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MTYPMFPPEINSALIEAGPGSAPMLGAAAAWCGLASELRAAAESFASITSDLASGAWQGPAATAMTQAAA PYAAWLCTAAAQSESAASQAGAVATAFEAARTAIVSPVIINANRALTALLANTNFFGLNFPAIAAAEGLY EEMWAQDVAVMSGYHATVSEIWSQLSQWPPLQQLLRLLPGCKAPSSSGGSPSPTPNPNPDPSPTPDPTPT PTPDPTPTPTPEPTPAPAPEPAPEPTPVEPAPVTVLPTM
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4491 | - | - | 100% (249) | PPE family protein |
| M. ulcerans Agy99 | MUL_0964 | - | 2e-50 | 53.44% (189) | PPE family protein |
| M. ulcerans Agy99 | MUL_0902 | - | 9e-50 | 57.22% (180) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3563c | PPE62 | 8e-53 | 59.78% (179) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-23 | 33.33% (174) | PPE protein |
| M. tuberculosis H37Rv | Rv3533c | PPE62 | 9e-53 | 59.78% (179) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 1e-29 | 44.44% (153) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 3e-29 | 38.17% (186) | PPE-family protein |
| M. marinum M | MMAR_4187 | - | 1e-143 | 96.89% (257) | PPE family protein |
| M. avium 104 | MAV_4704 | - | 3e-49 | 51.60% (188) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-26 | 34.72% (193) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 1e-26 | 37.11% (159) | PUTATIVE PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-27 | 40.00% (150) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4491|M.ulcerans_Agy99 ----------MT---YPMFPPEINSALIEAGPGSAPMLGAAAAWCGLASE
MMAR_4187|M.marinum_M ----------MT---YPMFPPEINSALIEAGPGSAPMLGAAAAWCGLASE
Mb3563c|M.bovis_AF2122/97 ----------MN---YAVLPPELNSLRMFTGAGSAPMLAAAVAWDGLAAE
Rv3533c|M.tuberculosis_H37Rv ----------MN---YAVLPPELNSLRMFTGAGSAPMLAAAVAWDGLAAE
MAV_4704|M.avium_104 ----------MTNPHFAWLPPEVNSALIYSGPGPGPLLAAAAAWDGLAEE
MLBr_01182|M.leprae_Br4923 ----------MFD--FAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_0669|M.abscessus_ATCC_1997 ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN
: : .** :* : *.*...:* *. * :. :
MUL_4491|M.ulcerans_Agy99 LRAAAESFASITSDLASGAWQGPAATAMTQAAAPYAAWLCTAAAQSESAA
MMAR_4187|M.marinum_M LRAAAESFASITSDLASGAWQGPAATAMTQAAAPYAAWLCTAAAQSESAA
Mb3563c|M.bovis_AF2122/97 LGSAASSFGSVTSDLASQAWQGPAAAAMAAAAAPYAGWLSAAAARAAGAA
Rv3533c|M.tuberculosis_H37Rv LGSAASSFGSVTSDLASQAWQGPAAAAMAAAAAPYAGWLSAAAARAAGAA
MAV_4704|M.avium_104 LASSAQSFSSVTSDLASGSWQGASSAAMMTVANQYVSWLSAAAAQAEEVS
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_0669|M.abscessus_ATCC_1997 YANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIA
:* : . : : :::* :: * ** :* . :
MUL_4491|M.ulcerans_Agy99 SQAGAVATAFEAARTAIVSPVIINANRALTALLANTNFFGLNFPAIAAAE
MMAR_4187|M.marinum_M SQAGAVATAFEAARTAIVSPVIINANRALTALLANTNFFGLNFPAIAAAE
Mb3563c|M.bovis_AF2122/97 AQAKAVASAFEAARAATVHPLLVAANRNAFAQLVMSNWFGLNAPLIAAVE
Rv3533c|M.tuberculosis_H37Rv AQAKAVASAFEAARAATVHPLLVAANRNAFAQLVMSNWFGLNAPLIAAVE
MAV_4704|M.avium_104 HQASAIATAFEVALAATVQPAVVAANRALVQALAATNWLGQNTPAIADIE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_0669|M.abscessus_ATCC_1997 AQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNE
: . * *: * : : *: * :* :* * ** *
MUL_4491|M.ulcerans_Agy99 GLYEEMWAQDVAVMSGYHATVSEIWSQLSQWPPLQQLLRLLP--------
MMAR_4187|M.marinum_M GLYEEMWAQDVAVMSGYHATVSEIWSQLSQWPPLQQLLRLLP--------
Mb3563c|M.bovis_AF2122/97 GAYEQMWAADVAAMVGYHSGASAAAEQLVPFQQALQQLPNLGIGNIGNAN
Rv3533c|M.tuberculosis_H37Rv GAYEQMWAADVAAMVGYHSGASAAAEQLVPFQQALQQLPNLGIGNIGNAN
MAV_4704|M.avium_104 AAYEQMWASDVAAMFGYHADASAAVAKLPPWNEVLQNL------------
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVG--------
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR---
