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ESAAQPHRIEVGETVCNDGTVIGHTAAGEGPALVLLPGWSLTAQIFRHQLAGLSRTWRVLAIDHRGHGRS STPQLGYHIHRLAADLRTVLQTHQLDQVHLLGHSMGCAVIWSYLELFGTDRLASLLLVDQMPCALRNPAW TDAQALEAGATMDPAGLFAFTDRLRADGDDPRPDFVTEVVSEGIGAHELAWLVEQGQTLDRRCAADLIFD VATHDWRGLMAHIGLPTLVLAGDSVNVPIASQRWMWRQIPGAQFARVPGRRGGTHFPFLENPQTFNDVVS QHLCAHRPG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2566 | - | - | 100% (290) | hydrolase |
| M. marinum M | MMAR_2866 | ephB | 3e-12 | 35.90% (117) | epoxide hydrolase EphB |
| M. marinum M | MMAR_1997 | - | 4e-11 | 25.70% (284) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2734 | - | 2e-12 | 24.91% (277) | hydrolase |
| M. gilvum PYR-GCK | Mflv_2561 | - | 1e-14 | 27.31% (271) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv2715 | - | 2e-12 | 24.91% (277) | hydrolase |
| M. leprae Br4923 | MLBr_00862 | ephD | 5e-10 | 33.33% (123) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3034 | - | 6e-10 | 24.91% (281) | hydrolase |
| M. avium 104 | MAV_5175 | - | 8e-15 | 27.31% (271) | non-haem bromoperoxidase BPO-A2 |
| M. smegmatis MC2 155 | MSMEG_4707 | - | 6e-12 | 25.67% (261) | non-heme bromoperoxidase BPO-A2 |
| M. thermoresistible (build 8) | TH_0684 | hpx | 4e-13 | 29.39% (279) | POSSIBLE NON-HEME HALOPEROXIDASE HPX |
| M. ulcerans Agy99 | MUL_3195 | - | 1e-169 | 97.59% (290) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_1865 | - | 3e-13 | 28.67% (279) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2566|M.marinum_M --------------------------------------------------
MUL_3195|M.ulcerans_Agy99 MKYPRRRPHKRRRDVHTAHRYPSRPALARMCGERRSQEIHPVERISALGS
Mflv_2561|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4707|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5175|M.avium_104 --------------------------------------------------
Mb2734|M.bovis_AF2122/97 ------------------------MTERKRNLRPVRD-------------
Rv2715|M.tuberculosis_H37Rv ------------------------MTERKRNLRPVRD-------------
MAB_3034|M.abscessus_ATCC_1997 ------------------------MNPPPRLLRPVPDTEHIDGVDGGGDT
TH_0684|M.thermoresistible__bu --------------------------------------------VEQMPP
Mvan_1865|M.vanbaalenii_PYR-1 ----------------------------MAPGTSTRSRSRGFAPAQALPP
MLBr_00862|M.leprae_Br4923 -----------------------------------------MPATQSIHK
MMAR_2566|M.marinum_M --MESAAQPHRIEVGETVCNDGTVIGHTAAGEGPALVLLPGWSLTAQIFR
MUL_3195|M.ulcerans_Agy99 KPMESAAQPHRIEVGETVCNDGTVIGHTAAGEGPALALLPGWSLTAQIFR
