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VVKTVTRHDGSLLESPAYGSWLLGDLNESQRDRRIRIRGMLTAVIAATNVIGICVGLVLATVAAPAPHVL SDAPLWITFAVMPAYVVIAFALGSYWLARRTTQMLRWAIERREPSPTDQRNTLLAPFRFAIFHLLVWGTF TILLTALYGMANSMFIPRFLFALSFCGLGVTTASYMFTEFALRPVAAMALAAGPPLLRWAPGIRGRTIVV WLTGSGVPLIGMALVVIFDESLWQISQAEFSISVVIVSSAMLALGLLLMWILSWLTTTPVKVVCAALKRV EMGDLPGDLVVFDGTELGQLQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERPKLGGEDRHIAVV FIDIVGSTRLVTTQPPAEVVKLLNRFFAIVVDEVDRHRGLVNKFLGDAALAIFGAPNRLEQPEDQALAAA RAIARRLAAEVPECQAGIGVAAGQAVAGNVGANERFEYTAIGEPVNEAARLCELAKSFPGRLLASAETLA GASESVSAQWCLGDSTLLRGLDQPTRLATPIETAELDE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3986 | - | - | 100% (528) | adenylate cyclase |
| M. ulcerans Agy99 | MUL_3944 | - | 0.0 | 61.27% (519) | adenylate cyclase |
| M. ulcerans Agy99 | MUL_1472 | - | e-138 | 51.97% (483) | adenylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1352c | - | 0.0 | 67.95% (521) | adenylate cyclase |
| M. gilvum PYR-GCK | Mflv_2336 | - | 0.0 | 60.92% (522) | putative adenylate/guanylate cyclase |
| M. tuberculosis H37Rv | Rv1318c | - | 0.0 | 67.95% (521) | adenylate cyclase |
| M. leprae Br4923 | MLBr_00201 | - | 3e-85 | 39.01% (464) | hypothetical protein MLBr_00201 |
| M. abscessus ATCC 19977 | MAB_1459c | - | 1e-164 | 54.74% (517) | hypothetical protein MAB_1459c |
| M. marinum M | MMAR_4120 | - | 0.0 | 99.43% (526) | adenylate cyclase |
| M. avium 104 | MAV_1540 | - | 0.0 | 67.24% (525) | HAMP domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4924 | - | 1e-177 | 59.96% (522) | adenylate cyclase, family protein 3 |
| M. thermoresistible (build 8) | TH_3474 | - | 0.0 | 61.92% (520) | PUTATIVE putative adenylate/guanylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_4309 | - | 0.0 | 63.27% (520) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3986|M.ulcerans_Agy99 ---------------MVKTVTRHDGSLLESP-AYGSWLLGDLNESQRDRR
MMAR_4120|M.marinum_M ----------------MKTVTRHDGSLLESP-AYGSWLLGDLNESQRDRR
Mb1352c|M.bovis_AF2122/97 --MSAKKSTAQRLGRVLETVTRQSGRLPETP-AYGSWLLGRVSESQRRRR
Rv1318c|M.tuberculosis_H37Rv --MSAKKSTAQRLGRVLETVTRQSGRLPETP-AYGSWLLGRVSESQRRRR
MAV_1540|M.avium_104 --MSATQSTAQRIGRVLEKITRQSGRLPETP-AYGSLLLGRVTESQHRRR
Mflv_2336|M.gilvum_PYR-GCK --MNATKSVPYRLGRVLERVTRQSGRLDTP--GYGSWLLGRPAESQSRRR
Mvan_4309|M.vanbaalenii_PYR-1 --MNATKSVPYRLGRVLERVTRQSGRLETP--DYGSWLLGKPEESQARRR
TH_3474|M.thermoresistible__bu --MTPNNRLARRLGHLLETLTRQSGRLSGAN-EYGSWLLGRVSESQRRRR