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR---
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS---
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD---
MAB_0669|M.abscessus_ATCC_1997 ADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG-GEARS---
. * .** .: * *:: :
MUL_4491|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4187|M.marinum_M --------------------------------------------------
Mb3563c|M.bovis_AF2122/97 LGGGNTGDLNTGNGNIGNTNLGSGNRGDANLGSGNIGNSNVGGGNVGNGN
Rv3533c|M.tuberculosis_H37Rv LGGGNTGDLNTGNGNIGNTNLGSGNRGDANLGSGNIGNSNVGGGNVGNGN
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 --------------------------------------------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_4491|M.ulcerans_Agy99 ------------------------------------GCKAPSSSGGSPSP
MMAR_4187|M.marinum_M ------------------------------------GCKAPSSSGGSPSP
Mb3563c|M.bovis_AF2122/97 FGSGNGRAGLPGSGNVGNGNLGNSNLGSGNTGNSNVGFGNTGNNNVGTGN
Rv3533c|M.tuberculosis_H37Rv FGSGNGRAGLPGSGNVGNGNLGNSNLGSGNTGNSNVGFGNTGNNNVGTGN
MAV_4704|M.avium_104 ------------------------------------GFSNAS--TAVTRP
MLBr_01182|M.leprae_Br4923 -----------------------------LAQEVVEEVVEEVVEEVVEAE
Mflv_0325|M.gilvum_PYR-GCK ----------------------------AAADMSAFAAQPMAAQAGAAFD
Mvan_0415|M.vanbaalenii_PYR-1 ----------------------------AAADVTAFAAQAQAAEAGSALD
MSMEG_0619|M.smegmatis_MC2_155 ----------------------------ASASVQQMSAQATAAESGSSLD
TH_3569|M.thermoresistible__bu ----------------------------AMATTQQIGSQATAADSGTALN
MAB_0669|M.abscessus_ATCC_1997 ----------------------------DQSDVPGSPDQ-----------
MUL_4491|M.ulcerans_Agy99 TPNPNPDPSPT---------------------------------------
MMAR_4187|M.marinum_M TPNPNPDPSPT---------------------------------------
Mb3563c|M.bovis_AF2122/97 AGSGNIGAGNTGSSNWGFGNNGIGNIGFGNTGNGNIGFGLTGNNQVGIGG
Rv3533c|M.tuberculosis_H37Rv AGSGNIGAGNTGSSNWGFGNNGIGNIGFGNTGNGNIGFGLTGNNQVGIGG
MAV_4704|M.avium_104 AGSGAVARGYT---------------------------------------
MLBr_01182|M.leprae_Br4923 QAISQAALDQAVN-------------------------------------
Mflv_0325|M.gilvum_PYR-GCK VSNIIADIIRLYGEVLRFLFEPIFNFLRDPIGNTFALITDFLTNPVQALI
Mvan_0415|M.vanbaalenii_PYR-1 LSNIIADLIRAYGELLRFLFEPIFDFLRDPLGNTIKLITDFLTNPAQALI
MSMEG_0619|M.smegmatis_MC2_155 LSSIISDLLNQYLQGVPGGQ-AILDFLKDPLGNLGRLLTDFMTNPAGALA
TH_3569|M.thermoresistible__bu LSDLIANLLQYYQDYLDQLFGPIVDFLRDPIGNLFQLIDDFLTNPAGALV
MAB_0669|M.abscessus_ATCC_1997 ----IMKMLQGFQQWFEKMG--FNPATSAVLAVIMLFLYDLLWYPY----
MUL_4491|M.ulcerans_Agy99 --------------PDPTPTPTPDPTPTPT--------PEPTPAPAPEPA
MMAR_4187|M.marinum_M --------------PDPTPTPTPDPTPTPTPDPTPAPTPEPTPAPAPEPA
Mb3563c|M.bovis_AF2122/97 LNSGSGNIGLFNSGTNNVGFFNSGNGNLGIGNSSDANVGIGNSGATVGPF
Rv3533c|M.tuberculosis_H37Rv LNSGSGNIGLFNSGTNNVGFFNSGNGNLGIGNSSDANVGIGNSGATVGPF
MAV_4704|M.avium_104 --------------SRIAGFLAPRAPQ-----------------------
MLBr_01182|M.leprae_Br4923 -------------EGMEATVVPQVDQQVNVDVATPQTAVPDSSSAAAPQL
Mflv_0325|M.gilvum_PYR-GCK TWGPFLLAVVYQAVSWVGASILYPSLFLLPLLATTLAIVAGVGQHLLSLL
Mvan_0415|M.vanbaalenii_PYR-1 TWGPFLAAVAYQAVSWVGASILYPSLLLLPLVATTLAIVLGVGAYLLENL
MSMEG_0619|M.smegmatis_MC2_155 TWWPFLFGVAYQVFFNLVGWPTWGMIFASPFLIPALAALGITGLVLLIDH
TH_3569|M.thermoresistible__bu TWWPLLFAVAYQVFTNLVGWPTWAMILASPVLIPLAITLGVAGLVMIADQ
MAB_0669|M.abscessus_ATCC_1997 -YASYLLPFLIPALSGLSG-LAALMHLRPAAPGPVPAAALSPGDRPIRRP
MUL_4491|M.ulcerans_Agy99 PEPTPVEPAPVTVLPTM---------------------------------
MMAR_4187|M.marinum_M PEPTPVEPAPVTVLPTM---------------------------------
Mb3563c|M.bovis_AF2122/97 VAGHNTGFGNSGSLNTGMGNAGGVNTGFGNGGAINLGFGNSGQLNAGSFN
