_MC2_155 AGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANG
TH_3810|M.thermoresistible__bu ------NGYRTTDNNALDGGHGG---------------------------
MMAR_4399|M.marinum_M -----AGGASTSATASGGAGGQGGAAGLLSGFVGADGGHG----------
MUL_3062|M.ulcerans_Agy99 -----VGGSGN----VGGNGGAGGAGGLLAGLVGAGGGDG----------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -----IDKSVTVVDDHSQRNTTNINDSFNTDRSTNIGSGN----------
MAV_4827|M.avium_104 ----LFASSTAALAYAQDPGTGAVDQYSLPDYLYVPVDPE----------
Mb0285c|M.bovis_AF2122/97 -------MFTDGGVG------GVGGKGGFGGAG--------------GAG
Rv0278c|M.tuberculosis_H37Rv -------LFATGGVG------GSGGAGSSGGAG--------------GAG
Mflv_5091|M.gilvum_PYR-GCK ------AVGAAGAAG------TVGTAGATGGTG---------------TG
Mvan_1264|M.vanbaalenii_PYR-1 ------AIGTAGVAG------AAGTAGATGGTG---------------VG
MSMEG_0868|M.smegmatis_MC2_155 GTVDGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATG
TH_3810|M.thermoresistible__bu ------------------------------------------------NG
MMAR_4399|M.marinum_M ---------GAGGHG------AAGGDGGAGGDG----------------G
MUL_3062|M.ulcerans_Agy99 ---------GSGGLG------AAGGDGGNGGRA----------------G
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------TTNTEIG---------------------------------SH
MAV_4827|M.avium_104 --------------------------------------------------
Mb0285c|M.bovis_AF2122/97 GNGGLFGAGGTGGAGGTIGAGV---------AGMGGAGGAGGAGGLFGAG
Rv0278c|M.tuberculosis_H37Rv GAGGLFGAGGTGGHGGFADS------------SFGGVGGAGGAGGLFGAG
Mflv_5091|M.gilvum_PYR-GCK ANGGAGGVGGVGGTGAAG--------------AAGGAGGLGETGTTGGAG
Mvan_1264|M.vanbaalenii_PYR-1 GNGGAGQAGGIGGTGAAG--------------AAGQAGTAGETGVTGGVG
MSMEG_0868|M.smegmatis_MC2_155 GDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAG
TH_3810|M.thermoresistible__bu GNVGFFSLFNLGG--------------------AGGWGGSGVDG------
MMAR_4399|M.marinum_M PLAGAGGSGGTGGSGNAG---------------GGAGGAGGNAGLLFGDG
MUL_3062|M.ulcerans_Agy99 LFGGAGGAGGMGATGGHS---------------GGDGGAGGDAGLLFGTG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 NQANIGTSTSAGGSAAVG----------------GNAGLAGNAGLAGNAG
MAV_4827|M.avium_104 PGDDELAYSAVGEEDAES--------------------PTVVIEKLFLPE
Mb0285c|M.bovis_AF2122/97 GTGGS-GGGGATTGGDGGAG------------GAGGFG------------
Rv0278c|M.tuberculosis_H37Rv GEGGS-GGHSLVAGGDGGAGGNAGMLALGAAGGAGGIGG-----------
Mflv_5091|M.gilvum_PYR-GCK GVGGQ--GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG-----
Mvan_1264|M.vanbaalenii_PYR-1 GIGGQ--GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG-----
MSMEG_0868|M.smegmatis_MC2_155 GMGEIYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGG
TH_3810|M.thermoresistible__bu ---------------VDVVGGNP---------------------------
MMAR_4399|M.marinum_M GVGGTGGTSGQGVGGIGGDGGSAGLLFSNGGAGGAG--------------
MUL_3062|M.ulcerans_Agy99 GAGGAGGHAFDGDGGAGGAGGNAGLMFSSGGSGGVG--------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGNAGLAGNAGLAGNAG--------------------------
