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VMHVNGFGGLAAQQVAASPICCAPLDERSAIPGPQPPVRLLVVDDADGVETLFGARFRTELRCDEYDLSF SNDPVQALKMVGDSPDIEVLVTNLNMPQMNGLDLLTEVAKLGRPLKTIVLTACNDLANIRAAMMRGAFDF QLTPLDLEDLRVTISKAVTIVRELQAGEAARQRAVELADQNRRVENIFGRYVSEEVKTHLLACPEGHQNS ERRTLTMLMADIRGFTRLSEILSPERALQVLNAYLERATDVVIRWNGTINEILGDGLLVFFGVPNTDGEA AEHAVAAALELQLAMGELNVSHREQGLPELGIGIGVHTGEAVVGTIGSPRRQKYTAIGKNVNLVARIESN TVGGQVLVSESTYHEICAIADTSGSTQVRVKGLTEPITVHDITGLAGRYNLRLPSIDRKVIPLVVPKPIG IAVIENKIIGAAHPAEVVGSGDGAVRVRTGLQVAPFCDLVLDVAGAQVFAKVVDCGVDGGICELMAVFTS VSDDVRRALAAPSTANSLS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0730 | - | - | 100% (509) | adenylylate/guanylate cyclase |
| M. marinum M | MMAR_2550 | - | 2e-22 | 31.28% (243) | transmembrane protein |
| M. marinum M | MMAR_4438 | - | 1e-21 | 33.87% (186) | hypothetical protein MMAR_4438 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3669 | - | 2e-19 | 28.69% (251) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_1395 | - | 5e-19 | 28.25% (308) | putative adenylate/guanylate cyclase |
| M. tuberculosis H37Rv | Rv3645 | - | 2e-19 | 28.69% (251) | transmembrane protein |
| M. leprae Br4923 | MLBr_00201 | - | 2e-20 | 29.48% (251) | hypothetical protein MLBr_00201 |
| M. abscessus ATCC 19977 | MAB_1459c | - | 8e-21 | 33.90% (236) | hypothetical protein MAB_1459c |
| M. avium 104 | MAV_4804 | - | 1e-19 | 30.04% (233) | GAF domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0228 | - | 4e-18 | 31.25% (192) | adenylate and guanylate cyclase catalytic domain-containing |
| M. thermoresistible (build 8) | TH_0858 | - | 4e-19 | 29.49% (234) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_3594 | - | 0.0 | 99.41% (508) | adenylylate/guanylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_1904 | - | 2e-23 | 39.08% (174) | adenylyl cyclase class-3/4/guanylyl cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0730|M.marinum_M --------------------------------------------------
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1904|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_4804|M.avium_104 MLDLDDRVTDRQRELARLRAAVDAAARGGGECVLISGVPGVGKSALMKAF
MMAR_0730|M.marinum_M --------------------------------------------------
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1904|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_4804|M.avium_104 GVEVAGRGCVFAYGRCRDGAPAPYAAVRDALGSLVRTMAATAPAERDRWR
MMAR_0730|M.marinum_M --------------------------------------------------
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1904|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_4804|M.avium_104 ADLAGGVSPIAGVLGELVPDLPRVLGETASHPELDATDSRRQLHRAATRL
