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MKTTGTTIKLGIVWLVLSVFTVMIIVVFGQVRFHHTTGYSAVFTHVSGLRAGQFVRAAGVEVGKVAKVTL IDGDKQVLVDFTVDRSLSLDQATTASIRYLNLIGDRYLELGRGHSGQRLAPGATIPLEHTHPALDLDALL GGFRPLFQTLDPDKVNSIASSIITVFQGQGATINDILDQTASLTATLADRDHAIGEVVNNLNTVLATTVK HQTEFDRTVDKLEVLITGLKNRADPLAAAAAHISSAAGTLADLLGRIVHCCTAASGTSRASSSRS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0590 | mce2B | - | 100% (275) | MCE-FAMILY PROTEIN MCE2B |
| M. tuberculosis H37Rv | Rv0170 | mce1B | 1e-89 | 64.59% (257) | MCE-family protein MCE1B |
| M. tuberculosis H37Rv | Rv1967 | mce3B | 4e-59 | 47.43% (253) | MCE-family protein MCE3B |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0605 | mce2B | 1e-141 | 100.00% (255) | MCE-family protein MCE2B |
| M. gilvum PYR-GCK | Mflv_0710 | - | 1e-100 | 73.62% (254) | virulence factor Mce family protein |
| M. leprae Br4923 | MLBr_02590 | mce1B | 7e-90 | 64.98% (257) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4152c | - | 4e-52 | 44.40% (250) | MCE-family protein |
| M. marinum M | MMAR_0413 | mce1B | 6e-91 | 65.12% (258) | MCE-family protein Mce1B |
| M. avium 104 | MAV_4550 | - | 1e-112 | 80.39% (255) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0135 | - | 2e-94 | 69.29% (254) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3551 | - | 1e-102 | 73.83% (256) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_1063 | mce1B | 9e-91 | 65.12% (258) | MCE-family protein Mce1B |
| M. vanbaalenii PYR-1 | Mvan_0135 | - | 3e-99 | 72.44% (254) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0590|M.tuberculosis_H37Rv MKTTGTTIKLGIVWLVLSVFTVMIIVVFGQVRFHHTTGYSAVFTHVSGLR
Mb0605|M.bovis_AF2122/97 MKTTGTTIKLGIVWLVLSVFTVMIIVVFGQVRFHHTTGYSAVFTHVSGLR
MAV_4550|M.avium_104 MRITGTAVKLVVFWSVLAMFTVMIIVVFGQVRFDRTTGYSAVFTDAGGLR
MSMEG_0135|M.smegmatis_MC2_155 MSIKGTLFKLGIFSLVLLTFTALIFVVFGQIRFNRTTEYSAIFKNVSGLR
TH_3551|M.thermoresistible__bu MKITGTAIKLGAFSVVLLVFTALIVVVFGQVRFDRTTGYTAVFSSASGLR
Mflv_0710|M.gilvum_PYR-GCK MKITGTAIKLGAFALVLLMFTAIIIVVFGQMRFDRTTGYSAIFSNASGLR
Mvan_0135|M.vanbaalenii_PYR-1 MKITGTAIKLGAFSLVLLMFTAIIIVVFGQMRFDRTTGYSAIFSSASGLR
MMAR_0413|M.marinum_M MKITGTAIRLGIFSLVLMLFSVMIIIVFGQIRFDRTYAYSAEFSNASGLR
MUL_1063|M.ulcerans_Agy99 MKITGTAIRLGIFSLVLMLFSVMIIIVFGQIRFDRTYAYSAEFSNASGLR
MLBr_02590|M.leprae_Br4923 MKLTGTVVRLSIFSLVLLLFTVMIIVVFGQMRFGRTNGYTAEFTNISGLR
MAB_4152c|M.abscessus_ATCC_199 MKR-ATQIKVIVFTVVMLLVAAGLIITFGEFRFGSGKRYHAMFSTASDLR
* .* .:: . *: .:. :.:.**:.** * * *. ..**
Rv0590|M.tuberculosis_H37Rv AGQFVRAAGVEVGKVAKVTLIDGDKQVLVDFTVDRSLSLDQATTASIRYL
Mb0605|M.bovis_AF2122/97 AGQFVRAAGVEVGKVAKVTLIDGDKQVLVDFTVDRSLSLDQATTASIRYL
