For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
IPDRNTRSRKAPCWRPRSLRQQLLLGVLAVVTVVLVAVGVVSVLSLSGYVTAMNDAELVESLHALNHSYT RYRDSAQTSTPTGNLPMSQAVLEFTGQTPGNLIAVLHDGVVIGSAVFSEDGARPAPPDVIRAIEAQVWDG GPPRVESLGSLGAYQVDSSAAGADRLFVGVSLSLANQIIARKKVTTVALVGAALVVTAALTVWVVGYALR PLRRVAATAAEVATMPLTDDDHQISVRVRPGDTDPDNEVGIVGHTLNRLLDNVDGALAHRVDSDLRMRQF ITDASHELRTPLAAIQGYAELTRQDSSDLPPTTEYALARIESEARRMTLLVDELLLLSRLSEGEDLETED LDLTDLVINAVNDAAVAAPTHRWVKNLPDEPVWVNGDHARLHQLVSNLLTNAWVHTQPGVTVTIGITCHR TGPNAPCVELSVTDDGPDIDPEILPHLFDRFVRASKSRSNGSGHGLGLAIVSSIVKAHRGSVTAESGNGQ TVFRVRLPMIEQQIATTA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1032c | trcS | - | 100% (509) | TWO COMPONENT SENSOR HISTIDINE KINASE TRCS |
| M. tuberculosis H37Rv | Rv3764c | - | 8e-81 | 42.09% (411) | two component sensor kinase |
| M. tuberculosis H37Rv | Rv0758 | phoR | 1e-46 | 33.67% (502) | two component system response sensor kinase membrane |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1061c | trcS | 0.0 | 100.00% (509) | two component sensor histidine kinase TRCS |
| M. gilvum PYR-GCK | Mflv_2267 | - | 6e-76 | 36.29% (529) | integral membrane sensor signal transduction histidine kinase |
| M. leprae Br4923 | MLBr_02440 | - | 2e-24 | 31.74% (334) | putative two-component system sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_2582 | - | 3e-70 | 39.86% (414) | putative two component sensor kinase |
| M. marinum M | MMAR_4456 | trcS | 0.0 | 79.32% (503) | two-component sensor histidine kinase TrcS |
| M. avium 104 | MAV_1175 | - | 0.0 | 73.51% (502) | two component sensor histidine kinase trcs |
| M. smegmatis MC2 155 | MSMEG_2915 | - | 1e-128 | 51.23% (486) | sensor histidine kinase |
| M. thermoresistible (build 8) | TH_2452 | - | 9e-29 | 27.65% (510) | PUTATIVE putative sensor histidine kinase PhoR |
| M. ulcerans Agy99 | MUL_4625 | trcS | 0.0 | 80.20% (490) | two component sensor histidine kinase TrcS |
| M. vanbaalenii PYR-1 | Mvan_2295 | - | 1e-133 | 53.06% (490) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2267|M.gilvum_PYR-GCK MSSSPRAERTPAPVLRPPRTWSLRTRLILTQLLLLAVVCAGVGVATEFAL
MAB_2582|M.abscessus_ATCC_1997 -------------------------------------------------M
Rv1032c|M.tuberculosis_H37Rv ---MIPDRNTRSRKAPCWRPRSLRQQLLLGVLAVVTVVLVAVGVVSVLSL
