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MTGHRNTPRWLPRSLRWQLLLGVLAVVTIVLVAVGGVSVLSLRGYVTAMNDAEVVESMHAFSHAYARYRN GEHTSIHTGTPPVSQALLEFTGQTPGNLIAVVRDGVVIGSAVFSEDAPRPAPPDVIHAIETQHWTDEPSR VETLGSLGSYQVDSRAAGSDRLIVGVSLSIADRIITRKQITTSVLVATALVITAALTVWVVGITLRPLRR VAATAATVAAMPLAGDDHQISVRVRPEDTDPDNEVGIVGHTLNRLLDNVDSALQHRVDSDLRMRQFITDA SHELRTPLAAIQGYAELTRQDSSDLPPTTEYALARIESEARRMASLVDELLLLSRLGEGEDLETEHLDLT DLVMNAVNDAAVAAPTHRWIKDLPDEPVWINGDHARLHQLVSNLLTNAWVHTPPGVTVKTGITSYPDDPS GPYTELTVSNDGPDIDPEVLPHLFERFVRSSKSRSSAPGHGLGLAIVNSIVKAHDGSVTAESAAGQTVFR IRLPLIDAPLNASAPGRPRQPSDY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4456 | trcS | - | 100% (514) | two-component sensor histidine kinase TrcS |
| M. marinum M | MMAR_5316 | tcrY | 2e-84 | 39.18% (490) | two-component sensor kinase TcrY |
| M. marinum M | MMAR_4941 | phoR | 4e-46 | 32.61% (506) | two-component system response phosphate sensor kinase, PhoR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1061c | trcS | 0.0 | 79.32% (503) | two component sensor histidine kinase TRCS |
| M. gilvum PYR-GCK | Mflv_2267 | - | 1e-71 | 35.32% (521) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv1032c | trcS | 0.0 | 79.32% (503) | two component sensor histidine kinase TRCS |
| M. leprae Br4923 | MLBr_00774 | mtrB | 6e-23 | 25.15% (497) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_2582 | - | 1e-68 | 38.98% (413) | putative two component sensor kinase |
| M. avium 104 | MAV_1175 | - | 0.0 | 72.80% (511) | two component sensor histidine kinase trcs |
| M. smegmatis MC2 155 | MSMEG_2915 | - | 1e-126 | 51.23% (486) | sensor histidine kinase |
| M. thermoresistible (build 8) | TH_2452 | - | 5e-30 | 26.99% (515) | PUTATIVE putative sensor histidine kinase PhoR |
| M. ulcerans Agy99 | MUL_4625 | trcS | 0.0 | 98.80% (500) | two component sensor histidine kinase TrcS |
| M. vanbaalenii PYR-1 | Mvan_2295 | - | 1e-129 | 50.80% (498) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2267|M.gilvum_PYR-GCK ---------------MSSSPRAERTPAPVLRPPRTWSLRTRLILTQLLLL
MAB_2582|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_4456|M.marinum_M -----------------------MTGHRNTPRWLPRSLRWQLLLGVLAVV
MUL_4625|M.ulcerans_Agy99 -------------------------------------MRWQLLLGVLAVV
Mb1061c|M.bovis_AF2122/97 ------------------MIPDRNTRSRKAPCWRPRSLRQQLLLGVLAVV
Rv1032c|M.tuberculosis_H37Rv ------------------MIPDRNTRSRKAPCWRPRSLRQQLLLGVLAVV
MAV_1175|M.avium_104 ------------------MTRDRDTASGGFPRWFPSSLRRQLLFGVLAVV
MSMEG_2915|M.smegmatis_MC2_155 -----------------------------MRTPKSWSLRRQLVVGVSAVV
Mvan_2295|M.vanbaalenii_PYR-1 -----------------------------MRAWKSWTLLRQLVVGVSVVV
TH_2452|M.thermoresistible__bu ----------------MTSEPPSPSGRPRWRRLLPSAARTRIIGWVLLLV