Rv3533c|M.tuberculosis_H37Rv VAGHNTGFGNSGSLNTGMGNAGGVNTGFGNGGAINLGFGNSGQLNAGSFN
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 WGGFAQHLSPINDTLSMINNHAGMAN------------AGLSLVNGMGSA
Mflv_0325|M.gilvum_PYR-GCK NTP-PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSA
Mvan_0415|M.vanbaalenii_PYR-1 PAP-AEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVAT
MSMEG_0619|M.smegmatis_MC2_155 VLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGISPAGVPGSAATAAAPAPA
TH_3569|M.thermoresistible__bu AQP-----PAEEAAPEEDVAAP-------------------VRAEPQNPL
MAB_0669|M.abscessus_ATCC_1997 TQHVEPNLAALPLPTSSVVPSGG---------------SSVPVSTPTAPA
MUL_4491|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4187|M.marinum_M --------------------------------------------------
Mb3563c|M.bovis_AF2122/97 AGSINTGNFNSGQGNTGDFNAGVRNTGWSNSGLTNTGAFNAGSLNTGFGA
Rv3533c|M.tuberculosis_H37Rv AGSINTGNFNSGQGNTGDFNAGVRNTGWSNSGLTNTGAFNAGSLNTGFGA
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 MKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLG----RA
Mflv_0325|M.gilvum_PYR-GCK GSPPAPGAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPAA
Mvan_0415|M.vanbaalenii_PYR-1 GTAPAPGAPAAATASFVPYAVAGRDPGTGFSPTVRDSTSAKAPASGIPAA
MSMEG_0619|M.smegmatis_MC2_155 PAGTTVAAPAPAAATFVPYAVANRDPGEGFTPTLGNKSQVAAPASGVPAA
TH_3569|M.thermoresistible__bu PLTXXX--------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 HTVSSVPAPSAAISYAIPGLVP---PGVSFGPKSTEKSSESAVDTVAAVA
MUL_4491|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4187|M.marinum_M --------------------------------------------------
Mb3563c|M.bovis_AF2122/97 VGTGSGPNSGFGNAGTNNSGFFNTGVGSSGFQNGGSNNSGLQNAVGTVIA
Rv3533c|M.tuberculosis_H37Rv VGTGSGPNSGFGNAGTNNSGFFNTGVGSSGFQNGGSNNSGLQNAVGTVIA
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 ASIGSLRVPQTWTTASQPVTAATRALSPARVAVATESESAPLLGGGLPMA
Mflv_0325|M.gilvum_PYR-GCK ASGIAASAAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRV
Mvan_0415|M.vanbaalenii_PYR-1 ASGVAASAAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRI
MSMEG_0619|M.smegmatis_MC2_155 ASGVAASLASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRV
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 AARGAVAAQARRRLRGKNKAEAGGR--RHEYLEETAGMGAT-ATADVPAY
MUL_4491|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4187|M.marinum_M --------------------------------------------------
Mb3563c|M.bovis_AF2122/97 AGFGNTGAQTVGIANSGVLNSGFFNSGVHNSGGFNSENQRSGFGN-----
Rv3533c|M.tuberculosis_H37Rv AGFGNTGAQTVGIANSGVLNSGFFNSGVHNSGGFNSENQRSGFGN-----
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 PMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG-----------------
Mflv_0325|M.gilvum_PYR-GCK TASTRGAGPMGFAGTVSRGDEQAGGLTTLAGDSFGGGPREPMLPGTWDPD
Mvan_0415|M.vanbaalenii_PYR-1 AATERGAGPMGFAGTVSRDAAQAGGLTTLPGDPFGGGPKAPMLPGTWDPD
MSMEG_0619|M.smegmatis_MC2_155 RASERGSDAMGFTGTVTRHDVTAAGLTTLTGDTFDDRPVTPMLPGTWDGD
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 AATGRGTGPLGFAGTAPAAASTHVAATVRLS-SDEARQVIPMLPSTWDAD
MUL_4491|M.ulcerans_Agy99 ----------------------
MMAR_4187|M.marinum_M ----------------------
Mb3563c|M.bovis_AF2122/97 ----------------------
Rv3533c|M.tuberculosis_H37Rv ----------------------
MAV_4704|M.avium_104 ----------------------
MLBr_01182|M.leprae_Br4923 ----------------------
Mflv_0325|M.gilvum_PYR-GCK ATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 TEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 ENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu ----------------------
MAB_0669|M.abscessus_ATCC_1997 -----------------GGDQN