Mb1061c|M.bovis_AF2122/97 ---MIPDRNTRSRKAPCWRPRSLRQQLLLGVLAVVTVVLVAVGVVSVLSL
MMAR_4456|M.marinum_M --------MTGHRNTPRWLPRSLRWQLLLGVLAVVTIVLVAVGGVSVLSL
MUL_4625|M.ulcerans_Agy99 ----------------------MRWQLLLGVLAVVTIVLVAVGGVSVLSL
MAV_1175|M.avium_104 ---MTRDRDTASGGFPRWFPSSLRRQLLFGVLAVVSVVLVTVGFVSVLSL
MSMEG_2915|M.smegmatis_MC2_155 --------------MRTPKSWSLRRQLVVGVSAVVMIALATIGTLSVFTL
Mvan_2295|M.vanbaalenii_PYR-1 --------------MRAWKSWTLLRQLVVGVSVVVMVALVSVGAMTVMTL
TH_2452|M.thermoresistible__bu -MTSEPPSPSGRPRWRRLLPSAARTRIIGWVLLLVMVALGVVTLTTWRLM
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
Mflv_2267|M.gilvum_PYR-GCK QRFLMNQLDEQVIEAGRRSSMIFEFGPPPPPGMGMPPPPGVGMPPPPGVG
MAB_2582|M.abscessus_ATCC_1997 NRFLNTQLDEQVRDAGNRSVVLFELGPPPP--LSLPRPLANGWRP-----
Rv1032c|M.tuberculosis_H37Rv SGYVTAMNDAELVESLHALNHSYTRYRDSA-----QTSTPTGNLP-----
Mb1061c|M.bovis_AF2122/97 SGYVTAMNDAELVESLHALNHSYTRYRDSA-----QTSTPTGNLP-----
MMAR_4456|M.marinum_M RGYVTAMNDAEVVESMHAFSHAYARYRNGE-----HTSIHTGTPP-----
MUL_4625|M.ulcerans_Agy99 RGYVTAMNDAEVVESMHAFSHAYARYRNGE-----HTSIHTGTPP-----
MAV_1175|M.avium_104 RGYVNAMSDADVAESLDAFSHQYTKYRNGE-----HVSPHPGTPP-----
MSMEG_2915|M.smegmatis_MC2_155 RSSMVGLIDAQLAGAADGFSKTVTKYRTTP-----LPGEDEVPPPG----
Mvan_2295|M.vanbaalenii_PYR-1 RSSVLGIIDTQLSVAADATISSVAKYRSTP-----GPG-GQMPAPG----
TH_2452|M.thermoresistible__bu VSSIDARMDEALHIEVDEFEELTASGLNPR-----TGAPFTGVAE-----
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
Mflv_2267|M.gilvum_PYR-GCK MPVPPVGPPPRRGHHMMIRDEGPGPAFLNAPGQAILTVGAVVSDGRADDA
MAB_2582|M.abscessus_ATCC_1997 -------------------TDGPGPAFLDAPGQSIGMVGAVAVNGHVTEA
Rv1032c|M.tuberculosis_H37Rv ----------------------MSQAVLEFTGQTPGNLIAVLHDGVVIGS
Mb1061c|M.bovis_AF2122/97 ----------------------MSQAVLEFTGQTPGNLIAVLHDGVVIGS
MMAR_4456|M.marinum_M ----------------------VSQALLEFTGQTPGNLIAVVRDGVVIGS
MUL_4625|M.ulcerans_Agy99 ----------------------LSQALLEFTGQTPGNLIAVMRDGVVIGS
MAV_1175|M.avium_104 ----------------------IQQAILEFTGQTPGNLIAVLRNGAVIGS
MSMEG_2915|M.smegmatis_MC2_155 ----------------------SMKPLIHVLGQAEGNVIALIQDGEVVDS
Mvan_2295|M.vanbaalenii_PYR-1 ----------------------AMKPLTHLIGQAPGNIVVLIQNGEVVDS
TH_2452|M.thermoresistible__bu ----------------------VIREAIAYNLARPNEKFLGYVDGEYHTQ
MLBr_02440|M.leprae_Br4923 -----------------------MFSALLLAGVLSGLAFVVGIVAGIRLS
.