MAV_4827|M.avium_104 DSEPRRRPVLLVGSGLAVVGISAVLALEIALAIGIR--------------
Mb0285c|M.bovis_AF2122/97 ----------RTTGGIGGTG---GNAGLLNG-------------------
Rv0278c|M.tuberculosis_H37Rv ------DGGTLTAGGIGGAGGAGGNAGLLFG-------------------
Mflv_5091|M.gilvum_PYR-GCK --------LQGGKGGDGGAGGKGGDADSMGS------------------A
Mvan_1264|M.vanbaalenii_PYR-1 --------LQGGQGGDGGTGGTGGDATSMGE------------------A
MSMEG_0868|M.smegmatis_MC2_155 KASGTAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAA
TH_3810|M.thermoresistible__bu ---------------DGGTPG-----------------------------
MMAR_4399|M.marinum_M ------GAGTALISGNGGAGGNGGNGGWLFSN------------------
MUL_3062|M.ulcerans_Agy99 ------GAG----SIDGGAGGAGGDAGWLGG-------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ---------------LAGNAGLAGNAGLAGN-------------------
MAV_4827|M.avium_104 --------------TTGTVALQPTPNQHLIVP------------------
Mb0285c|M.bovis_AF2122/97 --SGGAGGAGGAAIT-----GPGG------------------------TG
Rv0278c|M.tuberculosis_H37Rv --SGGSGGAGGFGFADGGQGGPGGNAGTVFGSGGAGGNGGVGQGFAGGIG
Mflv_5091|M.gilvum_PYR-GCK GATGGKGGNGGNGGRGGLFG----------------------------KG
Mvan_1264|M.vanbaalenii_PYR-1 GATGGKGGNGGNGGRGSLFG----------------------------RG
MSMEG_0868|M.smegmatis_MC2_155 SANGAVGGNGGFTNIAAIHGSITDSSATSGHGG-------------AAQG
TH_3810|M.thermoresistible__bu -AHGESHTPGVYTDRQ----------------------------------
MMAR_4399|M.marinum_M ---GGVGGAGGAGAPAMPSLGISAGS--------------------GGVG
MUL_3062|M.ulcerans_Agy99 ---GGAGGAGGFGT-------ISD----------------------GGAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --AGLAGNAGLAGNAG----------------------------------
MAV_4827|M.avium_104 -TEQAPAPPPVQASAPQPK-------------------------------
Mb0285c|M.bovis_AF2122/97 GAGGIPG----------------------LIGNGGNGGDGGASVTGTGGN
Rv0278c|M.tuberculosis_H37Rv GAGGTPG----------------------LIGNGGNGGNGGASAV-TGGN
Mflv_5091|M.gilvum_PYR-GCK GNAGNGAD----------------------GGTGGAGGAGGTGG--TGGA
Mvan_1264|M.vanbaalenii_PYR-1 GNAGNGGN----------------------GGTGGNGGNGGTGG--TGGN
MSMEG_0868|M.smegmatis_MC2_155 GNGGNGGNGWVQAYDPNGPAGTTIDKGKAAGGNGGDGGFNGTGGA-TGGR
TH_3810|M.thermoresistible__bu ----------------------------------GEDGEDGTGTG-IGGR
MMAR_4399|M.marinum_M GAGGTGGL---------------------LLGNGGAGGAGGTSGN-GGGT
MUL_3062|M.ulcerans_Agy99 GRGGGGGQ---------------------LLGNGGAGGAGGQGGN-DGGA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -----------------------------LAGNAGLAGNAGLAGN-AGLA
MAV_4827|M.avium_104 -----------------------------ISVPEPVAAPKPLSPPVAAPL
Mb0285c|M.bovis_AF2122/97 GGAGG-----------------NGVQIGNGGNGGSGGTGAAAGKAGLGGL
Rv0278c|M.tuberculosis_H37Rv GGIGG-----------------TGVLIGNGGNGGSGGIG--AGKAGVGGV
Mflv_5091|M.gilvum_PYR-GCK GGTGG-----------------TGGTGGIGGAGSTGGTGGTGGTGGTGGT