MSMEG_4924|M.smegmatis_MC2_155 --MNADNSLARQLGRVLETVTRQNSRLPSGTPEYGSWILGRVTESQSRRR
MAB_1459c|M.abscessus_ATCC_199 MANESIRAVSRRVGRALGAITGQTGNINTGN-GYGSWLLGTADESTFIQR
MLBr_00201|M.leprae_Br4923 -------------------MATQAAGLPGRIGAFVRWGIRTPWPLFSLSM
:: : . : : :
MUL_3986|M.ulcerans_Agy99 IRIRGMLTAVIAATNVIGICVGLVLATVAAPAPHVLSDAPLWITFAVMPA
MMAR_4120|M.marinum_M IRIQGMLTAVIAATNVIGICVGLVLATVAAPAPHVLSDAPLWITFAVMPA
Mb1352c|M.bovis_AF2122/97 VRIQVMLTALVVTANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPG
Rv1318c|M.tuberculosis_H37Rv VRIQVMLTALVVTANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPG
MAV_1540|M.avium_104 IRIQIIMTVMVLGANLIGIGAALILVIVAIPAPSVFNDAPAWITFGVGPA
Mflv_2336|M.gilvum_PYR-GCK VRIQIILTFFILFTNIMGIAVSLLLNTIAIPVPSVFSDAPAWLTFGVTPA
Mvan_4309|M.vanbaalenii_PYR-1 IRIQVILTFLLLFTNILGIAVSLLLNTVAIPVPSVFSDAPAWLTFGVVPA
TH_3474|M.thermoresistible__bu LRIQTILTTFIVGANVVGIAVAVTLVSFVFPVPSIFSDAPAWLTFGVSPA
MSMEG_4924|M.smegmatis_MC2_155 IRIQLILTTFVVIANLLGIAVSFLVLTVLFPSPSVFDARVAPYTYIVAPA
MAB_1459c|M.abscessus_ATCC_199 IRIQLILTVFVVAANLIGIGVVILLVTVAFPTPNVF-DAPAWVNFVIVPV
MLBr_00201|M.leprae_Br4923 LQSDIIGALFVLGFLRYGLPPQDRVELQDLPIRNLAISTLSVVVAFSTGF
:: : : .: *: : * :
MUL_3986|M.ulcerans_Agy99 YVVIAFALGSYWLARRTTQMLRWAIERREPSPTDQRNTLLAPFRFAIFHL
MMAR_4120|M.marinum_M YVVIAFALGSYWLTRRTTQMLRWAIERREPSPTDQRNTLLAPFRFAIFHL
Mb1352c|M.bovis_AF2122/97 YVLLALALGSYALTRQTVQALRWAIEGRKPTREEERRTFLAPWRVAVGHL
Rv1318c|M.tuberculosis_H37Rv YVLLALALGSYALTRQTVQALRWAIEGRKPTREEERRTFLAPWRVAVGHL
MAV_1540|M.avium_104 YVASALAVGTYWITRRTVLALRWAIEERKPTPTDERNTFLAPWRIALVDL
Mflv_2336|M.gilvum_PYR-GCK YMLVALFFGTAWITSRTVRSLRWAIEERQPTSTDQRNVFLAPARVAQKLL
Mvan_4309|M.vanbaalenii_PYR-1 YMVVALVLGTAWITSRTVGSLRWAIEERSPTRTDQRNVFVAPSRVAQMLL
TH_3474|M.thermoresistible__bu LVGVALVVGTTWITRGIVRNLRWAIEERPPSRTDQRNTFLAPWRVARAHL
MSMEG_4924|M.smegmatis_MC2_155 YVVGALVVGVIWATNRVIGNVRWALEERPPTPQDQRNTFFAPFRLTRVLL
MAB_1459c|M.abscessus_ATCC_199 YIALAVLIGAVWGTRRIFKAVRWALDERPPTKADQRNAFAVPWRLTVIQS
MLBr_00201|M.leprae_Br4923 AVNLKLLMPVFRWQRRDN---RLAEADPAATELARSRALRMPFYHTIISL
: . . * * .: . ..: * :
MUL_3986|M.ulcerans_Agy99 LVWGTFTILLTALYGMANSMFIPRFLFALSFCGLGVTTASYMFTEFALRP
MMAR_4120|M.marinum_M LVWGTFTILLTALYGMANSMFIPRFLFALSFCGLGVTTASYMFTEFALRP
Mb1352c|M.bovis_AF2122/97 MFWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLVATATYLHTEFALRP
Rv1318c|M.tuberculosis_H37Rv MFWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLVATATYLHTEFALRP
MAV_1540|M.avium_104 VLWGAGTLLLTVLYGLVDTMFIPRFLFGVSFCGVLVATACYLLAEFALRP
Mflv_2336|M.gilvum_PYR-GCK LLWGVGAVLLTVLYGLQDTAFIPRFLFAVGFPGIVVATACYMITEFALRP
Mvan_4309|M.vanbaalenii_PYR-1 LFWGFGAALLTLLYGLQDSAFIPRFLFAVGFPGIVVATACYMITEFALRP
TH_3474|M.thermoresistible__bu VLWGAGTAVLTTLYGLVDPAFIPRYLFTVSFAGIVVATICYLFTEFALRP
MSMEG_4924|M.smegmatis_MC2_155 ILWAAGTALLTTLYGMVDTNFIPKVLLGISFPGIVVSVSCHLFTEFALRP
MAB_1459c|M.abscessus_ATCC_199 VLWAGGVALFTLLYGLYDPMYIPKIFFAVGFSGAVVCAANYLFTEFAMRP
MLBr_00201|M.leprae_Br4923 VTWGIGGAVFIIASWSAARHSAPIVALATALGATATAIIGYLQSERVLRP
: *. :: * : .: . . :: :* .:**
MUL_3986|M.ulcerans_Agy99 VAAMALAAGPPLLRWAPGIRGRTIVVWLTGSGVPLIGMALVVIFD-ESLW
MMAR_4120|M.marinum_M VAAMALAAGPPLLRWAPGIRGRTIVVWLTGSGVPLIGMALVVIFD-ESLW
Mb1352c|M.bovis_AF2122/97 FAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAMFE-MVLL
Rv1318c|M.tuberculosis_H37Rv FAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAMFE-MVLL
MAV_1540|M.avium_104 VAAQALEAGPPPRRLTAGIMGRTMTVWFLGSGVPVIGIALLALFE-IWLR
Mflv_2336|M.gilvum_PYR-GCK IAAQALEAGRPPRRLAHGVMGRTMTVWLLSSGVPVLGILLLAVFS-LSLK
Mvan_4309|M.vanbaalenii_PYR-1 VAAQALEAGRPPRRLAHGVMGRTMTVWLLSSGVPVLGILLLAIFT-LSLR
TH_3474|M.thermoresistible__bu VAAQALEAGPPPRRLAHGIMGRTMTVWLLGSGVPLLGIMIAAAVS-LTQR
MSMEG_4924|M.smegmatis_MC2_155 VAAQALEAGPPPVRLAPGIMGRTMVVWALGSGVPILGILLAGVFA-VTLE
MAB_1459c|M.abscessus_ATCC_199 VAARALEAGYRRRRLASGVMVRTVLAWMLGSGVPAAGIVITGIGA-LVLH
MLBr_00201|M.leprae_Br4923 VAVAALRSGVPENVKTPGVTLRLMLTWVPSTGVPVLAIVLAVVADKIALL
.*. ** :* : *: * : .* .:*** .: :
MUL_3986|M.ulcerans_Agy99 QISQAEFSISVVIVSSAMLALGLLLMWILSWLTTTPVKVVCAALKRVEMG
MMAR_4120|M.marinum_M QISQAEFSISVVIVSSAMLALGLLLMWILSWLTTTPVKVVCAALKRVEMG
Mb1352c|M.bovis_AF2122/97 NLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERG
Rv1318c|M.tuberculosis_H37Rv NLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERG
MAV_1540|M.avium_104 NLTETEFAVGVLIVSTAALIFGCLLMWILAWLTATPVRVVRAALKRVERG
Mflv_2336|M.gilvum_PYR-GCK NLSATQFAVAVIFIAAFALVFGLTLMWLLSWLIATPVRVVRSALKQVEDG
Mvan_4309|M.vanbaalenii_PYR-1 NLSATQFAVAVMIISVVALMFGLILMWLLSWLIATPVRVVRSALKHVEDG
TH_3474|M.thermoresistible__bu HLSLVQFTIATMVLAAVALVFGFVLMWLVSWLTATPVRVVREALKQVENG
MSMEG_4924|M.smegmatis_MC2_155 NLTPTQFAYAVMGLAVFALVFGFILMWILSWLTATPIRVVRAALNRVEQG
MAB_1459c|M.abscessus_ATCC_199 NLTVSQLAVAVIIIAGAIPSFGLILIWIASWLMATPVKEVQTAIKRVAQN
MLBr_00201|M.leprae_Br4923 HAVPEQLFSPILLLALAVLVVGLVSTWLVAMSIADPLRQLRWALSEVQRG
: :: : :: .* *: : : *:: : *: .* .