Mflv_2267|M.gilvum_PYR-GCK GMIATDGSRTEISDVAARQLATVAVGGRPHTVDLDGLGRYRVVAFPSHM-
MAB_2582|M.abscessus_ATCC_1997 ARITADGSRERLSPQACREVEGLLQQS-TSTVDLDHAGLYRLVTMPTN--
Rv1032c|M.tuberculosis_H37Rv AVFSEDGARPAPPDVIRAIEAQVWDGGPPRVESLGSLGAYQVDSSAA---
Mb1061c|M.bovis_AF2122/97 AVFSEDGARPAPPDVIRAIEAQVWDGGPPRVESLGSLGAYQVDSSAA---
MMAR_4456|M.marinum_M AVFSEDAPRPAPPDVIHAIETQHWTDEPSRVETLGSLGSYQVDSRAA---
MUL_4625|M.ulcerans_Agy99 AVFSEDAPRPAPPDVIHAIETQHWTDEPSRVETLGSLGSYQVDSRAA---
MAV_1175|M.avium_104 AVFSEDEPRPAPPDVVRDLAAQSWKDSPPRTEILGRLGPYRVNSTVN---
MSMEG_2915|M.smegmatis_MC2_155 AFFSDGDAQAAPPAAVDTLRDLATTGPTPRNVDIPGLGWYRVVSHPGD--
Mvan_2295|M.vanbaalenii_PYR-1 AFFGDGDAQVAPAAAVETIADQSWTDPQPRTVELPGLGWYRMESRAGD--
TH_2452|M.thermoresistible__bu SRQEPGFPEVLAGDDAFTERVATVTEPVEGSYDHPEVGEVRYLAIPVTMA
MLBr_02440|M.leprae_Br4923 PRLIERRQR-----LANEWAGITVLQMLQRIIALMPLGAAVVDTYRD---
. * :
Mflv_2267|M.gilvum_PYR-GCK ---EGEAVVAGLPTTDVDDTLFWVAVIFGVVAVVALMAAGTAGAVIVRRQ
MAB_2582|M.abscessus_ATCC_1997 ---GGAVIVTGLPAEGVGQTLSSVFGIICVVGAAALITAIGAGIVIIRRQ
Rv1032c|M.tuberculosis_H37Rv ---GADRLFVGVSLSLANQIIARKKVTTVALVGAALVVTAALTVWVVGYA
Mb1061c|M.bovis_AF2122/97 ---GADRLFVGVSLSLANQIIARKKVTTVALVGAALVVTAALTVWVVGYA
MMAR_4456|M.marinum_M ---GSDRLIVGVSLSIADRIITRKQITTSVLVATALVITAALTVWVVGIT
MUL_4625|M.ulcerans_Agy99 ---GSDRLIVGVSLSIADRIITRKQITTSVLVATALVITAALTVWVVGIT
MAV_1175|M.avium_104 ---GSDVLVVGVSHNLADRIIARKQLTTVALTASALLLTAGLTVWVVGYT
MSMEG_2915|M.smegmatis_MC2_155 ---GDESLVTAVSYTPAWEAMMRVTGIVSAMTVVALILTAISTIAIVGFA
Mvan_2295|M.vanbaalenii_PYR-1 ---GDEVLVTGVSRTPAWNVMVRETAIVSGITAIALVVTALSTVAIVRFA
TH_2452|M.thermoresistible__bu GDPAQGVIVAAYLGDAERAAADDAARLMLLVGAATLFGAIGAAWLVAGRI
MLBr_02440|M.leprae_Br4923 --------VVYLNEQAKELGLVRDRQLDDQAWRAAQQALGGD---DVEFD
.. :
Mflv_2267|M.gilvum_PYR-GCK LAPLARVSEAAQQVADLELDRGEVRLPTPIVKVDPAAAQTEVGQLGSALN
MAB_2582|M.abscessus_ATCC_1997 LDPLSQVATAAQEVAELELHRGEVNLPTPIIDVASNRTHTELGQLGAALN
Rv1032c|M.tuberculosis_H37Rv LRPLRRVAATAAEVATMPLTD-DDHQISVRVRPGDTDPDNEVGIVGHTLN
Mb1061c|M.bovis_AF2122/97 LRPLRRVAATAAEVATMPLTD-DDHQISVRVRPGDTDPDNEVGIVGHTLN
MMAR_4456|M.marinum_M LRPLRRVAATAATVAAMPLAG-DDHQISVRVRPEDTDPDNEVGIVGHTLN
MUL_4625|M.ulcerans_Agy99 LRPLRRVAATAATVAAMPLAG-DDHQISVRVRPEDTDPDNEVGIVGHTLN
MAV_1175|M.avium_104 LRPLRRLAAIAAHVAAMPLTD-DDHRITVRVQPQDTDPQNEVGIVGHALN
MSMEG_2915|M.smegmatis_MC2_155 LRPLRRVAATAAEVATLPLDR-ENHAITPRVPACDTDPRTEVGRVGDTLN
Mvan_2295|M.vanbaalenii_PYR-1 LRPLRRVAATAAEVAGLPLDR-DNHAITPRVPAGDTDPSTEVGLVGDTLN
TH_2452|M.thermoresistible__bu LRPLRDVADTARTITDTDLSR----------RIPSRGEGDEMDSLVRTIN
MLBr_02440|M.leprae_Br4923 LLPGKRPAAGRSGLSVHGHAR----------------------LLSEKDR
* * : :: : .