MMAR_0730|M.marinum_M --------------------------------------------------
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 ------------------------------MVACGTCGTELRQGARFCDS
Mvan_1904|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_4804|M.avium_104 LSATASYRTVVLAIDDLQWADRDTLLLLAELLTVSLRDVLVVGAHRAGGF
MMAR_0730|M.marinum_M --------------------------------------------------
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 CGTAIVDGSKHAEYKQVTVLFADVVDSMRLAAAVGAERLREILSALVSRC
Mvan_1904|M.vanbaalenii_PYR-1 ----------------MTVLFADVVGSMRLAAELDPERLREIMNDLFNRS
MAV_4804|M.avium_104 DPAAAGIAAENLTTIELEPLARDDVEELLATVCGQSGELPEVAAEFHHRT
MMAR_0730|M.marinum_M --------------------------------------------------
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 SGVVGHYGGTVDKFTGDGIMALFG--APLALEDHALRACLAALDLQYESH
Mvan_1904|M.vanbaalenii_PYR-1 ATVVQRYHGTMDKFTGDGLMALFG--APMALEDHALRACIAALEIQAVVG
MAV_4804|M.avium_104 GGNPLQVRQLLYRAQREGALLPVGSGGPPRWDLRVLTSIEVSATAAEFLG
MMAR_0730|M.marinum_M ---------------MMHVNGFGGLAAQQVAASPICCAPLDERSAIPGPQ
MUL_3594|M.ulcerans_Agy99 ----------------MHVNGFGGLAAQQVAASPICCAPLDERSAIPGPQ
Mflv_1395|M.gilvum_PYR-GCK -------------------------MAADPT-ETGRISAFVR--WVARTP
TH_0858|M.thermoresistible__bu --------------------------------------------------
Mb3669|M.bovis_AF2122/97 -----MDAEAFVGFRQVPAARYGGLMATTAA-LPRRIHAFVR--WVVRTP
Rv3645|M.tuberculosis_H37Rv -----MDAEAFVGFRQVPAARYGGLMATTAA-LPRRIHAFVR--WVVRTP
MLBr_00201|M.leprae_Br4923 -------------------------MATQAAGLPGRIGAFVR--WGIRTP
MAB_1459c|M.abscessus_ATCC_199 -----MANESIRAVSRRVGRALG--AITGQTGNINTGNGYGS--WLLGTA
MSMEG_0228|M.smegmatis_MC2_155 RLADELDLPAGVGLQIRVGLNSGQVIAGEMSAGGFGYTAIGEQVGMAQRM
Mvan_1904|M.vanbaalenii_PYR-1 ELADEVEQRDGVRLQLRVGLNSGDVVVGDIGSGPGRYTAIGHAVGMAQRM
MAV_4804|M.avium_104 RYLDQLRPADREVLSALSCIGGEFDLDDAAAAAARTPDVVAHALWACLEL
MMAR_0730|M.marinum_M PPVRLLVVDDADGVETLFGARFRTELRCDEYDLSFSNDPVQALKMVGDSP
MUL_3594|M.ulcerans_Agy99 PPVRLLVVDDADGVETLFGARFRTELRCDEYDLSFSNDPVQALKMVGDSP
Mflv_1395|M.gilvum_PYR-GCK WPVFTLGMLQADIIGALLVLGFLRFGLPPEDRIQLQDLPAYNLAIFLGY-
TH_0858|M.thermoresistible__bu --VFALGMVQADIIGALFVLGFLRFGLPPGDRLELQDLPAFNLALFLGY-
Mb3669|M.bovis_AF2122/97 WPLFSLSMLQSDIIGALFVLGFLRYGLPPQDNIQLQDLPPVNLLIFVST-
Rv3645|M.tuberculosis_H37Rv WPLFSLSMLQSDIIGALFVLGFLRYGLPPQDNIQLQDLPPVNLLIFVST-
MLBr_00201|M.leprae_Br4923 WPLFSLSMLQSDIIGALFVLGFLRYGLPPQDRVELQDLPIRNLAISTLS-
MAB_1459c|M.abscessus_ATCC_199 DESTFIQRIRIQLILTVFVVAANLIGIGVVILLVTVAFPTPN--VFDAP-
MSMEG_0228|M.smegmatis_MC2_155 ESVAPHGGIMCSDTTARLVEDSVLLGAPEMLRVKGCDRPVAARRLLAATN
Mvan_1904|M.vanbaalenii_PYR-1 EAAASAGAVVCSLSTADLVEHATRLGAVQTVRIKGSDEPAPARRLVAVEA
MAV_4804|M.avium_104 RLLEALDMTGQRISNAISRDARYRFSHDRVAEAARAGLSPDEMRAVHLRI
: .