Mflv_2561|M.gilvum_PYR-GCK --MTMITAYRGPLRSTDLHVD------DSGGDGRPVVLIHGWPLHSDSWA
MSMEG_4707|M.smegmatis_MC2_155 --MAAITAYRGLLRSIELHVE------DTGGAGRPVVLVHGWPLTGESWG
MAV_5175|M.avium_104 --MPDVIAHHGLLKDTRLHVD------DTGGPGRPVLLMHPWPLSGQSWS
Mb2734|M.bovis_AF2122/97 -----VAPPTLQFRTVHGYRR----AFRIAGSGPAILLIHGIGDNSTTWN
Rv2715|M.tuberculosis_H37Rv -----VAPPTLQFRTVHGYRR----AFRIAGSGPAILLIHGIGDNSTTWN
MAB_3034|M.abscessus_ATCC_1997 PSAATSTRPRLAFRTIHGYRR----AYRIAGSGPVLLLIHGIGDNSATWD
TH_0684|M.thermoresistible__bu GRVVSVTAPDGVRLHAEVFGP---------ADAPPIVLAHGITCAIRVWA
Mvan_1865|M.vanbaalenii_PYR-1 GRIVDVRSKDGVRLHAEVFGP---------EDGYPIVLAHGITCSLRVWA
MLBr_00862|M.leprae_Br4923 VPHQFVESPDGVRLAIYQSGQ---------PEGPAIVLVHGFPDSHVLWD
. : * :
MMAR_2566|M.marinum_M HQLAGLSRT-WRVLAIDHRGHGRSSTP--QLGYHIHRLAADLRTVLQTHQ
MUL_3195|M.ulcerans_Agy99 HQLAGLSHT-WRVLAIDHRGHGRSSTP--QLGYHIHRLAADLRTVLQTHQ
Mflv_2561|M.gilvum_PYR-GCK HQVDALRDAGYRVITYDRRGFGRSDKP--LIGYTYESLSDDLSAVLEELD
MSMEG_4707|M.smegmatis_MC2_155 AQVEALTAAGHRVITYDRRGFGRSDTS--LVGYTYEALSDDLAAVLDELD
MAV_5175|M.avium_104 AQVPVLHAAGYRVVTYDRRGFGRSDKP--LTGYSYSQLTQDLHTLVESLD
Mb2734|M.bovis_AF2122/97 GVHAKLAQR-FTVIAPDLLGHGQSDKP--RADYSVAAYANGMRDLLSVLD
Rv2715|M.tuberculosis_H37Rv GVHAKLAQR-FTVIAPDLLGHGQSDKP--RADYSVAAYANGMRDLLSVLD
MAB_3034|M.abscessus_ATCC_1997 SVHAQLAEH-FTVIAPDLLGHGQSDKP--RADYSVAAYANGMRDLLAVLD
TH_0684|M.thermoresistible__bu HQIAELADD-YRVIAFDHRGHGRSSVPRRRWQYSLDHLASDLDAVLDATL
Mvan_1865|M.vanbaalenii_PYR-1 YQIAELARD-HRVIAFDHRGHGRSAIPPRRGGYSLDYLAGDLDAVLEATL
MLBr_00862|M.leprae_Br4923 GVVPLLAKR-FRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELS
* :: * * *:* . * : .: ::
MMAR_2566|M.marinum_M --LDQVHLLGHSMGCAVIWSYLELFGT---DRLASLLLVDQMPCALRN--
MUL_3195|M.ulcerans_Agy99 --LDQVHLLGHSMGCAVIWSYLELFGT---DRLASLLLVDQMPCALRN--
Mflv_2561|M.gilvum_PYR-GCK --LTDVTLVGFSMGGGEVAAYCARKGV---ERIRSVVFASSVTPFMSA--
MSMEG_4707|M.smegmatis_MC2_155 --VRDATLVGFSMGTGEVAAYCARKGT---ERLRSVVLAAPVTPYMLN--
MAV_5175|M.avium_104 --LRDLTLVGSSMGGGEVARYLSTYGP---ERVRSVVFASSVTPYLLQ--
Mb2734|M.bovis_AF2122/97 --IERVTIVGHSLGGGVAMQFAYQFPQ---LVDRLILVSAGGVTKDVN--
Rv2715|M.tuberculosis_H37Rv --IERVTIVGHSLGGGVAMQFAYQFPQ---LVDRLILVSAGGVTKDVN--
MAB_3034|M.abscessus_ATCC_1997 --IERVTVVGHSLGGGVAMQFTYQFPH---LVERLILVAPGGVTKDVN--
TH_0684|M.thermoresistible__bu DPGERAVIAGHSMGGIAISSWAERYPERVSERAAAVALINTTTGDLLHNV
Mvan_1865|M.vanbaalenii_PYR-1 APGERAVIAGHSMGGIAISSWSERLPHRVEQRADAVALINTTTGDLLRNV
MLBr_00862|M.leprae_Br4923 -PDRPVHVLAHDWGSVGVWEYLSRSGAS--DRVASFTSVSGPSQDQLVDY
: . . * : .