MLBr_00774|M.leprae_Br4923 MIFSSRRRIRGRWGRSGPMMRGMGALTRVVGVVWRRSLQLRVVALTFGLS
Mflv_2267|M.gilvum_PYR-GCK AVVCAGVGVATEFALQRFLMNQLDEQVIEAGRRSSMIFEFGPPPPPGMGM
MAB_2582|M.abscessus_ATCC_1997 --------------MNRFLNTQLDEQVRDAGNRSVVLFELGPPPP--LSL
MMAR_4456|M.marinum_M TIVLVAVGGVSVLSLRGYVTAMNDAEVVESMHAFSHAYARYRNGE-----
MUL_4625|M.ulcerans_Agy99 TIVLVAVGGVSVLSLRGYVTAMNDAEVVESMHAFSHAYARYRNGE-----
Mb1061c|M.bovis_AF2122/97 TVVLVAVGVVSVLSLSGYVTAMNDAELVESLHALNHSYTRYRDSA-----
Rv1032c|M.tuberculosis_H37Rv TVVLVAVGVVSVLSLSGYVTAMNDAELVESLHALNHSYTRYRDSA-----
MAV_1175|M.avium_104 SVVLVTVGFVSVLSLRGYVNAMSDADVAESLDAFSHQYTKYRNGE-----
MSMEG_2915|M.smegmatis_MC2_155 MIALATIGTLSVFTLRSSMVGLIDAQLAGAADGFSKTVTKYRTTP-----
Mvan_2295|M.vanbaalenii_PYR-1 MVALVSVGAMTVMTLRSSVLGIIDTQLSVAADATISSVAKYRSTP-----
TH_2452|M.thermoresistible__bu MVALGVVTLTTWRLMVSSIDARMDEALHIEVDEFEELTASGLNPR-----
MLBr_00774|M.leprae_Br4923 LAVILALGFVLTSQLTSRVLDVKVRVAIEQIERARTTVTGIVNGEETRSL
: :
Mflv_2267|M.gilvum_PYR-GCK PPPPGVGMPPPPGVGMPVPPVGPPPRRGHHMMIRDEGPGPAFLNAPGQAI
MAB_2582|M.abscessus_ATCC_1997 PRPLANGWRP------------------------TDGPGPAFLDAPGQSI
MMAR_4456|M.marinum_M HTSIHTGTPP---------------------------VSQALLEFTGQTP
MUL_4625|M.ulcerans_Agy99 HTSIHTGTPP---------------------------LSQALLEFTGQTP
Mb1061c|M.bovis_AF2122/97 QTSTPTGNLP---------------------------MSQAVLEFTGQTP
Rv1032c|M.tuberculosis_H37Rv QTSTPTGNLP---------------------------MSQAVLEFTGQTP
MAV_1175|M.avium_104 HVSPHPGTPP---------------------------IQQAILEFTGQTP
MSMEG_2915|M.smegmatis_MC2_155 LPGEDEVPPPG--------------------------SMKPLIHVLGQAE
Mvan_2295|M.vanbaalenii_PYR-1 GPG-GQMPAPG--------------------------AMKPLTHLIGQAP
TH_2452|M.thermoresistible__bu TGAPFTGVAE---------------------------VIREAIAYNLARP
MLBr_00774|M.leprae_Br4923 DSSLQLARN--------------------------TLTSKTDPTSGAGLV
Mflv_2267|M.gilvum_PYR-GCK LTVGAVVSDGRADDAGMIATDGSRTEISDVAARQLATVAVGGRPHTVDLD
MAB_2582|M.abscessus_ATCC_1997 GMVGAVAVNGHVTEAARITADGSRERLSPQACREVEGLLQQS-TSTVDLD
MMAR_4456|M.marinum_M GNLIAVVRDGVVIGSAVFSEDAPRPAPPDVIHAIETQHWTDEPSRVETLG
MUL_4625|M.ulcerans_Agy99 GNLIAVMRDGVVIGSAVFSEDAPRPAPPDVIHAIETQHWTDEPSRVETLG
Mb1061c|M.bovis_AF2122/97 GNLIAVLHDGVVIGSAVFSEDGARPAPPDVIRAIEAQVWDGGPPRVESLG
Rv1032c|M.tuberculosis_H37Rv GNLIAVLHDGVVIGSAVFSEDGARPAPPDVIRAIEAQVWDGGPPRVESLG
MAV_1175|M.avium_104 GNLIAVLRNGAVIGSAVFSEDEPRPAPPDVVRDLAAQSWKDSPPRTEILG
MSMEG_2915|M.smegmatis_MC2_155 GNVIALIQDGEVVDSAFFSDGDAQAAPPAAVDTLRDLATTGPTPRNVDIP
Mvan_2295|M.vanbaalenii_PYR-1 GNIVVLIQNGEVVDSAFFGDGDAQVAPAAAVETIADQSWTDPQPRTVELP
TH_2452|M.thermoresistible__bu NEKFLGYVDGEYHTQSRQEPGFPEVLAGDDAFTERVATVTEPVEGSYDHP
MLBr_00774|M.leprae_Br4923 GAFDAVLIVPGDGPRTATTAGPVDQVPNSLRGFIKAGQAAYQYATVHTEG
.