MMAR_0730|M.marinum_M D------------------------------------------IEVLVTN
MUL_3594|M.ulcerans_Agy99 D------------------------------------------IEVLVTN
Mflv_1395|M.gilvum_PYR-GCK ---------------------------------------------LFVSF
TH_0858|M.thermoresistible__bu ---------------------------------------------LVVSF
Mb3669|M.bovis_AF2122/97 ---------------------------------------------VIILF
Rv3645|M.tuberculosis_H37Rv ---------------------------------------------VIILF
MLBr_00201|M.leprae_Br4923 ---------------------------------------------VVVAF
MAB_1459c|M.abscessus_ATCC_199 ---------------------------------------------AWVNF
MSMEG_0228|M.smegmatis_MC2_155 A-AHGGRSDPTLVGRSWELNTIAGLLDEAVE-----------GRGGIVSV
Mvan_1904|M.vanbaalenii_PYR-1 ARMVVGRNEGLMLGRDGELHQLCDSLDRRR-------------RRHLVSV
MAV_4804|M.avium_104 GRRLITLGDDRLFEAARHVGVGGLAVSDEAERTRFVEVLRRAAHQARAQA
MMAR_0730|M.marinum_M LNMPQMNGLDLLTEVAKLGRPLKTIVLTACNDLANIRAAMMRG-------
MUL_3594|M.ulcerans_Agy99 LNMPQMNGLDLLTEVAKLGRPLKTIVLTACNDLANIRAAMMRG-------
Mflv_1395|M.gilvum_PYR-GCK TVA-SYLTLRMLIPVMRWQR---RDMLLGDRDPSDTEVARMR--------
TH_0858|M.thermoresistible__bu TVG-AYVTLRLLLPVIRWQR---RDTLLADPDPAATELARAR--------
Mb3669|M.bovis_AF2122/97 LAG-AVVNLKLLMPVFRWQR---RDNLLTEPDPAATELARSR--------
Rv3645|M.tuberculosis_H37Rv LAG-AVVNLKLLMPVFRWQR---RDNLLTEPDPAATELARSR--------
MLBr_00201|M.leprae_Br4923 STG-FAVNLKLLMPVFRWQR---RDNRLAEADPAATELARSR--------
MAB_1459c|M.abscessus_ATCC_199 VIVPVYIALAVLIGAVWGTRRIFKAVRWALDERPPTKADQRN--------
MSMEG_0228|M.smegmatis_MC2_155 VGPPGIGKSRMVRESIELARRRGVAVFYTYCESHASDVPFHVVVPLLR--
Mvan_1904|M.vanbaalenii_PYR-1 VGAPGVGKSRLVEEFCRRLRGAGTEVVLAGCDAHAMPIAFRALSRLLR--
MAV_4804|M.avium_104 SFPLALGYCRDALDLLGEQRWAGQFVLTRELALDAADAALRVGDVPVLNT
*
MMAR_0730|M.marinum_M ------------AFDFQLTPLDLEDLRVTISKAVTIVRELQAGEAARQRA
MUL_3594|M.ulcerans_Agy99 ------------AFDFQLTPLDLEDLRVTISKAVTIVRELQAGEAARQRA
Mflv_1395|M.gilvum_PYR-GCK ------------ALKMPFYRSLISATNWLLGSVVFIVASWPVASKSAPVV
TH_0858|M.thermoresistible__bu ------------ALRMPFYRTLISGTNWFLGTIVFIVASWPVAGHSAPVI
Mb3669|M.bovis_AF2122/97 ------------ALRMPLYRTLISLAVWATGGGVFILASWSVAKHAAPVV
Rv3645|M.tuberculosis_H37Rv ------------ALRMPLYRTLISLAVWATGGGVFILASWSVAKHAAPVV
MLBr_00201|M.leprae_Br4923 ------------ALRMPFYHTIISLVTWGIGGAVFIIASWSAARHSAPIV
MAB_1459c|M.abscessus_ATCC_199 ------------AFAVPWRLTVIQSVLWAGGVALFTLLYGLYDPMYIPKI
MSMEG_0228|M.smegmatis_MC2_155 ------EGFGVAGLDPAAARVRVRSLVPDADPEDLLLLDDVLGIADPDVP
Mvan_1904|M.vanbaalenii_PYR-1 ------AMFSADDLGDDDARELVLSQVPMG-STDAQIIFEAMGIADGAAP
MAV_4804|M.avium_104 LLDEAEEFLREPPDRARLAYLRMKGRVAENRLQEALEIGLAALDELGERV
:
