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AFFLVVATALTWMVYVTLRRDVKGPTARYGALFTDVFGLREGDDVRVAGVRVGRVQKVELDQTLARVSFI VQQGQPILTDTIASITYQNIVGQRYLALAPGRTGRGIPIPPGSVIPVERTEPSFDIGTLLNGYEPLFAVL DPDQVNNFTKAVIASLQGDTSALATLVDQTSMLTATFAGNDDALANVIGSLDRVAGSLASQSAEFEHTIA QTRQMVSQFNSRRSELVESTGNMAAVVRQLGGILADVNPQIRQILDRQPGYTKHLLDIEPQAAFVGMNTP LLLKGLARVFGQGTYMNVYGCDVNFYGYFPGLNDMVPIIVAAATPGGKPMYTPKCRNVTDG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4918 | mce6B | - | 100% (342) | MCE-family protein Mce6B |
| M. ulcerans Agy99 | MUL_3797 | mce5B | e-114 | 57.89% (342) | Mce family protein, Mce5B |
| M. ulcerans Agy99 | MUL_1063 | mce1B | 5e-38 | 30.35% (313) | MCE-family protein Mce1B |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0605 | mce2B | 7e-41 | 32.01% (303) | MCE-family protein MCE2B |
| M. gilvum PYR-GCK | Mflv_0009 | - | 1e-113 | 55.85% (342) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv0590 | mce2B | 1e-37 | 35.92% (245) | MCE-family protein MCE2B |
| M. leprae Br4923 | MLBr_02590 | mce1B | 1e-40 | 30.42% (309) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_1696 | - | 1e-133 | 68.13% (342) | putative Mce family protein |
| M. marinum M | MMAR_0178 | mce6B | 0.0 | 99.12% (342) | MCE-family protein Mce6B |
| M. avium 104 | MAV_2387 | - | 1e-121 | 60.53% (342) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_1144 | - | 1e-114 | 57.60% (342) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3156 | - | 1e-116 | 57.60% (342) | PUTATIVE virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0960 | - | 1e-116 | 58.48% (342) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4918|M.ulcerans_Agy99 ---------------MAFFLVVATALTWMVYVTLRRDVKGPTARYGALFT
MMAR_0178|M.marinum_M MTSPRTRTRRGALLWVAFFLVVATALTWMVYVTLRRDVKGPTARYGALFT
MAB_1696|M.abscessus_ATCC_1997 ---MRGTAARGPLIGLAVFLVIATALTWLVYVTLRRDVKGATVSYGAMFT
Mflv_0009|M.gilvum_PYR-GCK ------MKYRGPLIGLSLFMIVAITLTWLVYVTLRRDVAGEKVPYSAMFT
Mvan_0960|M.vanbaalenii_PYR-1 ------MKYRGALVGLSLFMVVAVTLTWLVYVTLRRDVAGSTAPYAAVFT
MSMEG_1144|M.smegmatis_MC2_155 ------MKIRGALIGLSLFMVVALTLTWMVYVTLRRDVAGRTVPYTAVFT
TH_3156|M.thermoresistible__bu ------MRSRGALIGLSLFMAVAVVLTWLVYVTLRRDVAGSTVPYSAVFT