Mvan_1264|M.vanbaalenii_PYR-1 GGTGG-----------------TGGTGGIGGAGSTGGTGGTGGTGGTGGT
MSMEG_0868|M.smegmatis_MC2_155 GGDGAGASVWKANGQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGA
TH_3810|M.thermoresistible__bu GGNGG----------------SSSGTHPMAEDG--------EHVKALDGR
MMAR_4399|M.marinum_M GGAGGAA--------------GSGVLIGNGGNGGIGGAGPTPGGNGIGGT
MUL_3062|M.ulcerans_Agy99 GGLG-----------------GNGVLIGNGGNGGVGGVGETPGGDGGGGI
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GNAG------------------LAGNAGLAGNAGLAGNAGLAGNAGLAGN
MAV_4827|M.avium_104 PAAP------------------PPAAPPLPEAPPIPAAPPVVPVPVVVPP
Mb0285c|M.bovis_AF2122/97 GGQLIGLDGSNAPVSTS-VHTLQQAALNVVNEPFQTLTGRPLIGNGAN--
Rv0278c|M.tuberculosis_H37Rv SGLLLGLDGFNAPASTSPLHTLQQNVLNVVNEPFQTLTGRPLIGNGANGT
Mflv_5091|M.gilvum_PYR-GCK GGTG-GTGGTGGTGG----------------------TGGKGGTGGTG--
Mvan_1264|M.vanbaalenii_PYR-1 GGTG-GTGGTGGTGG----------------------TGGKGGTGGTG--
MSMEG_0868|M.smegmatis_MC2_155 GGVSEGEGGTGGHGG----------------------DGGRGGDGALG--
TH_3810|M.thermoresistible__bu PGLD---GGNGSHGG----------------------NGGHGGRGGFL--
MMAR_4399|M.marinum_M SGLLLGLDGFNAPTSTSPIHTLQQQALNAINAPIQAATGRPLIGNGTP--
MUL_3062|M.ulcerans_Agy99 SGLLLGADGFNAPAGSSPVHALQQQALAAINAPVQELTGRPLIGNGLP--
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 AGLAGNAAVAGNAAVAG--------------------NAAVAGNAAVG--
MAV_4827|M.avium_104 VPVPVPVRIPVPDPVS---------------------PPQLLAPPRLS--
Mb0285c|M.bovis_AF2122/97 -------------------GTPGTGAAGGAGGWLFGNGGNGGHGATN---
Rv0278c|M.tuberculosis_H37Rv PGTGADGGAGGWLFGNGANGTPGTGAAGGAGGWLFGNGGNGGHGATN---
Mflv_5091|M.gilvum_PYR-GCK -------------------GAGGTG----GDGGTGGTGGTGGTG------
Mvan_1264|M.vanbaalenii_PYR-1 -------------------GDGGTG----GTGGTGGTGGTGGTG------
MSMEG_0868|M.smegmatis_MC2_155 -------------------GNGGTGGVGLGNGGKGGNGGNGGNGGTYVDP
TH_3810|M.thermoresistible__bu -------------------GIGGSG-------GWGGHGGNGGD-------
MMAR_4399|M.marinum_M -------------------GDAGSGTDGTPGGWLLGDGGAGGSGGT----
MUL_3062|M.ulcerans_Agy99 -------------------GSAGSGAAGAPGGWLLGDGGAGGSAAAT---
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -------------------GVLNTG----VSGAIGGSSHVGGAIN-----
MAV_4827|M.avium_104 --------------------VPQPVQPPVRVPQPPSPPQVGGTVPQS---
Mb0285c|M.bovis_AF2122/97 --TAATATGGAGGAGG--------ILFGTGGNGGTGGIATGAGGIGGAGG
Rv0278c|M.tuberculosis_H37Rv --TAATATGGAGGAGG--------ILFGTGGNGGTGGIATGAGGIGGAGG
Mflv_5091|M.gilvum_PYR-GCK ---GTGGTGGTGGAG-----------DGTGGTGGTGG----TGGQGGQGG
Mvan_1264|M.vanbaalenii_PYR-1 ---GTGGTGGTGGAG-----------DGLGGTGGTGG----TGGFGGQGG
MSMEG_0868|M.smegmatis_MC2_155 SHTGAGGNGGNGGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGG
TH_3810|M.thermoresistible__bu ----TDADGGNGGDG---------------GNGGSAG-------------
MMAR_4399|M.marinum_M -----GLDGGDGGAAG------------LMGTGGTGGAGGWGGTDEITGG
