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MLGLLLARAGVDVTVMEKHADFLRDFRGDTVHASTLRLLDELGLGSQFAQIPHRLIDTISMKVQGQPVDL DLKHLPGAHQHIALVPQWDFLELLAAAAEAEPTFRLLRSTEVTGVLWGDGPDRGRVVGVTYRAQSGETKH MHADLTVACDGRGSTVRSALGMATRSFGAPMDVWWFRLPRRPDDPTGLAGIFNSGHGGIAIDRGDYYQIA YIIPKGSDAQLRAQGIEALHRALADLMPWLADRVDALKSLDDVKLLDVQLNRLRRWYCDGALCIGDAAHA MSPVGGVGINLALADAVATARMLAPSLRVGRVSTGQLARVQARRWAPTAFLQGIQRAIHAAIVAVAVTGG PPQPPPVVRLVSRSVPARRIMGYLVAIGPLPEHAPKYARRAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3720 | - | - | 100% (392) | FAD-dependent oxidoreductase |
| M. marinum M | MMAR_2627 | - | e-100 | 50.26% (392) | oxidoreductase |
| M. marinum M | MMAR_3394 | - | 9e-92 | 47.41% (386) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1780 | - | 1e-102 | 50.77% (392) | hypothetical protein Mb1780 |
| M. gilvum PYR-GCK | Mflv_0304 | - | 1e-102 | 53.30% (394) | hypothetical protein Mflv_0304 |
| M. tuberculosis H37Rv | Rv1751 | - | 1e-102 | 50.77% (392) | hypothetical protein Rv1751 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1646c | - | 1e-128 | 57.43% (397) | hypothetical protein MAB_1646c |
| M. avium 104 | MAV_4364 | - | 5e-81 | 45.36% (388) | hypothetical protein MAV_4364 |
| M. smegmatis MC2 155 | MSMEG_4962 | - | 1e-105 | 52.26% (398) | hypothetical protein MSMEG_4962 |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3663 | - | 0.0 | 97.96% (392) | hypothetical protein MUL_3663 |
| M. vanbaalenii PYR-1 | Mvan_0442 | - | 1e-100 | 51.02% (394) | hypothetical protein Mvan_0442 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3720|M.marinum_M --------------------------------------------------
MUL_3663|M.ulcerans_Agy99 ---------------------------------------------MPQPS
MAB_1646c|M.abscessus_ATCC_199 -------------------------------------------MIKPELP
Mb1780|M.bovis_AF2122/97 MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
Rv1751|M.tuberculosis_H37Rv MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
Mflv_0304|M.gilvum_PYR-GCK -MR----------DDDTVS-------------------------------
Mvan_0442|M.vanbaalenii_PYR-1 -MRKQLGRPSGSCHHDQMN-------------------------------
MSMEG_4962|M.smegmatis_MC2_155 -MT-----------------------------------------------
MAV_4364|M.avium_104 --------------------------------------------------