Mflv_2267|M.gilvum_PYR-GCK RMLDRIAGALSARHASETRVRQFVADASHELRTPLAAIRGYTELAQRKQA
MAB_2582|M.abscessus_ATCC_1997 RMLERIDDALSARHVSETRVRQFVADASHELRTPLAAISGYAELARRNHD
Rv1032c|M.tuberculosis_H37Rv RLLDNVDGALAHRVDSDLRMRQFITDASHELRTPLAAIQGYAELTRQDSS
Mb1061c|M.bovis_AF2122/97 RLLDNVDGALAHRVDSDLRMRQFITDASHELRTPLAAIQGYAELTRQDSS
MMAR_4456|M.marinum_M RLLDNVDSALQHRVDSDLRMRQFITDASHELRTPLAAIQGYAELTRQDSS
MUL_4625|M.ulcerans_Agy99 RLLDNVDSALQHRVASDLRMRQFITDASHELRTPLAAIQGYAELTRQDSS
MAV_1175|M.avium_104 RLLDNVDSALAHRVDSDLRMRQFITDASHELRTPLAAIQGYAELTRQDSS
MSMEG_2915|M.smegmatis_MC2_155 QLLDHVERALADVAASDRRMRQFITDASHELRTPLAAIHGYAELTRQDSS
Mvan_2295|M.vanbaalenii_PYR-1 RLLDHVEHALADVAASDRRMRQFITDASHELRTPLAAIHGYAELTRQDSS
TH_2452|M.thermoresistible__bu GMLDRIEAGVS-------AQRRFIDDAGHELRTPITIVRGHLEVLDPDD-
MLBr_02440|M.leprae_Br4923 RFAVVFVHDQSDYVRMEAARRDFVANVSHELKTPVGAMALLAEALLASAD
: . * *: :..***:**: : * .
Mflv_2267|M.gilvum_PYR-GCK ELPDDVAHAMSRVESETARMTQLVEDMLLLARLDTGRPLD-RDSVDLTRL
MAB_2582|M.abscessus_ATCC_1997 ALPTDVAHAMSRVQSEAARMTELVEDLLLLARLDSGRPLA-QEPVDLSRL
Rv1032c|M.tuberculosis_H37Rv DLPPTTEYALARIESEARRMTLLVDELLLLSRLSEGEDLE-TEDLDLTDL
Mb1061c|M.bovis_AF2122/97 DLPPTTEYALARIESEARRMTLLVDELLLLSRLSEGEDLE-TEDLDLTDL
MMAR_4456|M.marinum_M DLPPTTEYALARIESEARRMASLVDELLLLSRLGEGEDLE-TEHLDLTDL
MUL_4625|M.ulcerans_Agy99 DLPPTTEYALARIESEARRMASLVDELLLLSRLGEGEDLE-TEHLDLTDL
MAV_1175|M.avium_104 ALPPTTEYALARIESEARRMALLVDELLLLSRLGEGQDLQ-SEDVDLTEV
MSMEG_2915|M.smegmatis_MC2_155 VLPETTEYSLARIEAEAQRMNSLVSDLLLLARLDEGQELD-TTEVDLTEL
Mvan_2295|M.vanbaalenii_PYR-1 VLPQTTEYSLARIEAEAQRMHALVADLLLLARLDEGQDRQ-TTEVDLADL
TH_2452|M.thermoresistible__bu --PDDVRSTVALVDDELVRMNRMVTDLLLLARSEQPTFLT-PEPTDIGAL
MLBr_02440|M.leprae_Br4923 D-AETVSRFAEKVLIEANRLGYMVAELIELSRLQGAERLPNVTDIDVDII
. . : * *: :* ::: *:* *: :