MUL_3986|M.ulcerans_Agy99 DLPGDLVVFDGTELGQLQRGFNAMVAGLRERERVRDLFGRHVGREVAAAA
MMAR_4120|M.marinum_M DLPGDLVVFDGTELGQLQRGFNAMVAGLRERERVRDLFGRHVGREVAAAA
Mb1352c|M.bovis_AF2122/97 ELRTNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAA
Rv1318c|M.tuberculosis_H37Rv ELRTNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAA
MAV_1540|M.avium_104 DLRGDLVVFDGTELGELQRGFNAMVDGLRERERVRDLFGRHVGREVALAA
Mflv_2336|M.gilvum_PYR-GCK DLDCNLVVFDGTELGELQRGFNSMVHGLRERERVRDLFGRHVGREVALAA
Mvan_4309|M.vanbaalenii_PYR-1 DLDCNVVVFDGTELGELQRGFNSMVHGLRERERVRDLFGRHVGREVARAA
TH_3474|M.thermoresistible__bu NLDCNVVVFDGTELGELQRGFNAMVDGLRERERVRDLFGRHVGREVARAA
MSMEG_4924|M.smegmatis_MC2_155 DLDTNLVVFDGTELGQLQRGFNSMVHGLRERERVRDLFGRHVGREVAVLA
MAB_1459c|M.abscessus_ATCC_199 DLDIDLVVYDGTELGELQAGFNTMVEGLRERERVRDLFGKHVGREVAAAA
MLBr_00201|M.leprae_Br4923 NYNAHMQIYDASELGLLQAGFNDMVRELSERQRLRDLFGRYVGEDVARRA
: .: ::*.:*** ** *** ** * **:*:*****::**.:** *
MUL_3986|M.ulcerans_Agy99 ERERPKLGGEDRHIAVVFIDIVGSTRLVTTQPPAEVVKLLNRFFAIVVDE
MMAR_4120|M.marinum_M ERERPKLGGEDRHIAVVFIDIVGSTRLVTTQPPAEVVKLLNRFFAIVVDE
Mb1352c|M.bovis_AF2122/97 ERERSKLGGEERHVAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDE
Rv1318c|M.tuberculosis_H37Rv ERERSKLGGEERHVAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDE
MAV_1540|M.avium_104 ERERPKLGGEERHVAVVFIDIVGSTQLVTRRPPAEVVSVLNQFFGIVVEE
Mflv_2336|M.gilvum_PYR-GCK EKQQVELGGEERRAAVIFVDIIGSTKLVTSRPAAEVVELLNRFFDVVVDE
Mvan_4309|M.vanbaalenii_PYR-1 EKQKIELGGEERHAAVIFVDIIGSTQLVTSRPAVEVVELLNRFFDVVVEE
TH_3474|M.thermoresistible__bu EEQQLELGGEERHVAVIFVDIVGSTQLVTTRPAAEVVSLLNRFFAVIVEE
MSMEG_4924|M.smegmatis_MC2_155 EQQKFTLGGEERHAAVVFVDVIGSTQLVTSRPAVEVVELLNRFFAVIVDE
MAB_1459c|M.abscessus_ATCC_199 EQQQPELGGEERHIAVLFADIVGSTRLAATRPAVEVVALLNRFFTVVVEE
MLBr_00201|M.leprae_Br4923 LEHGTELGGQERDVAVLFVDLIGSTQLAETKPPTKVVHLLNEFFRVVVDT
.. ***::* **:* *::***:*. :*...** :**.** ::*:
MUL_3986|M.ulcerans_Agy99 VDRHRGLVNKFLGDAALAIFGAPNRLEQPEDQALAAARAIARRLAAEVPE
MMAR_4120|M.marinum_M VDRHRGLVNKFLGDAALAIFGAPNRLEQPEDQALAAARAIARRLAAEVPE
Mb1352c|M.bovis_AF2122/97 VDRHHGLVNKFEGDASLTIFGAPNRLPCPEDKALAAARAIADRLVNEMPE
Rv1318c|M.tuberculosis_H37Rv VDRHHGLVNKFEGDASLTIFGAPNRLPCPEDKALAAARAIADRLVNEMPE
MAV_1540|M.avium_104 VDRHCGLVNKFEGDATLAIFGAPNHLDCPEDAALTAARAIADRLANEMPQ
Mflv_2336|M.gilvum_PYR-GCK VDKHHGLVNKFEGDAVLAVFGAPVSLDNAEAEALAAARAMSRRLAAEVPE
Mvan_4309|M.vanbaalenii_PYR-1 VDNHHGLVNKFEGDAVLAVFGAPVSLDSAETEALSAARAMARRLRTEVPE
TH_3474|M.thermoresistible__bu VDRHRGLVNKFEGDATLAIFGAPNRLDNPEDAALAAARAIAARLRTEVPE
MSMEG_4924|M.smegmatis_MC2_155 VDAHRGLVNKFEGDAVLAVFGAPVALDNAEDEALGAARGIARRLREEVPE
MAB_1459c|M.abscessus_ATCC_199 IDRYEGMVNKFEGDATLAVFGAPVRQDRPESQALAAARAIARRLRTEVPE
MLBr_00201|M.leprae_Br4923 VGRHGGFVNKFQGDAALAIFGAPIEHPDSAGAALSAARELHDELLPVLGS
:. : *:**** *** *::**** . ** *** : .* : .