MMAR_0730|M.marinum_M VELADQNRRVENIFGRYVSEEVKTHLLACPEGHQNSER--------RTLT
MUL_3594|M.ulcerans_Agy99 LELADQNRRVENIFGRYVSEEVKTHLLACPEGHQNSER--------RTLT
Mflv_1395|M.gilvum_PYR-GCK AVATGLGATATAIIGYLQSERVLRPVAVAALRGGVPENFRAPGVILRQVL
TH_0858|M.thermoresistible__bu AVATGLGATATAIIGYLQAERVLRPVAVAALRGGVPENFRAPGVVLRQVL
Mb3669|M.bovis_AF2122/97 AVATALGATATAIIGYLQSERVLRPVAVAALRSGVPENVNAPGVILRLML
Rv3645|M.tuberculosis_H37Rv AVATALGATATAIIGYLQSERVLRPVAVAALRSGVPENVNAPGVILRLML
MLBr_00201|M.leprae_Br4923 ALATALGATATAIIGYLQSERVLRPVAVAALRSGVPENVKTPGVTLRLML
MAB_1459c|M.abscessus_ATCC_199 FFAVGFSGAVVCAANYLFTEFAMRPVAARALEAGYRRRRLASGVMVRTVL
MSMEG_0228|M.smegmatis_MC2_155 MPDLDADARRRRVAALVNAASLARREPGLYVLEDAHWIDEVSESMLAEFL
Mvan_1904|M.vanbaalenii_PYR-1 PLHVGADGRRHRLVETMAQFVRLRSTPMVLVLEDAHWIDAASEAVLCEFA
MAV_4804|M.avium_104 ATQAGKPRMGNAIVRMRLTMARWSTERLLQLPHCTDQRVIALHPILAELC
.
MMAR_0730|M.marinum_M MLMADIR---------GFTRLSEILSPERALQVLNAYLERATDVVIRWNG
MUL_3594|M.ulcerans_Agy99 MLMADIR---------GFTRLSEILSPERALQVLNAYLERATDVVIRWNG
Mflv_1395|M.gilvum_PYR-GCK TWVLSTG---------VPVLAIVLALVASKFEVLTAPADRLITTILLLAI
TH_0858|M.thermoresistible__bu TWVLSTG---------VPVLAIVLALVASKVGILTAPAEQLTTPLLVLAI
Mb3669|M.bovis_AF2122/97 AWIPSTG---------VPLLAIVLAVAADKIALLHATPEALFNPILMMAL
Rv3645|M.tuberculosis_H37Rv AWIPSTG---------VPLLAIVLAVAADKIALLHATPEALFNPILMMAL
MLBr_00201|M.leprae_Br4923 TWVPSTG---------VPVLAIVLAVVADKIALLHAVPEQLFSPILLLAL
MAB_1459c|M.abscessus_ATCC_199 AWMLGSG---------VPAAGIVITGIG-ALVLHNLTVSQLAVAVIIIAG
MSMEG_0228|M.smegmatis_MC2_155 TVVTHTHSVMLITYRPEYTGVLARVSGAQTIALRPLTDGQTSTLLTELLG
Mvan_1904|M.vanbaalenii_PYR-1 TVLERTSTVLVTTCRPEYRGGLRKRS-AHTVTVAPLNDSLTMDLVLNLLG
MAV_4804|M.avium_104 NMAVLVRPN-LLPLLVRKQLELTLAHGHTSSSPLVITGYGIVLVLLGDHA
:
MMAR_0730|M.marinum_M TINEILGDGLLVFFGV-----------------------PNTDGEAAEHA
MUL_3594|M.ulcerans_Agy99 TINEILGDGLLVFFGV-----------------------PNTDGEAAEHA
Mflv_1395|M.gilvum_PYR-GCK VALIIGLSSTVLVAMS-----------------------IADPLRQLRWA
TH_0858|M.thermoresistible__bu ATLVIGLSGTVLVAMS-----------------------IADPLRQLRWA
Mb3669|M.bovis_AF2122/97 AALGIGSVSTLLVAMS-----------------------IADPLRQLRWA
Rv3645|M.tuberculosis_H37Rv AALGIGSVSTLLVAMS-----------------------IADPLRQLRWA
MLBr_00201|M.leprae_Br4923 AVLVVGLVSTWLVAMS-----------------------IADPLRQLRWA
MAB_1459c|M.abscessus_ATCC_199 AIPSFGLILIWIASWL-----------------------MATPVKEVQTA
MSMEG_0228|M.smegmatis_MC2_155 PDAAAHQLAGLIADRA-----------------------AGNPFFTQEIV
Mvan_1904|M.vanbaalenii_PYR-1 GDGAMGGLASRIVGVA-----------------------AGNPYFVEEIV
MAV_4804|M.avium_104 GSQRFGEVGMLLAQRPELREARPQTVFMYLDYIHHWRHPIRDGLGELRDA
: . .