MMAR_3720|M.marinum_M ---------------MLGLLLARAGVDVTVMEKHADFLRDFRGDTVHAST
MUL_3663|M.ulcerans_Agy99 ETTSVLVAGGGPAGMVLGLLLARAGVDVTVMEKHADFLRDSRGDTVHAST
MAB_1646c|M.abscessus_ATCC_199 QGTTCAIAGGGPAGMMLALLLARAGIDVTVLEKHPDFLRDFRGDTVHAST
Mb1780|M.bovis_AF2122/97 ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTT
Rv1751|M.tuberculosis_H37Rv ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTT
Mflv_0304|M.gilvum_PYR-GCK DTTTCAIVGGGPAGMVLGLLLARAGVEVTVLEKHADFLRDFRGDTVHPTT
Mvan_0442|M.vanbaalenii_PYR-1 AKTTCAVVGGGPAGMVLGLLLARAGVEVTVLEKHADFLRDFRGDTVHPTT
MSMEG_4962|M.smegmatis_MC2_155 EKTTCAVVGGGPAGMVLGLLLARAGIEVTVFEKHADFLRDFRGDTVHPAT
MAV_4364|M.avium_104 --------------MVHALLLARAGIPVVVLEKHNDFLRDFRGDTVHPTT
: .*******: *.::*** ***** ******.:*
MMAR_3720|M.marinum_M LRLLDELGLGSQFAQIPHRLIDTISMKV-QGQPVDL-DLKHLPGA---HQ
MUL_3663|M.ulcerans_Agy99 LRLLDELGLGSQFAQIPHRLIDTISMKV-QGQPVDL-DLKHLPGA---HQ
MAB_1646c|M.abscessus_ATCC_199 LNLIDELGLGPRFAAMPHNLVEQVTVDL-GEQTFRLGDLNRLPGP---HK
Mb1780|M.bovis_AF2122/97 MRLLDELGLWERFAALPYSEVRTATLHS-NGRAVTYIDFERLHQP---YP
Rv1751|M.tuberculosis_H37Rv MRLLDELGLWERFAALPYSEVRTATLHS-NGRAVTYIDFERLHQP---YP
Mflv_0304|M.gilvum_PYR-GCK LRLLDDLGLWPRFADISHSRLDHATVDVGAGRSVTMVDFRRLRQP---HP
Mvan_0442|M.vanbaalenii_PYR-1 LRLIDELGLWPKFSALPHSRLERATVDVGAGRTITVVDFGRLRQP---HP
MSMEG_4962|M.smegmatis_MC2_155 LRLLDELGLFEKFDALPHSRVERARFDL-GGREVTVVDFGRLNLP---HR
MAV_4364|M.avium_104 LRIMDELGLIDEFLRLPHTKIDTVAFDT-DGSIRTFGNFKVLKRLGFNQP
:.::*:*** .* :.: : .. :: *
MMAR_3720|M.marinum_M HIALVPQWDFLELLAAAAEAEPTFRLLRSTEVTGVLWGDGPDRGRVVGVT
MUL_3663|M.ulcerans_Agy99 HIALVPQWDFLELLAAAAEAEPTFRLLRSTEVTGVLWGDGPDPGRVVSAT
MAB_1646c|M.abscessus_ATCC_199 HIAMAPQWDFLEMLATAAETEPTFRLRRSTEVTGLLRSGD----RITGIE
Mb1780|M.bovis_AF2122/97 YVAMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLREGG----KVTGVR
Rv1751|M.tuberculosis_H37Rv YVAMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLREGG----KVTGVR
Mflv_0304|M.gilvum_PYR-GCK YIAMVPQWDLLNLLADAGRAEPTFTLRMSTEVTGVLREGS----RVTGVR
Mvan_0442|M.vanbaalenii_PYR-1 YIAMVPQWDLLNLLAEAGEAEPTFTLRMCTEATGLIREGG----RVVGVR
MSMEG_4962|M.smegmatis_MC2_155 YIALVPQWDFLDLLADAAKEEPTFTLRMQTEVTGLLKDGD----TVTGVR
MAV_4364|M.avium_104 YIAMMPQWDFLDFIAEKASAYPEFTLIRNAEVTDLILEDD----RVAGVR
::*: ****:*:::* . * * * :*.*.:: .. :..