MAV_2387|M.avium_104 ------MRFRGPLIALTLFMIVSLTLTWLVYVSLRRDVAGDTARYSAVFS
Mb0605|M.bovis_AF2122/97 ------MKTTGTTIKLGIVWLVLSVFTVMIIVVFGQVRFHHTTGYSAVFT
Rv0590|M.tuberculosis_H37Rv ------MKTTGTTIKLGIVWLVLSVFTVMIIVVFGQVRFHHTTGYSAVFT
MLBr_02590|M.leprae_Br4923 ------MKLTGTVVRLSIFSLVLLLFTVMIIVVFGQMRFGRTNGYTAEFT
: .. : :* :: * : : . * * *:
MUL_4918|M.ulcerans_Agy99 DVFGLREGDDVRVAGVRVGRVQKVELDQ--TLARVSFIVQQGQPILTDTI
MMAR_0178|M.marinum_M DVFGLREGDDVRVAGVRVGRVQKVELDQ--TLARVSFIVQQGQPILTDTI
MAB_1696|M.abscessus_ATCC_1997 DVFGLREGDDVRIAGVRVGRVQHIELVG--TTAKVSFAVQDGQRLPASIN
Mflv_0009|M.gilvum_PYR-GCK DVFGLREGDDVRMAGVRVGRVEKIELDG--KLAKVSFVVQGDQQVLGTTV
Mvan_0960|M.vanbaalenii_PYR-1 DVFGLREGDDVRMAGVRVGRVEKIELQG--DLAKVSFVVQNDQQVLGTTV
MSMEG_1144|M.smegmatis_MC2_155 DVFGLREGDDVRMAGVRVGRVEKIELDG--KHAKVSFVVQADQQVFGNTV
TH_3156|M.thermoresistible__bu DVFGLREGDDVRMAGVRVGRVERIELDG--KYAKVSFVVQSDQQVLGNTV
MAV_2387|M.avium_104 DVYGLREGDDVRMAGVRVGRVEKIELDG--KLAKVSFVVQSEQRLYGNTL
Mb0605|M.bovis_AF2122/97 HVSGLRAGQFVRAAGVEVGKVAKVTLIDGDKQVLVDFTVDRSLSLDQATT
Rv0590|M.tuberculosis_H37Rv HVSGLRAGQFVRAAGVEVGKVAKVTLIDGDKQVLVDFTVDRSLSLDQATT
MLBr_02590|M.leprae_Br4923 NISGLRTGQFVRASGVEVGKVNSVALINGGTRVRVKFNVDRSVPLYQSTT
.: *** *: ** :**.**:* : * . *.* *: :
MUL_4918|M.ulcerans_Agy99 ASITYQNIVGQRYLALAPGR-TGRGIPIPPGSVIPVERTEPSFDIGTLLN
MMAR_0178|M.marinum_M ASITYQNIVGQRYLALAPGR-TGRGIPIPPGSVIPVERTEPSFDIGTLLN
MAB_1696|M.abscessus_ATCC_1997 ASVTYQNIVGQRYLALTQTH-PDQGGLLAPGAVIPVERTEPSFDIGTLLN
Mflv_0009|M.gilvum_PYR-GCK ASVTYQNIVGQRYLGLTLGS-QGEPVPLPAGSVLPLERSDPSFDVTTLLN
Mvan_0960|M.vanbaalenii_PYR-1 ASVTYQNIVGQRYLGLSLGN-TGDPRPLPAGSVIPLERSEASFDVTTLLN
MSMEG_1144|M.smegmatis_MC2_155 ASVTYQNIVGQRYLGLSLGK-EGDPTLLAAGSVIPLERTDPSFDVGTLLN
TH_3156|M.thermoresistible__bu ASVTYQNIVGQRYLGLSLGN-LGDPHPLPPGATIPVEQTDPSFDVGALLN
MAV_2387|M.avium_104 ASVTYQNIVGQRYLGLSLGK-EGNPAQLPPGSTIPLERTEPSFDVTTLLN
Mb0605|M.bovis_AF2122/97 ASIRYLNLIGDRYLELGRG---HSGQRLAPGATIPLEHTHPALDLDALLG
Rv0590|M.tuberculosis_H37Rv ASIRYLNLIGDRYLELGRG---HSGQRLAPGATIPLEHTHPALDLDALLG
MLBr_02590|M.leprae_Br4923 AQIRYLDLIGNRYLELKHGEGQGSEKIMPAGGLIPLSRTSPALDLDALIG
*.: * :::*:*** * :..*. :*:.:: .::*: :*:.