MMAR_0730|M.marinum_M VAAALE-------LQLAMGELNVSHRE-------------------QGLP
MUL_3594|M.ulcerans_Agy99 VAAALE-------LQLAMGELNVSHRE-------------------QGLP
Mflv_1395|M.gilvum_PYR-GCK LGEVQR-------GNYNAHMQIYDASE-------------------LGLL
TH_0858|M.thermoresistible__bu LGEVQR-------GNFNAHMQIYDASE-------------------LGLL
Mb3669|M.bovis_AF2122/97 LSEVQR-------GNYNAHMQIYDASE-------------------LGLL
Rv3645|M.tuberculosis_H37Rv LSEVQR-------GNYNAHMQIYDASE-------------------LGLL
MLBr_00201|M.leprae_Br4923 LSEVQR-------GNYNAHMQIYDASE-------------------LGLL
MAB_1459c|M.abscessus_ATCC_199 IKRVAQ-------NDLDIDLVVYDGTE-------------------LGEL
MSMEG_0228|M.smegmatis_MC2_155 RDLAERGVLRGERGAYRFHGADVEIGV-------------------PATL
Mvan_1904|M.vanbaalenii_PYR-1 RDLVGRGVLAGSRGDYRLIRDVDDIGV-------------------PVTV
MAV_4804|M.avium_104 VEEALDRGDQENAGFLTAVLLSQSFWVGRPLPEIDALASSLIPHIRSQPV
. .
MMAR_0730|M.marinum_M ELGIG-----------IGVHTGEAVVGTIGSPRRQKYTAIGKNVNLVARI
MUL_3594|M.ulcerans_Agy99 ELGIG-----------IGVHTGEAVVGTIGSPRRQKYTAIGKNVNLVARI
Mflv_1395|M.gilvum_PYR-GCK QAGFNDMVRDLAERQRLRDLFGRYVGEDVARRALERGTELGGQERDVAVL
TH_0858|M.thermoresistible__bu QAGFNDMVRDLAERQRLRDLFGRYVGEDVARRALERGTELGGQERDVAVL
Mb3669|M.bovis_AF2122/97 QAGFNDMVRELSERQRLRDLFGRYVGEDVARRALERGTELGGQERDVAVL
Rv3645|M.tuberculosis_H37Rv QAGFNDMVRELSERQRLRDLFGRYVGEDVARRALERGTELGGQERDVAVL
MLBr_00201|M.leprae_Br4923 QAGFNDMVRELSERQRLRDLFGRYVGEDVARRALEHGTELGGQERDVAVL
MAB_1459c|M.abscessus_ATCC_199 QAGFNTMVEGLRERERVRDLFGKHVGREVAAAAEQQQPELGGEERHIAVL
MSMEG_0228|M.smegmatis_MC2_155 QATIAARIDRLEVEAKRTLSAAAVIGLRFGPDMLAALGADVS---MQALI
Mvan_1904|M.vanbaalenii_PYR-1 QAVLAARIDRLAPATKAVLNAAAVIGNRFDAETLQVLTPNARSGELAELV
MAV_4804|M.avium_104 PSALCQAVQQLCLNLMGRSADPFLLAGESGYDERQVLPAARQQGDEVALG
: :
MMAR_0730|M.marinum_M ESNTVGG----------------QVLVSES------TYHEICAIADTSGS
MUL_3594|M.ulcerans_Agy99 ESNTVGG----------------QVLVSES------TYHEICAIADTSGS
Mflv_1395|M.gilvum_PYR-GCK FVDLVGS----------------THLAATI------PASEVVSLLNEFFR
TH_0858|M.thermoresistible__bu FVDLVGS----------------TRLAATT------PPADVVNLLNEFFR
Mb3669|M.bovis_AF2122/97 FVDLVGS----------------TQLAATR------PPAEVVQLLNEFFR
Rv3645|M.tuberculosis_H37Rv FVDLVGS----------------TQLAATR------PPAEVVQLLNEFFR
MLBr_00201|M.leprae_Br4923 FVDLIGS----------------TQLAETK------PPTKVVHLLNEFFR
MAB_1459c|M.abscessus_ATCC_199 FADIVGS----------------TRLAATR------PAVEVVALLNRFFT
MSMEG_0228|M.smegmatis_MC2_155 DAELVDQ----------------VMFAPRPEYAFRHPLIRMVALESQLKS
Mvan_1904|M.vanbaalenii_PYR-1 ATELIDQ----------------MEFAPRQRYCFRHPLVRAVAYDSQISA
MAV_4804|M.avium_104 AAAAMKQGLHFWCGDHAGAAEATTEAIEHLGGLAGVAASQLVHLIGALSM
: . .