MMAR_3720|M.marinum_M YRAQSGETKHMHADLTVACDGRGSTVRSALGMATRSFGAPMDVWWFRLPR
MUL_3663|M.ulcerans_Agy99 YRAQSGETKHMHADLTVACDGRGSTVRSALGMATRSFGAPMDVWWFRLPR
MAB_1646c|M.abscessus_ATCC_199 YRTASGETGALKADLTVACDGRGSALRAAAGMRPRQFGVPIDIWWFRLPK
Mb1780|M.bovis_AF2122/97 YQGAEG-PGELRAELTVACDGRWSIARHEAGLKAREFPVNFDVWWFKLPR
Rv1751|M.tuberculosis_H37Rv YQGAEG-PGELRAELTVACDGRWSIARHEAGLKAREFPVNFDVWWFKLPR
Mflv_0304|M.gilvum_PYR-GCK YETADG-TGELQAGLTVACDGRGSLLREKTGLRTQEFPVGFDVWWFRLPR
Mvan_0442|M.vanbaalenii_PYR-1 YQDPDG-PGELRADLTVGCDGRGSVLRGLAGLQVREFPVSFDAWWFRLPR
MSMEG_4962|M.smegmatis_MC2_155 YHGPDG-PGELRADLTVACDGRTSRVRKEAGLAPREYPVPFDVGWFRIDR
MAV_4364|M.avium_104 TP-----HDEVRADLVIAADGRKSAVRAAAGLRTAQAHSPMDVLWFRLKW
::* *.:..*** * * *: . :* **::
MMAR_3720|M.marinum_M -RPDDPTGLAGIFNSGHGGIAIDRGDYYQIAYIIPKGSDAQLRAQGIEAL
MUL_3663|M.ulcerans_Agy99 -RPDDPTGLAGIFNSGHGGIAIDRGDYYQIAYIIPKGSDAQLRAQGIEAL
MAB_1646c|M.abscessus_ATCC_199 -HPDDPQGPRARVGANRFMVLLDRGDYFQCGYLIGKGTDSQMRSGDVQVL
Mb1780|M.bovis_AF2122/97 -EGDAEFSFLPRFSPGKGLGVIPREGYFQIAYLGPKGTDAQLRERGIEEF
Rv1751|M.tuberculosis_H37Rv -EGDAEFSFLPRFSPGKGLGVIPREGYFQIAYLGPKGTDAQLRERGIEEF
Mflv_0304|M.gilvum_PYR-GCK PETDEMYTLFPRLAPGRAMIVIPREGYLQIALLIEKGTDAALRAHGLDAF
Mvan_0442|M.vanbaalenii_PYR-1 PADDSIYTLVPRIAPGKAMIVIPREGYLQIAMLIPKGTDAERRARGLDAF
MSMEG_4962|M.smegmatis_MC2_155 -IKETAYQLTPRISSGQALILIPREGYFQAGCFLPKGGEKQLHARGLEVF
MAV_4364|M.avium_104 -RPGDPRELFGVFRKGLMMAMIYRGDYWQVAYLMPKG--ASPKGGSLEEF
. . : * .* * . : ** : .:: :
MMAR_3720|M.marinum_M HRALADLMPWLADRVDALKSLDDVKLLDVQLNRLRRWYCDGALCIGDAAH
MUL_3663|M.ulcerans_Agy99 HRALADLMPWLADRVDALKSFDDVKLLDVQLNRLRRWYCDGALCIGDAAH
MAB_1646c|M.abscessus_ATCC_199 RDRVAEMAPWLAARTNAIASWDDVKLLDIQLNRLRKWYRDGLLFIGDAAH
Mb1780|M.bovis_AF2122/97 RRDVSELLPEATASVAALASTDEVKHLNVKVNRLRRWHIDGLLCIGDAAH
Rv1751|M.tuberculosis_H37Rv RRDVSELLPEATASVAALASMDEVKHLNVKVNRLRRWHIDGLLCIGDAAH
Mflv_0304|M.gilvum_PYR-GCK HADVLALLPEAAGTVGSIASLDEVKMLDVKLNRLRCWHIEGMLCIGDAAH
Mvan_0442|M.vanbaalenii_PYR-1 RADVLALLPEAATTIETITSLDDVKHLDVRLNRLRRWHTDGLLFIGDAAH
MSMEG_4962|M.smegmatis_MC2_155 RAQVAEAVPEAS--VDRLTSWDDVKVLDVKLNRLRRWYRDGLLCIGDAAH