MMAR_2566|M.marinum_M ---PAWTDAQALEAGATMDPAGLFAFTDRLRADGDDPRPDFVTEVVSEGI
MUL_3195|M.ulcerans_Agy99 ---PAWTGAQALEAGATMDPTGLFAFTDRLRADGDDPRPDFVTEVVSEGI
Mflv_2561|M.gilvum_PYR-GCK ---RKDNPEGPLGKLEAARMA--ASLTTDQDAFFEQFMTDVFSADGELQV
MSMEG_4707|M.smegmatis_MC2_155 ---TADNPEGPLSKTQAAQMA--AALTTNSDAFYREMMTGVFSADGVLTI
MAV_5175|M.avium_104 ---TTDNPDGPLTMKDAARAT--ASFVKDQDAFYDHQMTEFFSANGQLRV
Mb2734|M.bovis_AF2122/97 ---IVFRLASLPMGSEAMALLRLPLVLPAVQIAGRIVGKAIGTTSLGHDL
Rv2715|M.tuberculosis_H37Rv ---IVFRLASLPMGSEAMALLRLPLVLPAVQIAGRIVGKAIGTTSLGHDL
MAB_3034|M.abscessus_ATCC_1997 ---IVLRCASLPFIGDALGLLRLPMAMPMLRLGGAVARATFGRASMARDI
TH_0684|M.thermoresistible__bu QLLPVPDRFAAVRVRTASAVIKTVAGMP-ARLAAVPSRYVVSMMAVGRDA
Mvan_1865|M.vanbaalenii_PYR-1 NLLPVPPALADVRVRAAGEVLRRFGGVPLVRAVDRPNRRFVSSIAVGRDA
MLBr_00862|M.leprae_Br4923 ILSGLRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIR
:
MMAR_2566|M.marinum_M GAHE---LAWLVEQGQTLDRRCAADLIFDVA-------THDWRGLMAHIG
MUL_3195|M.ulcerans_Agy99 GADE---LAWPVEQGQTLDRRCAADLIFDVA-------THDWRGLMAHIG
Mflv_2561|M.gilvum_PYR-GCK TEQE---RQEALSMCGDADKPATLACMAAFG-------GTDFREDLPKVT
MSMEG_4707|M.smegmatis_MC2_155 SEDA---LQQVLDMCGQASKNAALACMAAFS-------NTDFREDLPRVT
MAV_5175|M.avium_104 SPAT---RAEALRLCKQAGKEASLACMAAWA-------NTDFRPDLTRVS
Mb2734|M.bovis_AF2122/97 PNVLR-ILDDLPEPTASAAFGRTLRAVVDWRGQM----VTMLDRCYLTEA
Rv2715|M.tuberculosis_H37Rv PNVLR-ILDDLPEPTASAAFGRTLRAVVDWRGQM----VTMLDRCYLTEA
MAB_3034|M.abscessus_ATCC_1997 PDVLR-VLADLPEPRASAAFTRTLRAVVDWRGQV----VTMLDRCYLTES
TH_0684|M.thermoresistible__bu DPAITNFVHELFTETPPAARDGWARTLVDAMG--------PRHIGLHNLT
Mvan_1865|M.vanbaalenii_PYR-1 DPAIADFVFELFNSTSPAGRGGWARVLVDHLG--------PRHIALKNLT
MLBr_00862|M.leprae_Br4923 RTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVN
MMAR_2566|M.marinum_M LPTLVLAGDS-VNVPIAS-QRWMWRQIPGAQFARVPGRRGGTHFPFLENP
MUL_3195|M.ulcerans_Agy99 LPTLVLAGDS-VNVPIAS-QRWMWQQIPGAQFARVPGRRGGTHFPFLENP
Mflv_2561|M.gilvum_PYR-GCK VPSLVIHGDSDATVPFEGSGKRTYELLPDGRLHVIAG---GPHGIPVSHA
MSMEG_4707|M.smegmatis_MC2_155 VPALVIHGDADATTPLQNCGERTHAALPNSRLHVISG---GPHGIPVSHT
MAV_5175|M.avium_104 VPALIIHGEGDESVPLAGSARRTHRAIPGSRLCVIAD---GPHGCHISHA
Mb2734|M.bovis_AF2122/97 IPVQIIWGTKDVVLPVRH-AHMAHAAMPGSQLEIFEG---SGHFPFHDDP
Rv2715|M.tuberculosis_H37Rv IPVQIIWGTKDVVLPVRH-AHMAHAAMPGSQLEIFEG---SGHFPFHDDP
MAB_3034|M.abscessus_ATCC_1997 VPVQLIWGSDDLVIPVSH-GHLAHAAMPGSALEIFDK---SGHFPFHDDP
TH_0684|M.thermoresistible__bu VPTLVIGSDRDRLLPLVSSRRIAEAAPNLFDFVELPG----GHCAILECP
Mvan_1865|M.vanbaalenii_PYR-1 VPTLVIGSTKDRLLPMASARRIAATAPNLARFVEVPG----GHCAILERP
MLBr_00862|M.leprae_Br4923 VPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAG-----HFSPMSHP
:* :: . * . .