MUL_3062|M.ulcerans_Agy99 ----PGAAGGAGGAAG------------LVGAGGAGGAG--ANTGISNPG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -----ESLGGSGSVGG--------------STAVGGG-------------
MAV_4827|M.avium_104 ----PPQHQTPPGEGT---------------PPKPDG-------------
Mb0285c|M.bovis_AF2122/97 AGG-----------VSLLIGSGGTGGNGGNSIGVAGIGGAGGRGGDAG--
Rv0278c|M.tuberculosis_H37Rv AGG-----------VSLLIGSGGTGGNGGNSIGVAGIGGAGGRGGDAG--
Mflv_5091|M.gilvum_PYR-GCK QGG-----------------TGGTGG------QGG-LGGGGGTG------
Mvan_1264|M.vanbaalenii_PYR-1 QGG-----------------TGGTGG------QGG-LGGVGGTG------
MSMEG_0868|M.smegmatis_MC2_155 DGGEALIRATVIGSNASGTATGGDGG------NGGTLGATNGTGGAATIV
TH_3810|M.thermoresistible__bu --------------------RGGTGG------LRGVFGINGGNG------
MMAR_4399|M.marinum_M TGG-----------------AGGTGGGGGWLSGSGGIGGGGGAGGYGGAI
MUL_3062|M.ulcerans_Agy99 FGG-----------------AGGAGG--------AGAGAGGGVG------
MLBr_01183|M.leprae_Br4923 ------------------------------------MPLFLN--------
MAB_4284c|M.abscessus_ATCC_199 -------------------AHTGVGG-----------GVSTGVG------
MAV_4827|M.avium_104 --------------------PGNYGG-----------GHVPTPG------
Mb0285c|M.bovis_AF2122/97 --------------LLFGAAGTGGHGAAGGVPAGVGGAGGNG-----GLF
Rv0278c|M.tuberculosis_H37Rv --------------LLFGAAGTGGHGAAGGVPAGVGGAGGNG-----GLF
Mflv_5091|M.gilvum_PYR-GCK -----------------GQGGTGGTGGQGGT-GGTGGTGGTG--------
Mvan_1264|M.vanbaalenii_PYR-1 -----------------GTGGTGGTGGQGGT-GGTGGTGGTG--------
MSMEG_0868|M.smegmatis_MC2_155 AYNVVQANPQASGTATDGHGGSGINGGHGGN-GGQGTIEANGPSAVASGI
TH_3810|M.thermoresistible__bu ------------------RAGLGGRGXXXXG-GGVGAAVRSG--------
MMAR_4399|M.marinum_M I---------PGNGGAGGSAGAGGAGGLFGG-GGTGGAGGTGGPAGLGVF
MUL_3062|M.ulcerans_Agy99 --------------------EAGGAGGLLGA-GGTGGGGGVA--------
MLBr_01183|M.leprae_Br4923 -------------------AEPQALTAAANTLEGLSAATVAS--------
MAB_4284c|M.abscessus_ATCC_199 -------------------VGSHVGGGISESLGGSGSVGGST--------
MAV_4827|M.avium_104 ------------------AGGSGGSGGGHVPTPGAGGSGGSG--------
* .
Mb0285c|M.bovis_AF2122/97 ANGGAGGAGGFNAAGGNGGNGGLFGTGGTGGAGTNFGAGGNGGNGGLFGA
Rv0278c|M.tuberculosis_H37Rv ANGGAGGAGGFNAAGGNGGNGGLFGTGGTGGAGTNFGAGGNGGNGGLFGA
Mflv_5091|M.gilvum_PYR-GCK GTGGAGGDGGLGGLGGFGGSGGTGGQGGLGGPGGSTGGAGGAGG--QAGT
Mvan_1264|M.vanbaalenii_PYR-1 GTGGAGGDGGLGGLGGFGGVGGTGGQGGQGGPGGSTGGAGGAGG--QAGV
MSMEG_0868|M.smegmatis_MC2_155 GAGGNGGDGIDGGLGGNGGDGVVNTTANAANPGSATGTATGGDGGKATGT
TH_3810|M.thermoresistible__bu -------NGVFSGGGGTPSAGFGVPTTIQFPAGSCTSRAVSREG------
MMAR_4399|M.marinum_M VGVPTFGDGGGGGAGGAGGAG--GLLSGLVGAGGGDGGAGGQGGIGFGGS
MUL_3062|M.ulcerans_Agy99 ---PSLVDGGTGGAGGAGGAG--GLFGGIFGAGGGDGGAGGFT----GGI
MLBr_01183|M.leprae_Br4923 ---NAAAAQLTTEIAPPAADDVSILLAHFFSGHGRQYQAHASQG------
MAB_4284c|M.abscessus_ATCC_199 ----AVGGGAHTGVGGGVSTGVGVGSHVGGGISESLGGSGSVGGSTAVGG
MAV_4827|M.avium_104 --------GGHVPTPGTGGPGGTGGSGGGHVPTPGAGTPGGSGG------
. .