MAV_4364|M.avium_104 KERIVTAQPRLREHVNDLTSWDDTSELDVRVDRLETWWRTGLLCIGDAAH
: : * : * *:.. *:::::**. * * * ******
MMAR_3720|M.marinum_M AMSPVGGVGINLALADAVATARMLAPSLRVGRVSTGQLARVQARRWAPTA
MUL_3663|M.ulcerans_Agy99 AMSPVGGVGINLALADAVATARMLAPSLRVGRVSTGQLARVQARRWAPTA
MAB_1646c|M.abscessus_ATCC_199 AMSPVGGVGINLAIADAVATARILAEPLRTGTLTTADLRKVQLRRWVPTA
Mb1780|M.bovis_AF2122/97 AMSPVAGVGINLAVQDAVAAATILAEPLREHRVSSRHLAAVRRRRAFPTA
Rv1751|M.tuberculosis_H37Rv AMSPVAGVGINLAVQDAVAAATILAEPLREHRVSSRHLAAVRRRRAFPTA
Mflv_0304|M.gilvum_PYR-GCK AMSPAGGVGINLAIQDAVAAARLLAEPLRRGTVTGRDLARVRRRRILPTV
Mvan_0442|M.vanbaalenii_PYR-1 AMSPAGGVGINVAIQDAVATARLLADPLRRGAVTERDLAAVRRRRVVPAA
MSMEG_4962|M.smegmatis_MC2_155 AMSPVGGVGINLAIADAVAAARILAEPLRTGRVTRRDLAAVEKRRYVPAA
MAV_4364|M.avium_104 AMSPAGGVGINLAVADAVAAANILCAPLQQGRVTDRDLAKVQRRRELPTR
****..*****:*: ****:* :*. .*: :: .* *. ** *:
MMAR_3720|M.marinum_M FLQGIQRAIH----AAIVAVAVTGGPPQPPPVVR-LVSRSVPARRIMGYL
MUL_3663|M.ulcerans_Agy99 FLQGIQRAIH----AAIVAVAVTGGPPQPPPVVR-LVSRSVPVRRIMGYL
MAB_1646c|M.abscessus_ATCC_199 LIQRIQRAVHRRVFSAVDSSTTAASNAKIASVLS-IATKYPWLQAVPAYG
Mb1780|M.bovis_AF2122/97 VTQAVQRVLHRRLLGPLLQGRDPTPPAALLGLV----ERLPWLSAVPAYF
Rv1751|M.tuberculosis_H37Rv VTQAVQRVLHRRLLGPLLQGRDPTPPAALLGLV----ERLPWLSAVPAYF
Mflv_0304|M.gilvum_PYR-GCK VTQALQRLIDRRLLGPIVRGGSGGPSPGLIRTV----ERLPWLTVIPAYL
Mvan_0442|M.vanbaalenii_PYR-1 LTQALQRQIDKRFLRPILDGDVTGPPPALVRAI----ERAPWLTFVPAYL
MSMEG_4962|M.smegmatis_MC2_155 VIQAVQRVLHIGLRRALLGGEIRQPPERVLKAVGAVLSRFPGLAKVPAYL
MAV_4364|M.avium_104 IVQAVQVLMQDNAIAPNLNGDLS--PIHVPKIVG-----FGPLQAIPPLV
. * :* :. . : :
MMAR_3720|M.marinum_M VAIGPLPEHAPKYARRAR------
MUL_3663|M.ulcerans_Agy99 VAIGPLPEHAPKYPRRAR------
MAB_1646c|M.abscessus_ATCC_199 VAIGPLPEHAPDFARRSPID----
Mb1780|M.bovis_AF2122/97 VGVGVRPEHAPAFARRGPGNRKGP
Rv1751|M.tuberculosis_H37Rv VGVGVRPEHAPAFARRGPGNRKGP
Mflv_0304|M.gilvum_PYR-GCK VGVGVRPERAPRFARRRPQ-----
Mvan_0442|M.vanbaalenii_PYR-1 VGVGVRPERAPEFAKRRPT-----
MSMEG_4962|M.smegmatis_MC2_155 VGVGPLPEHAPDFARRSR------
MAV_4364|M.avium_104 VGRGFRPEHVRTPDVHAR------
*. * **:. :