Mflv_2267|M.gilvum_PYR-GCK VVDAVSDAHVAAPDHVWELDL-PDEPLTVCGDEARLHQVLANLLANAGIH
MAB_2582|M.abscessus_ATCC_1997 VVDAASDAHIAASEHRWLLNL-PEDPVIVCGDTPRLHQVVANLLSNCRIH
Rv1032c|M.tuberculosis_H37Rv VINAVNDAAVAAPTHRWVKNL-PDEPVWVNGDHARLHQLVSNLLTNAWVH
Mb1061c|M.bovis_AF2122/97 VINAVNDAAVAAPTHRWVKNL-PDEPVWVNGDHARLHQLVSNLLTNAWVH
MMAR_4456|M.marinum_M VMNAVNDAAVAAPTHRWIKDL-PDEPVWINGDHARLHQLVSNLLTNAWVH
MUL_4625|M.ulcerans_Agy99 VMNAVNDAAVAAPTHRWIKDL-PDEPVWVNGDHARLHQLVSNLLTNAWVH
MAV_1175|M.avium_104 VSDAVNDAMVAAPAHHWVKDL-PDEPVWVRGDQARLHQLVSNLLGNARVH
MSMEG_2915|M.smegmatis_MC2_155 VADAVNDAAVSAPTHHWSVRV-PDDPVWVRADHARLHQTLANLLSNARVH
Mvan_2295|M.vanbaalenii_PYR-1 VVDAVNDATVCAPEHRWLTSV-PDELVNVLGDRAQLHQMLANLLSNARVH
TH_2452|M.thermoresistible__bu TR-AIFDKVVQLGDRDYQLQS-VAEVTAVL-DAQRITQALIALADNACRY
MLBr_02440|M.leprae_Br4923 VSEAIARHKVAADTAAIEVRTDPPSGLRVLGDQTLLVTALANLVSNAIAY
. * : . : * : : * *. :
Mflv_2267|M.gilvum_PYR-GCK TPAGTTVTTSLTAT----DTGDVLVRVVDDGPGIPARLQPDVFERFARGD
MAB_2582|M.abscessus_ATCC_1997 TPPGTTVTVTLRS-----DGNSTYLTVADDGPGIPAGQQNEIFERFARGD
Rv1032c|M.tuberculosis_H37Rv TQPGVTVTIGITCHRTGPNAPCVELSVTDDGPDIDPEILPHLFDRFVRAS
Mb1061c|M.bovis_AF2122/97 TQPGVTVTIGITCHRTGPNAPCVELSVTDDGPDIDPEILPHLFDRFVRAS
MMAR_4456|M.marinum_M TPPGVTVKTGITSYPDDPSGPYTELTVSNDGPDIDPEVLPHLFERFVRSS
MUL_4625|M.ulcerans_Agy99 TPPGVTVKTGITNYPDDPNGPYTELTVSNDGPDIDPEVLPHLFERFVRSS
MAV_1175|M.avium_104 TPPGVTVTTAIRCHRGGREAPFAELTVTDDGPGIDADLLPNLFERFVRAD
MSMEG_2915|M.smegmatis_MC2_155 TPEGTSVQTTLVVHGNGD-TSHAEVTVSDNGPGINPDLLPHLFERFVRAD
Mvan_2295|M.vanbaalenii_PYR-1 TPAGTTVTTTVSKGTAADGTGYVELTVTDDGPGIDPQLLPHLFERFVRAD
TH_2452|M.thermoresistible__bu TRDGDWIAVGSGLY-----DGWLRFWVSDSGPGVSDADRDRIFERFARGS
MLBr_02440|M.leprae_Br4923 SPGGSLVSISRRRR-----GDNIEIAVTDRGIGIALEDQERVFERFFRGD
: * : . * : * .: :*:** *..