Mb0285c|M.bovis_AF2122/97 GGTGGAAG-----SGGSGITTGGGGHGGNAGLLSLGASGGAGGSG-----
Rv0278c|M.tuberculosis_H37Rv GGTGGAAG-----SGGSGITTGGGGHGGNAGLLSLGASGGAGGSG-----
Mflv_5091|M.gilvum_PYR-GCK AGKGGLFG----GSGSAGKAGATGAAGASGGKGAQGATGAQGATG-----
Mvan_1264|M.vanbaalenii_PYR-1 AGKGGLFG----GSGSAGTAGVTGASGASGGKGAQGATGAQGATG-----
MSMEG_0868|M.smegmatis_MC2_155 ASQGGNGGPSWVQSGYGSTLGGNATGTATAGKGGEASNGGVAGNGGNALV
TH_3810|M.thermoresistible__bu ------------------IMPSSRAASARAG-------------------
MMAR_4399|M.marinum_M GGSGGGGG----VGGNAGLLGGPGGAGGSGGAAGPALFGIGVDGT-----
MUL_3062|M.ulcerans_Agy99 DGAGGVGG----AGGNTGLLGGPGGSGGSGGD-GIAKLGFNVDG------
MLBr_01183|M.leprae_Br4923 ------------ATNHQDLIQSLLTSS-----------------------
MAB_4284c|M.abscessus_ATCC_199 GAHTGVGG---------GVNTGVGVGSHVGGGISESLGGSGSVGG-----
MAV_4827|M.avium_104 -----------------GHLPFPGAGSTPGG-------------------
Mb0285c|M.bovis_AF2122/97 ---GASSLAGGAGGTGGNGALLFGFGGAGGAG-------------GHGGA
Rv0278c|M.tuberculosis_H37Rv ---GASSLAGGAGGTGGNGALLFGFRGAGGAG-------------GHGGA
Mflv_5091|M.gilvum_PYR-GCK -AQGATG-ATGAAGKAGATGAAGAAGAAGSAG-----------TTGAQGS
Mvan_1264|M.vanbaalenii_PYR-1 -AQGATG-ATGASGAQGSAGSAGSAGVAGSAG-----------TTGAQGS
MSMEG_0868|M.smegmatis_MC2_155 MAAGTTGVATGNTATGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAI
TH_3810|M.thermoresistible__bu --------AACASSTSRSRRSFCCSRA-----------------------
MMAR_4399|M.marinum_M ---------AGVGGAGGNAGLLFGSGGAGGDG--------------GFG-
MUL_3062|M.ulcerans_Agy99 ----------GAGGAGVNGGFLFGSGGTGGFG--------------GVGG
MLBr_01183|M.leprae_Br4923 --------SAYAGTETANHDSL----------------------------
MAB_4284c|M.abscessus_ATCC_199 --------STAVGGGAHTSAINDALGGSGSVG------------------
MAV_4827|M.avium_104 ----------SGGGHLPTPGAGTPGGGLGGFG------------------
Mb0285c|M.bovis_AF2122/97 ALTSIQQGGAGGAGGNGGLLFGSAGAGGAGGSGAN-ALGAGTGGTGGDGG
Rv0278c|M.tuberculosis_H37Rv ALTSIQQGGAGGAGGNGGLLFGSAGAGGAGGSGAN-ALGAGTGGTGGDGG
Mflv_5091|M.gilvum_PYR-GCK AGTNGA-NGANGSQGAAGKAGATGTTGATG--------AAGEDGDAGSGG
Mvan_1264|M.vanbaalenii_PYR-1 AGTNGA-NGANGSQGAAGKAGATGTTGATG--------AAGDAGDPGSEA
MSMEG_0868|M.smegmatis_MC2_155 SGHGGAGNGGNGGKGADGWVQAYDPAGPVGSKIANSSAVAGNGGDGGVNG
TH_3810|M.thermoresistible__bu --------------------------------------------------
MMAR_4399|M.marinum_M ----PGAGGTGGRGGNAGLLFSSAGAGGFGGYGTTGGGTGGAGGDAGWLG