MAV_4550|M.avium_104 AGQFVRASGVEVGKVAAVTLSGKDSRVLVEFNVDRSLALDQGTTASIRYL
MSMEG_0135|M.smegmatis_MC2_155 DGQFVRAAGVEVGKVKSVDLINGGEQAEVKFTVERSLPLFQETTAAIRYQ
TH_3551|M.thermoresistible__bu AGQFVRAAGVEVGKVSKVELIDGGQRVRVDFNVDRSLPLFQDTTATIRYL
Mflv_0710|M.gilvum_PYR-GCK SGQFVRASGVEVGKVKGVELIDNGSKVRVDFDVDRSLELFDETTASVRYL
Mvan_0135|M.vanbaalenii_PYR-1 PGQFVRASGVEVGKVKGVELIEGGSKVRVDFNVDRSLELFDESTASIRYL
MMAR_0413|M.marinum_M PGQFVRASGVEIGKVKSVSLIDGGKRVRVNFDVDRSVPLYQSTSAQIRYL
MUL_1063|M.ulcerans_Agy99 PGQFVRASGVEIGKVKSVSLIDGGKRVRVNFDVDRSVPLYQSTSAQIRYL
MLBr_02590|M.leprae_Br4923 TGQFVRASGVEVGKVNSVALINGGTRVRVKFNVDRSVPLYQSTTAQIRYL
MAB_4152c|M.abscessus_ATCC_199 SGQKVRIAGVPVGRVKNVSL-NRDNSVEVTFDVDSKYQLYSSSRAIIRYE
** ** :** :*:* * * . . * * *: . * . : * :**
Rv0590|M.tuberculosis_H37Rv NLIGDRYLELGRGH---SGQRLAPGATIPLEHTHPALDLDALLGGFRPLF
Mb0605|M.bovis_AF2122/97 NLIGDRYLELGRGH---SGQRLAPGATIPLEHTHPALDLDALLGGFRPLF
MAV_4550|M.avium_104 NLIGDRYLELKRGT---SGRRLPPGGRIPVEHTQPALDLDALIGGFRPLF
MSMEG_0135|M.smegmatis_MC2_155 DLIGNRYLELKRGD---SDQILPPGSTIPVERTEPALDLDALVGGFRPLF
TH_3551|M.thermoresistible__bu NLIGDRYLELKRGN---SNERLPAGGEIPLERTQPALDLDALVGGFRPLF
Mflv_0710|M.gilvum_PYR-GCK NLIGDRYLELARGD---SNTRLAAGGTIPVERTQPALDLDALIGGFRPVF
Mvan_0135|M.vanbaalenii_PYR-1 NLIGDRYLELARGE---SNTRMAAGGTIPIERTQPALDLDALIGGFRPVF
MMAR_0413|M.marinum_M DLIGNRYLELKRGEGDGSDRIMPPGGFIPLSRTSPALDLDALIGGFKPVF
MUL_1063|M.ulcerans_Agy99 DLIGNRYLELKRGEGDGSDRIMPPGGFIPLSRTSPALDLDALIGGFKPVF
MLBr_02590|M.leprae_Br4923 DLIGNRYLELKHGEGQGSEKIMPAGGLIPLSRTSPALDLDALIGGFKPLF
MAB_4152c|M.abscessus_ATCC_199 NLVGDRYLEITAGPG--ELHKLPDGGTLDKEHTQPALDLDALLGGLRPVL
:*:*:****: * . :. *. : .:* ********:**::*::
Rv0590|M.tuberculosis_H37Rv QTLDPDKVNSIASSIITVFQGQGATINDILDQTASLTATLADRDHAIGEV
Mb0605|M.bovis_AF2122/97 QTLDPDKVNSIASSIITVFQGQGATINDILDQTASLTATLADRDHAIGEV
MAV_4550|M.avium_104 QALDPNKVNSIAQSIITVFQGQGATITDILDQTAALTAALADRDKAIGEV
MSMEG_0135|M.smegmatis_MC2_155 RSLEPEKVNTIATSLITIFQGQGGTINDILDQTAQLTASLADRDQAIGEV
TH_3551|M.thermoresistible__bu RALDAEKVNTIAQSIITVFQGQGGTINDILDQTAQLTATLADRDQAIGEV
Mflv_0710|M.gilvum_PYR-GCK QSLDPEKVNTIAQSLITVFQGQGGTINDILDQTASLTSALADRDQAIGEV
Mvan_0135|M.vanbaalenii_PYR-1 QSLEPEKVNTIAQSIITVFQGQGGTINDILDQTASLTSALADRDQAIGEV
MMAR_0413|M.marinum_M RALDPDKVNTIASALVTVFQGQGGTINDILDQTAQLTSQLAERDQAIGEV
MUL_1063|M.ulcerans_Agy99 RALDPDKVNTIASALVTVFQGQGGTINDILDQTAWLTSQLAERDQAIGEV
MLBr_02590|M.leprae_Br4923 RALDPDKINTIASAIVAAFQGQGGTINDILDQTAQLTTAIGERDQAIGEV
MAB_4152c|M.abscessus_ATCC_199 KGFDAAKVNEISNAFIQILQGQGGTLSQLLGDTSSFTSGLAERDQLIGDV
: ::. *:* *: ::: :****.*:.::*.:*: :*: :.:**: **:*