MMAR_0730|M.marinum_M TQVRVKGLTEPITVHDITGLAGRYNLRLPSIDRKV-----------IPLV
MUL_3594|M.ulcerans_Agy99 TQVRVKGLTEPITVHDITGLAGRYNLRLPSIDRKV-----------IPLV
Mflv_1395|M.gilvum_PYR-GCK VVVDTVNRHG-GFVNKFQGDAALAIFGAPIEHPDA-----------SGAA
TH_0858|M.thermoresistible__bu VVVDTVNRHG-GFVNKFQGDAALAIFGAPIEHPDA-----------CGAA
Mb3669|M.bovis_AF2122/97 VVVETVARHG-GFVNKFQGDAALAIFGAPIEHPDG-----------AGAA
Rv3645|M.tuberculosis_H37Rv VVVETVARHG-GFVNKFQGDAALAIFGAPIEHPDG-----------AGAA
MLBr_00201|M.leprae_Br4923 VVVDTVGRHG-GFVNKFQGDAALAIFGAPIEHPDS-----------AGAA
MAB_1459c|M.abscessus_ATCC_199 VVVEEIDRYE-GMVNKFEGDATLAVFGAPVRQDRP-----------ESQA
MSMEG_0228|M.smegmatis_MC2_155 DRAELHRRLAVDIERRAPHAADEHAALIADHYEEAGDLRAAFTWHMRAGT
Mvan_1904|M.vanbaalenii_PYR-1 NRARAHRLLAGAIETRDPAAKDENAALIATHLEGAGDFETACRWHLRAAD
MAV_4804|M.avium_104 IHCAPRDSATIRFVRQALASHRKWAAGAPENYAAPYALIQGAWARARGQH
.
MMAR_0730|M.marinum_M VPKPIGIAVIENKIIGAAHPAEVVGSG---DGAVRVRTG-----------
MUL_3594|M.ulcerans_Agy99 VPRPTGIAVIENKIIGAAHPAEVVGSG---DGAVRVRTG-----------
Mflv_1395|M.gilvum_PYR-GCK LAASRELHDELINVLGETEFGIGVSAGRAIAGHIGAQAR-----------
TH_0858|M.thermoresistible__bu LAAARELHDELIAVLGETEFGIGVSAGRAIAGHIGAQAR-----------
Mb3669|M.bovis_AF2122/97 LSAARELHDELIPVLGSAEFGIGVSAGRAIAGHIGAQAR-----------
Rv3645|M.tuberculosis_H37Rv LSAARELHDELIPVLGSAEFGIGVSAGRAIAGHIGAQAR-----------
MLBr_00201|M.leprae_Br4923 LSAARELHDELLPVLGSAEFGIGVSAGRAIAGHIGAQAR-----------
MAB_1459c|M.abscessus_ATCC_199 LAAARAIARRLRTEVPECQAGIGVASGQAVAGNIGAHDR-----------
MSMEG_0228|M.smegmatis_MC2_155 WLTNRDIDAARLSWQRARHVADQLPHDAEDRAAMTIAPRTLLCLSTWRAG
Mvan_1904|M.vanbaalenii_PYR-1 WLRMRDLLAARNQWEIAMRVADGLPGADDAVTALRIAPRTMLVSTELFVG
MAV_4804|M.avium_104 GKAERHLHQAIELAEEHRLPAIGARAHEEAAALYAETGRQTLREHMLRSA
: .