Mflv_2267|M.gilvum_PYR-GCK GLGRYRVVAFPSHM----EGEAVVAGLPTTDVDDTLFWVAVIFGVVAVVA
MAB_2582|M.abscessus_ATCC_1997 HAGLYRLVTMPTN-----GGAVIVTGLPAEGVGQTLSSVFGIICVVGAAA
MMAR_4456|M.marinum_M SLGSYQVDSRAA------GSDRLIVGVSLSIADRIITRKQITTSVLVATA
MUL_4625|M.ulcerans_Agy99 SLGSYQVDSRAA------GSDRLIVGVSLSIADRIITRKQITTSVLVATA
Mb1061c|M.bovis_AF2122/97 SLGAYQVDSSAA------GADRLFVGVSLSLANQIIARKKVTTVALVGAA
Rv1032c|M.tuberculosis_H37Rv SLGAYQVDSSAA------GADRLFVGVSLSLANQIIARKKVTTVALVGAA
MAV_1175|M.avium_104 RLGPYRVNSTVN------GSDVLVVGVSHNLADRIIARKQLTTVALTASA
MSMEG_2915|M.smegmatis_MC2_155 GLGWYRVVSHPGD-----GDESLVTAVSYTPAWEAMMRVTGIVSAMTVVA
Mvan_2295|M.vanbaalenii_PYR-1 GLGWYRMESRAGD-----GDEVLVTGVSRTPAWNVMVRETAIVSGITAIA
TH_2452|M.thermoresistible__bu EVGEVRYLAIPVTMAGDPAQGVIVAAYLGDAERAAADDAARLMLLVGAAT
MLBr_00774|M.leprae_Br4923 FSGPALIIGTPTSS--QVTNLELYLIFPLKNEQATVTLVRGTMATGGMVL
* :
Mflv_2267|M.gilvum_PYR-GCK LMAAGTAGAVIVRRQLAPLARVSEAAQQVADLELDRGEVRLPTPIVKVDP
MAB_2582|M.abscessus_ATCC_1997 LITAIGAGIVIIRRQLDPLSQVATAAQEVAELELHRGEVNLPTPIIDVAS
MMAR_4456|M.marinum_M LVITAALTVWVVGITLRPLRRVAATAATVAAMPLAG-DDHQISVRVRPED
MUL_4625|M.ulcerans_Agy99 LVITAALTVWVVGITLRPLRRVAATAATVAAMPLAG-DDHQISVRVRPED
Mb1061c|M.bovis_AF2122/97 LVVTAALTVWVVGYALRPLRRVAATAAEVATMPLTD-DDHQISVRVRPGD
Rv1032c|M.tuberculosis_H37Rv LVVTAALTVWVVGYALRPLRRVAATAAEVATMPLTD-DDHQISVRVRPGD
MAV_1175|M.avium_104 LLLTAGLTVWVVGYTLRPLRRLAAIAAHVAAMPLTD-DDHRITVRVQPQD
MSMEG_2915|M.smegmatis_MC2_155 LILTAISTIAIVGFALRPLRRVAATAAEVATLPLDR-ENHAITPRVPACD
Mvan_2295|M.vanbaalenii_PYR-1 LVVTALSTVAIVRFALRPLRRVAATAAEVAGLPLDR-DNHAITPRVPAGD
TH_2452|M.thermoresistible__bu LFGAIGAAWLVAGRILRPLRDVADTARTITDTDLSR----------RIPS
MLBr_00774|M.leprae_Br4923 LVLLSGIALLVSRQVVVPVRSASRIAERFAEGHLSE-----------RMP
*. : : *: : * .: *
Mflv_2267|M.gilvum_PYR-GCK AAAQTEVGQLGSALNRMLDRIAGALSARHASETRVRQFVADASHELRTPL