MUL_3062|M.ulcerans_Agy99 VGTSTGIGGAGGRGGNAGLLFSDAGVGGFGGFG-------GTGGNAGWLG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --GSTAVGGGAHTSAINESMNSSINASHSSSMNESFGSSMGSHGAAG---
MAV_4827|M.avium_104 --------GGHAPAPGGGLGGGGGHAPAPG--------------------
Mb0285c|M.bovis_AF2122/97 HAGVFGN-GGDGGAGGFG----------AGTGGSGGVGGNAVLIGNGGNG
Rv0278c|M.tuberculosis_H37Rv HAGVFGN-GGDGGCRRVWRRYRRQRWCRRQRRADRQRRQRRQRRQSRGHA
Mflv_5091|M.gilvum_PYR-GCK SG-INGGAGGAGG-----------AGGEGGEGGDGGKGGAGAEGGAGGGG
Mvan_1264|M.vanbaalenii_PYR-1 VD-INGGAGGAGG-----------AGGEGGEGGAGGAGGDGSEGGAGGSG
MSMEG_0868|M.smegmatis_MC2_155 TGGASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPGGNG
TH_3810|M.thermoresistible__bu --------------------------------------------------
MMAR_4399|M.marinum_M CGGAGGAGGITIGGTGGTGGAGGTGGQLLGAGGAGGAGGQTDPLG-GSTG
MUL_3062|M.ulcerans_Agy99 SGGSGGAGGGSNG-DGGAGGTGGSGGQIVGDGGAGGAGGQGDLLAAGGSG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----------------------------TGFEAQGHAQGHASETAHTTLP
MAV_4827|M.avium_104 -------------------------------GGLGGFGGGHSGGGLGGLG
Mb0285c|M.bovis_AF2122/97 GNAGKAGATPG-----AGGTGGLLLG-----ENGLNGLP-----------
Rv0278c|M.tuberculosis_H37Rv RCRRHRRAAAR-----RERTQRLAIAGRPATTRGVEGISCSPQMMP----
Mflv_5091|M.gilvum_PYR-GCK GAGGSGAGGAG-------GAGGSGGSGGSGGSGGSGGAAGDSDD------
Mvan_1264|M.vanbaalenii_PYR-1 GAGGSGTGGAG-------GAGGSGGSGGSGGAGGSGGAAGDSD-------
MSMEG_0868|M.smegmatis_MC2_155 AGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP---
TH_3810|M.thermoresistible__bu --------------------------------------------------
MMAR_4399|M.marinum_M GSGGVGGNAVLIGTGGNGGNGGAGTAKGTPGTGGTGG-LIGVDGLSGAS-
MUL_3062|M.ulcerans_Agy99 GDGGQGGDAVLIGTGGNGGNGASGVLAGIGGDGGSRGLLLGEDGVNGEAA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GAEHH---------------------------------------------
MAV_4827|M.avium_104 GGHK----------------------------------------------
Mb0285c|M.bovis_AF2122/97 ------------------
Rv0278c|M.tuberculosis_H37Rv ------------------
Mflv_5091|M.gilvum_PYR-GCK ------------------
Mvan_1264|M.vanbaalenii_PYR-1 ------------------
MSMEG_0868|M.smegmatis_MC2_155 ------------------
TH_3810|M.thermoresistible__bu ------------------
MMAR_4399|M.marinum_M ------------------
MUL_3062|M.ulcerans_Agy99 PPMTHIVLLGGDFPAAAS
MLBr_01183|M.leprae_Br4923 ------------------
MAB_4284c|M.abscessus_ATCC_199 ------------------
MAV_4827|M.avium_104 ------------------