Rv0590|M.tuberculosis_H37Rv VNNLNTVLATTVKHQTEFDRTVDKLEVLITGLKNRADPLAAAAAHISSAA
Mb0605|M.bovis_AF2122/97 VNNLNTVLATTVKHQTEFDRTVDKLEVLITGLKNRADPLAAAAAHISSAA
MAV_4550|M.avium_104 INNLNTVLATTVKHEKEFDRTVDKLELLITGLKNRADPLAAAAAHISDAA
MSMEG_0135|M.smegmatis_MC2_155 IKNLNTVLDTTVRHQKQFDETLVNFETLITGLKNRADPIATSVADISDAA
TH_3551|M.thermoresistible__bu IRNLNTVLETTVRHQKEFDETIHNFEVLITGLRNRADPIAESTANISNAA
Mflv_0710|M.gilvum_PYR-GCK VTNLNTVLDTTVRHQQEFDDTVKNFEVLITGLKNRADPLAESVADISDAA
Mvan_0135|M.vanbaalenii_PYR-1 ITNLNTVLDTTVRHQQEFDDTVKNFEVLITGLKNRADPIATSVADISDAA
MMAR_0413|M.marinum_M IKNLNTVLDATVRHRKDFDQTVNNLEVLITGLNEHRDDLSGGIAHVSNAA
MUL_1063|M.ulcerans_Agy99 IKNLNTVLDATVRHRKDFDQTVNNLEVLITGLNEHRDDLSGGIAHVSNAA
MLBr_02590|M.leprae_Br4923 VKNLNVVLDTTVRHRKEFDQTVNNLEILITGLKDHGDQLAGSFAHISNAA
MAB_4152c|M.abscessus_ATCC_199 INHLNEVLATVDSKSTQFSSSVDQLQQLISGLAQQRDVVAGALPPLASTA
: :** ** :. : :*. :: ::: **:** :: * :: . . ::.:*
Rv0590|M.tuberculosis_H37Rv GTLADLLG--------------------------------------RIVH
Mb0605|M.bovis_AF2122/97 GTLADLLGADRPLLHSSFGHLEGIQQPLIDELAELDHVLGKLPDAYRIIG
MAV_4550|M.avium_104 ATVAGLLGEDRPSLHGTLGHLEGIQQALINDLPTADNVLEKLPGAFRVIG
MSMEG_0135|M.smegmatis_MC2_155 GSLADLLSDNRPLLKDTIGYLDVIQAPLVEQKQEVSDILVQMPQALKIIG
TH_3551|M.thermoresistible__bu GTLADVLAQNRPLLDNSIDHLEAVQGPLVEQSAELNNILVQLPTALKTIG
Mflv_0710|M.gilvum_PYR-GCK GTIGDLLADNRPLLQSTISKLEILNQPLVDQKDQLNQLLEQIPDALAIIG
Mvan_0135|M.vanbaalenii_PYR-1 GTIGDLLADNRPLLKDTVSKLEILNQPLVDQRDQLNDLLVKLPDALAIIG
MMAR_0413|M.marinum_M GTVADLLGEDRALLHKTVNYLDAVQQPLIDQRQELADFLHKVPTALNMIG
MUL_1063|M.ulcerans_Agy99 GTVADLLGEDRALLHKTVNYLDAVQQPLIDQRQELADFLHKVPTALNMIG
MLBr_02590|M.leprae_Br4923 GTVANLLAEDHALLHKSINYLDGIQQPLIDQRLQLEDYLHKLPTVLNQIG
MAB_4152c|M.abscessus_ATCC_199 SSLESVLKDTRPYIKGTIEQARQLATRVDERKADVNVVVENLAENYLRLN
.:: .:* :
Rv0590|M.tuberculosis_H37Rv CCT----------------AASGTSRASSSRS-----------------
Mb0605|M.bovis_AF2122/97 RAGGIYGDFFNFYLCDISLKVNGLQPGGPVRTVKLFGQPT-GRCTPQ--
MAV_4550|M.avium_104 RAGGIYGDFYNFYLCDISIKVNGLQPGGPVRTIKLFGQPT-GRCTPQ--
MSMEG_0135|M.smegmatis_MC2_155 RAGGIYGDFFNFYACDLTLKLNGLQPGGPVRTVRITTQPS-GRCTPK--
TH_3551|M.thermoresistible__bu RAGGVYGDFFNFYACDISLKLNGLQPGGPVRTVKITTQPS-GRCTPQ--
Mflv_0710|M.gilvum_PYR-GCK RSGGIYGDFFNFYACDVTLKLNGLQPGGPVRTVRVWSQPT-GRCTPQ--
Mvan_0135|M.vanbaalenii_PYR-1 RSGGVYGDFFNFYACDVTLKLNGLQPGGPVRTVKVWSQPS-GRCTPQ--
MMAR_0413|M.marinum_M RAIGSYGDFVNFYSCDISLKINGLQPGGPVRTVRLFSQPT-GRCAPQ--
MUL_1063|M.ulcerans_Agy99 RAIGSYGDFVNFYSCDISLKINGLQPGGPVRTVRLFSQPT-GRCAPQ--
MLBr_02590|M.leprae_Br4923 RTIGSYGDFVNFYSCDITLKINGLQPGGPVRTVRLFQQPT-GRCTPQ--
MAB_4152c|M.abscessus_ATCC_199 -ALGAYGSFFNIYYCSIRIKVNGPVGTDWLIPFGGPPDPSKGRCAFKNE
.* . .