MAB_2582|M.abscessus_ATCC_1997 NRTHTELGQLGAALNRMLERIDDALSARHVSETRVRQFVADASHELRTPL
MMAR_4456|M.marinum_M TDPDNEVGIVGHTLNRLLDNVDSALQHRVDSDLRMRQFITDASHELRTPL
MUL_4625|M.ulcerans_Agy99 TDPDNEVGIVGHTLNRLLDNVDSALQHRVASDLRMRQFITDASHELRTPL
Mb1061c|M.bovis_AF2122/97 TDPDNEVGIVGHTLNRLLDNVDGALAHRVDSDLRMRQFITDASHELRTPL
Rv1032c|M.tuberculosis_H37Rv TDPDNEVGIVGHTLNRLLDNVDGALAHRVDSDLRMRQFITDASHELRTPL
MAV_1175|M.avium_104 TDPQNEVGIVGHALNRLLDNVDSALAHRVDSDLRMRQFITDASHELRTPL
MSMEG_2915|M.smegmatis_MC2_155 TDPRTEVGRVGDTLNQLLDHVERALADVAASDRRMRQFITDASHELRTPL
Mvan_2295|M.vanbaalenii_PYR-1 TDPSTEVGLVGDTLNRLLDHVEHALADVAASDRRMRQFITDASHELRTPL
TH_2452|M.thermoresistible__bu RGEGDEMDSLVRTINGMLDRIEAGVS-------AQRRFIDDAGHELRTPI
MLBr_00774|M.leprae_Br4923 VRGEDDMARLAVSFNDMAESLSRQITQLEEFGNLQRRFTSDVSHELRTPL
:: : ::* : : : : *:* *..******:
Mflv_2267|M.gilvum_PYR-GCK AAIRGYTELAQRKQAELPDDVAHAMSRVESETARMTQLVEDMLLLARLDT
MAB_2582|M.abscessus_ATCC_1997 AAISGYAELARRNHDALPTDVAHAMSRVQSEAARMTELVEDLLLLARLDS
MMAR_4456|M.marinum_M AAIQGYAELTRQDSSDLPPTTEYALARIESEARRMASLVDELLLLSRLGE
MUL_4625|M.ulcerans_Agy99 AAIQGYAELTRQDSSDLPPTTEYALARIESEARRMASLVDELLLLSRLGE
Mb1061c|M.bovis_AF2122/97 AAIQGYAELTRQDSSDLPPTTEYALARIESEARRMTLLVDELLLLSRLSE
Rv1032c|M.tuberculosis_H37Rv AAIQGYAELTRQDSSDLPPTTEYALARIESEARRMTLLVDELLLLSRLSE
MAV_1175|M.avium_104 AAIQGYAELTRQDSSALPPTTEYALARIESEARRMALLVDELLLLSRLGE
MSMEG_2915|M.smegmatis_MC2_155 AAIHGYAELTRQDSSVLPETTEYSLARIEAEAQRMNSLVSDLLLLARLDE
Mvan_2295|M.vanbaalenii_PYR-1 AAIHGYAELTRQDSSVLPQTTEYSLARIEAEAQRMHALVADLLLLARLDE
TH_2452|M.thermoresistible__bu TIVRGHLEVLDPDD---PDDVRSTVALVDDELVRMNRMVTDLLLLARSEQ
MLBr_00774|M.leprae_Br4923 TTVRMAADLIYDHSSDLDPTLRRSTELMVSELDRFETLLNDLLEISRHDA
: : :: . : : * *: :: ::* ::*
Mflv_2267|M.gilvum_PYR-GCK GR-PLDRDSVDLTRLVVDAVSDAHVAAPDH--VWELDLPDEPLTVCGDEA
MAB_2582|M.abscessus_ATCC_1997 GR-PLAQEPVDLSRLVVDAASDAHIAASEH--RWLLNLPEDPVIVCGDTP