MMAR_2566|M.marinum_M QTFNDVVSQHLCAHRPG---------------------------------
MUL_3195|M.ulcerans_Agy99 QTFNDVVSQHLCAHRPG---------------------------------
Mflv_2561|M.gilvum_PYR-GCK DEFNAVLLEFLEQDFADGRGR-----------------------------
MSMEG_4707|M.smegmatis_MC2_155 EEFNRVLLDFLAEDLAAAR-------------------------------
MAV_5175|M.avium_104 QEFNAALLDFLAA-------------------------------------
Mb2734|M.bovis_AF2122/97 ARFIDIVERFMDTTEPAEYDQAALRALLRRGGGEATVTGSADTRVAVLNA
Rv2715|M.tuberculosis_H37Rv ARFIDIVERFMDTTEPAEYDQAALRALLRRGGGEATVTGSADTRVAVLNA
MAB_3034|M.abscessus_ATCC_1997 ERFIGIVRQFIASTEPGEYNEDELRRLLRTGVTEHAISGAARTRMAVLDA
TH_0684|M.thermoresistible__bu DRVNDHLRALAAAAADARRATS----------------------------
Mvan_1865|M.vanbaalenii_PYR-1 DDVNDHLRWLVRSVTGQGDATGATG-------------------------
MLBr_00862|M.leprae_Br4923 QVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIG
. :
MMAR_2566|M.marinum_M --------------------------------------------------
MUL_3195|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2561|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4707|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5175|M.avium_104 --------------------------------------------------
Mb2734|M.bovis_AF2122/97 IGSNERSAT-----------------------------------------
Rv2715|M.tuberculosis_H37Rv IGSNERSAT-----------------------------------------
MAB_3034|M.abscessus_ATCC_1997 MGTDERSAT-----------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
Mvan_1865|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 RETALALARRGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAA
MMAR_2566|M.marinum_M --------------------------------------------------
MUL_3195|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2561|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4707|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5175|M.avium_104 --------------------------------------------------
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
Rv2715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3034|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
Mvan_1865|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 VEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVV
MMAR_2566|M.marinum_M --------------------------------------------------
MUL_3195|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2561|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4707|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5175|M.avium_104 --------------------------------------------------
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
Rv2715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3034|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
Mvan_1865|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 NCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDC
MMAR_2566|M.marinum_M --------------------------------------------------
MUL_3195|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2561|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4707|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5175|M.avium_104 --------------------------------------------------
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
Rv2715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3034|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
Mvan_1865|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMM
MMAR_2566|M.marinum_M --------------------------------------------------
MUL_3195|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2561|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4707|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5175|M.avium_104 --------------------------------------------------
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
Rv2715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3034|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
Mvan_1865|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 FRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTA
MMAR_2566|M.marinum_M -----
MUL_3195|M.ulcerans_Agy99 -----
Mflv_2561|M.gilvum_PYR-GCK -----
MSMEG_4707|M.smegmatis_MC2_155 -----
MAV_5175|M.avium_104 -----
Mb2734|M.bovis_AF2122/97 -----
Rv2715|M.tuberculosis_H37Rv -----
MAB_3034|M.abscessus_ATCC_1997 -----
TH_0684|M.thermoresistible__bu -----
Mvan_1865|M.vanbaalenii_PYR-1 -----
MLBr_00862|M.leprae_Br4923 RIRVI