MUL_4918|M.ulcerans_Agy99 GYEPLFAVLDPDQVNNFTKAVIASLQGDTSALATLVDQTSMLTATFAGND
MMAR_0178|M.marinum_M GYEPLFAVLDPDQVNNFTKAVIASLQGDTSALATLVDQTSTLTATFAGND
MAB_1696|M.abscessus_ATCC_1997 GYEPLFAVLDPAQVNNLTQAVIGSLQGDTAAFATLVDQTSTLTKTFTGRD
Mflv_0009|M.gilvum_PYR-GCK GYEPLFSLLDPQAADDLTQGVIQSLQGDEASLVALVDQTSQLTESFAGHD
Mvan_0960|M.vanbaalenii_PYR-1 GYEPLFSLLNPRDADNLTQGVIQSLQGDEASIVGLVDQTSQLTESLAGRD
MSMEG_1144|M.smegmatis_MC2_155 GYEPLFSVLDPKYANNLTEGVIQSLQGDQGSITALIDQTAQLTEAFAGRE
TH_3156|M.thermoresistible__bu GYEPLFSVLDPKHADNLTKGVIESLQGDEASITALVDQTAQLTEAFAGRD
MAV_2387|M.avium_104 GYEPLFSLLNPHDADNLTKGIIASLQGDTSSLATLVGQTSTLTQTFAGRD
Mb0605|M.bovis_AF2122/97 GFRPLFQTLDPDKVNSIASSIITVFQGQGATINDILDQTASLTATLADRD
Rv0590|M.tuberculosis_H37Rv GFRPLFQTLDPDKVNSIASSIITVFQGQGATINDILDQTASLTATLADRD
MLBr_02590|M.leprae_Br4923 GFKPLFRALDPDKINTIASAIVAAFQGQGGTINDILDQTAQLTTAIGERD
*:.*** *:* : ::..:: :**: .:: ::.**: ** :: .:
MUL_4918|M.ulcerans_Agy99 DALANVIGSLDRVAGSLASQSAEFEHTIAQTRQMVSQFNSRRSELVESTG
MMAR_0178|M.marinum_M DALGNVIGSLDRVAGSLASQSAEFEHTIAQTRQMVSQFNSRRSELVESTG
MAB_1696|M.abscessus_ATCC_1997 DALDHVIASLDTVVGTLAAQNRDFEDAIGATRQVVDHFDSRRPELVSSVG
Mflv_0009|M.gilvum_PYR-GCK EELGAVITDLNTVMSNLAKHNDSMDQVLTETQAAVSIFDAQRQELVDSTG
Mvan_0960|M.vanbaalenii_PYR-1 EELGTVITDLNAVMGNLARHNDSLDQVLTQVQSAVTTFDGQRQELVDSTG
MSMEG_1144|M.smegmatis_MC2_155 EELGSVITDLNAVAANLARHNDDLDHIVSEAQSVVATFEARRPELVESMG
TH_3156|M.thermoresistible__bu EELGAVITDLNTVVANLARHNDDLDHVIGEARSVVSTFDDRRDQLIDSMG
MAV_2387|M.avium_104 QALGNVITNLNKVVGNLAAQNDNLDGVITQTRSVVGELDRRRPDLVASVG
Mb0605|M.bovis_AF2122/97 HAIGEVVNNLNTVLATTVKHQTEFDRTVDKLEVLITGLKNRADPLAAAAA
Rv0590|M.tuberculosis_H37Rv HAIGEVVNNLNTVLATTVKHQTEFDRTVDKLEVLITGLKNRADPLAAAAA
MLBr_02590|M.leprae_Br4923 QAIGEVVKNLNVVLDTTVRHRKEFDQTVNNLEILITGLKDHGDQLAGSFA
. : *: .*: * . . : .:: : . : :. : * : .