MMAR_4456|M.marinum_M GE-DLETEHLDLTDLVMNAVNDAAVAAPTH--RWIKDLPDEPVWINGDHA
MUL_4625|M.ulcerans_Agy99 GE-DLETEHLDLTDLVMNAVNDAAVAAPTH--RWIKDLPDEPVWVNGDHA
Mb1061c|M.bovis_AF2122/97 GE-DLETEDLDLTDLVINAVNDAAVAAPTH--RWVKNLPDEPVWVNGDHA
Rv1032c|M.tuberculosis_H37Rv GE-DLETEDLDLTDLVINAVNDAAVAAPTH--RWVKNLPDEPVWVNGDHA
MAV_1175|M.avium_104 GQ-DLQSEDVDLTEVVSDAVNDAMVAAPAH--HWVKDLPDEPVWVRGDQA
MSMEG_2915|M.smegmatis_MC2_155 GQ-ELDTTEVDLTELVADAVNDAAVSAPTH--HWSVRVPDDPVWVRADHA
Mvan_2295|M.vanbaalenii_PYR-1 GQ-DRQTTEVDLADLVVDAVNDATVCAPEH--RWLTSVPDELVNVLGDRA
TH_2452|M.thermoresistible__bu PT-FLTPEPTDIGALTR-AIFDKVVQLGDR--DYQLQSVAEVTAVL-DAQ
MLBr_00774|M.leprae_Br4923 GVAELSVEAVDLRVMVNNALGNVGHLAEEAGIELLVDMPVDEVIAEVDAR
*: :. * : : *
Mflv_2267|M.gilvum_PYR-GCK RLHQVLANLLANAGIHTPAGTTVTTSLTAT----DTGDVLVRVVDDGPGI
MAB_2582|M.abscessus_ATCC_1997 RLHQVVANLLSNCRIHTPPGTTVTVTLRS-----DGNSTYLTVADDGPGI
MMAR_4456|M.marinum_M RLHQLVSNLLTNAWVHTPPGVTVKTGITSYPDDPSGPYTELTVSNDGPDI
MUL_4625|M.ulcerans_Agy99 RLHQLVSNLLTNAWVHTPPGVTVKTGITNYPDDPNGPYTELTVSNDGPDI
Mb1061c|M.bovis_AF2122/97 RLHQLVSNLLTNAWVHTQPGVTVTIGITCHRTGPNAPCVELSVTDDGPDI
Rv1032c|M.tuberculosis_H37Rv RLHQLVSNLLTNAWVHTQPGVTVTIGITCHRTGPNAPCVELSVTDDGPDI
MAV_1175|M.avium_104 RLHQLVSNLLGNARVHTPPGVTVTTAIRCHRGGREAPFAELTVTDDGPGI
MSMEG_2915|M.smegmatis_MC2_155 RLHQTLANLLSNARVHTPEGTSVQTTLVVHGNGD-TSHAEVTVSDNGPGI
Mvan_2295|M.vanbaalenii_PYR-1 QLHQMLANLLSNARVHTPAGTTVTTTVSKGTAADGTGYVELTVTDDGPGI
TH_2452|M.thermoresistible__bu RITQALIALADNACRYTRDGDWIAVGSGLY-----DGWLRFWVSDSGPGV
MLBr_00774|M.leprae_Br4923 RVERILRNLIANAIDHS-EHKPVRIRMAAD-----EDTVAVTVRDYGIGL
:: : : * *. :: : . * : * .:
Mflv_2267|M.gilvum_PYR-GCK PARLQPDVFERFARGDTSRSRRGGSTGLGLAIVAAVVRAHHGTISLHSVP
MAB_2582|M.abscessus_ATCC_1997 PAGQQNEIFERFARGDTSRSRRAGSTGLGLAIAAAVIKAHHGEIRVNSVA
MMAR_4456|M.marinum_M DPEVLPHLFERFVRSSKSRSSAPG-HGLGLAIVNSIVKAHDGSVTAESAA
MUL_4625|M.ulcerans_Agy99 DPEVLPHLFERFVRSSKSRSSAPG-HGLGLAIVNSIVKAHDGSVTAESAA