MMAR_0730|M.marinum_M -------------------------------------LQVAPFCDLVLDV
MUL_3594|M.ulcerans_Agy99 -------------------------------------LQVAPFCDLVLDV
Mflv_1395|M.gilvum_PYR-GCK -------------------------------------FEYTVIGDPVNEA
TH_0858|M.thermoresistible__bu -------------------------------------FEYTVIGDPVNEA
Mb3669|M.bovis_AF2122/97 -------------------------------------FEYTVIGDPVNEA
Rv3645|M.tuberculosis_H37Rv -------------------------------------FEYTVIGDPVNEA
MLBr_00201|M.leprae_Br4923 -------------------------------------FEYTVIGDPVNEA
MAB_1459c|M.abscessus_ATCC_199 -------------------------------------FEYTVIGDPVNEA
MSMEG_0228|M.smegmatis_MC2_155 GHLS--------------------------------DTGFDELCALAAAA
Mvan_1904|M.vanbaalenii_PYR-1 ADPDN-------------------------------DQRLVELRELTARV
MAV_4804|M.avium_104 YQRWLNLGFAVRADWLAREHPWLLRRDLRTGSAGIDPIGAHQLVHALSGA
: .
MMAR_0730|M.marinum_M AGAQVFAKVVDCGVDGGICE------------------------------
MUL_3594|M.ulcerans_Agy99 AGAQVFAKVVDCGVDGGICE------------------------------
Mflv_1395|M.gilvum_PYR-GCK ARLTELAKLEPGHVLASSLA------------------------------
TH_0858|M.thermoresistible__bu ARLTELAKLEEGHVLASAMA------------------------------
Mb3669|M.bovis_AF2122/97 ARLTELAKLEDGHVLASAIA------------------------------
Rv3645|M.tuberculosis_H37Rv ARLTELAKLEDGHVLASAIA------------------------------
MLBr_00201|M.leprae_Br4923 ARLTELAKLEDGHVLASAIA------------------------------
MAB_1459c|M.abscessus_ATCC_199 ARLCELSKTVPGHLVASLDT------------------------------
MSMEG_0228|M.smegmatis_MC2_155 DDKVSLATAMAGQVSALLVH------------------------------
Mvan_1904|M.vanbaalenii_PYR-1 DDSHSLALALAGRIVTFIVN------------------------------
MAV_4804|M.avium_104 RTPDALANIILGSVADTTGAGRVLFITGEADNQSVRAIHDHGEVLIVEGP
:: :
MMAR_0730|M.marinum_M ---LMAVFTSVSDDVRR----ALAAPSTANSLS-----------------
MUL_3594|M.ulcerans_Agy99 ---LMAVFTSVSDDVRR----ALAAPSTANSLS-----------------
Mflv_1395|M.gilvum_PYR-GCK ---VADALDAEALCWNVGEVVELRGRTAPTQLARPVNLIRPPRVEEKVAD
TH_0858|M.thermoresistible__bu ---VSGALDAEALCWDVGETVELRGRTVPTQLARPVKLAFSNGPGPSNNS
Mb3669|M.bovis_AF2122/97 ---VSGALDAEALCWDVGEVVELRGRAAPTQLARPMNLAAP----EEVSS
Rv3645|M.tuberculosis_H37Rv ---VSGALDAEALCWDVGEVVELRGRAAPTQLARPMNLAAP----EEVSS
MLBr_00201|M.leprae_Br4923 ---VSGALDAEALCWNVGEIVELRGRTAPTQLARPLNLAVP----EQITS
MAB_1459c|M.abscessus_ATCC_199 ---VLRAHHREALHWRSGDTVTLRGRTEPTELAVPV--------------
MSMEG_0228|M.smegmatis_MC2_155 ---AHYR-ESSSLASELTSLLESVGDR-RLTVALLFAALG-AKFQTGEAN
Mvan_1904|M.vanbaalenii_PYR-1 ---SNRVPEALPLAAELAELVDTLGPTPAAELEIIYTAMSFAHLASCEFD
MAV_4804|M.avium_104 WTEVPYRRDVVRRVIDGGAPVIVAADRAAATNSVLAAPIALHDRTLGVIY
.