MUL_3986|M.ulcerans_Agy99 CQAGIGVAAGQAVAGNVGANERFEYTAIGEPVNEAARLCELAKSFPGRLL
MMAR_4120|M.marinum_M CQAGIGVAAGQAVAGNVGANERFEYTAIGEPVNEAARLCELAKSFPGRLL
Mb1352c|M.bovis_AF2122/97 CQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEAARLCELAKSRPGKLL
Rv1318c|M.tuberculosis_H37Rv CQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEAARLCELAKSRPGKLL
MAV_1540|M.avium_104 CRAGIGVAAGQVVAGNVGARERFEYTVIGEPVNEAARLCELAKSHSGRLL
Mflv_2336|M.gilvum_PYR-GCK CTAGIGVASGQVVAGNVGAKERFEYTVIGEPVNEAARLCELSKKIDGHLV
Mvan_4309|M.vanbaalenii_PYR-1 CPAGIGVAAGQVVAGNVGAKQRFEYTVIGEPVNEAARLCELAKNVPALLV
TH_3474|M.thermoresistible__bu VRAGIGVASGQVVAGNVGARERFEYTVIGEPVNEGARLCELAKTKPGLLV
MSMEG_4924|M.smegmatis_MC2_155 LDAGIGVAAGQVVAGNVGAKQRFEYTVIGEPVNEAARLCEFAKSVPGHVV
MAB_1459c|M.abscessus_ATCC_199 CQAGIGVASGQAVAGNIGAHDRFEYTVIGDPVNEAARLCELSKTVPGHLV
MLBr_00201|M.leprae_Br4923 AEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEDGHVL
****::*:.:**::**. *****.**:****.*** *::* . ::
MUL_3986|M.ulcerans_Agy99 ASAETLAGASESVSAQWCLGDSTLLRGLDQPTRLATPIETAELDE-----
MMAR_4120|M.marinum_M ASAETLAGASESVSAQWCLGDSTLLRGLGQPTRLATPIETAELDG-----
Mb1352c|M.bovis_AF2122/97 ASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPRR-----
Rv1318c|M.tuberculosis_H37Rv ASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPRR-----
MAV_1540|M.avium_104 ATGDAIEGASEKERARWSLGDTVTLRGHERPTRLASPAGAADRPAGTD--
Mflv_2336|M.gilvum_PYR-GCK ASADAVHNATETERRHWELGETVTLRGHAEPTTLATPVDRD---------
Mvan_4309|M.vanbaalenii_PYR-1 ASADAVGGATESERALWKLGETVTLRGHDQPTRLATPAGEL---------
TH_3474|M.thermoresistible__bu ASADAVANAGEQERAHWVLGETVTLRGHNQPTRLALPA------------
MSMEG_4924|M.smegmatis_MC2_155 ASSDTLANASESERARWSLGESVTLRGLDEPTRLAVPV------------
MAB_1459c|M.abscessus_ATCC_199 ASLDTVLRAHHREALHWRSGDTVTLRGRTEPTELAVPV------------
MLBr_00201|M.leprae_Br4923 ASAIAVSGALDAEALCWNVGEIVELRGRTAPTQLARPLNLAVPEQITSEV
*: :: * . * * . *** *. ** *
MUL_3986|M.ulcerans_Agy99 --
MMAR_4120|M.marinum_M --
Mb1352c|M.bovis_AF2122/97 --
Rv1318c|M.tuberculosis_H37Rv --
MAV_1540|M.avium_104 --
Mflv_2336|M.gilvum_PYR-GCK --
Mvan_4309|M.vanbaalenii_PYR-1 --
TH_3474|M.thermoresistible__bu --
MSMEG_4924|M.smegmatis_MC2_155 --
MAB_1459c|M.abscessus_ATCC_199 --
MLBr_00201|M.leprae_Br4923 TG