Mb1061c|M.bovis_AF2122/97 DPEILPHLFDRFVRASKSRSNGSG-HGLGLAIVSSIVKAHRGSVTAESGN
Rv1032c|M.tuberculosis_H37Rv DPEILPHLFDRFVRASKSRSNGSG-HGLGLAIVSSIVKAHRGSVTAESGN
MAV_1175|M.avium_104 DADLLPNLFERFVRADKSRSDGSG-HGLGLAIVSSIVKAHHGSVGVESTA
MSMEG_2915|M.smegmatis_MC2_155 NPDLLPHLFERFVRADKSRSRAAGSFGLGLSIAASIVEAHGGTISAQSGS
Mvan_2295|M.vanbaalenii_PYR-1 DPQLLPHLFERFVRADRSRSRQNGSFGLGLAIVASIVESHGGTIDATSGS
TH_2452|M.thermoresistible__bu SDADRDRIFERFARGSAGGQRSDG-AGLGLSIVRAIAGAHGGHVDLDTVV
MLBr_00774|M.leprae_Br4923 RPGEEKLVFSRFWRSDPSRVRRSGGTGLGLAISIEDARLHQGRLEAWGEP
:*.** *.. . * ****:* * * :
Mflv_2267|M.gilvum_PYR-GCK GR-TEFAVVLPGDTQAVHSVGPR---------------------------
MAB_2582|M.abscessus_ATCC_1997 GE-TVFTITLPTAGTQHGAFTEKLP-------------------------
MMAR_4456|M.marinum_M GQ-TVFRIRLPLIDAPLNASAPGRPRQPSDY-------------------
MUL_4625|M.ulcerans_Agy99 GQ-TVFRIRLPLIDAPLNASAPGRPRQPSDY-------------------
Mb1061c|M.bovis_AF2122/97 GQ-TVFRVRLPMIEQQIATTA-----------------------------
Rv1032c|M.tuberculosis_H37Rv GQ-TVFRVRLPMIEQQIATTA-----------------------------
MAV_1175|M.avium_104 GR-TVFRVRLPLIDGPGTLGAAGL--------------------------
MSMEG_2915|M.smegmatis_MC2_155 GK-TSFVIRLPSIPVTAPHKTSV---------------------------
Mvan_2295|M.vanbaalenii_PYR-1 GT-TAFRVRLPTAAVGAAQPVSA---------------------------
TH_2452|M.thermoresistible__bu GRGSTFTITIPAVLEAPWPAS-----------------------------
MLBr_00774|M.leprae_Br4923 GQGACFRLTLPLVRGHKVTTSPLPMKPILQPSPQASTAGQQHGTQRQRLR
* : * : :*
Mflv_2267|M.gilvum_PYR-GCK -------
MAB_2582|M.abscessus_ATCC_1997 -------
MMAR_4456|M.marinum_M -------
MUL_4625|M.ulcerans_Agy99 -------
Mb1061c|M.bovis_AF2122/97 -------
Rv1032c|M.tuberculosis_H37Rv -------
MAV_1175|M.avium_104 -------
MSMEG_2915|M.smegmatis_MC2_155 -------
Mvan_2295|M.vanbaalenii_PYR-1 -------
TH_2452|M.thermoresistible__bu -------
MLBr_00774|M.leprae_Br4923 EHAERSR