MUL_4918|M.ulcerans_Agy99 NMAAVVRQLGGILADVNPQIRQILDRQPGYTKHLLDIEPQAAFVGMNTPL
MMAR_0178|M.marinum_M NMAAVVRQLGGILADVNPQIHQILDRQPGYTKHLLDIEPQAAFVGMNTPL
MAB_1696|M.abscessus_ATCC_1997 KMTEVVRNLSRIARDVDPSVHELLTREPGYTRHMLDIEPQIAYTGLNTPL
Mflv_0009|M.gilvum_PYR-GCK SISRVVSRLSTVSDDVYPSLNELIEREPGFAQHLVSIEPQLAFTGANLPL
Mvan_0960|M.vanbaalenii_PYR-1 SMARVVRQLSTISDEVYPSLNELITREPGFTQHMVSIEPQLAFTGANLPL
MSMEG_1144|M.smegmatis_MC2_155 SIAKVVRQLSTISDEVYPSLSEMVQRQPGFAAHMLGIEPQLAFVGANLPL
TH_3156|M.thermoresistible__bu SAAKVIRQLSAISDEVYQPLNEMVQREPGFAKHMLGIEPQLAFVGANLPL
MAV_2387|M.avium_104 SLARLSDRLSASAADVYPALREFIDRQPGVTKHIMDVEPQVAFFGDNIPL
Mb0605|M.bovis_AF2122/97 HISSAAGTLADLLGADRPLLHSSFGHLEGIQQPLIDELAELDHVLGKLPD
Rv0590|M.tuberculosis_H37Rv HISSAAGTLADLLG------------------------------------
MLBr_02590|M.leprae_Br4923 HISNAAGTVANLLAEDHALLHKSINYLDGIQQPLIDQRLQLEDYLHKLPT
: :.
MUL_4918|M.ulcerans_Agy99 LLKGLARVFGQ-GTYMNVYGCDVNFYGYFPGLNDMVPIIVAAATPGGKPM
MMAR_0178|M.marinum_M LLKGLARVFGQ-GTYMNVYGCDVNFYGYFPGLNDMVPIIVAAATPGGKPM
MAB_1696|M.abscessus_ATCC_1997 FLKGLARMFGE-GAYMNAYACDVNPYGFFPGLNEVVPIIVDAATPGNKAK
Mflv_0009|M.gilvum_PYR-GCK LLKGFARITSE-GAYANAYACDLNATGFFPGLNDVTPIIVDAATPGNDAQ
Mvan_0960|M.vanbaalenii_PYR-1 LLKGFARITGE-GAYANAYACDLNIQGFFPGLNDVVPIIVDAATPGNDAR
MSMEG_1144|M.smegmatis_MC2_155 MLKGFARITQE-GTYANAYLCDLNATAFFPGLNDVTPIIVDAATPGNKAQ
TH_3156|M.thermoresistible__bu MLKGFARVTGE-GTYANAYACNLDGTAFFPGLNDITPIIVAAATPGNKAR
MAV_2387|M.avium_104 LLKGLTRVGNQ-GAYGNAYVCDVNFMGFFPGLNDVVPIIINAATPGNRAW
Mb0605|M.bovis_AF2122/97 AYRIIGRAGGIYGDFFNFYLCDI--SLKVNGLQPGGPVRTVKLFGQPTGR
Rv0590|M.tuberculosis_H37Rv --RIVHCCT------------------AASGTSRASSSRS----------
MLBr_02590|M.leprae_Br4923 VLNQIGRTIGSYGDFVNFYSCDI--TLKINGLQPGGPVRTVRLFQQPTGR
. . * . .
MUL_4918|M.ulcerans_Agy99 YTPKCRNVTDG-
MMAR_0178|M.marinum_M YTPKCRNVTDG-
MAB_1696|M.abscessus_ATCC_1997 HTARCRNAGDGG
Mflv_0009|M.gilvum_PYR-GCK YSPKCRNMANG-
Mvan_0960|M.vanbaalenii_PYR-1 YTPKCRNMANG-
MSMEG_1144|M.smegmatis_MC2_155 HTPKCRSMANG-
TH_3156|M.thermoresistible__bu YTPKCRNLANG-
MAV_2387|M.avium_104 HTPRCRSTVDG-
Mb0605|M.bovis_AF2122/97 CTPQ--------
Rv0590|M.tuberculosis_H37Rv ------------
MLBr_02590|M.leprae_Br4923 CTPQ--------