Mflv_2267|M.gilvum_PYR-GCK TSRSRRGGSTGLGLAIVAAVVRAHHGTISLHSVPGR-TEFAVVLPGDTQA
MAB_2582|M.abscessus_ATCC_1997 TSRSRRAGSTGLGLAIAAAVIKAHHGEIRVNSVAGE-TVFTITLPTAGTQ
Rv1032c|M.tuberculosis_H37Rv KSRSNGSG-HGLGLAIVSSIVKAHRGSVTAESGNGQ-TVFRVRLPMIEQQ
Mb1061c|M.bovis_AF2122/97 KSRSNGSG-HGLGLAIVSSIVKAHRGSVTAESGNGQ-TVFRVRLPMIEQQ
MMAR_4456|M.marinum_M KSRSSAPG-HGLGLAIVNSIVKAHDGSVTAESAAGQ-TVFRIRLPLIDAP
MUL_4625|M.ulcerans_Agy99 KSRSSAPG-HGLGLAIVNSIVKAHDGSVTAESAAGQ-TVFRIRLPLIDAP
MAV_1175|M.avium_104 KSRSDGSG-HGLGLAIVSSIVKAHHGSVGVESTAGR-TVFRVRLPLIDGP
MSMEG_2915|M.smegmatis_MC2_155 KSRSRAAGSFGLGLSIAASIVEAHGGTISAQSGSGK-TSFVIRLPSIPVT
Mvan_2295|M.vanbaalenii_PYR-1 RSRSRQNGSFGLGLAIVASIVESHGGTIDATSGSGT-TAFRVRLPTAAVG
TH_2452|M.thermoresistible__bu AGGQRSDG-AGLGLSIVRAIAGAHGGHVDLDTVVGRGSTFTITIPAVLEA
MLBr_02440|M.leprae_Br4923 KARSRATGGSGLGLAIVKHVAANHNGSIGVWSKPGTGSTFTLSIPAAMPL
. . * ****:*. : * * : : * : * : :*
Mflv_2267|M.gilvum_PYR-GCK VHSVGPR-------------------------------------------
MAB_2582|M.abscessus_ATCC_1997 HGAFTEKLP-----------------------------------------
Rv1032c|M.tuberculosis_H37Rv IATTA---------------------------------------------
Mb1061c|M.bovis_AF2122/97 IATTA---------------------------------------------
MMAR_4456|M.marinum_M LNASAPGRPRQPSDY-----------------------------------
MUL_4625|M.ulcerans_Agy99 LNASAPGRPRQPSDY-----------------------------------
MAV_1175|M.avium_104 GTLGAAGL------------------------------------------
MSMEG_2915|M.smegmatis_MC2_155 APHKTSV-------------------------------------------
Mvan_2295|M.vanbaalenii_PYR-1 AAQPVSA-------------------------------------------
TH_2452|M.thermoresistible__bu PWPAS---------------------------------------------
MLBr_02440|M.leprae_Br4923 YQDNDEQSGQPRGCDMWLNRPQREEEEFKSMTPAQAMMQSEVTRGNVNDK
Mflv_2267|M.gilvum_PYR-GCK -----------
MAB_2582|M.abscessus_ATCC_1997 -----------
Rv1032c|M.tuberculosis_H37Rv -----------
Mb1061c|M.bovis_AF2122/97 -----------
MMAR_4456|M.marinum_M -----------
MUL_4625|M.ulcerans_Agy99 -----------
MAV_1175|M.avium_104 -----------
MSMEG_2915|M.smegmatis_MC2_155 -----------
Mvan_2295|M.vanbaalenii_PYR-1 -----------
TH_2452|M.thermoresistible__bu -----------
MLBr_02440|M.leprae_Br4923 CPDCGGRGIAG