MMAR_0730|M.marinum_M --------------------------------------------------
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK DVP------STTR-------------------------------------
TH_0858|M.thermoresistible__bu DAPGTRTTGSVSRADAETTAPES---------------------------
Mb3669|M.bovis_AF2122/97 EVRG----------------------------------------------
Rv3645|M.tuberculosis_H37Rv EVRG----------------------------------------------
MLBr_00201|M.leprae_Br4923 EVTG----------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 EVVRLADRLIELADGDANMGNLIIGSPLVTAWTVGGMARACLGDPDWRTG
Mvan_1904|M.vanbaalenii_PYR-1 AALEVIGRSIALEPEYP-------STDRALAYAIGGLCEVCLGSRERGIG
MAV_4804|M.avium_104 AEQGEPGRNFGADHEEAIAFLCAQAAAPLWSFQLEARLRAADEYRQSLID
MMAR_0730|M.marinum_M --------------------------------------------------
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 -LDRATPLVRDFGITTRALMLTYKCIGLPTGLLLPSPELLEESCEVLEVA
Mvan_1904|M.vanbaalenii_PYR-1 HIRLATELARAMSPVSFSAVSLYWGILAAMGMHV-AEDLVDDMREWLARA
MAV_4804|M.avium_104 VQSRFVPNELLRILDIDDLRRVRNGHRVEREMTVLISDIRSYTAMIEDMN
MMAR_0730|M.marinum_M --------------------------------------------------
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 QRSADDLALAGAQVSRGLLLLWQGGPYRDEALELLSLGREASVREQFTMA
Mvan_1904|M.vanbaalenii_PYR-1 ESFGDRFGIIAAQWTYATLLLQAGSPRRDEAFVLLRRAEVGITTHNLQSF
MAV_4804|M.avium_104 VAEAGNLAMGFLRAVELPIISYHGMIQDVRGDEIVAVFESEADAVRAGLG
MMAR_0730|M.marinum_M --------------------------------------------------
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 AVPAVDTELARDMAARGDLDGAIELARDVVDTSIDSGEAINMSASVTVLV
Mvan_1904|M.vanbaalenii_PYR-1 ALAITGMQLAREAARNGHRDEAIDSIRHLVTLHTRDAPLLHLGCPAESLC
MAV_4804|M.avium_104 MLRSLHEHNQERRALGSEELRAGIGINTGAVAVGLVGGVNRMVLTIIGDA
MMAR_0730|M.marinum_M --------------------------------------------------
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 QSLIARGDRDDLDHAQRVIDRFAALPTDPGFVLYDVQLMRLRALLARARG
Mvan_1904|M.vanbaalenii_PYR-1 EMLIDRGGTRDLLEVEEVLEQWCSR--SPGTAPMDLWTIRIRALLASARG
MAV_4804|M.avium_104 VNLAARIESTNKRYGSALLISDRTYQRIAGSEEFDVRRMERVMVVNRRRP
MMAR_0730|M.marinum_M --------------------------------------------------
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 DEERYRECSDRYRELATAYRYEGHMA-----LAARMA-------------
Mvan_1904|M.vanbaalenii_PYR-1 ERQRYAQLADEYAAACEFTGYRHHWGGPYPVLSDRRG-------------
MAV_4804|M.avium_104 VTIYEVYNGDSGPLRAAKRAAQPAFDEAFALFDAGDVDAARAAFQRCRDM
MMAR_0730|M.marinum_M ---------------------------------
MUL_3594|M.ulcerans_Agy99 ---------------------------------
Mflv_1395|M.gilvum_PYR-GCK ---------------------------------
TH_0858|M.thermoresistible__bu ---------------------------------
Mb3669|M.bovis_AF2122/97 ---------------------------------
Rv3645|M.tuberculosis_H37Rv ---------------------------------
MLBr_00201|M.leprae_Br4923 ---------------------------------
MAB_1459c|M.abscessus_ATCC_199 ---------------------------------
MSMEG_0228|M.smegmatis_MC2_155 ---------------------------------
Mvan_1904|M.vanbaalenii_PYR-1 ---------------------------------
MAV_4804|M.avium_104 LPDDPIAPLHLAHCDAVARGEMLPGQEIALQNK